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3D Printing of tough Hydrogel Scaffolds with Functional Surface Structures for tissue Regeneration

Nano-Micro Letters 2025年第2期17卷 18-45页

作者： ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He State key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-t,cross-linking-C,PtC&PCt)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(t).Finally,the training results are fixed by photo-cross-linking processing(C).the tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PtC or PCt *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing tough hydrogel scaffold Functional surface structure tissue regeneration Biomaterials

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Structure Heterogeneity in Metallic Glass: Modeling and Experiment

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Journal of Materials Science & technology 2014年第6期30卷 560-565页

作者： H.B.ke J.F.Zeng C.t.Liu Y.Yang Centre for Advanced Structural Materials Department of Mechanical and Biomedical EngineeringCity University of Hong Kong

Despite the great efforts dedicated to metallic glasses （MGs）, their structure still remains a mystery to be understood. With comparison to the existing mJciomechanical models, such as the free-volume and shear transformation zone （StZ） models, we first discuss in this article our recently proposed ＇core-shell＇ model, which contains a solid-like matrix and liquid-like inclusions. this serves as the theoretical basis to understand the structural heterogeneity in MGs in our analytical framework. After that, a scanning ultrafast nanoindentation technique is used to map out the structure heterogeneity in a Zr-based bulk metallic glass （BMG）. With these ongoing research efforts, we hope that more research work could be stimulated in the pursuit of the structure-property relation in MGs.

关键词： Metallic glass Structure heterogeneity Nanoindentation Core-shell model

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Introduction to the CDEX experiment

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Frontiers of physics 2013年第4期8卷 412-437页

作者： ke-Jun Kang Department of Engineering Physics Tsinghua University Beijing 100084

It is believed that weakly interacting massive particles （WIMPs） are candidates for dark matter （DM） in our universe which come from outer space and might interact with the standard model （SM） matter of our detectors on the earth. Many collaborations in the world are carrying out various experiments to directly detect DM particles. China Jinping underground Laboratory （CJPL） is the deepest underground laboratory in the world and provides a very promising environment for DM search. China Dark matter EXperiment （CDEX） is going to directly detect the WIMP flux with high sensitivity in the low WIMP-mass region. Both CJPL and CDEX have achieved a remarkable progress in recent three years. CDEX employs a point-contact germanium （PCGe） semi-conductor detector whose energy threshold is less than 300 eV. In this report we present the measurement results of muon flux, monitoring of radioactivity and radon concentration carried out in CJPL, as well describing the structure and performance of the 1 kg-PCGe detector in CDEX-1 and 10 kg- PCGe detector array in CDEX-10 including the detectors, electronics, shielding and cooling systems. Finally we discuss the physics goals of CDEX-1, CDEX-10 and the future CDEX-1t experiments.

关键词： China Dark matter EXperiment (CDEX) dark matter poit-contact germanium detector China Jinping underground Laboratory (CJPL)

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Cytotoxicity of ti–6Al–4V–5Cu Alloy to MC3t3-E1 Cells

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Acta Metallurgica Sinica(English Letters) 2021年第5期34卷 694-700页

作者： Ji Zhang Ling Ren ke Yang Institute of Metal Research Chinese Academy of SciencesShenyang110016China

the aim of this work was to study the cytotoxicity of ti–6 Al–4 V–5 Cu(tC4–Cu)alloy for dental applications and evaluate the cell viability of diff erent fabricated tC4–Cu alloys in contact with MC3 t3-E1 cells in ***–6 Al–4 V(tC4)alloy was used as a negative control to evaluate the cytotoxicity level of tC4–Cu alloy so as to provide basic support for the dental clinical *** group tC4 and experimental group tC4–Cu with diff erent fabrications were incubated in the cell culture *** absorbance value of mouse osteoblast MC3 t3-E1 cells was detected by CCK-8 assay after 1,3 and 7 days,*** relative proliferation rate of cells was calculated,and then the toxicity level was valued for each *** morphology on the surface was also studied by observing the cytoskeleton through F-actin filament *** experimental results showed that the absorbance values for the experimental and the negative control groups were not same at diff erent time *** with diff erent fabricated tC4–Cu alloys,the annealing-tC4–Cu alloy showed much better *** mouse osteoblast MC3 t3-E1 cells cultured with annealing-tC4–Cu,rolling-tC4–Cu and solution+aging-tC4–Cu have no toxic eff ects,and these alloys could promote the proliferation of mouse osteoblasts.

关键词： Cytotoxicity ti–6Al–4V–5Cu alloy Fabrication Biocompatibility

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Limiting current oxygen sensor based on Y,In co-doped SrtiO_(3)as a dense diffusion barrier layer

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Nano Research 2022年第6期15卷 4880-4885页

作者： ke Shan Zhongzhou Yi Jing Wang College of Science Honghe UniversityMengzi 661199China

A novel dense diffusion barrier material(Y_(x)Sr_(1−x)ti_(0.9)In_(0.1)O_(3−δ)(x=0.03,0.05,0.07))was prepared by using a sol-gel *** crystal structure,microstructures,electrical conductivity and ionic conductivity of barrier material were *** results show that the samples exhibit the formation of cubic perovskite structure *** increase of Y-doping amount on A-site improved electrical conductivity and sinterability of materials.A limiting current oxygen sensor based on Y_(0.07)Sr_(0.97)ti_(0.9)In_(0.1)O_(3–δ)as a dense diffusion barrier shows excellent sensing *** linear relationship between limiting current logIL and 1000/t can described logIL=4.603,8−3.847,5·1,000/*** 750°C,0.25%≤x(O_(2))≤5.0%,the linear relationship between limiting current(IL)and oxygen amount(x(O_(2)))can described as I_(L)=7.047,6+3.875,1·x(O_(2)).

关键词： limiting current oxygen sensor dense diffusion barrier strontium titanate mixed conductivity

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ALtERNAtIVE MEtHODS FOR CONDUCtING COMPARAtIVE ANALYSES OF CADAStRAL SYStEMS

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Chinese Geographical Science 2002年第4期12卷 366-372页

作者： BELEJMiroslaw ZROBEKSabina LIANGLiu-ke DepartmentofGeodesyandLandManagement FacultyofLandManagementandRuralDevelopmentUniversityofWarmiaandMazuryinOlsztyn10-724OlsztynPrawochenskiego15Poland CollegeofEnvironmentandPlanning HenanUniversityKaifeng475001P.R.China

the conception of an efficient cadastral system is an important element in the development of each *** is crucial for the efficient operation of the real estate market-the security and liberty of making tr ansactions,register-ing a property,planning operations,the introduction of an ad valorem tax on property and more rational use of *** Europe there are different types of c adastral systems,because the count ries in Europe have different cultur al back-grounds,different economical and s ocial *** the cent uries,many types of cadastral syste ms evolved and their differences often depend u pon local cultural heritage,physic al geography,land use,technology,***-tive analyses of cadastral systems h ave been the subjects of many publica tions and studies in world literatur *** was as-sessed that the useful tools in conducting comparative analyses of vario us cadastral systems include the pro cedures of statisti-cal *** paper presents t he results of a project to compare the performance of ten cadastral system s international-ly by creating appropriate integrated indicators of a cadastral system u sing statistical *** in dicators will make it possible to compare differen t cadastral systems and present them hierarchically in relation to their quality,struc-ture,as well as legal,organization al and technological *** m a good number of methods available,techniques originating from two spheres of statistic inference were selected:distribution free methods and multivariate analysis *** analyses with the distribut ion free methods,FRIEDMAN’s test(FRIENDMAN’s non-parametric varian ce analy-sis)as well as keNDALL’s test.keNDALL’s compatibility ratio)were *** analyses with the multivariate analy-sis methods,factor analysis was selected.

关键词： cadastral system comparative analyses statistical techniques indicators property

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PPP models and performances from single-to quad-frequency BDS observations

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Satellite Navigation 2020年第1期1卷 179-191页

作者： Shuanggen Jin ke Su Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China School of Remote Sensing and Geomatics Engineering Nanjing University of Information Science and TechnologyNanjing 210044China Jiangsu Engineering Center for Collaborative Navigation/Positioning and Smart Applications Nanjing 210044China University of Chinese Academy of Sciences Beijing 100049China

Nowadays,China BeiDou Navigation Satellite System(BDS)has been developed well and provided global services with highly precise positioning,navigation and timing(PNt)as well as unique short-message communication,particularly global system(BDS-3)with higher precision multi-frequency *** precise point positioning(PPP)can provide the precise position,receiver clock,and zenith tropospheric delay(ZtD)with a stand-alone receiver compared to the traditional double differenced relative positioning mode,which has been widely used in PNt,geodesy,meteorology and so ***,it has a lot of challenges for multi-frequency BDS PPP with different strategies and more unknown *** this paper,the detailed PPP models using the single-,dual-,triple-,and quad-frequency BDS observations are presented and ***,BDS system and PPP method are ***,the stochastic models of time delay bias in BDS-2/BDS-3 PPP including the neglection,random constant,random walk and white noise are ***,three single-frequency,four dual-frequency,four triple-frequency and four quad-frequency BDS PPP models are ***,the BDS PPP models progress and performances including theoretical comparison of the models,positioning performances,precise time and frequency transfer,ZtD,inter-frequency bias(IFB)and differential code bias(DCB)are presented and evaluated as well as future *** results show that the multi-frequency BDS observations will greatly improve the PPP performances.

关键词： BDS GNSS PPP IFB ZtD DCB

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Ramp Scheme Based on CRt for Polynomial Ring over Finite Field

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Journal of Systems Science & Complexity 2023年第1期36卷 129-150页

作者： DING Jian ke Pinhui LIN Changlu WANG Huaxiong College of Computer and Cyber Security Fujian Normal UniversityFuzhou 350007China School of Mathematics and Big Data Chaohu UniveristyHefei 238024China School of Mathematics and Statistics and Fujian Provincial Key Lab of Network Security and CryptologyFujian Normal UniversityFuzhou 350007China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 639798Singapore

Chinese Reminder theorem(CRt)for integers has been widely used to construct secret sharing schemes for different scenarios,but these schemes have lower information rates than that of Lagrange interpolation-based *** ASIACRYPt 2018,Ning,et *** a perfect(r,n)-threshold scheme based on CRt for polynomial ring over finite field,and the corresponding information rate is one which is the greatest case for a(r,n)-threshold ***,for many practical purposes,the information rate of Ning,et *** is low and perfect security is too much *** this work,the authors generalize the Ning,et al.(r,n)-threshold scheme to a(t,r,n)-ramp scheme based on CRt for polynomial ring over finite field,which attains the greatest information rate(r−t)for a(t,r,n)-ramp ***,for any given 2≤r_(1)the ramp scheme can be used to construct a(r_(1),n)-threshold scheme that is threshold changeable to(r′,n)-threshold scheme for all r′∈{r_(1)+1,r_(1)+2,···,r_(2)}.the threshold changeable secret sharing(tCSS)scheme has a greater information rate than other existing tCSS schemes of this type.

关键词： Chinese Reminder theorem polynomial ring ramp scheme threshold changeable secret sharing

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Multilocus Phylogeny of Lycodon and the taxonomic Revision of Oligodon multizonatum

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Asian Herpetological Research 2014年第1期5卷 26-37页

作者： Juan LEI Xiaoyu SUN ke JIANG Gernot VOGEL David t.BOOtH Li DING Chengdu Institute of Biology Chinese Academy of Sciences College of Life and Sciences Sichuan University School of Biological Science The University of Queensland State key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Society for Southeast Asian Herpetology

Classification of the Asian snake genera Lycodon and Oligodon has proven challenging. We conducted a molecular phylogenetic analysis to estimate the phylogenetic relationships in the genus of Lycodon and clarify the taxonomic status of Oligodon multizonatum using mitochondrial（cyt b, ND4） and nuclear（c-mos） genes. Phylogenetic trees estimated using Maximum Likelihood and Bayesian Inference indicated that O. multizonatum is actually a species of Lycodon. Comparing morphological data from O. multizonatum and its closest relatives also supported this conclusion. Our results imply that a thorough review of the evolutionary relationships in the genus of Lycodon is strong suggested.

关键词： Bayesian inference China classifi cation c-mos cyt b Lycodon maximum likelihood ND4 Oligodon

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Corrosion of Artificial Aged Magnesium Alloy AZ80 in 3.5 wt pct NaCl Solutions

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Journal of Materials Science & technology 2007年第3期23卷 353-358页

作者： Rongchang ZENG Enhou HAN Wei ke Environmental Corrosion Center Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Department of Materials Science Chongqing Institute of Technology Chongqing 400050 China

the corrosion morphologies of aged magnesium alloy AZ80 were investigated by immersion corrosion tests, scanning electron microscopy （SEM）, electrochemical measurement. the t5 heat treatment was carried out in a vacuum furnace, holding for 16 h at 177℃, and then cooling in air. the results showed intergranular corrosion （IGC） occurred as an aged AZ80 sample was immersed in 3.5 wt pct NaCI aqueous solution for 1 h and the narrow path attack progressed predominantly along the bulk β phase in the grain boundaries or took place in the eutectic areas. IGC was attributed to the network distribution of β phase along the grain boundaries, the depleted aluminium in the precipitation areas and the breakdown potential.

关键词： Magnesium alloy AZ80 Intergranular corrosion NaCl solution

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