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前列腺t1加权MRI所见的出血除外征对前列腺癌检出的价值

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国际医学放射学杂志 2012年第4期 384-385页

作者： t. barrett H.A. Vargas O. Akin D.A. Goldman H. Hricak 唐光健 Department of Radiology Memorial Sloan -Kettering Cancer Center1275 York Ave New York NY 10065 USA

摘要目的回顾性确定t1加权MRI上所见的出血除外征结合t2加权影像表现在前列腺癌检出中的出现率与阳性预期值(PPV),采用前列腺切除全量逐层切片病理标本作为参考标准。材料与方法此项回顾性研究由学院审查委员会批准,免除知情同意通知。... 详细信息

摘要目的回顾性确定t1加权MRI上所见的出血除外征结合t2加权影像表现在前列腺癌检出中的出现率与阳性预期值(PPV),采用前列腺切除全量逐层切片病理标本作为参考标准。材料与方法此项回顾性研究由学院审查委员会批准,免除知情同意通知。292例活检证实为前列腺癌的病人接受了直肠

关键词：前列腺癌 t1 检出 MRI

伯明翰钢铁公司雀点钢厂提高钢包耐火材料寿命

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现代冶金（内蒙古） 2004年第3期 14-17页

作者： JamesO.barrett 赵鑫聂福安

提高钢包使用寿命和降低成本是伯明翰钢铁公司雀点钢厂不断追求的目标。从80年代初期以来，通过选用改进后的钢包衬砖使雀点钢厂的钢包使用寿命有了显著提高，特别是最近几年，使用整体式耐火材料衬后，300t钢包周转使用寿命为125次—13... 详细信息

提高钢包使用寿命和降低成本是伯明翰钢铁公司雀点钢厂不断追求的目标。从80年代初期以来，通过选用改进后的钢包衬砖使雀点钢厂的钢包使用寿命有了显著提高，特别是最近几年，使用整体式耐火材料衬后，300t钢包周转使用寿命为125次—130次。

关键词：钢包衬钢厂钢铁公司耐火材料使用寿命伯明翰降低成本周转目标追求

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亚洲新生儿永久性糖尿病1例

世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 37-38页

作者： Porter J. R. Shaw N. J. barrett t. G. 虎小毅

We describe a novel homozygous missense glucokinase mutation (R397L) resulting in insulin-treated neonatal diabetes in an infant from a consanguineous Asian family. Both parents were heterozygous for R397L and had mild hyperglycemia. Glucokinase mutations should be considered in infants of all ethnic groups with neonatal diabetes and consanguinity.

关键词：葡萄糖激酶纯合子高血糖杂合子错义突变

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Sugammadex: Role in current anaesthetic practice and its safety benefits for patients

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World Journal of Anesthesiology 2015年第3期4卷 66-72页

作者： Michael V Copp thomas F barrett Department of Anaesthesia Cheltenham General Hospital

Sugammadex has revolutionized anaesthetic management of reversal of neuromuscular block(NMB) by way of its unique mechanism of action encapsulating the amino steroid neuromuscular blocking drugs rocuroniumand vecuronium. the cholinesterase inhibitors have significant pharmacological and clinical limitations whereas sugammadex allows predictable, safe and rapid reversal from any depth of blockade. the financial cost of sugammadex is significant. Many hospitals in the United Kingdom use clinical guidelines to direct best use of sugammadex in their institutions. Auditing the use of sugammadex provides useful information on which patients are benefiting from sugammadex. the clinical benefits of sugammadex are well understood. No patient should now be subjected to the danger of post-operative residual curarization. Versatility in the ability to reverse NMB has brought opportunities to the anaesthetist in the management of rapid sequence induction using high dose rocuronium with the knowledge that safe reversal of NMB is now possible in the unlikely event of a "can't intubate can't ventilate" situation. Do we still need suxamethonium to be available? the nature of surgery continues to evolve with ever-increasing enthusiasm for minimally invasive laparoscopic techniques. there is evidence to support using a deeper level of NMB to improve the working space and operating conditions in laparoscopic surgery. It is now possible to maintain a deep level of NMB right up until the end of surgery with no concerns about the ability to effect safe reversal of NMB. Vigilance about the possibility of allergic sensitivity to sugammadex needs to be maintained. the increased usage of rocuronium has the potential for rocuroniuminduced anaphylaxis. Conversely, there is a potential role for sugammadex in the treatment of rocuronium anaphylaxis. Clinicians who have used sugammadex are struck with the quality of recovery seen in their patients. It is important that the economic implications of

关键词： Sugammadex Neuromuscular block Clinical benefits Patient safety Cost benefit

Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of t cells

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Burns & trauma 2022年第1期10卷 546-557页

作者： Lucy W.barrett Vanessa S.Fear Bree Foley Katherine Audsley Samantha Barnes Hannah Newnes Alison McDonnell Fiona M.Wood Mark W.Fear Jason Waithman Burn Injury Research Unit School of Biomedical SciencesUniversity of Western AustraliaCrawleyWA6009Australia telethon Kids Institute University of Western AustraliaNorthern EntrancePerth Children’s Hospital15 Hospital AveNedlandsWA6009Australia Fiona Wood Foundation Fiona Stanley HospitalMNH(B)Main HospitalCD 15Level Burns Unit 102-118 Murdoch DriveMurdochWA6150Australia and 4Burns Service of Western AustraliaWA Department of HealthNedlandsWA6009Australia

Background:Recent evidence suggests that burn patients are at increased risk of hospital admission for infection,mental health conditions,cardiovascular disease and cancer for many years after discharge for the burn injury *** injury has also been shown to induce sustained immune system *** change to immune function may contribute to the increased risk of chronic disease ***,the mechanisms that disrupt long-term immune function in response to burn trauma,and their link to long-term morbidity,remain *** this study we investigated changes to immune function after burn injury using a murine model of non-severe ***:An established mouse model of non-severe burn injury(full thickness burn equivalent to 8%total body surface area)was used in combination with an orthotopic model of B16 melanoma to investigate the link between burns and *** that CD8^(+)t cells are important drivers of effective tumour suppression in this model,we also investigated potential dysregulation of this immune population using mouse models of burn injury in combination with herpes simplex virus *** cytometry was used to detect and quantify cell populations of interest and changes in immune ***:We demonstrate that 4 weeks after a non-severe burn injury,mice were significantly more susceptible to tumour development than controls using an orthotopic model of B16 *** addition,our results reveal that CD8^(+)t cell expansion,differentiation and memory potential is significantly impaired at 1 month ***:Our data suggests that CD8^(+)t cell-mediated immunity may be dysfunctional for a sustained period after even non-severe burn *** studies in patients to validate these findings may support clinical intervention to restore or protect immunity in patients after burn injury and reduce the increased risk of secondary morbidities observed.

关键词： Immunology Surgery Burn injury t cells Immune dysfunction Cancer

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World Journal of Critical Care Medicine 2022年第4期11卷 236-245页

作者： Vincent Issac Lau Jeffrey A Johnson Sean M Bagshaw Oleksa G Rewa John Basmaji Kimberley A Lewis M Elizabeth Wilcox Kali barrett Francois Lamontagne Francois Lauzier Niall D Ferguson Simon J W Oczkowski Kirsten M Fiest Daniel J Niven Henry t Stelfox Waleed Alhazzani Margaret Herridge Robert Fowler Deborah J Cook Bram Rochwerg Feng Xie Department of Critical Care Medicine University of AlbertaEdmonton T6G 2B7ABCanada School of Public Health Inst Hlth EconUniversity of AlbertaEdmonton T6G 2B7ABCanada Department of Medicine Division of Critical CareWestern UniversityLondon N6A 5W9Canada Division of Critical Care McMaster UniversityHamilton L8N 4A6Canada Interdepartmental Division of Critical Care University of TorontoToronto M5T 2S8Canada Department of Medicine University SherbrookeSherbrooke J1H 5N4Canada Departments of Medicine and Anesthesiology University LavalLaval G1V 4G2Canada Department Critical Care Medicine University of TorontoToronto M5G 2C4Canada Department of Medicine McMaster ClinHamilton Gen HospMcMaster UniversityHamilton L8N 4A6Canada Department of Community Health Sciences&Institute for Public Health University of CalgaryCalgary T2N 2T9Canada Department of Critical Care Medicine University CalgaryCalgary T2N 2T9Canada Department of Community Health Sciences University of CalgaryCalgary T2N 2T9Canada Department of Medicine McMaster UniversityHamilton L8N 4A6Canada Indepartmental Division of Critical Care University Health NetworkToronto M5G 2C4Canada Departments of Medicine and Critical Care Medicine Sunnybrook Health Sciences CenterInstitute of Health Policy Management and EvaluationUniversity of TorontoToronto M4N 3M5Canada Health Research Methods Evidence and ImpactMcMaster UniversityHamilton L8N 3Z5Canada

Mortality is a well-established patient-important outcome in critical care *** contrast,morbidity is less uniformly reported(given the myriad of critical care illnesses and complications of each)but may have a common end-impact on a patient’s functional capacity and health-related quality-of-life(HRQoL).Survival with a poor quality-of-life may not be acceptable depending on individual patient values and ***,as mortality decreases within critical care,it becomes increasingly important to measure intensive care unit(ICU)survivor *** measurements with a preference-based scoring algorithm can be converted into health utilities on a scale anchored at 0(representing death)and 1(representing full health).they can be combined with survival to calculate quality-adjusted life-years(QALY),which are one of the most widely used methods of combining morbidity and mortality into a composite *** QALYs have been use for health-technology assessment decision-making,an emerging and novel role would be to inform clinical decision-making for patients,families and healthcare providers about what expected HRQoL may be during and after ICU *** care randomized control trials(RCts)have not routinely measured or reported HRQoL(until more recently),likely due to incapacity of some patients to participate in patient-reported outcome *** differences in HRQoL measurement tools can lead to non-comparable *** this end,we propose the validation of a gold-standard HRQoL tool in critical care,specifically the *** combined health-utility and mortality(disaggregated)and QALYs(aggregated)can be reported,with disaggregation allowing for determination of which components are the main drivers of the QALY *** use of HRQoL,health-utility,and QALYs in critical care RCts has the potential to:(1)Increase the likelihood of finding important effects if they exist;(2)improve research efficiency;and(3)help inform optimal m

关键词： Critical care health-related quality of life Quality-adjusted life-years Health-utility Mortality Morbidity Kaplan-Meier curves

Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma

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World Journal of Clinical Cases 2019年第3期7卷 260-269页

作者： Henna K S?derstr?m Juha t Kauppi Niku Oksala timo Paavonen Leena Krogerus Jari R?s?nen tuomo Rantanen Department of General thoracic Surgery Helsinki University Central Hospital Faculty of Medicine and Life Sciences University of Tampere Department of Vascular Surgery Tampere University Hospital Department of Pathology Fimlab Laboratories and Department of Medicine and Life Sciences University of Tampere Department of Pathology Helsinki University Central Hospital Department of Surgery Kuopio University Hospital Department of Surgery Institute of Clinical Medicine University of Eastern Finland

BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer *** to evaluate the expressions of HSP27 and HSP70 and their effect on survival in *** Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on *** tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). the results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. the HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), *** HSP27 and HSP70 overexpression i

关键词： Esophageal adenocarcinoma Heat shock proteins Heat shock protein 27 Heat shock protein 70 Overexpression Survival

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长江中下游长江江豚种群数量研究

长江中下游长江江豚种群数量研究

Complete oxidation of 1,4-dioxane over zeolite-13X-supported Fe catalysts in the presence of air

野生动物生态与资源保护第四届全国学术研讨会

作者：赵修江王丁 Barlow,J. Pitman,R.L. taylor,B.L. 王克雄魏卓张先锋李松海 barrett.L.A. Akamatsu,t. turvey,S.t. Reeves,R.R. Stewart,B.S. Richlen,M. Brandon,J.R. 中国科学院水生生物研究所中国科学院研究生院 NOAA Fisheries Southwest Fisheries Science CenterLa Jolla CA 92037USA

长江江豚是唯一的江豚淡水亚种,仅分布于长江中下游及其主要附属湖泊中。为评价其种群现状,2006年11月至12月,我们在长江中下游干流江段进行了截线抽样法考察。考察采用两条大型考察船,航程约3400千米。根据动物密度,考察区域被划分为...

长江江豚是唯一的江豚淡水亚种,仅分布于长江中下游及其主要附属湖泊中。为评价其种群现状,2006年11月至12月,我们在长江中下游干流江段进行了截线抽样法考察。考察采用两条大型考察船,航程约3400千米。根据动物密度,考察区域被划分为三个江段进

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Chinese Journal of Catalysis 2016年第2期37卷 240-249页

作者： C.Ramakrishna R.Krishna t.Gopi G.Swetha Bijendra Saini S.Chandra Shekar Anchal Srivastava 国防研发局、防化装备评估设备(CDEF) 印度那格浦尔MH-441108

Zeolite-13X-supported Fe（Fe/zeolite-13X） catalysts with various Fe contents were prepared by the wet impregnation *** catalysts were characterized by N2 adsorption-desorption isotherms to estimate the Brunauer-Emmett-teller surface areas and barrett-Joyner-Hanlenda pore size distributions.X-ray diffraction,scanning electron microscopy,temperature-programmed reduction,and temperature-programmed desorption of NH3 were used to investigate the textural properties of the Fe/zeolite-13 X *** catalytic activities were determined for the complete oxidation of1,4-dioxane using air as the oxidant in a fixed-bed flow reactor in the temperature range 100-400℃.the influences of various process parameters,such as reaction temperature,metal loading,and gas hourly space velocity（GHSV）,on the dioxane removal efficiency by catalytic oxidation were *** stability of the catalyst was tested at 400℃ by performing time-on-stream analysis for 50 *** Fe/zeolite-13 X catalyst with 6 wt%Fe exhibited the best catalytic activity among the Fe/zeolite-13 X catalysts at 400℃ and a GHSV of 24000 h^（-1）,with 97%dioxane conversion and95%selectivity for the formation of carbon oxides（CO and CO2）.trace amounts（ 3%） of acetaldehyde,ethylene glycol monoformate,ethylene glycol diformate,1,4-dioxane-2-ol,1,4-dioxane-2-one,and 2-methoxy-1,3-dioxalane were also formed as degradation products.A plausible degradation mechanism is proposed based on the products identified by GC-MS analysis.

关键词： Iron Zeolite-13X 1 4-Dioxane Catalytic degradation Complete oxidation Degradation mechanism

维普期刊数据库