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血管内皮生长因子(VEGF)基因与ALS的潜在性别依赖性

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 8-8页

作者： Fernández-Santiago R. Sharma M. Mueller J.C. t.gasser 牛亚利 Dr.Department of Neurodegenerative Diseases Hertie-Institute for Brain ResearchHoppe-Seyler Str.3Tuebingen72076Germany

Individuals homozygous for haplotypes-2578-A/-1154-A/634-G or-2578-A/-1154-G/-634-G in the promoter/5'UtR of the VEGF gene have a 1.8-fold increased risk of ALS in several European *** did not observe any significant association with single markers,or haplotype pairs,in a German sample of 580 sporadic ALS patients and 628 ***,the promoter SNP-1154(rs1570360)was associated with affection status in women(p = 0.036),suggesting that the VEGF effect may be dependent on the sex ratio of the sample.

关键词：生长因子血管内皮 VEGF ALS

Climate Warming Mitigation from Nationally Determined Contributions

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Advances in Atmospheric Sciences 2022年第8期39卷 1217-1228页

作者： Bo FU Jingyi LI thomas gasser Philippe CIAIS Shilong PIAO Shu tAO Guofeng SHEN Yuqin LAI Luchao HAN Bengang LI Sino-French Institute for Earth System Science MOE Key Laboratory for Earth Surface ProcessesCollege of Urban and Environmental SciencesPeking UniversityBeijing 100871China International Institute for Applied Systems Analysis(IIASA) 2361 LaxenburgAustria Laboratoire des Sciences du Climat et de l’Environnement CEA-CNRS-UVSQ91191 Gif-sur-YvetteFrance

Individual countries are requested to submit nationally determined contributions(NDCs)to alleviate global warming in the Paris ***,the global climate effects and regional contributions are not explicitly considered in the countries’decision-making *** this study,we evaluate the global temperature slowdown of the NDC scenario(Δt=0.6°C)and attribute the global temperature slowdown to certain regions of the world with a compact earth system *** reductions in CO_(2),CH_(4),N_(2)O,BC,and SO_(2),the R5OECD(the Organization for Economic Co-operation and Development in 1990)and R5ASIA(Asian countries)are the top two contributors to global warming mitigation,accounting for 39.3%and 36.8%,respectively.R5LAM(Latin America and the Caribbean)and R5MAF(the Middle East and Africa)followed behind,with contributions of 11.5%and 8.9%,*** remaining 3.5%is attributed to R5REF(the Reforming Economies).Carbon Dioxide emission reduction is the decisive factor of regional contributions,but not the only *** greenhouse gases are also important,especially for *** contribution of short-lived aerosols is small but significant,notably SO_(2)reduction in *** argue that additional species beyond CO_(2)need to be considered,including short-lived pollutants,when planning a route to mitigate climate *** needs to be emphasized that there is still a gap to achieve the Paris Agreement 2-degree target with current NDC efforts,let alone the ambitious 1.5-degree *** countries need to pursue stricter reduction policies for a more sustainable world.

关键词： climate mitigation nationally determined contributions attribution regional contribution integrated assessment models

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转基因作物

世界科学 1992年第11期 13-15页

作者： Cearles S.gasser Robert t.Fraley 江世亮

人类在改良粮食作物方面至少已作了10,000年的努力,早期的朝作者通过贮藏有用作物的种子来改善作物的品种。在上一世纪,这种世代延续的植物育种方法已经十分完善,而在作物方面堪称重大改良的举措则归功于对同种的不同个体进行的成功的... 详细信息

人类在改良粮食作物方面至少已作了10,000年的努力,早期的朝作者通过贮藏有用作物的种子来改善作物的品种。在上一世纪,这种世代延续的植物育种方法已经十分完善,而在作物方面堪称重大改良的举措则归功于对同种的不同个体进行的成功的杂交育种。其后更进一步,专家们又成功地对同一品系的不相容种作了性杂交。今天,由于遗传工程的问世,开发

关键词：遗传工程技术杂草细胞壁植物遗传工程作物原生质体植物细胞聚集素孟山都植物生长基因表达 DNA

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DNA损伤反应会激活身体免疫系统

医学动物防制 2008年第2期24卷 110-113页

作者： Stephan gasser David H．Raulet 李军涛（译）朱伟（校）加利福尼亚波克利、加利福尼亚大学、分子细胞生物学系、癌症研究实验室广州市疾病预防控制中心广东省510080

目的人们虽然对于DNA损伤启动细胞周期停止、DNA修复和凋亡等方面的机理已经比较了解,但是其对免疫系统的潜在作用却了解的比较少。最近研究发现,在自然杀伤细胞、某些t细胞,以及各种可以攻击肿瘤细胞的细胞,基因毒性应激和延迟DNA复制... 详细信息

目的人们虽然对于DNA损伤启动细胞周期停止、DNA修复和凋亡等方面的机理已经比较了解,但是其对免疫系统的潜在作用却了解的比较少。最近研究发现,在自然杀伤细胞、某些t细胞,以及各种可以攻击肿瘤细胞的细胞,基因毒性应激和延迟DNA复制又能够诱导NKG2D受体的链接酶的表达。肿瘤细胞内的慢性激活反应有利于免疫辨认,同时也会影响到免疫逃逸和恶性化过程。这种DNA损伤特殊反应有利于理解治疗反应(其中很多可以诱导出DNA损伤反应),也有利于设计更为有效的癌症治疗方案。

关键词： DNA损伤免疫基因毒性应激

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分子生物学在神经病学的应用

德国医学 1994年第3期11卷 136-138页

作者： G.D.Borasio th.gasser th.Brandt 施琪嘉 Neurologische Klinik Ludwig-Maximilians-UniversittKlinikum GrosshadernD-81366 MünchenGermany 同济医科大学附属同济医院

分子生物学在神经病学临床上的应用发展迅速,本文将从分子生物学角度对一些神经系统的疾病的发病机制、诊断及治疗方面的进展作出描述。

关键词：分子生物学神经病学

主动脉壁应力峰值与腹主动脉瘤事件相关性破裂指数的关系

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国际医学放射学杂志 2023年第5期 627-627页

作者： t.P.Singh J.V.Moxon t.C.gasser J.Jenkins M.Bourke B.Bourke 王施佳

摘要目的探讨主动脉壁应力峰值（PWS）和主动脉壁破裂指数峰值（PWRI）是否与小型腹主动脉瘤病人腹主动脉瘤（AAA）破裂或修复（定义为AAA事件）的风险相关。方法

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Empirical estimates of regional carbon budgets imply reduced global soil heterotrophic respiration

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National Science Review 2021年第2期8卷 60-73页

作者： Philippe Ciais Yitong Yao thomas gasser Alessandro Baccini Yilong Wang Ronny Lauerwald Shushi Peng Ana Bastos Wei Li Peter A.Raymond Josep G.Canadell Glen P.Peters Rob J.Andres Jinfeng Chang Chao Yue A.Johannes Dolman Vanessa Haverd Jens Hartmann Goulven Laruelle Alexandra G.Konings Anthony W.King Yi Liu Sebastiaan Luyssaert Fabienne Maignan Prabir K.Patra Anna Peregon Pierre Regnier Julia Pongratz Benjamin Poulter Anatoly Shvidenko Riccardo Valentini Rong Wang Grégoire Broquet Yi Yin Jakob Zscheischler Bertrand Guenet Daniel S.Goll Ashley-P.Ballantyne Hui Yang Chunjing Qiu Dan Zhu State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F University CSIRO Oceans and Atmosphere 15. Institute for Geology CEN—Center for Earth System Research and SustainabilityUniversity of Hamburg 16. Department of Earth System ScienceStanford University 17. Department of Earth System ScienceStanford UniversityStanford 18. School of Geographical SciencesNanjing University of Information Science and Technology 19. Department of Ecological SciencesVrije Universiteit Amsterdam 20. Research Institute for Global ChangeJAMSTEC Laboratoire des Sciences du Climat et de l'Environnement CEA-CNRS-UVSQ-UPSACLAY Center for Environmental Remote Sensing Chiba University Institute of Soil Science and Agrochemistry Siberian Branch of the Russian Academy of Sciences (SB RAS) tuva State University Republic of tuva Max Planck Institute for Meteorology NASA Goddard Space Flight Center Biospheric Sciences Lab. 26. Department for Innovation in BiologicalAgro-food and Forest systems (DIBAF)University of Tuscia RUDN University Department of Environmental Science and Engineering Shanghai Key Laboratory of Atmospheric Particle Pollution and PreventionInstitute of Atmospheric SciencesFudan University 29. Division of Geological and Planetary SciencesCalifornia Institute of Technology 30. Climate and Environmental Physics and Oeschger Centre for Climate Change ResearchUniversity of Bern 31. Department of Ecosystem and Conservation Sci

Resolving regional carbon budgets is critical for informing land-based mitigation policy. For nine regions covering nearly the whole globe, we collected inventory estimates of carbon-stock changes complemented by satellite estimates of biomass changes where inventory data are missing. the net land–atmospheric carbon exchange(NEE) was calculated by taking the sum of the carbon-stock change and lateral carbon fluxes from crop and wood trade, and riverine-carbon export to the ocean. Summing up NEE from all regions, we obtained a global ‘bottom-up’ NEE for net land anthropogenic CO2uptake of –2.2 ± 0.6 Pg C yr-1consistent with the independent top-down NEE from the global atmospheric carbon budget during 2000–2009. this estimate is so far the most comprehensive global bottom-up carbon budget accounting, which set up an important milestone for global carbon-cycle studies. By decomposing NEE into component fluxes, we found that global soil heterotrophic respiration amounts to a source of CO2of 39 Pg C yr-1with an interquartile of 33–46 Pg C yr-1—a much smaller portion of net primary productivity than previously reported.

关键词： carbon budget human appropriation of ecosystems soil carbon

LRRK2的常见变异体与散发性帕金森病无关

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世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 13-13页

作者： Biskup S Mueller J.C Sharma M. t. gasser 袁海峰 Hertie Institute for Clinical Brain Research Department of Neurodegenerative Disease Hoppe-Seyler Str. 3 Tü bingen GermanyDr.

Multiple mutations in the gene for the leucine-rich repeat kinase (LKRK2) cause autosomal dominant late-onset parkinsonism (PARK8). the Gly2019Ser mutation appears to be common in different populations. to investigate whether this novel gene influences the non-Mendelian sporadic form of Parkinson’s disease, we genotyped 121 single nucleotide polymorphisms comprehensively covering the entire LRRK2 gene region in a set of 340 Parkinson’s disease patients and 680 matched control subjects from Germany. No association could be demonstrated. We have therefore no evidence for the existence of a common variant in LRRK2 that has a strong influence on Parkinson’s disease risk.

关键词：散发性帕金森病变异体常染色体显性遗传性单核苷酸多态性迟发帕金森病富亮氨酸重复基因型分析不同人群正常对照证据支持