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International Journal of Dermatology And Venereology 1984年第4期10卷 206-208页

作者： chang t W 李顺凡吴国凤

认识单纯疱疹病毒(HSV)引起的疾病已经几个世纪了,但有关病毒的分子、遗传、疾病的流行病学特点、潜伏性和致癌性、免疫学以及诊断、预防和治疗等方面的发展,取得重大突破还是近十年的事.本文就上述几方面作一概述.

关键词： HSV DNA 病毒株阿糖

中国道教协会第七届理事会会长、副会长、秘书长简历

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中国道教 2005年第4期 22-25页

作者：中国道教协会

任法融男，汉族，生于1937年6月，籍贯甘肃省天水市。1952年3月在陇县龙门洞出家，人道教全真派，师从王嗣琳道长。

关键词：中国道教协会理事会会长副会长秘书长宗教信仰

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超重和正常体质量患者的心力衰竭新发率的荟萃分析

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中华高血压杂志 2018年第4期26卷 399-399页

作者： Krittanawong c tunhasiriwet A Wang Z Zhang H Prokop LJ chirapongsathorn S Sun t Kitai t tang WHW 刘青叶鹏

肥胖和新发心力衰竭之间的关系已经反复确立,关于超重与心力衰竭发展风险知之甚少。该系统回顾和荟萃分析旨在探讨超重、肥胖与新发心力衰竭发生率的关系。在该研究中,研究者从数据库创建开始到2017年6月,系统检索了MEDLINE,Medline InP... 详细信息

肥胖和新发心力衰竭之间的关系已经反复确立,关于超重与心力衰竭发展风险知之甚少。该系统回顾和荟萃分析旨在探讨超重、肥胖与新发心力衰竭发生率的关系。在该研究中,研究者从数据库创建开始到2017年6月,系统检索了MEDLINE,Medline InProcess and Other Non-Indexed citations,EMBASE,Scopus和cochrane对照试验中心登记册。

关键词：心力衰竭荟萃分析超重体质量 cochrane MEDLINE Medline 患者

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校园智能卡应用系统的构想

天津城市建设学院学报 1999年第2期5卷 57-60页

作者：金甦文陈琪天津城市建设学院图书馆 天津城市建设学院图书馆

介绍了智能卡及其应用系统的特点和工作过程，提出了建设校园智能卡应用系统的设计目标和设计原则。

关键词：校园智能卡计算机网络 1c卡数据库

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长期照护中质量和结果框架的作用:系统评价

中国全科医学 2017年第36期 4479-4479页

作者： FORBES L J MARcHAND c DORAN t 本刊编辑部

背景改善患者的长期照护质量是NHS政策的核心。质量和结果框架(QOF)是对需长期照护患者采取有效干预措施的初级护理绩效奖励方案。该方案被认为并不能提高长期照护质量。目的查证QOF是否能够提高长期照护质量。设计与场所英国QOF有效性... 详细信息

背景改善患者的长期照护质量是NHS政策的核心。质量和结果框架(QOF)是对需长期照护患者采取有效干预措施的初级护理绩效奖励方案。该方案被认为并不能提高长期照护质量。目的查证QOF是否能够提高长期照护质量。设计与场所英国QOF有效性研究系统评价。方法通过检索电子数据库进行同行评议的实证定量研究,探索QOF对长期照护质量的影响,其中包括护理协调和整合、全人和个人护理、自我护理、患者体验、生理和生化结果、卫生服务利用率及病死率。由于研究是异构的,所以进行了叙述性合成。结果确定了符合纳入标准的3个系统评价和5个初步研究。QOF与急症住院人数增加有所放缓、重性精神疾病(SMI)咨询人数增加有所放缓、糖尿病护理有所改善相关。证据的性质无法确定这些关联是否具有因果关系。未发现QOF对病死率的明显影响。QOF对护理协调和整合、全人护理、自我护理和患者体验无影响。结论 NHS应更广泛地考虑高质量长期照护的影响因素以及其他激励方式。

关键词：长期照护 NHS 自我护理

WONcA研究论文摘要汇编——患者及医生对用药依从性及其重要性的评价差异

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中国全科医学 2016年第32期 3965-3965页

作者： SIDORKIEWIcZ S tRAN V t cOUSYN c 本刊编辑部

目的比较长期服药治疗的患者自述用药依从性与医生评估的用药重要性之间的差异。方法本研究选取的患者在法国医院内及医院外接受了至少1个周期的长期药物治疗。使用开放式问卷调查患者用药非依从性的原因,并将其分为有意或无意两类。采... 详细信息

目的比较长期服药治疗的患者自述用药依从性与医生评估的用药重要性之间的差异。方法本研究选取的患者在法国医院内及医院外接受了至少1个周期的长期药物治疗。使用开放式问卷调查患者用药非依从性的原因,并将其分为有意或无意两类。采用Spearman相关系数就患者与医生对用药依从性及其重要性的评价数据进行比较分析。结果 2014年4—8月选取服用498种药物的128例患者。患者和医生在对用药依从性及其重要性的评价上表现出很大分歧〔r=-0.25,95%cI(-0.37,-0.11);r=0.07,95%cI(0,0.13)〕。医生评价的用药重要性与患者自述的用药依从性之间没有任何关联〔r=-0.04,95%cI(-0.14,0.06)〕。共有94种(18.9%)医生认为重要的药物而患者没有认真遵循医嘱服用。患者有意没有坚持服用的药物有26种(48.1%)。结论患者与医生对用药依从性及其重要性评价之间存在很大的差异;约有20%的医生认为重要的药物,患者没有认真遵循医嘱服用,这些情况表明医生与患者在药物治疗方面需要更好地协作。

关键词：依从性患者用药

Long-term live-cell microscopy with labeled nanobodies delivered by laser-induced photoporation

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Nano Research 2020年第2期13卷 485-495页

作者： Jing Liu tim Hebbrecht toon Brans Eef Parthoens Saskia Lippens chengnan Li Herlinde De Keersmaecker Winnok H.De Vos Stefaan c.De Smedt Rabah Boukherroub Jan Gettemans Ranhua Xiong Kevin Braeckmans Laboratory of General Biochemistry and Physical Pharmacy Faculty of PharmacyGhent UniversityGhent B-9000Belgium Department of Biomolecular medicine Faculty of Medicine and Health SciencesGhent UniversityGhent B-9000Belgium VIB-UGent center for Inflammation Research VIBGhent B-9000Belgium VIB Bioimaging core Ghent VIBGhent B-9000Belgium Department of Biomedical Molecular Biology Ghent UniversityGhent B-9000Belgium Univ.Lille CNRSCentrale LilleISENUniv.ValenciennesUMR 8520-IEMNLille F-59000Franc Laboratory of cell Biology and Histology Department of Veterinary SciencesUniversity of Antwerp2020 AntwerpBelgium centre for Advanced Light Microscopy Ghent UniversityGhent B-9000Belgium

Fluorescence microscopy is the method of choice for studying intracellular ***,its success depends on *** of specific and stable markers.A prominent example of markers that are rapidly gaining interest are nanobodies(Nbs.-15 kDa),which can be functionalized with bright and photostable organic *** to their relatively small size and high specificity,Nbs offer great potential for high-quality long-term subcellular imaging,but suffer from the fact that they cannot spontaneously cross the plasma membrane of live *** have recently discovered that laser-induced photoporation is well suited to deliver extrinsic labels to living cells without compromising their *** a laser-based technology,it is readily compatible with light microscopy and the typical cell recipients used for *** by these promising initial results,we demonstrate here for the first time successful long-term imaging of specific subcellular structures with labeled nanobodies in living *** illustrate this using Nbs that target GFP/YFP-protein constructs accessible in the cytoplasm,actin-bundling protein Fascin,and the histone H2A/H2B *** an efficiency of more than 80%labeled cells and minimal toxicity(-2%),photoporation proved to be an excellent intracellular delivery method for ***-lapse microscopy revealed that cell division rate and migration remained unaffected,confirming excellent cell viability and *** conclude that laser-induced photoporation labeled Nbs can be easily delivered into living cells,laying the foundation for further development of a broad range of Nbs with intracellular targets as a toolbox for long-term live-cell microscopy.

关键词： laser-induced photoporation vapor nanobubble long-term microscopy imaging nanobody intracellular delivery living cell labeling

chemical ordering and magnetic phase transitions in multiferroic BiFeO_(3)-AFe_(1/2)Sb_(1/2)O_(3)(A-Pb,Sr)solid solutions fabricated by a high-pressure

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Journal of Advanced Dielectrics 2022年第1期12卷 12-18页

作者： S.I.Raevskaya N.M.Olekhnovich A.V.Pushkarev Y.V.Radyush S.P.Kubrin V.V.titov E.A.Artseva I.P.Raevski I.N.Zakharchenko c-c.chou M.A.Malitskaya Research Institute of Physics and Faculty of Physics Southern Federal University Rostov-on-Don 344090 Russia Scientific-Practical Materials Research centre of NAS of Belarus 220072 MinskBelarus National taiwan University of Science and technology taipei 106 Taiwan

synthesisceramic samples of BiFeO_(3)-based perovskite solid solutions with the highly ordered complex perovskites PbFe_(1/2)Sb_(1/2)O_(3)(PFS)and SrFe_(1/2)Sb_(1/2)O_(3)(SFS)were obtained using high-pressure synthesis at 4-6 GPa.Mössbauer studies revealed that BiFeO_(3)-SFS compositions are characterized by a larger compositional inhomogeneity as compared to BiFeO_(3)-PFS *** line with this result,concentration dependence of the magnetic phase transition temperature tN for BiFeO_(3)-SFS compositions is close to the tN(x)dependence for BiFeO_(3)solid solution with disordered perovskite PbFe_(1/2)Nb_(1/2)O_(3)(PFN).In contrast to this tN(x)dependence for BiFeO_(3)-PFS compositions nicely follows the theoretical tN(x)dependence calculated for the case of the ordered distribution of Fe3+and non-magnetic Sb^(5)+ions in the lattice(chemical ordering).

关键词： Multiferroics chemical ordering magnetic phase transition BiFeO_(3) high-pressure synthesis

cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma

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World Journal of Gastroenterology 2009年第28期15卷 3493-3497页

作者： Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs t Wobbes Ben JM Witteman Adriaan cItL tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters Department of Gastroenterolog Radboud University Nijmegen Medical center PO Box 9106500 HB Nijmegen The Netherlands Department of Surgery Radboud UniversityNijmegen Medical Center PO Box 9101 6500 HB NijmegenThe Netherlands Department of Gastroenterology Hospital Gelderse Vallei PO Box 9025 6710 HN Ede The Netherlands Department of Gastroenterology Canisius Wilhelmina Hospital Weg door Jonkerbos 100 6532 SZ Nijmegen The Netherlands

AIM： tO determine whether -1195 A→G and/or -765 G→c polymorphisms in cyclooxygenase-2 ccOX-2） may have a risk modifying effect on the development of esophageal carcinoma in a Dutch caucasian population. MEtHODS： two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area. DNA was isolated from whole blood and used for genotyping. PcR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis. Odds ratios （OR） and 95% confidence intervals （cI） were estimated. RESULtS： the distribution of the -1195A→G polymorphism was significantly different in esophageal cancer patients compared to controls. the -1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma （OR = 3.85, 95% cI： 1.45-10.3） compared with the -1195AA genotype as a reference. the -765 G→c genotype distribution was not different between the two groups. the GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls （OR = 3.45, 95% cI： 1.24-9.58; with AG/AG as a reference）. the same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical significance. cONcLUSION： Presence of the cOX-2 -1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma.

关键词： Adenocarcinoma cyclooxygenase-2 Esophagus Genetic polymorphism Squamous cellcarcinoma

Assessment of infectivity and the impact on neutralizing activity of immune sera of the cOVID-19 variant,cAL.20c

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Signal transduction and targeted therapy 2021年第8期6卷 2322-2324页

作者： Zhongcheng Zhou Peng Du Meixing Yu Daniel t.Baptista-Hon Man Miao Andy P.Xiang Johnson Yiu-Nam Lau cOVID-Immunity Investigation Group Gen Li Kang Zhang Guangzhou Women and children’s Medical center Guangzhou Medical UniversityGuangzhouChina University Hospital and center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacaoChina center for Stem cell Biology and tissue Engineering Key Laboratory for Stem Cells and Tissue EngineeringMinistry of EducationSun Yat-sen UniversityGuangzhouChina Department of Biology Hong Kong Baptist UniversityKowloon TongHong KongChina Department of Bioinformatics and Al Bioland LaboratoryGuangzhouChina

Dear Editor,New variants of SARS-coV-2 have been emerging since the initial outbreak in 2019;1 one of the latest ones was identified in Southern california in October 2020 and was subsequently detected in 26 other sta... 详细信息

关键词： neutral impact california