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Probiotics intervention in colorectal cancer:From traditional approaches to novel strategies

Chinese Medical Journal 2024年第1期137卷 8-20页

作者： Suki ha Xiang Zhang Jun Yu Institute of Digestive Disease and Department of Medicine and therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina

the intestine harbors a large population of microorganisms that interact with epithelial cells to maintain host healthy physiological *** intestinal microbiota engage in the fermentation of non-digestible nutrients and produce beneficial metabolites to regulate host homeostasis,metabolism,and immune *** disruption of microbiota,known as dysbiosis,has been implicated in many intestinal diseases,including colorectal cancer(CRC).As the third most common cancer and the second leading cause of cancer-related death worldwide,CRC poses a significant health *** is an urgent need for novel interventions to reduce CRC incidence and improve clinical *** the intestinal microbiota has emerged as a promising approach for CRC prevention and *** research efforts in CRC probiotics primarily focus on reducing the incidence of CRC,alleviating treatment-related side effects,and potentiating the efficacy of anticancer therapy,which is the key to successful translation to clinical *** paper aims to review the traditional probiotics and new interventions,such as next-generation probiotics and postbiotics,in the context of *** underlying mechanisms of probiotic anti-cancer effects are also discussed,including the restoration of microbial composition,reinforcement of gut barrier integrity,induction of cancer cell apoptosis,inactivation of carcinogens,and modulation of host immune *** paper further evaluates the novel strategy of probiotics as an adjuvant therapy in boosting the efficacy of chemotherapy and *** all the promising findings presented in studies,the evaluation of potential risks,optimization of delivery methods,and consideration of intra-patient variability of gut microbial baseline must be thoroughly interpreted before bench-to-bedside translation.

关键词： colorectal cancer probiotics gut microbiota dysbiosis adjuvant therapy immune modulation gut barrrier

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Malignant triton tumor in the abdominal wall:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1467-1473页

作者： Ho Jik Yang Donghyun Kim Won Suk Lee Sang-ha Oh Department of Plastic and Reconstructive Surgery Chungnam National University Sejong HospitalSejong 30099South Korea Department of Plastic and Reconstructive Surgery Chungnam National University HospitalDaejeon 35015South Korea Department of Emergency Eulji University HospitalDaejeon 35233South Korea Department of Plastic and Reconstructive Surgery Chungnam National University College of MedicineDaejeon 35015South Korea

BACKGROUND Malignant triton tumors(Mtts)comprise a subgroup of malignant peripheral nerve sheath tumors(MPNSts)that exhibits rhabdomyosarcomatous differen-tiation and follow an aggressive *** are primarily located along peripheral *** of Mtts in the abdominal wall have not been *** has a poorer prognosis than classic MPNSts,and accurate diagnosis necessitates a keen understanding of the clinical history and knowledge of its differential diagnosis *** for Mtts mirrors that for MPNSts and is predominantly *** SUMMARY A 49-year-old woman presented with a subcutaneous mass in her lower abdo-minal wall and a pre-existing surgical scar that had grown slowly over 3-4 months before the *** had previously undergone radical hysterectomy and concurrent chemo-radiotherapy for cervical cancer approximately 5 years prior to the *** computed tomography(Ct)showed a 1.3 cm midline mass in the lower abdomen with infiltration into the rectus abdominis *** was no sign of metastasis(t1N0M0).An incisional biopsy identified sporadic Mtt of the lower abdomen.A comprehensive surgical excision with a 3 cm margin inclusive of the peritoneum was ***-quently,the general surgeon utilized an approach akin to the open peritoneal onlay mesh *** patient underwent additional treatment with an excision shaped as a mini-abdominoplasty for the skin *** complications arose,and annual follow-up Cts did not show signs of recurrence or *** An abdominal Mtt was efficaciously treated with extensive excision and abdominal wall reconstruction,eliminating the need for postoperative radiotherapy.

关键词： Malignant triton tumor Abdominal wall Surgical excision Reconstruction Case report

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Visible light promoted aerobic selective photo-oxidation of cyclohexene on LaCo_(x)Cu_(1−x)O_(3) catalyst

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Nano Research 2024年第8期17卷 6940-6950页

作者： Xu Guo Liru Song Wenyu Wang Fengfeng Li Minh Ngoc ha Jun tang Qiang Ling Ping Cui Qingping Ke College of Chemistry and Chemical Engineering Anhui University of TechnologyMaanshan 243000China VNU Key Laboratory of Advanced Material for Green Growth Faculty of ChemistryUniversity of ScienceVietnam National UniversityHanoi 100000Vietnam

Heterogeneously catalyzed liquid oxidation of olefins with O_(2) provides an alternative way for synthesizing high-value added ***,we report a straightforward urea-redox and sol-gel process for synthesizing LaCo_(x)Cu_(1−x)O_(3) for aerobic photooxidation of *** research highlights a marked increase in the proportions of Co^(2+) and Cu+species in a low chemical state,as well as enhanced visible light absorption through this *** investigations suggest that the catalytic process,particularly with LaCo_(0.7)Cu_(0.3)O_(3),involves a radical pathway mediated by reactive oxygen *** presence of Cu+/Co^(2+) species and surface oxygen vacancies is proposed to boost O_(2) adsorption and activation on the catalyst,facilitating the formation of ***,Cu^(2+)/Co^(3+) species are thought to aid in generating cyclohexenederived radical *** efficient aerobic oxidation of cyclohexene on LaCo_(0.7)Cu_(0.3)O_(3) catalyst relies on the formation of reactive oxygen species and carbon radicals,facilitated by its strong visible light *** achieves a cyclohexene conversion of 89.4% and selectivity to cyclohex-2-ene-1-one of 72.2%,along with stable recyclability after six *** creation of nano-structured LaCo_(x)Cu_(1−x)O_(3) through the urea-redox and sol-gel process offers a promising avenue for the development of highly efficient catalysts for the aerobic photo-oxidation of cyclohexene to cyclohex-2-ene-1-one in the future.

关键词： perovskite oxide photocatalysis oxidation cyclohexene LaCoCuO_(3) cyclohex-2-ene-1-one

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towards the performance limit of catenary meta-optics via field-driven optimization

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Opto-Electronic Advances 2024年第5期7卷 33-42页

作者： Siran Chen Yingli ha Fei Zhang Mingbo Pu hanlin Bao Mingfeng Xu Yinghui Guo Yue Shen Xiaoliang Ma Xiong Li Xiangang Luo National Key Laboratory of Optical Field Manipulation Science and technology Chinese Academy of SciencesChengdu 610209China State Key Laboratory of Optical technologies on Nano-Fabrication and Micro-Engineering Institute of Optics and ElectronicsChinese Academy of SciencesChengdu 610209China College of Materials Science and Opto-Electronic technology University of Chinese Academy of SciencesBeijing 100049China Research Center on Vector Optical Fields Institute of Optics and ElectronicsChinese Academy of SciencesChengdu 610209China Department of Electrical and Computer Engineering University of California Los Angeles(UCLA)Los AngelesCalifornia 90095USA

Catenary optics enables metasurfaces with higher efficiency and wider bandwidth,and is highly anticipated in the imaging system,super-resolution lithography,and broadband ***,the periodic boundary approximation without considering aperiodic electromagnetic crosstalk poses challenges for catenary optical devices to reach their performance ***,perfect control of both local geometric and propagation phases is realized through field-driven optimization,in which the field distribution is calculated under real boundary *** from other optimization methods requiring a mass of iterations,the proposed design method requires less than ten iterations to get the efficiency close to the optimal *** on the library of shape-optimized catenary structures,centimeter-scale devices can be designed in ten seconds,with the performance improved by ~15%.Furthermore,this method has the ability to extend catenary-like continuous structures to arbitrary polarization,including both linear and elliptical polarizations,which is difficult to achieve with traditional design *** provides a way for the development of catenary optics and serves as a potent tool for constructing high-performance optical devices.

关键词： catenary optics catenary structures field-driven optimization

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Body-Shaping Membrane to Regenerate Breast Fat by Elastic Structural Holding

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Research 2024年第1期2023卷 165-180页

作者： Hye-Seon Kim Jeongeun Park Hyun-Su ha Sewoom Baek Chan Hee Lee Kyubae Lee Suji Park Jueun Kim Se Won Yi hak-Joon Sung Department of Medical Engineering Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoul 03722Republic of Korea tMD LAB Co.Ltd. 6th Floor31Gwangnaru-ro 8-gilSeongdong-guSeoul 04799Republic of Korea

tissue regeneration requires structural holding and movement support using tissue-type-specific aids such as bone casts,skin bandages,and joint ***,an unmet need exists in aiding breast fat regeneration as the breast moves following continuous body motion by exposing the breast fat to dynamic ***,the concept of elastic structural holding is applied to develop a shape-fitting moldable membrane for breast fat regeneration(“adipoconductive”)after surgical defects are *** membrane has the following key characteristics:(a)It contains a panel of honeycomb structures,thereby efficiently handling motion stress through the entire membrane;(b)a strut is added into each honeycomb in a direction perpendicular to gravity,thereby suppressing the deformation and stress concentration upon lying and standing;and(c)thermo-responsive moldable elastomers are used to support structural holding by suppressing large deviations of movement that occur *** elastomer became moldable upon a temperature shift above t_(m).the structure can then be fixed as the temperature *** a result,the membrane promotes adipogenesis by activating mechanotransduction in a fat miniature model with pre-adipocyte spheroids under continuous shaking in vitro and in a subcutaneous implant placed on the motion-prone back areas of rodents in vivo.

关键词： thereby shaking Elastic

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Liquid Metal Grid Patterned thin Film Devices toward Absorption‑Dominant and Strain‑tunable Electromagnetic Interference Shielding

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Nano-Micro Letters 2024年第11期16卷 541-553页

作者： Yuwen Wei Priyanuj Bhuyan Suk Jin Kwon Sihyun Kim Yejin Bae Mukesh Singh Duy thanh tran Minjeong ha Kwang‑Un Jeong Xing Ma Byeongjin Park Sungjune Park Department of Polymer‑Nano Science and technology Department of Nano Convergence EngineeringJeonbuk National UniversityJeonju 54896Republic of Korea School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Composites Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea School of Materials Science and Engineering and Sauvage Laboratory for Smart MaterialsHarbin Institute of Technology(Shenzhen)ShenzhenGuangdong 518055People’s Republic of China

the demand of high-performance thin-film-shaped deformable electromagnetic interference(EMI)shielding devices is increasing for the next generation of wearable and miniaturized soft *** highly reflective conductive materials can effectively shield EMI,they prevent deformation of the devices owing to rigidity and generate secondary electromagnetic pollution ***,soft and stretchable EMI shielding thin film devices with absorption-dominant EMI shielding behavior is *** devices consist of liquid metal(LM)layer and LM grid-patterned layer separated by a thin elastomeric film,fabricated by leveraging superior adhesion of aerosol-deposited LM on *** devices demonstrate high electromagnetic shielding effectiveness(SE)(SE_(t) of up to 75 dB)with low reflectance(SER of 1.5 dB at the resonant frequency)owing to EMI absorption induced by multiple internal reflection generated in the LM grid ***,the excellent stretchability of the LM-based devices facilitates tunable EMI shielding abilities through grid space adjustment upon strain(resonant frequency shift from 81.3 to 71.3 GHz@33%strain)and is also capable of retaining shielding effectiveness even after multiple strain *** newly explored device presents an advanced paradigm for powerful EMI shielding performance for next-generation smart electronics.

关键词： Absorption-dominant electromagnetic interference shielding Liquid metals Soft and stretchable electronics thin film devices tunable electromagnetic interference shielding

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M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： ha Eun Shin Jun-Hyeok han Seungyong Shin Ga-Hyun Bae Boram Son tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and technology(KISt) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting t and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor tumor microenvironment(tME)

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EP Aquarii:A New Picture of the Circumstellar Envelope

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Research in Astronomy and Astrophysics 2024年第3期24卷 83-105页

作者： Pham t.Nhung Do t.Hoai Pierre Darriulat Pham tuan-Anh Pham N.Diep Nguyen B.Ngoc tran t.thai Department of Astrophysics Vietnam National Space CenterVietnam Academy of Science and Technology18Hoang Quoc VietNghia DoCau GiayHa Noivietnam

New analyses of earlier ALMA observations of oxygen-rich AGB star EP Aquarii are presented,which complete a previously published analysis and offer a different interpretation of the morpho-kinematics of the circumstellar *** birth of the equatorial density enhancement(EDE)is shown to occur very close to the star where evidence for rotation has been *** to the star and where outflows have been observed:their interaction with the gas of the nascent EDE is seen to play an important role in the development of the wind and the evolution of its radial velocity from 8 to 10 km s^(-1) on the polar symmetry axis to~2 km s^(-1) at the *** implies complex morpho-kinematics:making reliable interpretations with reasonable confidence is *** particular,it questions an earlier interpretation implying the presence of a white dwarf companion orbiting the star at an angular distance of -0″4 from its *** proposes instead an interpretation in terms of a standard mass ejection associated with a shock wave leaving a void of emission in its *** Doppler velocity wings are seen to consist of two components,the upper velocity end of the global wind,reaching above±12 km s^(-1),and an effective line broadening,confined within 200 mas from the center of the star,reaching above±20 km s^(-1) and interpreted as caused by the pattern of shock waves resulting from the interaction between stellar pulsation and convective cell partition.

关键词： stars AGB and post-AGB-(stars) circumstellar matter-radio lines stars

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Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

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Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-Hyeon Eom Dong-Hyeok Kwon Dae-Jin Jung Dae-Hyun Kim Jun-Koo Yi Jae-Jung ha Ji-Hyun Lee Seong-Beom Lee Woo-Jae Son Soo-Young Yum Won-Wu Lee Goo Jang Laboratory of theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARtBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNt)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by t7E1 *** first combination,mutation rates for MStN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MStN/BLG,mutation rates were 83.9%±23.6%for MStN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep *** recipients were transferred for MStN/PRNP,4 calves were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MStN/BLG,and four of the six calves that were born had mutations in both *** these data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MStN and PRNP from beef cattle and MStN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 Electroporation Knockout MStN PRNP

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2018—2022年广东省5岁以下儿童意外死亡流行分析

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中国儿童保健杂志 2024年第2期32卷 218-222页

作者：哈林娜徐昊立暨南大学基础医学与公共卫生学院广东广州510632 广东省妇幼保健院保健部广东广州510632

目的了解2018—2022年广东省5岁以下儿童意外死亡的主要死因及其流行病学分布情况,为制订进一步的预防措施和干预方法提供理论依据。方法以广东省2018—2022年死亡的5岁以下儿童为研究对象,将ICD10中S00-t98和V01-Y98系列疾病作为分... 详细信息

目的了解2018—2022年广东省5岁以下儿童意外死亡的主要死因及其流行病学分布情况,为制订进一步的预防措施和干预方法提供理论依据。方法以广东省2018—2022年死亡的5岁以下儿童为研究对象,将ICD10中S00-t98和V01-Y98系列疾病作为分类标准筛选出其中意外原因导致死亡的个案,计算相关的率、构成比等,分析儿童意外死亡原因及三间分布。结果 2018—2022年广东省总死亡率为2.94‰,死亡人数21 329人,其中意外死亡人数3 819人(0.53‰),男女性别比为1.29∶1,不同年龄组间意外伤害的性别构成差异有统计学意义(χ^(2)=16.38,P<0.01)。意外死亡原因前三位为意外窒息(1 590/3 819)、溺水(926/3 819)和交通意外(527/3 819)。各年龄段男童意外死亡率均高于女童,差异无统计学意义(χ^(2)=13.68,P=0.19),不同意外死因儿童的年龄组差异有统计学意义(χ^(2)=1 723.28,P<0.01),死前救治情况差异有统计学意义(χ^(2)=174.31,P<0.01)。结论广东省5岁以下儿童死亡的主要原因为意外窒息、溺水。应分年龄采取不同的预防措施提高儿童及家长的意外伤害识别防范意识,降低5岁以下儿童意外死亡率。

关键词： 5岁以下儿童意外死亡意外伤害

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