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Analytical Solution for the Reissner-Sagoci Problem of a Piezoelectric Half-Space

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Acta Mechanica Solida Sinica 2024年第3期37卷 363-370页

作者： Keqiang hu Cun-Fa Gao Zengtao Chen Zheng Zhong State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China Department of Mechanical Engineering University of AlbertaEdmontonABT6G 1H9Canada School of Science Harbin Institute of TechnologyShenzhen518055China

In this paper,a transversely isotropic piezoelectric half-space with the isotropy axis parallel to the z-axis is considered under rotation on a rigid circular disk bonded to the surface of the piezoelectric *** is a type of Reissner-Sagoci mixed boundary value *** utilizing the Hankel transform,the mixed boundary value problem is simplified into solving a pair of dual integral ***-field analytical expressions for displacement,stresses,and electric displacement inside the half-space are *** shear stresses and electric displacement on the surface are found to be singular at the edge of the rigid circular disk,and the stress intensity factors and electric displacement intensity factor are *** results show that material properties and geometric size have significant effects on displacement,shear stresses,and electric displacement.

关键词： Piezoelectric half-space Circular disk Reissner-Sagoci problem Stress intensity factor Electric displacement intensity factor

Mutations in Ras homolog family member A in patients with peripheral t-cell lymphoma and implications for personalized medicine

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Cancer Biology & Medicine 2024年第9期21卷 754-768页

作者： Lina hu Xuanye Zhang Shengbing Zang Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060China

Genome sequencing has revealed frequent mutations in Ras homolog family member A(RHOA)among various cancers with unique aberrant profiles and pathogenic effects,especially in peripheral t-cell lymphoma(PtCL).the discrete positional distribution and types of RHOA amino acid substitutions vary according to the tumor type,thereby leading to different functional and biological properties,which provide new insight into the molecular pathogenesis and potential targeted therapies for various ***,the similarities and discrepancies in characteristics of RHOA mutations among various histologic subtypes of PtCL have not been fully *** we highlight the inconsistencies and complexities of the type and location of RHOA mutations and demonstrate the contribution of RHOA variants to the pathogenesis of PtCL by combining epigenetic abnormalities and activating multiple downstream *** promising potential of targeting RHOA as a therapeutic modality is also *** review provides new insight in the field of personalized medicine to improve the clinical outcomes for patients.

关键词： Drug target mutation pathogenesis personalized medicine peripheral t-cell lymphoma Ras homolog family member A

A Quasi-Linear Relationship between Planetary Outgoing Longwave Radiation and Surface temperature in a Radiative-Convective-transportive Climate Model of a Gray Atmosphere

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Advances in Atmospheric Sciences 2024年第1期41卷 8-18页

作者： Jie SUn Michael SECOR Ming CAI Xiaoming hu Department of Earth Oceanand Atmospheric ScienceFlorida State UniversityTallahasseeFlorida 32304USA School of Atmospheric Sciences Sun Yat-sen University and Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Guangdong Province Key Laboratory for Climate Change and natural Disaster Studies Zhuhai 519082China

In this study,we put forward a radiative-convective-transportive energy balance model of a gray atmosphere to examine individual roles of the greenhouse effect of water vapor,vertical convection,and atmospheric poleward energy transport as well as their combined effects for a quasi-linear relationship between the outgoing longwave radiation(OLR)and surface temperature(t_(S)).the greenhouse effect of water vapor enhances the meridional gradient of surface temperature,thereby directly contributing to a quasi-linear OLR-t_(S) *** atmospheric poleward energy transport decreases the meridional gradient of surface *** a result of the poleward energy transport,tropical(high-latitude)atmosphere-surface columns emit less(more)OLR than the solar energy input at their respective locations,causing a substantial reduction of the meridional gradient of the *** combined effect of reducing the meridional gradients of both OLR and surface temperature by the poleward energy transport also contributes to the quasi-linear OLR-t_(S) *** convective energy transport reduces the meridional gradient of surface temperature without affecting the meridional gradient of OLR,thereby suppressing part of the reduction to the increasing rate of OLR with surface temperature by the greenhouse effect of water vapor and poleward energy *** of the nature of the energy balance in the climate system,such a quasi-linear relationship is also a good approximation for the relationship between the annual-mean net downward solar energy flux at the top of the atmosphere and surface temperature.

关键词： outgoing longwave radiation greenhouse effect poleward energy transport

triple signal amplification electrochemical sensing platform for Hg^(2+) in water without direct modification of the working electrode

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 157-167页

作者： Liuyin hu Jiahua Cui tao Lu Yalin wang Jinping Jia School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China International Copper Association Ltd.Shanghai 200020China

An ultrasensitive electrochemical biosensor to detect trace Hg^(2+)in environmental samples was developed utilizing nanogold-decorated magnetic reduced graphene oxide(MrGO-AunPs),exonuclease III-assisted target cycle(Exo Ⅲ-AtC)and hybridization chain reaction(HCR)synergistic triple signal *** MrGO-AunPs is a superior carrier for capture DnA(cDnA)and acts as magnetic media for automatic separation and *** innovative utilization of the magnetism and improved sensing efficiency obviates the need for direct modification and repeated polishing of the working ***,the three DnA hairpins(cDnA,methylene blue(MB)labeled HP1 and HP2)further contribute to biosensor specificity and *** cDnA captures Hgt,it activates Exo Ⅲ-AtC due to the formation of a sticky end in the DnA stem via thymine-Hig-thymidine(t-Hg^(2+)-t),this leads to the hydrolysis of self-folded DnA by Exo Ⅲ-AtC to form"key"DnA(kDnA).the kDnA subsequently initiates HCR,resulting in massive super-sandwich structures(kDnA-[HP1/HP2])carrying signaling molecules on MrGO-AunPs,and this overall structure serves as a signal probe(SP).Leveraging magnetic adsorption,the SP was automatically adsorbed onto the magneto-glass carbon electrode(MGCE),generating an amplified *** biosensor's detection limit(LOD)was 3.14 pmol/L,far below the limit of 10 nmol/L for mercury in drinking water set by the US *** biosensor also showed excellent selectivity when challenged by interfering ions,and the results of its application in actual samples indicate that it has good potential for practical applications in environmental monitoring.

关键词： Electrochemical sensing Hg^(2+) Amplification Graphene Hybridization chain reaction Exonuclease Ⅲ

Defect-mode and Fabry-Perot resonance induced multi-band nonreciprocal thermal radiation

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Science China(technological Sciences) 2024年第8期67卷 2405-2412页

作者： CHEn ZiHe YU ShiLv YUAn Cheng CUI XinYou hu Run School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan 430074China wuhan Fiberhome Fuhua Electric Co. Ltd.Wuhan 430074China

According to Kirchhoff's radiation law,the spectral-directional absorptivity(α)and spectral-directional emissivity(e)of an object are widely believed to be identical,which places a fundamental limit on photonic energy conversion and *** introduction of weyl semimetals and magneto-optical(MO)materials into photonic crystals makes it possible to violate Kirchhoff's law,but most existing work only report the unequal absorptivity and emissivity spectra in a single band,which cannot meet the requirements of most practical ***,we introduce a defect layer into the structure composed of one-dimensional(1D)magnetophotonic crystal and a metal layer,which realizes dual-band nonreciprocal thermal radiation under a 3-t magnetic field with an incident angle of 60°.the realization of dual-band nonreciprocal radiation is mainly due to the Fabry-Perot(FP)resonance occurring in the defect layer and the excitation of tamm plasmon,which is proved by calculating the magnetic field *** addition,the effects of incident angle and structural parameters on nonreciprocity are also *** is more,the number of nonreciprocal bands could be further increased by tuning the defect layer *** the defect layer thickness increases to 18.2μm,tri-band nonreciprocal thermal radiation is realized due to the enhanced number of defect modes in the photonic band gap and the FP resonance occurring in the defect ***,the effect of defect location on nonreciprocity is also *** present work provides a new way for the design of multi-band or even broad-band nonreciprocal thermal emitters.

关键词： Kirchhoff's law multi-band nonreciprocal thermal radiation magnetophotonic crystal tamm plasmon defect layer Fabry-Perot resonance

A two-pronged strategy utilizing exosomes extracted from antigenpresenting cells to combat hepatitis B

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nano Research 2024年第10期17卷 9084-9094页

作者： Fumin hu Dangyang wang ting Lu Guanghui Ma hua Yue State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100190China

Chronic hepatitis B(CHB)is consistently challenging to conquer with numerous complications and *** the effectiveness of antiviral therapies in suppressing hepatitis B virus(HBV)replication,there is an urgent need for novel and more effective treatment *** strategies predominantly emphasize immune activation but still face challenges in sufficiently eliciting t cell *** into account the targeted delivery of nanoparticles to the liver and spleen via intravenous injection,we have proposed a dual-pronged therapeutic strategy based on antigen-presenting cells(APCs)-derived ***,exosomes targeted to the spleen can activate specific immune responses,while those targeted to the liver can modulate or reverse the liver’s immunosuppressive *** immunization,exosome formulations exhibit the remarkable ability to effectively activate APCs,thereby triggering the proliferation of CD8^(+)t ***,they also play an immunoregulatory role by converting M2 macrophages into M1 *** two-pronged therapeutic strategy precisely addresses the issues of t cell dysfunction and immune suppression,both characteristic features of CHB *** combined with Aluminum(Alum)-adjuvanted vaccine,these exosome formulations not only demonstrate a high level of cellular immune response but also secrete specific antibodies comparable to those induced by Alum *** combined approach effectively enhances both cellular and humoral immunity,offering a promising avenue for the development of therapeutic hepatitis B vaccines based on exosome formulations.

关键词： chronic hepatitis B antigen-presenting cells(APCs)-derived exosomes immunoregulatory role two-pronged therapeutic strategy

Ramsey numbers of trees Versus Multiple Copies of Books

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 600-612页

作者： Xiao-bing GUO Si-nan hu Yue-jian PEnG School of Mathematical Sciences Luoyang Normal UniversityLuoyang 471934China School of Mathematics Hunan UniversityChangsha 410082China

Given two graphs G and H,the Ramsey number R(G,H) is the minimum integer n such that any two-coloring of the edges of K_(n) in red or blue yields a red G or a blue *** v(G) be the number of vertices of G and χ(G) be the chromatic number of *** s(G) denote the chromatic surplus of G,the number of vertices in a minimum color class among all proper χ(G)-colorings of *** showed that R(G,H)≥(v(G)-1)(χ(H)-1)+s(H) if G is connected and v(G)≥s(H).A connected graph G is H-good if R(G,H)=(v(G)-1)(χ(H)-1)+s(H).Let tH denote the disjoint union of t copies of graph H,and let G∨H denote the join of G and *** a complete graph on n vertices by K_(n),and a tree on n vertices by t_(n).Denote a book with n pages by B_(n),i.e.,the join K_(2) ∨■.Erd?s,Faudree,Rousseau and Schelp proved that t_(n) is B_(m)-good if n≥*** this paper,we obtain the exact Ramsey number of t_(n) versus 2B_(2).Our result implies that t_(n) is 2B_(2)-good if n≥5.

关键词： ramsey number ramsey goodness tree book

On the Responsible Use of Chatbots in Bioinformatics

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 1-3页

作者： Gangqing hu Li Liu Dong Xu Department of Microbiology Immunology&Cell BiologyWest Virginia UniversityMorgantownWV 26506USA College of Health Solutions Arizona State UniversityPhoenixAZ 85004USA Biodesign Institute Arizona State UniversityTempeAZ 85281USA Department of Electrical Engineer and Computer Science Christopher S.Bond Life Sciences CenterUniversity of MissouriColumbiaMO 65211USA

Large language model(LLM)-based chatbots like Chat Generative Pre-trained transformer(ChatGPt),equipped with broad biological knowledge[1],have demonstrated an impressive capability for bioinformatics coding[2].when given well-crafted instructions,these chatbots hold the potential to significantly augment bioinformatics education and research[3,4].However,opportunities entail both rewards and *** commentary explores the challenges of using chatbots in bioinformatics and proposes strategies to manage the associated risks while maximizing the benefits.

关键词： equipped while education

ZnSb/ti_(3)C_(2)t_(x)MXene van der waals heterojunction for flexible near-infrared photodetector arrays

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Journal of Semiconductors 2024年第5期45卷 99-105页

作者： Chuqiao hu Ruiqing Chai Zhongming wei La Li Guozhen Shen State Key Laboratory for Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronic Engineering University of Chinese Academy of SciencesBeijing 100049China School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081China

two-dimension(2D)van der waals heterojunction holds essential promise in achieving high-performance flexible near-infrared(nIR)***,we report the successful fabrication of ZnSb/ti_(3)C_(2)t_(x)MXene based flexible nIR photodetector array via a facile photolithography *** single ZnSb/ti_(3)C_(2)t_(x)photodetector exhibited a high light-to-dark current ratio of 4.98,fast response/recovery time(2.5/1.3 s)and excellent stability due to the tight connection between 2D ZnSb nanoplates and 2D ti_(3)C_(2)t_(x)MXene nanoflakes,and the formed 2D van der waals *** polyethylene terephthalate(PEt)substrate enables the ZnSb/ti_(3)C_(2)t_(x)photodetector withstand bending such that stable photoelectrical properties with non-obvious change were maintained over 5000 bending ***,the ZnSb/ti_(3)C_(2)t_(x)photodetectors were integrated into a 26×5 device array,realizing a nIR image sensing application.

关键词： ZnSb nanoplates ti_(3)C_(2)t_(x)MXene van der waals heterojunction flexible photodetector image sensing