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MutL homolog 1 methylation and microsatellite instability in sporadic colorectal tumors among Filipinos

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2101-2113页

作者： Loraine Kay d Cabral Cynthia A Mapua Filipinas F Natividad Caecilia H C Sukowati Edgardo R Cortez Ma Luisa d Enriquez Research and Biotechnology Group St.Luke's Medical CenterQuezon City 1112Philippines Centro Studi Fegato Fondazione Italiana Fegato ONLUSTrieste 34149Italy department of Surgery St.Luke's Medical CenterQuezon City 1112Philippines Center for Natural Science and Environmental Research De La Salle UniversityManila 1004Philippines

BACKGROUNd Colorectal cancer(CRC)ranks third in terms of incidence and second in mortality *** CRC,the silencing of mismatch repair genes,including the mutL homolog 1(hMLH1)has been linked to microsatellite instability(MSI),the lengthening or shortening of microsatellite *** limited data have been presented so far on the link of hMLH1 methylation and MSI in Southeast Asia populations with sporadic CRC,and on its clinical *** to investigate the significance of the MSI status and hMLH1 methylation in CRC Filipino *** Fifty-four sporadic CRC patients with complete clinical data were included in this *** dNA from CRC tumor biopsies and their normal tissue counterparts were profiled for MSI by high resolution melting(HRM)analysis using the Bethesda Panel of Markers(BAt25,BAt26,d2S123,d5S346,and d17S250).hMLH1 methylation screening was performed using bisulfite conversion and methylation specific polymerase chain *** analysis was conducted to calculate their associations to clinicopathological characteristics and survival relevance(Kaplan-Meier curves and the log-rank test).RESULtS hMLH1 methylation was observed in 9%and 35%of CRC and normal samples,*** incidence of consistently methylated hMLH1 found in both normal and CRC was noticed for relation to location of tumor(Ptatus,d2S123 the most common unstable microsatellite and MSI-high(MSIH)was the most common MSI profile,counted for 46%and 50%of normal and CRC tissues,*** presence of MSI-low(MSI-L)and microsatellite stable(MSS)was 43%and 11%for normal,and 31%and 19%for CRC *** mean month of patients’survival was shorter in patients whose normal and tumor tissues had methylated compared to those with unmethylated hMLH1 and with MSI-H compared to those with MSI-L/MSS(Pthis was supported by significant difference in Kaplan-Meier with log-rank *** data indicated that hMLH1 methylation

关键词： Sporadic colorectal cancer dNA methylation Microsatellite instability Population genetic Colorectal cancer

Comparison of body mass index, anti-müllerian hormone and insulin resistance parameters among different phenotypes of polycystic ovary syndrome

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Gynecology and Obstetrics Clinical Medicine 2022年第4期2卷 164-170页

作者： türkan Gürsu Alper Eraslan Berk Angun University of Health Sciences turkey Zeynep Kamil Maternity and Children's Training and Research HospitalDepartment of Obstetrics and GynecologyIstanbulTurkey dunya IVF Center KyreniaCyprus Department of Reproductive Endocrinology and InfertilityTurkey

Background:diagnosis of polycystic ovary syndrome(PCOS)depends on 2003 Rotterdam *** to these criteria there are four possible combinations resulting in various *** aimed(i)to confirm that the levels of body mass index(BMI),anti-müllerian hormone(AMH)levels and insulin resistance(IR)are higher in PCOS patients and higher in phenotype-A among PCOS patients,and(ii)to determine cut-off values for the diagnosis of PCOS and *** and methods:this study was conducted in an IVF Center,between November 2019 and January *** of infertile women participating in the study was evaluated *** such as menstruation pattern,clinical hyperandrogenism,age,BMI,follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol,thyroid stimulating hormone(tSH),prolactin,AMH,dehydroepiandrosterone sulphate(dHEA-S),fasting blood glucose,fasting insulin levels,antral follicle counts(AFC)and ovarian volumes were recorded for each *** were grouped as PCOS and non-PCOS,and PCOS group was further divided into 4 subgroups according to their *** of infertile patients with PCOS patients were compared with infertile non-PCOS patients and PCOS phenotypes were compared among each ***:data of 244 infertile patients was included in the ***,AMH,AFC,and HOMA-IR were statistically higher in PCOS patients,compared to non-PCOS *** found the AMH level of>3.105 ng/ml to be having 90.8%sensitivity and 90%specificity to diagnose a patient as *** different phenotypes,also BMI,AMH,and insulin resistance index(HOMA-IR)levels were significantly higher in infertile PCOS phenotype-A when compared to other three phenotypes(p:0.003,p:0.000,and p:0.000,respectively).the AMH cut-off value to estimate phenotype-A was found as 6.095 ng/ml with 69.2%sensitivity and 86.7%*** did not found threshold levels of BMI and HOMA-IR with high sensitivity to identify ***:Properly di

关键词： Polycystic ovarian syndrome Body mass index Anti-müllerian hormone Insulin resistance PCOS Phenotypes

An open-access endoscopy screen correctly and safely identifies patients for conscious sedation

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Gastroenterology Report 2016年第4期4卷 281-286,I0001页

作者： darshan Kothari Joseph d.Feuerstein Laureen Moss Julie d’Souza Kerri Montanaro daniel A.Leffler Sunil G.Sheth department of Medicine and division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA department of Nursing Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Background and aims:Open-access scheduling is highly utilized for facilitating generally low-risk *** screening addresses sedation requirements;however,procedural safety may be compromised if screening is *** sought to determine the reliability of our open-access scheduling system for appropriate use of conscious ***:We prospectively and consecutively enrolled outpatient procedures booked at an academic center by open-access using screening after in-office gastroenterology(GI)*** collected the cases inappropriately booked for conscious sedation and compared the characteristics for significant ***:A total of 8063 outpatients were scheduled for procedures with conscious sedation,and 5959 were booked with *** 78 patients(0.97%,78/8063)were identified as subsequently needing anesthesiologist-assisted sedation;44(56.4%,44/78)were booked through open-access,of which chronic opioid(47.7%,21/44)or benzodiazepine use(34.1%,15/44)were the most common reasons for needing anesthesiologist-assisted *** on chronic benzodiazepines required more midazolam than those not on chronic benzodiazepines(P=0.03)of those patients who underwent conscious ***,patients with chronic opioid use required more fentanyl than those without chronic opioid use(P=0.04).Advanced liver disease and alcohol use were common reasons for patients being booked after in-office consultation and were significantly higher than those booked with open-access(both Pd that the majority of patients can be triaged for conscious sedation using a multi-tiered screening ***,few patients(tely booked for conscious *** most common reasons for considering anesthesiologist-assisted sedation were chronic opioid,benzodiazepine and/or alcohol use and advanced liver *** suggests that these entities could be included in screening proces

关键词： open-access endoscopy sedation screen

Sedentary behavior and physical activity predicting depressive symptoms in adolescents beyond attributes of health-related physical fitness

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Journal of Sport and Health Science 2018年第4期7卷 489-496页

作者： gene l.farren tao zhang xiangli gu katherine t.thomas department of Kinesiology Health Promotionand RecreationUniversity of North TexasDentonTX 76203USA Corresponding author.E-mail address：Gene.Farren@unt.edu

Background： Sedentary behavior （SB）, physical activity （PA）, and attributes of physical fitness have been shown to be related to depressive symptoms in adolescents. the purpose of the present study was to investigate whether SB and fitness-producing activity predicted depression in active adolescents over and above gender and fitness attributes. Methods： Participants were 249 adolescents （age： 12.85 ± 0.89 years, mean ± Sd） from 3 public middle schools who wore Actical accelerometers to assess their SB and PA. Participants also completed the FItNESSGRAM health-related fitness assessment and a brief depression questionnaire. A 3-step hierarchical regression analysis was conducted with gender and fitness attributes （i.e., body mass index （BMI）, maximal volume oxygen uptake （VO2max）, curlups, and pushups）, moderate- and vigorous-intensity activity, and SB entered in respective steps. Results： Regression analysis indicated activity variables （i.e., moderate- and vigorous-intensity activity） significantly predicted depression （△R^2= 0.12, p 〈 0.01） beyond gender and fitness attributes. Overall, gender, fitness attributes, activity variables, SB explained 31% of the variance in depression. Structure coefficients revealed VO2max （rs= -0.77）, moderate-intensity activity （rs= -0.67）, vigorous-intensity activity （rs = -0.81）, and SB （rs = 0.57） were substantially correlated with the criterion variable; thus, they were the strongest predictors of depression. Conclusion： the findings of the current study indicated SB and PA were both significant predictors of depression; however, sufficient fitness-producing activity and adequate cardiorespiratory fitness may nullify the negative influence of SB on depressive symptoms in active adolescents.2018 Published by Elsevier B.V. on behalf of Shanghai University of Sport. this is an open access article under the CC BY-NC-Nd license. （http：//***/licenses/by-nc-nd/4.0/）.

关键词： Accelerometers Adolescent health Cardiorespiratory fitness FItNESSGRAM Mental health Moderate-to-vigorous-intensity activity

An MPI parallel dEM-IMB-LBM framework for simulating fluid-solid interaction problems

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2219-2231页

作者： Ming Xia Liuhong deng Fengqiang Gong tongming Qu Y.t.Feng Jin Yu Hunan Key Laboratory of Geomechanics and Engineering Safety Xiangtan UniversityXiangtan411105China School of Civil Engineering Southeast UniversityNanjing211189China department of Civil and Environmental Engineering Hong Kong University of Science and TechnologyHong KongChina Zienkiewicz Centre for Computational Engineering Swansea UniversitySwanseaSA18ENUK Fujian Research Center for tunneling and Urban Underground Space Engineering Huaqiao UniversityXiamen361021China

the high-resolution dEM-IMB-LBM model can accurately describe pore-scale fluid-solid interactions,but its potential for use in geotechnical engineering analysis has not been fully unleashed due to its prohibitive computational *** overcome this limitation,a message passing interface(MPI)parallel dEM-IMB-LBM framework is proposed aimed at enhancing computation *** framework utilises a static domain decomposition scheme,with the entire computation domain being decomposed into multiple subdomains according to predefined processors.A detailed parallel strategy is employed for both contact detection and hydrodynamic force *** particular,a particle Id re-numbering scheme is proposed to handle particle transitions across sub-domain *** benchmarks are conducted to validate the accuracy and overall performance of the proposed ***,the framework is applied to simulate scenarios involving multi-particle sedimentation and submarine *** numerical examples effectively demonstrate the robustness and applicability of the MPI parallel dEM-IMB-LBM framework.

关键词： discrete element method(dEM) Lattice Boltzmann method(LBM) Immersed moving boundary(IMB) Multi-cores parallelization Message passing interface(MPI) CPU Submarine landslides

Magnetic, Structural and Morphological Characterization of Sr<sub>2</sub>GdRuO<sub>6</sub>double Perovskite

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Journal of Modern Physics 2011年第3期2卷 154-157页

作者： L.t. Corredor d.A. Landínez téllez J.L. Pimentel Jr P. Pureur J. Roa-Rojas 不详

We report structural, morphological and magnetic properties of the Sr2GdRuO6 compound, which is used as precursor oxide in the production process of RuSr2GdCu2O8 superconducting ruthenocuprates. the crystalline structure was studied by X-ray diffraction and Rietveld refinement. Results reveal that material crystallizes in a monoclinic double perovskite, space group P21/n (#14). Scanning Electron Microscopy experiments on samples show homogeneous granular morphology with grain size from 3 up to 7 μm. Semiquantitative analysis of composition was performed by the Energy dispersive X-ray technique. Experimental results are 98% in agreement with the theoretical stoichiometry. Curves of magnetization as a function of temperature exhibit an antiferromagnetic-like behaviour, with Néel temperature tN=15.3 K and magnetic effective moment 8.72μB.

关键词： Complex Perovskite Structure Magnetic Properties

Load shedding scheme for an interconnected hydro-thermal hybrid system with SMES

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Frontiers in Energy 2012年第3期6卷 227-236页

作者： d. tYAGI Ashwani KUMAR Saurabh CHANANA department of Electrical Engineering National Institute of TechnologyKurukshetra 136119 India

the frequency of based on the load pattern the power system varies of the consumers. With continuous increase in the load, the frequency of the system keeps decreasing and may reach its minimum allowable limits. Further increase in the load will result in more frequency drop leading to the need of load shedding, if excess generation is not available to cater the need. this paper proposed a methodology in a hybrid thermal-hydro system for finding the required amount of load to be shed for setting the frequency of the system within its minimum allowable limits. the load shedding steps were obtained based on the rate of change of frequency with the increase in the load in both areas. the impact of superconducting magnetic energy storage （SMES） was obtained on load shedding scheme. the comparison of the results was presented on the two-area system.

关键词： critical load frequency response load shedding multi-area system rate of change of frequency,superconducting magnetic energy storage (SMES) device

thymic carcinoma:review and update

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Journal of Cancer Metastasis and treatment 2022年第1期8卷 476-487页

作者： Kirill Karlin Phillip d.Michaels department of Pathology Beth Israel Deaconess Medical CenterBostonMA 02115USA

thymic carcinoma(tC)is a rare thymic epithelial neoplasm with an aggressive clinical *** are many recognized histologic subtypes as described by the fifth edition of the World Health Organization(WHO)Classification of thoracic tumors;however,given the rarity of this tumor group,diagnosis remains a challenge,especially on limited tissue ***,rare variants of tC are continuing to be established,particularly in the era of molecular ***,histologic subtypes are described as the rare subtypes of tC in the context of their immunoprofile,cytogenetic or molecular features,clinical presentation,and ensuing challenges.

关键词： thymic carcinoma NUt carcinoma thymus KIt thymoma

Iron,the endolysosomal system and neuroinflammation:a matter of balance

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Neural Regeneration Research 2022年第5期17卷 1003-1004页

作者： daniel A.Bórquez Pamela J.Urrutia Marco t.Núñez Center for Biomedical Research Faculty of MedicineUniversidad Diego PortalesSantiagoChile department of Biology Faculty of SciencesUniversidad de ChileSantiagoChile

Iron accumulation and neuroinflammation are cardinal features of many neurodegenerative diseases(Urrutia et al.,2021).However,the hierarchy in the pathogenic mechanisms and the molecular connections between these proc... 详细信息

关键词： Iron system showing