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量子电荷和自旋输运研讨会

作者：董锦明翁红明 Y.Kawazoe t.fukumura M.Kawasaki 南京大学物理系和固体微结构物理实验室计算凝聚态物理组南京大学物理系和固体微结构物理实验室计算凝聚态物理组 IMR Tohoku University Sendai Japan IMR Tohoku University Sendai Japan IMR Tohoku University Sendai Japan

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Fractionation of gamma-glutamyltransferase in patients with nonalcoholic fatty liver disease and alcoholic liver disease

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World Journal of Hepatology 2016年第36期8卷 1610-1616页

作者： Shigeo Sueyoshi Setsu Sawai Mamoru Satoh Masanori Seimiya Kazuyuki Sogawa Atsushi fukumura Mikihiro tsutsumi Fumio Nomura Department of Molecular Diagnosis Graduate School of Medicine Chiba University Clinical Proteomics Research Center Chiba University Hospital Department of Hepatology Kanazawa Medical University

AIM to assess how serum gamma-glutamyltransferase(GGt) fractions vary in patients with alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD). MEtHODS Serum samples were obtained from 14 patients with biopsy-proven alcoholic liver diseases and 9 patients with biopsy proven non-alcoholic fatty liver disease. In addition to these biopsy-proven cases, 16 obese(body mass index > 25) patients without any history of alcohol consumption but with a fatty liver on ultrasound examination and with elevated GGt were included for an additional analysis. Serum GGt fractionation was conducted by high-performance gel filtration liquid chromatography and was separated into the four fractions, big-GGt, medium-GGt, small-GGt(s-GGt), and free-GGt(f-GGt).RESULtS the results were expressed as a ratio of each fraction including the total GGt(t-GGt). the s-GGt/t-GGt ratioswere lowest for the control group and highest for the ALD group. the differences between the control and NAFLD groups and also between the NAFLD and ALD groups were statistically significant. In contrast, the f-GGt/t-GGt ratios were highest in the control group and lowest in the ALD group, with the differences being statistically significant. As a result, the s-GGt/f-GGt ratios were markedly increased in the NAFLD group as compared with the control group. the increase of the s-GGt/t-GGt ratios, the decrease of the f-GGt/t-GGt ratios, and the increase of s-GGt/F-GGt ratios as compared with the control group subjects were also found in obese patients with clinically diagnosed fatty change of the *** Serum GGt fractionation by high-performance gel filtration liquid chromatography is potentially useful for the differential diagnosis of ALD and NAFLD.

关键词： Gamma-glutamyltransferase f-GGt/t-GGt ratios Alcoholic liver disease Non-alcoholic fatty liver disease Gel filtration liquid chromatography

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Wide-field three-photon excitation in biological samples

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Light(Science & Applications) 2016年第1期5卷 65-73页

作者： Christopher J Rowlands Demian Park Oliver t Bruns Kiryl D Piatkevich Dai fukumura Rakesh K Jain Moungi G Bawendi Edward S Boyden Peter tC So Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Media Lab Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Chemistry Massachusetts Institute of TechnologyCambridgeMA 02139USA Edwin L.Steele Laboratories Department of Radiation OncologyMassachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA Department of Brain and Cognitive Sciences McGovern Institute and MIT Center for Neurobiological EngineeringMassachusetts Institute of TechnologyCambridgeMA 02139-4307USA Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

three-photon wide-field depth-resolved excitation is used to overcome some of the limitations in conventional point-scanning two-and three-photon *** of chromophores as diverse as channelrhodopsins and quantum dots is shown,and a penetration depth of more than 700μm into fixed scattering brain tissue is achieved,approximately twice as deep as that achieved using two-photon wide-field *** with live animal experiments is confirmed by imaging the cerebral vasculature of an anesthetized mouse;a complete focal stack was obtained without any evidence of *** an additional validation of the utility of wide-field three-photon excitation,functional excitation is demonstrated by performing threephoton optogenetic stimulation of cultured mouse hippocampal neurons expressing a channelrhodopsin;action potentials could reliably be excited without causing photodamage.

关键词： biophotonics multiphoton microscopy optogenetics temporal focusing three-photon

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肝脏组织特征的MR指纹技术与组织病理学相关性研究

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国际医学放射学杂志 2023年第2期 229-229页

作者： S.Fujita K.Sano G.Cruz Y.fukumura H.Kawasaki I.Fukunaga 李文萃

摘要肝脏MR指纹技术(MRF)能够在单次屏息采集中同时量化t1、t2、t2*和质子密度脂肪分数(PDFF)图。其临床应用需要进行组织病理学相关性研究。目的比较弥漫性肝

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