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Management and treatment of Hepatocellular Carcinoma with Immunotherapy:A Review of Current and Future Options

Journal of Clinical and translational Hepatology 2020年第2期8卷 168-176页

作者： Shima Ghavimi tehila Apfel Hamed Azimi Alana Persaud Nikolaos t.Pyrsopoulos division of Gastroenterology and Hepatology Department of MedicineRutgers New Jersey Medical SchoolNewarkNJUSA

With mortality rates of liver cancer doubling in the last 20 years, this disease is on the rise and has become the fifth most common cancer in men and the seventh most common cancer in women. Hepatocellular carcinoma (HCC) represents approximately 90% of all primary liver cancers and is a major global health concern. Patients with HCC can be managed curatively with surgical resection or with liver transplantation, if they are diagnosed at an early stage. Unfortunately, most patients with HCC present with ad-vanced stages of the disease and have underlying liver dysfunction, which allows only 15%of patients to be eligible for curative treatment. Several different treatment modal-ities are available, including locoregional therapy radiofre-quency ablation, microwave ablation, percutaneous ethanol injection, trans-arterial chemoembolization, transarterial radio-embolization, cryoablation, radiation therapy, stereo-tactic radiotherapy, systemic chemotherapy, molecularly targeted therapies, and immunotherapy. Immunotherapy has recently become a promising method for inhibiting HCC tumor progression, recurrence, and metastasis. the term"Immunotherapy"is a catch-all, encompassing a wide range of applications and targets, including HCC vaccines, adoptive cell therapy, immune checkpoint inhibitors, and use of oncolytic viruses to treat HCC. Immunotherapy in HCC is a relatively safe option for treating patients with advanced disease in the USA who are either unable to receive or failed sorafenib/lenvatinib therapy and thus may offer an addi-tional survival benefit for these patients. the purpose of this review is to elaborate on some of the most recent advance-ments in immunotherapy.

关键词： Carcinoma Hepatocellular Immunotherapy Immunotherapy Adoptive Nivolumab

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Chitosan coatings with distinct innate immune bioactivities differentially stimulate angiogenesis,osteogenesis and chondrogenesis in poly-caprolactone scaffolds with controlled interconnecting pore size

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Bioactive Materials 2022年第4期7卷 430-442页

作者： Caroline d.Hoemann Javier Rodríguez Gonzalez Jessica Guzman-Morales Gaoping Chen Ebrahim Jalali dil Basil d.Favis department of Chemical Engineering Polytechnique MontrealQCCanada department of Bioengineering George Mason University VAUSA Centre de Recherche sur les Systemes Polymeres et Composites a Haute Performance(CREPEC) Canada

this study tested whether osseous integration into poly(ε-caprolactone)(PCL)bioplastic scaffolds with fully-interconnecting 155±8μm pores is enhanced by an adhesive,non-inflammatory 99% degree of deacetylation(ddA)chitosan coating(99-PCL),or further incorporation of pro-inflammatory 83% ddA chitosan microparticles(83-99-PCL)to accelerate *** Zealand White rabbit osteochondral knee defects were press-fit with PCL,99-PCL,83-99-PCL,or allowed to bleed(drill-only).Between day 1 and 6 weeks of repair,drill-only defects repaired by endochondral ossification,with an 8-fold higher bone volume fraction(BVF)versus initial defects,compared to a 2-fold(99-PCL),1.1-fold(PCL),or 0.4-fold(83-99-PCL)change in *** innate immune cells swarmed to 83-99-PCL,elicited angiogenesis throughout the pores and induced slight bone *** and 99-PCL pores were variably filled with cartilage or avascular mesenchyme near the bone plate,or angiogenic mesenchyme into which repairing trabecular bone infiltrated up to 1 mm *** repair cartilage covered the 99-PCL scaffold(65%)than PCL(18%)or 83-99-PCL(0%)(pt the novel finding that non-inflammatory chitosan coatings promoted cartilage infiltration into and over a bioplastic scaffold,and were compatible with trabecular bone *** study also revealed that in vitro osteogenesis assays have limited ability to predict osseous integration into porous scaffolds,because(1)in vivo,woven bone integrates from the leading edge of regenerating trabecular bone and not from mesenchymal cells adhering to scaffold surfaces,and(2)bioactive coatings that attract inflammatory cells induce bone resorption.

关键词： Bone tissue engineering Cartilage tissue engineering Hematoma Chitosan Angiogenesis Osteogenesis Inflammation

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dietary glutamine,glutamic acid and nucleotide supplementation accelerate carbon turnover(δ^(13)C)on stomach of weaned piglets

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Animal Nutrition 2017年第3期3卷 225-231页

作者： Amanda d.Assoni Alessandro B.Amorim Mayra A.d.Saleh Marcos L.P.tsea dirlei A.Berto department of of Animal Production UNESP-Sao Paulo State UniversityLageado Experimental Form Institute of Agricultural Sciences and technologies Federal University of Mato Grosso

the use of stable isotope analysis as a tool for characterization of carbon turnover(δ^(13)C) in piglet's tissues by tracing its feeding system has drawn attention. thus, this study aimed at evaluating the influence of dietary glutamine, glutamic acid and nucleotides supplementation on carbon turnover in fundic-stomach region of weaned piglets at an average age of 21 days. the diets consisted of additive-free diet — control(C); 1% glutamine(G); 1% glutamic acid(GA) and 1% nucleotides(Nu). At weaning day(day 0: baseline), 3 piglets were slaughtered to quantify the δ^(13)C of stomach. the remaining 120 piglets were blocked by weight and sex, randomly assigned to pens with 3 piglets slaughtered per treatment at days 1,2,4, 5,7,9,13.20.27 and 49 after weaning in order to verify the fundic-stomach isotopic composition by *** were analyzed in terms of ^(13)C/^(12)C ratio by mass spectrometry and converted to relative isotopic enrichment values(δ^(13)C ‰) used to plot the first order exponential curves over time using OriginPro 8.0 software. the inclusion of glutamine, glutamate and nucleotides in piglet's diets has accelerated the carbon turnover in stomach during the post-weaning period, demonstrating also that glutamate has guaranteed fastest 13 C incorporation rate on fundic-stomach region and pH-lowering. Besides that, stable isotopes technique(δ^(13)C) has proved to be an important methodology to determine the time-scales at which piglets shift among diets with different isotopic values, characterizing the trophic effects of additives and the phenotypic flexibility of stomach.

关键词： Additives Biochemistry Isotopic dilution Mass spectrometry Nutrition Swine

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Strategies for prevention and management of partial flap loss or fat necrosis in microvascular autologous breast reconstruction

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Plastic and Aesthetic Research 2023年第1期10卷 295-304页

作者： Gabriela d García Nores Angela Cheng department of Surgery Division of Plastic and Reconstructive SurgeryEmory UniversityAtlantaGA 30322USA

Partial flap loss(skin involved)or fat necrosis following autologous breast reconstruction remains a dreaded postoperative complication despite significant advances in microsurgical *** strategies have been proposed in the preoperative and intraoperative period to prevent this complication ranging from preoperative imaging,intra-operative tissue perfusion assessment,appropriate perforator selection(location and number),maximizing inflow and outflow with additional anastomoses and/or pedicles,and minimizing ischemia *** management of partial flap loss(when there is skin involvement)and fat necrosis remains a challenge,with very little published data focusing on classification,timing,and *** intervention versus close observation may depend on multiple patient factors and the degree or volume of *** intervention options include hyperbaric oxygen therapy,fat aeration with a needle,liposuction,fat grafting,addition of another flap or implant,depending on the nature of the *** review summarizes the current evidence for each of these strategies to help the current surgeon understand their options in preventing and managing patients suffering from partial flap loss.

关键词： Partial flap loss fat necrosis prevention of fat necrosis

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人为因素导致的盐度变化对Kinneret湖水细菌种群的影响

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水生生物学报 2000年第4期24卷 326-330页

作者：胡章立 t.Bergstein Ben-dan d.Wynne 刘永定深圳大学生物工程系 IOLR the Yigal Allon Kinneret Limnological Laboratory 中国科学院水生生物研究所武汉430072

由于Ｋｉｎｎｅｒｅｔ湖周围的诸多盐泉被人为地导入其下游的约旦河，使得Ｋｉｎｎｅｒｅｔ湖水的盐度逐渐下降，这对作为主要工农业用水和饮用水资源的Ｋｉｎｎｅｒｅｔ湖来说是非常有价值的。然而，对湖水中的细菌来说则可能产生不同... 详细信息

由于Ｋｉｎｎｅｒｅｔ湖周围的诸多盐泉被人为地导入其下游的约旦河，使得Ｋｉｎｎｅｒｅｔ湖水的盐度逐渐下降，这对作为主要工农业用水和饮用水资源的Ｋｉｎｎｅｒｅｔ湖来说是非常有价值的。然而，对湖水中的细菌来说则可能产生不同的影响。作者通过实验研究发现，湖水盐度的变化导致细菌种群的改变，从而使我们观察到盐度与细菌之间的关系。这些结果表明：盐度变化对湖水水质保护对策和将来一段时间内湖水管理政策的制定都具有重要的意义。

关键词： Kinneret湖盐度细菌种群水质保护

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Multiple ecological strategies explain the distribution of exotic and native C_(4) grasses in heterogeneous early successional sites in Hawai’i

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Journal of Plant Ecology 2017年第3期10卷 426-439页

作者： Rafael de Oliveira Xavier Carla M.d’Antonio Ecology and Conservation Lab Department of HydrobiologyFederal University of São CarlosWashington Luís Highwaykm 235São CarlosSão Paulo 13565-905Brazil Environmental Studies Program 4312-L Bren University of CaliforniaSanta BarbaraCA 93106USA

Aims Biotic homogenization results in novel communities contain-ing multiple exotic *** attributes that contribute to the dominance of invaders and increase invasibility of communities have been identified,but rarely have factors governing the domi-nance of co-occurring invaders been *** we assess the presence and performance of five exotic and one native C_(4) grass species across local(microsite)and more broad-scale variation in fire history,soil age,altitude and *** ask whether species show preferences for the same conditions,whether all are constrained by poor soil development,and how their performance changes when alone versus *** addition to providing information useful to managers who want to control some of these species,such information can help to predict how distributions might change with climate change Methods We measured percent cover and plant height of each grass species in 64 plots in each of 15 sites,located in young volcanic substrates across environmental gradients in Hawai’i Volcanoes National Park,Hawai’i,*** varied in fire history and soil age,across altitu-dinal and precipitation *** estimated microsite heteroge-neity by measuring rock cover and soil depth,where each species was present and in plots as a *** analyzed effects of pos-sible controlling variables using chi-square tests and Generalized Additive Mixed *** Findings two species(Schizachyrium condensatum and Hyparrhenia rufa)were absent in shallow soil,restricted to more mesic sites and showed increasing performance with soil *** contrast,two other species(Andropogon virginicus and Melinis repens)tended to occur in shal-low soil with high rock cover across a wide range of *** addi-tional species(Melinis minutiflora)was weakly affected by soil depth and was the dominant at higher elevation(more mesic)and on burned sites,especially in old *** species was largely absent from lower elevation si

关键词： elevation gradient fire invasive species Melinis minutiflora soil depth

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An Easy Access to Oxime Ethers by Pd-Catalyzed C—O Cross-Coupling of Activated Aryl Bromides with Ketoximes and Chalcone Oximes

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Chinese Journal of Chemistry 2020年第8期38卷 830-836页

作者： Reeta t.M.Rangarajan Raj Pal Singh R.P.Singh Manjula Singh Centre for Fire Explosive and Environment SafetyDRDODelhiIndia department of Chemistry University of DelhiDelhiIndia department of Chemistry Sri Venkateswara CollegeUniversity of DelhiNew DelhiIndia department of Chemistry Shivaji CollegeUniversity of DelhiNew DelhiIndia

An efficient Pd-catalyzed method for C—O cross-coupling of ketoximes and chalcone oximes with activated aryl bromides and bromo-chalcones has been *** oxime ethers were obtained in good to excellent yields by[(π-allyl)PdCl]2/tBuXPhos(L7)catalyst ***(L11)was also found to be effective for the oxime *** method offers an easy and smooth coupling of chalcone oximes with activated aryl bromides and bromo-chalcones,which has not been previously explored.

关键词： coupling coupling bromide

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Retrieval of dislodged AmplifEYE using balloon dilator during colonoscopy

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Gastroenterology Report 2019年第2期7卷 139-140,I0002页

作者： Jihui Li Luke Blake Steven d.Wexner department of General Surgery Paris Community HospitalParisILUSA department of Colorectal Surgery Cleveland Clinic FloridaWestonFLUSA

AmplifEYE can increase the detection rate of adenomatous polyps and stabilize the mucosa for easy biopsy and *** it can also become a foreign body when it is dislodged during the *** report a case of dislodged AmplifE... 详细信息

关键词： colonoscopy AmplifEYE foreign-body retrieval balloon dila

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利用低能质子束产生高强度放射性束流

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高能物理与核物理 2006年第7期30卷 675-679页

作者：郭冰柳卫平 trinczek M Lapi S Ames F Buckley K R d’Auria J M Jayamanna K Ruiz C Ruth t J 中国原子能科学研究院核物理研究所北京102413 tRIUMF Vancouver B.C.CANADAV6T 2A3 Simon Fraser University Burnaby B.C.CANADAV5A 1S6 tRIUMF Vancouver B.C.CANADAV6T 2A3 Simon Fraser UniversityBurnabyB.C.CANADAV5A 1S6

加拿大tRIUMF实验室利用11C成功验证了一种产生高强度(-108ions／s)放射性束流的方法．该方法不同于普通在线同位素分离方法,它利用了13MeV的低能强流质子束,可以产生一系列核天体物理实验感兴趣的高强度放射性束流．

关键词：放射性束流在线同位素分离炮弹碎裂束流强度

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Antibacterial screening of silver nanoparticles synthesized by marine micro algae

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Asian Pacific Journal of tropical Medicine 2010年第10期3卷 797-799页

作者： d devina Merin S Prakash B Valentine Bhimba department of Biotechnology Udaya School of EngineeringUdaya NagarVellamodiAmmandivillai post-629204Kanyakumari DistrictTamil NaduIndia department of Biotechnology Sathyabama UniversityChennai-600 119TamilnaduIndia

Objective:to explore the biosynthesis of silver nanoparticles synthesized by marine microalgae. Methods:Marine microalgae was collected from Central Marine Fisheries Research Institute (CMFRI,tuticorin) and cultured in the *** nanoparticles synthesis were observed in normal and microwave irradiated microalgae and screened against human pathogens for the presence of ***:the presence of silver nanoparticle was confirmed by UV-Visible spectroscopy at 420 nm by the presence of plasmon *** confirmation was done by scanning electron microscope(SEM).Conclusions:these results not only provide a base for further research but are useful for drug development in the present and future.

关键词： Silver nanoparticle Marine microalgae Screening antimicrobials Synthesize

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