检索结果-南通市图书馆

Medical Review 2022年第1期2卷 110-113页

作者： Zheng Yin Stephen t.c.wong Department of Systems Medicine and Bioengineering Houston Methodist Cancer Center and Ting Tsung&Wei Fong Chao Center for BRAINHouston Methodist Research InstituteWeill Cornell MedicineHouston 77030TXUSA

Alzheimer’s disease and related dementias(AD/ADRD)affects more than 50 million people worldwide but there is no clear therapeutic option affordable for the general patient ***,drug repositioning studies featuring collaborations between academic institutes,medical centers,and hospitals are generating novel therapeutics candidates against these devastating diseases and filling in an important area for healthcare that is poorly represented by pharmaceutical *** drug repositioning studies converge expertise from bioinformatics,chemical informatics,medical informatics,artificial intelligence,high throughput and high-content screening and systems *** also take advantage of multi-scale,multi-modality datasets,ranging from transcriptomic and proteomic data,electronical medical records,and medical imaging to social media information of patient behaviors and emotions and epidemiology profiles of disease populations,in order to gain comprehensive understanding of disease mechanisms and drug *** proposed a recursive drug repositioning paradigm involving the iteration of three processing steps of modeling,prediction,and validation to identify known drugs and bioactive compounds for AD/*** recursive paradigm has the potential of quickly obtaining a panel of robust novel drug candidates for AD/ADRD and gaining in-depth understanding of disease mechanisms from those repositioned drug candidates,subsequently improving the success rate of predicting novel hits.

关键词： Alzheimer’s disease drug repositioning modeling multi-omics prediction systems biology validation.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

认识酸渣特征,提高原油产量

内蒙古石油化工 1998年第A1期24卷 91-100页

作者： t.c.wong R.J.Hwang 殷海军

在德克萨斯州西部的二叠纪盆地，有许多油井存在与酸化有关的酸渣问题，不同油井的酸渣是相同的，经鉴定是被富含沥青烯的有机固体所稳定的一种粘性乳状液。原油中酸渣的形成随着沥青烯和树脂的含量、原油的基类数和酸中的Fe3+含量的增... 详细信息

在德克萨斯州西部的二叠纪盆地，有许多油井存在与酸化有关的酸渣问题，不同油井的酸渣是相同的，经鉴定是被富含沥青烯的有机固体所稳定的一种粘性乳状液。原油中酸渣的形成随着沥青烯和树脂的含量、原油的基类数和酸中的Fe3+含量的增加而增加。在测试的9种工业用酸体系中，只有3种对防止酸渣的形成有效，都采用了新颖的控铁技术，即三价铁离子的催化还原。有几种工业溶剂和普通溶剂体系能有效分解酸渣，其中包括一种芳香族溶剂（如二甲苯）与异乙醇（以2：1的体积比配制或与乙二醇-丁醚（EGMBE）（以2：1或3：1的体积比配制）的混合液。酸的配方和溶剂体系的选择原则是效益好、操作安全，已在矿场成功实施。如果在二叠纪盆地的一些油井上早日采用该研究成果，可以从99口井中多采出原油574桶／天，据此估计一年可增加收入300万美元。

关键词：油井酸渣特征原油产量酸化井下作业

在线全文

学校读者我要写书评

暂无评论

认识酸渣特征　提高原油产量

石油石化节能 1998年第1期 9-13页

作者： t.c.wong R.J.Hwang 殷海军华北石油管理局

德克萨斯州西部的二叠纪盆地的许多油井存在与酸化有关的酸渣问题，不同井的酸渣是相同的，经鉴定是被富含沥青烯的有机固体所稳定的一种粘性乳状液。原油中酸渣的形成随着沥青烯和树脂的含量、原油的基类数和酸中的三价铁离子含量的增... 详细信息

德克萨斯州西部的二叠纪盆地的许多油井存在与酸化有关的酸渣问题，不同井的酸渣是相同的，经鉴定是被富含沥青烯的有机固体所稳定的一种粘性乳状液。原油中酸渣的形成随着沥青烯和树脂的含量、原油的基类数和酸中的三价铁离子含量的增加而增加。在测试的9种工业用酸体系中，只有3种对防止酸渣的形成有效，都采用了新颖的控铁技术，即三价铁离子的催化还原。有几种工业用和普通溶剂体系能有效分解酸渣，其中包括一种芳香族溶剂（如二甲苯）与异乙醇（以2：1的体积比配制）或与乙二醇－丁醚（EGMEB）（以2：1或3：1的体积比配制）的混合液。酸的配方和溶剂体系的选择原则是效益好、操作安全、已在矿场成功实施。如果在二叠纪盆地的一些油井上早日采用该研究成果，可以从99口井中多采出原油574bbl／d，据此估计一年可增加收入300万美元。

关键词：原油产量粘性乳状液酸渣注水试验

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

认识酸渣特征　提高原油产量

国外油田工程 1998年第1期14卷 9-13页

作者： t.c.wong R.J.Hwang 殷海军华北石油管理局

关键词：原油产量酸渣注水油田

Artificial intelligence analysis of videos to augment clinical assessment:an overview

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第4期19卷 717-718页

作者： David c.wong Stefan Williams University of Leeds Leeds teaching Hospitals trust LeedsUK

Observation is a fundamental part of the practice of clinical *** of movement is particularly important for the *** such as Parkinson’s disease,multiple sclerosis,stroke,epilepsy,and many others affect a person’s movement in characteristic *** some conditions,changes in the patient’s voice can be included in this-changes in sound caused by changes in the movements of *** clinician’s detection of a characteristic abnormality,and their judgment of its severity,plays a central role in both diagnosis and the assessment of prognosis or response to ***,that practice depends upon a limited resource of experienced *** addition,these experts are limited by human visual judgment,which cannot reliably or precisely detect and measure small or subtle changes in movement(Williams et al.,2023).

关键词： clinical epilepsy diagnosis

Free-electron crystals for enhanced X-ray radiation

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第7期13卷 1299-1309页

作者： Lee Wei Wesley wong Xihang Shi Aviv Karnieli Jeremy Lim Suraj Kumar Sergio carbajo Ido Kaminer Liang Jie wong School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore. Solid State Institute and Faculty of Electrical and computer Engineering Technion–Israel Institute of TechnologyHaifa 3200003Israel. School of Electrical Engineering Fleischman Faculty of EngineeringTel Aviv UniversityTel Aviv 69978Israel Department of Applied Physics Stanford UniversityStanfordCA 94305USA. Science Mathematics and TechnologySingapore University of Technology and Design8 Somapah RoadSingapore 487372Singapore. Electrical and computer Engineering Department UCLA420 WestwoodLos AngelesCA 90095USA. Physics and Astronomy Department UCLA475 Portola PlazaLos AngelesCA 90095USA. SLAc National Accelerator Laboratory Stanford University2575 Sand Hill RoadMenlo ParkCA 94025USA

Bremsstrahlung—the spontaneous emission of broadband radiation from free electrons that are deflected by atomic nuclei—contributes to the majority of X-rays emitted from X-ray tubes and used in applications ranging from medical imaging to semiconductor chip ***,we show that the bremsstrahlung intensity can be enhanced significantly—by more than three orders of magnitude—through shaping the electron wavefunction to periodically overlap with atoms in crystalline ***,we show how to shape the bremsstrahlung X-ray emission pattern into arbitrary angular emission profiles for purposes such as unidirectionality and ***,we find that these enhancements and shaped emission profiles cannot be attributed solely to the spatial overlap between the electron probability distribution and the atomic centers,as predicted by the paraxial and nonrecoil theory for free electron light *** work highlights an unprecedented regime of free electron light emission where electron waveshaping provides multi-dimensional control over practical radiation processes like *** results pave the way towards greater versatility in table-top X-ray sources and improved fundamental understanding of quantum electron-light interactions.

关键词： overlap attributed arbitrary

Effects of layer interactions on instantaneous stability of finite Stokes flows

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 69-84页

作者： chen ZHAO Zhenli cHEN c.t.MUtASA Dong LI School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China

the stability analysis of a finite Stokes layer is of practical importance in flow control. In the present work, the instantaneous stability of a finite Stokes layer with layer interactions is studied via a linear stability analysis of the frozen phases of the base flow. the oscillations of two plates can have different velocity amplitudes, initial phases, and frequencies. the effects of the Stokes-layer interactions on the stability when two plates oscillate synchronously are analyzed. the growth rates of two most unstable modes when δ t equal, and δ = δ*/h*, where δ*and h*are the Stokes-layer thickness and the half height of the channel, respectively. However, their vorticities are different. the vorticity of the most unstable mode is symmetric, while the other is asymmetric. the Stokes-layer interactions have a destabilizing effect on the most unstable mode when δ tabilizing effect when δ > 0.68. However, the interactions always have a stabilizing effect on the other unstable mode. It is explained that one of the two unstable modes has much higher dissipation than the other one when the Stokes-layer interactions are strong. We also find that the stability of the Stokes layer is closely related to the inflectional points of the base-flow velocity profile. the effects of inconsistent velocity-amplitude, initial phase, and frequency of the oscillations on the stability are analyzed. the energy of the most unstable eigenvector is mainly distributed near the plate of higher velocity amplitude or higher oscillation frequency. the effects of the initial phase difference are complicated because the base-flow velocity is extremely sensitive to the initial phase.

关键词： finite Stokes layer instantaneous stability Stokes-layer interaction asynchronous oscillation

Near resonance vibration isolation on a levered-dual response(LEDAR)coulomb-damped system by differential preloads/offsets in linear springs

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1033-1050页

作者： t.I.tOLUWALOJU c.K.tHEIN D.HALIM Department of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Nottingham Ningbo china Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

the levered-dual response(LEDAR)coulomb-damped system attains near resonant vibration isolation by differential preloads/offsets in linear *** takes the advantages of both the preloads/offsets in linear springs and the guiderail friction for realizing different levels of vibration *** isolation capacities are investigated on the strategies with both the horizontal and vertical guiderails,with the horizontal rail only,and without *** compressive preloads generally result in the consumption of most of the initial excitation energy so as to overcome the potential *** isolation onsets at the frequency ratio of 1∓0.095 on the left-hand side(LHS)and the right-hand side(RHS)of the lever are relative to the load plate *** observed near resonant isolation thus makes the LEDAR system a candidate for the isolation of the mechanical systems about resonance while opening a path for simultaneous harvesterisolation functions and passive functions at extreme frequencies.

关键词： lever ratio coulomb damping preload tension/compression isolation band/depth offset potential

Efficient guiding and focusing of intense laser pulse using periodic thin slits

在线全文

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2024年第4期9卷 29-39页

作者： L.Xu t.W.Huang K.Jiang c.N.Wu H.Peng P.c.hen R.Li H.B.Zhuo c.t.Zhou Shenzhen Key Laboratory of Ultraintense Laser and Advanced Material technology Center for Intense Laser ApplicationTechnologyand College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118People’s Republic of China

Slits have been widely used in laser-plasma interactions as plasma optical components for generating high-harmonic light and controlling laser-driven particle ***,we propose and demonstrate that periodic thin slits can be regarded as a new breed of optical elements for efficient focusing and guiding of intense laser *** fundamental physics of intense laser interaction with thin slits is studied,and it is revealed that relativistic effects can lead to enhanced laser focusing far beyond the pure diffractive focusing *** addition,the interaction of an intense laser pulse with periodic thin slits makes it feasible to achieve multifold enhancement in both laser intensity and energy transfer efficiency compared with conventional *** results provide a novel method for manipulating ultra-intense laser pulses and should be of interest for many laser-based applications.

关键词： laser pulse intense

Mitochondria-targeted atovaquone promotes anti-lung cancer immunity by reshaping tumor microenvironment and enhancing energy metabolism of anti-tumor immune cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

cancer communications 2024年第3期44卷 448-452页

作者： Donghai Xiong Zheng Yin Mofei Huang Yian Wang Micael Hardy Balaraman Kalyanaraman Stephen t wong Ming You center for cancer Prevention Houston Methodist Neal Cancer CenterHouston Methodist HospitalWeill Cornell MedicineHoustonTexasUSA Department of Systems Medicine and Bioengineering Houston Methodist Cancer CenterHouston Methodist HospitalWeill Cornell MedicineHoustonTexasUSA Aix Marseille Univ Centre Nationaldela Recherche Scientifique(CNRS)Institut de Chimie Radicalaire(ICR)UnitéMixte de Recherche(UMR)7273MarseilleFrance Department of Biophysics Medical College of WisconsinMilwaukeeWisconsinUSA

Dear Editor,Atovaquone(AtO),a mitochondrial inhibitor,has anti-cancer effects[1].Based on AtO,we developed mitochondria-targeted atovaquone(Mito-AtO)that had even stronger anti-tumor efficacy than AtO[2].We syn-thesized Mito-AtO by attaching the bulky triphenylphos-phonium(tPP)group to AtO via a ten-carbon alkyl chain(Supplementary file of methods;Supplementary Figure S1).

关键词： metabolism immunity targeted