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cD4^(+)t.c.lls produce IFN-I to license cDc1s for induction of cytotoxic t.c.ll activity in human tumors

cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël c.de Groot Marij J.P.Welters tom de wit Ellen Schrama Hans van Eenennaam Saskia J.Santegoets timo Oosenbrug Annemarthe van der Veen Joris L.Vos charlotte L.Zuur Noel F.c.c.de Miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands department of tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of Otorhinolaryngology Leiden University Medical center LeidenThe Netherlands department of Pathology Leiden University Medical CenterLeidenThe Netherlands

cD4^(+)t.c.lls can"help"or"license" conventional type 1 dendrit.c.cells(cDc1s)to induce cD8^(+)cytotoxic t lymphocyte(ctL)ant.c.ncer responses,as proven in mouse *** recently identified cDc1s with a transcriptomic imprint of cD4^(+)t.c.ll help,specifically in t.c.ll-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDc1 licensing by cD4^(+)t.c.lls in *** cD4^(+)t.c.lls produce IFNβvia the StING pathway,which promotes MHc-I antigen(cross-)presentation by cDc1s and thereby improves their ability to induce ctL ant.c.ncer *** cooperation with cD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDc1s required for ctL response ***-I-producing cD4^(+)t.c.lls are present in diverse t.c.ll-infiltrated cancers and likely deliver“help”signals to ctLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDcs and tumor-reactive cD8^(+)t *** agreement with this scenario,the presence of IFN-I-producing cD4^(+)t.c.lls in the tME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： cD4^(+)t.c.ll help cDc1 licensing IFN-I signaling cD40 costimulation (cross-)presentation ctL priming tumor control

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Effects of layer interactions on instantaneous stability of finite Stokes flows

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Applied Mathemat.c. and Mechanics(English Edition) 2024年第1期45卷 69-84页

作者： chen ZHAO Zhenli cHEN c.t.MUtASA Dong LI School of Aeronaut.c. Northwestern Polytechnical UniversityXi'an 710072China

the stability analysis of a finite Stokes layer is of pract.c.l importance in flow control. In the present work, the instantaneous stability of a finite Stokes layer with layer interactions is studied via a linear stability analysis of the frozen phases of the base flow. the oscillations of two plates can have different velocity amplitudes, initial phases, and frequencies. the effects of the Stokes-layer interactions on the stability when two plates oscillate synchronously are analyzed. the growth rates of two most unstable modes when δ t equal, and δ = δ*/h*, where δ*and h*are the Stokes-layer thickness and the half height of the channel, respectively. However, their vort.c.ties are different. the vort.c.ty of the most unstable mode is symmetric, while the other is asymmetric. the Stokes-layer interactions have a destabilizing effect on the most unstable mode when δ tabilizing effect when δ > 0.68. However, the interactions always have a stabilizing effect on the other unstable mode. It is explained that one of the two unstable modes has much higher dissipation than the other one when the Stokes-layer interactions are strong. We also find that the stability of the Stokes layer is closely related to the inflectional points of the base-flow velocity profile. the effects of inconsistent velocity-amplitude, initial phase, and frequency of the oscillations on the stability are analyzed. the energy of the most unstable eigenvector is mainly distributed near the plate of higher velocity amplitude or higher oscillation frequency. the effects of the initial phase difference are complicated because the base-flow velocity is extremely sensitive to the initial phase.

关键词： finite Stokes layer instantaneous stability Stokes-layer interaction asynchronous oscillation

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Near resonance vibration isolation on a levered-dual response(LEDAR)coulomb-damped system by differential preloads/offsets in linear springs

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Applied Mathemat.c. and Mechanics(English Edition) 2024年第6期45卷 1033-1050页

作者： t.I.tOLUWALOJU c.K.tHEIN D.HALIM department of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Nottingham Ningbo china Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

the levered-dual response(LEDAR)coulomb-damped system attains near resonant vibration isolation by differential preloads/offsets in linear *** takes the advantages of both the preloads/offsets in linear springs and the guiderail friction for realizing different levels of vibration *** isolation capacities are investigated on the strategies with both the horizontal and vert.c.l guiderails,with the horizontal rail only,and without *** compressive preloads generally result in the consumption of most of the initial excitation energy so as to overcome the potential *** isolation onsets at the frequency ratio of 1∓0.095 on the left-hand side(LHS)and the right-hand side(RHS)of the lever are relative to the load plate *** observed near resonant isolation thus makes the LEDAR system a candidate for the isolation of the mechanical systems about resonance while opening a path for simultaneous harvesterisolation functions and passive functions at extreme frequencies.

关键词： lever ratio coulomb damping preload tension/compression isolation band/depth offset potential

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Efficient guiding and focusing of intense laser pulse using periodic thin slits

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Matter and Radiation at Extremes 2024年第4期9卷 29-39页

作者： L.Xu t.W.Huang K.Jiang c.N.Wu H.Peng P.c.hen R.Li H.B.Zhuo c.t.Zhou Shenzhen Key Laboratory of Ultraintense Laser and Advanced Material t.c.nology Center for Intense Laser ApplicationTechnologyand College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118People’s Republic of China

Slits have been widely used in laser-plasma interactions as plasma opt.c.l components for generating high-harmonic light and controlling laser-driven part.c.e ***,we propose and demonstrate that periodic thin slits can be regarded as a new breed of opt.c.l elements for efficient focusing and guiding of intense laser *** fundamental physics of intense laser interaction with thin slits is studied,and it is revealed that relativist.c.effects can lead to enhanced laser focusing far beyond the pure diffractive focusing *** addition,the interaction of an intense laser pulse with periodic thin slits makes it feasible to achieve multifold enhancement in both laser intensity and energy transfer efficiency compared with conventional *** results provide a novel method for manipulating ultra-intense laser pulses and should be of interest for many laser-based applications.

关键词： laser pulse intense

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HI in High Gas-phase Metallicity Dwarf Galaxy WISEA J230615.06+143927.9

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Research in Astronomy and Astrophysics 2024年第1期24卷 292-299页

作者： Yan Guo c.Sengupta t.c.Scott P.Lagos Y.Luo Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Sciences University of Science and Technology of ChinaHefei 230026China Institute of Astrophysics and Space Sciences(IA Porto) Rua das Estrelas4150-762PortoPortugal

We present resolved Giant Metrewave Radio telescope H I observations of the high gas-phase metallicity dwarf galaxy WISEA J230615.06+143927.9(z = 0.005)(hereafter J2306) and investigate whether it.c.uld be a tidal Dwarf Galaxy(tDG) candidate. tDGs are observed to have higher metallicities than normal dwarfs. J2306 has an unusual combination of a blue g-r color of 0.23 mag, irregular opt.c.l morphology and high-metallicity(12 +log(O/H) = 8.68 ± 0.14), making it an interesting galaxy to study in more detail. We find J2306 to be an H I rich galaxy with a large extended, unperturbed rotating H I disk. Using our H I data we estimated its dynamical mass and found the galaxy to be dark matter(DM) dominated within its H I radius. the quantity of DM, inferred from its dynamical mass, appears to rule out J2306 as an evolved tDG. A wide area environment search reveals J2306 to be isolated from any larger galaxies which could have been the source of its high gas metallicity. Additionally, the H I morphology and kinemat.c. of the galaxy show no indication of a recent merger to explain the *** detailed opt.c.l spectroscopic observations of J2306 might provide an answer to how a seemingly ordinary irregular dwarf galaxy achieved such a high level of metal enrichment.

关键词： galaxies:abundances galaxies:dwarf galaxies:irregular radio lines:galaxies radio lines:ISM

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Effect of Moringa oleifera on semen quality profiles in endangered teressa goat under tropical humid island ecosystem

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Asian pacific Journal of Reproduction 2024年第2期13卷 89-96页

作者： P.Perumal Jai Sunder A.K.de A.K.Nahak D.K.chaurasia t.c.Balamurugan D.Bhatt.c.arya IcAR-central Island Agricultural Research Institute Port Blair-744105Andaman and Nicobar IslandsIndia OUAt.c.llege of Veterinary Science and Animal Husbandry Bhubaneswar-751003OdishaIndia tANUVAS-Veterinary college and Research Institute Salem-636112Tamil NaduIndia

Objective:to investigate the effect of Moringa oleifera leaf extract on semen quality parameters in teressa goat ***:A total of 25 semen samples from six bucks were selected for the *** of 150×10^(6) were incubated in 0,300,500 and 700μg of leaf extract as groupⅠ,Ⅱ,Ⅲ and Ⅳ,*** stored semen samples were analysed for motility,viability,total sperm abnormalities,plasma membrane,acrosomal and nuclear integrities,seminal plasma intracellular enzymes[aspartate aminotransferase(ASt),alanine aminotransferase(ALt)and lactate dehydrogenase(LDH)]and total antioxidant.c.pacity(t.c.and spermatozoa malondialdehyde(MDA)and cholesterol efflux in comparison with the control group(groupⅠ)for up to 72 ***:Moringa oleifera leaf extract(500μg/150×10^(6) spermatozoa)-treated semen had significantly higher motility,viability,plasma membrane,acrosomal and nuclear integrities,and t.c.Pcantly lower total sperm abnormalities,ASt,ALt,LDH,MDA production and cholesterol efflux compared to those in other Moringa oleifera leaf extract treated(300 or 700μg/150×10^(6) spermatozoa)and control groups at different hours of liquid storage(Pty parameters and t.c.showed an increasing trend and total sperm abnormalities,MDA production,leakage of intra-cellular enzymes and cholesterol efflux showed a decreasing trend from group Ⅰto group Ⅲand then an opposite trend from group Ⅲ to group Ⅳ at different hours of liquid ***:Moringa oleifera leaf extract 500μg/150×10^(6) spermatozoa can be used for liquid semen preservation in teressa goat at Andaman and Nicobar Islands.

关键词： Moringa oleifera Semen teressa goat Andaman and Nicobar Islands

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Radiative decays D*(s)→ D(s)γ in covariant.c.nfined quark model

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chinese Physics c 2024年第2期48卷 45-56页

作者： c.t.tran M.A.Ivanov P.Santorelli Q.c.Vo department of Physics HCMC University of Technology and EducationVo Van Ngan 1700000 Ho Chi Minh CityVietnam Bogoliubov Laboratory of theoret.c.l Physics Joint Institute for Nuclear Research141980 DubnaRussia Dipartimento di Fisica"E.Pancini" Universitàdi Napoli Federico ⅡComplesso Universitario di Monte S.AngeloVia CintiaEdificio 680126 NapoliItaly Istituto Nazionale di Fisica Nucleare Sezione di Napoli80126 NapoliItaly University of Science 700000 Ho Chi Minh CityVietnam

Radiative decays D((s))*→D((s))γare revisited in light of new experimental data from the BaBar and BESⅢ*** radiative couplings gD*Dγencoding nonperturbative QcD effects are calculated in the framework of the covariant.c.nfined quark model developed by *** compare our results with other theoret.c.l studies and experimental *** couplings(in GeV-1)|g(D*+D+γ)|=0.45(9)and|g(D*0D0γ)|=1.72(34)calculated in our model agree with the corresponding experimental data|g(D*+D+γ)|=0.47(7)and|g(D*0D0γ)|=1.77(16).the most interesting case is the decay Ds*→Dsγ,for which a recent prediction based on light.c.ne sum rules at next-to-leading order|gDs*Dsγ|=0.60(19)deviates from the first(and only to date)latt.c. QcD result|gDs*Dsγ|=0.11(2)at nearly3σ.Our calculation yields|gDs*Dsγ|=0.29(6),which falls somehow between the two mentioned results,although it is larger than those predicted in other studies using quark models or QcD sum rules.

关键词： covariant quark model radiative decay charmed meson

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Finite barrier bound state

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Light(Science & Applications) 2024年第4期13卷 664-671页

作者： tao Liu Kai Bai Yicheng Zhang Duanduan Wan Yun Lai c.t.c.an Meng Xiao Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education and School of Physics and t.c.nology Wuhan University430072 WuhanChina. National Laboratory of Solid State Microstructures School of Physicsand Collaborative Innovation Center of Advanced MicrostructuresNanjing University210093 NanjingChina. department of Physics The Hong Kong University of Science and TechnologyClear Water BayKowloon999077Hong KongChina. Wuhan Institute of Quantum t.c.nology 430206 WuhanChina

A boundary mode localized on one side of a finite-size latt.c. can tunnel to the opposite side which results in unwanted *** wisdom tells that the tunneling probability decays exponentially with the size of the system which thus requires many latt.c. sites before eventually becoming negligibly *** we show that the tunneling probability for some boundary modes can apparently vanish at specific ***,similar to bound states in the continuum,a boundary mode can be completely trapped within very few latt.c. sites where the bulk bandgap is not even *** intriguingly,the number of trapped states equals the number of latt.c. sites along the normal direction of the *** provide two configurations and validate the existence of this peculiar finite barrier-bound state experimentally in a dielectric photonic crystal at microwave *** work offers extreme flexibility in tuning the coupling between localized states and channels as well as a new mechanism that facilitates unprecedented manipulation of light.

关键词： boundary state eventually

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thermoluminescence characterization of natural and synthet.c.irradiated ce-monazites

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Journal of Rare Earths 2024年第4期42卷 643-650页

作者： V.correcher c.Boronat J.Garcia-Guinea J.F.Benavente t.Rivera-Montalvo cIEMAt Av.Complutense 4028040MadridSpain MNcN-cSIc J.Gutierrez Abascal 228006MadridSpain Instituto Polit.c.ico Nacional CICATA-IPNAv.Legaria 694Mexico City11500Mexico

the thermoluminescence(tL)emission of synthet.c.and natural ce-monazites was characterized here to determine the potential application in the identification of microscopic defects from a qualitative point of view trying to link each tL peak to a chemical-physical *** kinet.c.parameters that lead the luminescence processes were calculated by means of variable heating rate and computing glow curve deconvolution methods and allow identifying three groups of components at~90,130 and 290℃(for the mineral sample)and~90,170,220,270 and 320℃(for the synthet.c.cePO_(4):Nd_(0.20),La_(0.25)).the main differences appreciated in these complex tL curves are mainly due to(i)the content of impurities(natural sample contains lanthanides as well as U 0.60%and th 5.22%)and(ii)the degree of crystallinity of the samples which is directly related to the type of impurities(synthet.c.monazite relies only on Nd and La).the behavior of the dose response in the range of 1-8 Gy is similar for both samples;the tL intensity increases linearly as the dose increases without.c.anges in the position of the maxima,denoting first-order kinet.c.luminescence *** peak could be mostly associated with structural defects(i.e.,phase transitions),chemical reactions(i.e.,ce3+?ce4+redox reaction,dehydration or dehydroxylation processes)or intrinsic defects(i.e.,Frenkel defects,ODcs or NBOHcs).

关键词： thermoluminescence Kinet.c.arameters Phosphate ce-monazite defects Rare earths

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Editorial for Multiscale&Multifield coupling in Geomechanics

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Journal of Rock Mechanics and Geot.c.nical Engineering 2024年第6期16卷 1919-1921页

作者： Min Wang Pengzhi Pan Andrew H.c.chan Y.t.Feng t-3 Fluid Dynamics and Solid Mechanics Theoretical DivisionLos Alamos National LaboratoryNew MexicoUSA Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhanChina School of Engineering University of TasmaniaTasmaniaAustralia college of Engineering Swansea UniversityWalesUK

We are delighted to serve as guest editors for this special issue in the Journal of Rock Mechanics and Geot.c.nical *** purpose of this special issue is dedicated to gathering the latest research work on Multiscale&Multifield coupling in Geomechanics,where we delve into the intricate interplay of various fields and scales that govern the behavior of *** total,30 manuscripts from USA,china,UK,Germany,canada,India and United Arab Emirates are selected to be included in this issue.

关键词： materials. gathering mechanics

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