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Research on a toolpath generation method of NC milling based on space-filling curve

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High technology Letters 2017年第4期23卷 418-425页

作者：隋秀凛 Chen Xiaoqi ge Jianghua Jiao Yan Department of Mechanical and Power Engineering Harbin University of Science and Technology Harbin 150080 P. R. China

tool path generated by space-filling curve always turns frequently causing trembling to machine,reducing toollife and affecting workpiece quality. Length and generation time of tool paths are both relatively long. In order to solve these problems,a toolpath generation method of NC milling based on space-filling curve is proposed. First,t-spline surface is regarded as the modeling surface,the grid,which is based on the limited scallop-height,can be got in the parameter space,and the influence value of grid node is determined. Second,a box is defined and planned,and the tool paths are got preliminarily,which is based on minimal spanning tree; Finally,based on an improved chamfering algorithm,the whole tool paths are got. A simulation system is developed for computer simulation,and an experiment is carried out to verify the method. the results of simulation and experiment show that the method is effective and feasible,and length and time of the tool paths are reduced.

关键词： space-filling curve toolpath generation method NC milling t-spline surface minimal spanning tree

Co-administration of Interleukin-2 Enhances Cellular and Humoral Immune Responses to HIV Vaccine DNA Prime/MVA Boost Regime

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Chemical Research in Chinese Universities 2005年第3期21卷 287-290页

作者： JIANGChun-lai YUXiang-hui WUYong-ge LIWei KONGWei VaccineResearchCenter CollegeofLifeScienceJilinUniversityChangchun130023P.R.China

Interleukine-2(IL-2) is a growth factor for antigen-stimulated t lymphocytes and is responsible for ~t-cell clonal expansion after antigen recognition. It has been demonstrated that DNA vaccine-elicited immune responses in mice could be augmented substantially by using either an IL-2 protein or a plasmid expressing ~IL-2. twenty mice, divided into four experimental groups, were immunized with: (1) sham plasmid; ^(2) HIV-1 DNA vaccine alone; (3) HIV-1 DNA vaccine and IL-2 protein; or (4) HIV-1 DNA vaccine and IL-2 plasmid, separately. All the groups were immunized 3 times at a 2-week interval. Fourteen days after the last DNA vaccine injection, recombinant MVA was injected into all the mice except those in group 1. ELISA and ELISPOt were employed to investigate the effect of IL-2 on DNA vaccine immune responses. the obtained results strongly indicate that the efficacy of HIV vaccine can be enhanced by co-administration of a plasmid encoding IL-2.

关键词： HIV DNA vaccine IL-2 adjuvant Immune responses

Adult hippocampal neurogenesis and its impairment in Alzheimer's disease

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Zoological Research 2022年第3期43卷 481-496页

作者： thomas A.Kim Michelle DSyty Kaitlyn Wu Shaoyu ge Department of Neurobiology&Behavior SUNY at Stony BrookStony BrookNY 11794USA Medical Scientist training Program(MStP) Renaissance School of Medicine at SUNYStony BrookStony BrookNY 11794USA

Adult neurogenesis is the creation of new neurons which integrate into the existing neural circuit of the adult *** evidence suggests that adult hippocampal neurogenesis(AHN)persists throughout life in mammals,including *** newborn neurons have been implicated to have a crucial role in brain functions such as learning and ***,studies have also found that hippocampal neurogenesis is impaired in neurodegenerative and neuropsychiatric ***’s disease(AD)is one of the most common forms of dementia affecting millions of *** dysfunction is a common symptom of AD patients and progressive memory loss has been attributed to the degeneration of the ***,there has been growing interest in identifying how hippocampal neurogenesis is affected in ***,the link between cognitive decline and changes in hippocampal neurogenesis in AD is poorly *** this review,we summarized the recent literature on AHN and its impairments in AD.

关键词： Hippocampal function Adult hippocampal neurogenesis Cognitive function Alzheimer’s disease Alzheimer’s disease animal models

ENO1 promotes antitumor immunity by destabilizing PD-L1 in NSCLC

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Cellular & Molecular Immunology 2021年第8期18卷 2045-2047页

作者： Chunyi Zhang Kunpeng Zhang Jie Gu Di ge Department of Biochemistry and Molecular Biology School of Basic Medical SciencesFudan UniversityShanghaiChina Department of Chest Surgery Zhongshan HospitalFudan UniversityShanghaiChina

PD-L1 plays an important role in inhibiting t-cell activity and driving tumor cell escape from immune surveillance by binding its ligand,PD-1,on t cells.1 Several intracellular and extracellular factors,such as interferon-γ(IFN-γ),MYC,transforming growth factorβ,and miR-200,may modulate PD-L1 expression by transcriptional and posttranscriptional mechanisms.

关键词： immunity interferon inhibiting

In situ tEM investigation of electron irradiation and aging-induced high-density nanoprecipitates in an Mg-10Gd-3Y-1Zn-0.5Zr alloy

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Journal of Magnesium and Alloys 2024年第5期12卷 1841-1853页

作者： M.Lv H.L.ge Q.Q.Jin X.H.Shao Y.t.Zhou B.Zhang X.L.Ma Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Materials Science and Engineering Research Center Guangxi University of Science and TechnologyLiuzhou 545006China

In-situ electron irradiation and aging are applied to introduce high-density precipitates in an Mg-10Gd-3Y-1Zn-0.5Zr(GWZ1031K,wt.%)alloy to improve the *** results show that the hardness of the Mg alloy after irradiation for 10 h and aging for 9 h at 250℃ is 1.64 GPa,which is approximately 64% higher than that of the samples before being *** is mainly attributed to γ'precipitates on the basal plane after irradiation and the high-density nanoscale β'precipitates on the prismatic plane after aging,which should be closely related to the irradiation-induced homogenous *** latter plays a key role in precipitation *** result paves a way to improve the mechanical properties of metallic materials by tailoring the precipitation through irradiation and aging.

关键词： Mg alloy Electron beam irradiation Hardening Precipitates In-situ tEM

Boundedness in a fully parabolic quasilinear repulsion chemotaxis model of higher dimension

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Applied Mathematics(A Journal of Chinese Universities) 2020年第2期35卷 244-252页

作者： ZHOU Shuang-shuang GONG ting YANG Jin-ge School of Science Hunan City UniversityYiyang 413000China. School of Mathematics Dongbei University of Finance and EconomicsDalian 116024China School of Sciences Nanchang Institute of TechnologyNanchang 330099China

We deal with the boundedness of solutions to a class of fully parabolic quasilinear repulsion chemotaxis systems{ut=∇・(ϕ(u)∇u)+∇・(ψ(u)∇v),(x,t)∈Ω×(0,t),vt=Δv−v+u,(x,t)∈Ω×(0,t),under homogeneous Neumann boundary conditions in a smooth bounded domainΩ⊂R^N(N≥3),where 0thα,K,K1,K2>0 and m∈*** is shown that ifα−mthen for any sufficiently smooth initial data,the classical solutions to the system are uniformly-in-time *** extends the known result for the corresponding model with linear diffusion.

关键词： chemotaxis repulsion quasilinear fully parabolic boundedness high dimension

Emerging nanozymes for potentiating radiotherapy and radiation protection

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Chinese Chemical Letters 2022年第7期33卷 3315-3324页

作者： Yu Chong Jiayu Ning Shengyi Min Jiaquan Ye Cuicui ge State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSchool for Radiological and Interdisciplinary Sciences(RAD-X)Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China

While radiotherapy is a mainstay therapeutic modality for malignant tumor,the intrinsic tumor resistance to radiotherapy,as well as the concomitant radiation injury to adjacent healthy tissues,greatly limits the efficacy of cancer *** a result,the development of novel radioenhancers and radioprotectants is highly desired for clinical *** recent years,nanozymes have inspired ever-growing research interest because of their multi-enzyme activities and microenvironment-responsive *** view of the significant progress of nanozymes in radiation medicine,we,in this review,systematically illustrate the impressive progress of nanozymes for potentiating radiotherapy and radiation ***,the types of nanozymes used in tumor radiotherapy are briefly ***,the main strategies of nanozymes to enhance the radiotherapy efficiency,including promoting the generation of reactive oxygen species(ROS),relieving hypoxia in tumor microenvironment and combining with other cancer therapeutic regimens,are ***,the advances of typical nanozymes for preventing radiation-induced hematopoietic damage and gastrointestinal damage are highlighted.

关键词： Nanozyme Radiation therapy Radiosensitization ROS Hypoxia

Channel measurements and models for high-speed train wireless communication systems in tunnel scenarios: a survey

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Science China(Information Sciences) 2017年第10期60卷 107-123页

作者： Yu LIU Ammar GHAZAL Cheng-Xiang WANG Xiaohu ge Yang YANG Yapei ZHANG Shandong Provincial Key Laboratory of Wireless Communication technologies Shandong University School of Engineering and Sustainable Development De Montfort University Institute of Sensors Signals and Systems School of Engineering & Physical Sciences Heriot-Watt University Department of Electronics and Information Engineering Huazhong University of Science and Technology Key Laboratory of Wireless Sensor Network & Communication Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences

the rapid developments of high-speed trains(HSts) introduce new challenges to HSt wireless communication systems. Realistic HSt channel models play a critical role in designing and evaluating HSt communication systems. Due to the length limitation, bounding of tunnel itself, and waveguide effect, channel characteristics in tunnel scenarios are very different from those in other HSt scenarios. therefore, accurate tunnel channel models considering both large-scale and small-scale fading characteristics are essential for HSt communication systems. Moreover, certain characteristics of tunnel channels have not been investigated sufficiently. this article provides a comprehensive review of the measurement campaigns in tunnels and presents some tunnel channel models using various modeling methods. Finally, future directions in HSt tunnel channel measurements and modeling are discussed.

关键词： 5G high-speed train(HSt) tunnel scenario tunnel channel measurement tunnel channel model non-stationary statistical property

Optimization of electrocatalytic properties of NiMoCo foam electrode for water electrolysis by post-treatment processing

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Rare Metals 2015年第11期34卷 802-807页

作者： Jian-Wei Wang Yue-Fa Wang Jing-Guo Zhang Yan-Lin Yu ge-ge Zhou Lei Cheng Lin-Shan Wang Z.Zak Fang State Key Laboratory of Nonferrous Metals and Processes General Research Institute for Nonferrous Metals GRIPM Advanced Materials Co. Ltd General Research Institute for Nonferrous Metals Department of Metallurgical Engineering University of UtahSalt Lake City

Hydrogen is a potential alternative to fossil fuels in coping with the increased global energy demand,and water electrolysis is an attractive approach for H2production. Nickel–molybdenum–cobalt（Ni Mo Co） foam electrodes used for water electrolysis were prepared by the electrodeposition method, and the influence of heat treatments on the surface structure of Ni Mo Co foam electrodes,mechanical properties, and electrochemical performance of the synthesized electrodes was investigated in order to optimize the post-treatment processes. the residual carbon in the surface of the electrode was removed by decarbonization in the atmospheric condition. the carbon content decreases to lower than 200 ×10-6when the temperature exceeds 500 °C. Next, the material is reduced in hydrogen atmosphere from 500 to 1100 °C to remove the surface oxides. As the temperature increases, the surface molybdenum content increases significantly between 500 and 800 °C, the surface grains become coarser, and the tensile strength and elongation increase as well. the lowest polarization overpotential is obtained at 800 °C. Below 800 °C, the electrode is only partially reduced and some black oxide zones are observed on the electrode surface,which leads to the higher polarization overpotential. thesamples heat-treated at the temperatures of higher than 800 °C show better strength and toughness as well as brighter appearance. However, the surface particle coarsening leads to a decrease in the specific surface area and a higher overpotential.

关键词： Water electrolysis Foam electrode Ni Mo Co Post-tr