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Metabolomic and elemental profiling of blood serum in bladder cancer

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Journal of Pharmaceutical Analysis 2022年第6期12卷 889-900页

作者： Krzysztof Ossolinski tomasz Ruman Valerie Copie brian P.tripet Leonardo b.Nogueira Katiane O.P.C.Nogueira Artur Kołodziej Aneta Płaza-Altamer Anna Ossolinska tadeusz Ossolinski Joanna Nizioł department of Urology John Paul II Hospital36-100KolbuszowaPoland Rzeszow University of technology Faculty of Chemistry35-959RzeszowPoland the department of Chemistry and biochemistry Montana State UniversityBozemanMT59717USA department of Geology Federal University of Ouro Preto35400-000Ouro PretoBrazil department of biological sciences Federal University of Ouro Preto35400-000Ouro PretoBrazil doctoral school of Engineering and technical sciences at the Rzeszow University of technology 35-959RzeszowPoland

bladder cancer(bC)is one of the most frequently diagnosed types of urinary *** advances in treatment methods,no specific biomarkers are currently in *** and untargeted profiling of metabolites and elements of human blood serum from 100 bC patients and the same number of normal controls(NCs),with external validation,was attempted using three analytical methods,i.e.,nuclear magnetic resonance,gold and silver-109 nanoparticle-based laser desorption/ionization mass spectrometry(LdI-Ms),and inductively coupled plasma optical emission spectrometry(ICP-OEs).All results were subjected to multivariate statistical *** potential serum biomarkers of bC,namely,isobutyrate,pyroglutamate,choline,and acetate,were quantified with proton nuclear magnetic resonance,which had excellent predictive ability as judged by the area under the curve(AUC)value of *** elements,Li and Fe,were also found to distinguish between cancer and control samples,as judged from ICP-OEs data and AUC of 0.807(in validation set).twenty-five putatively identified compounds,mostly related to glycans and lipids,differentiated bC from NCs,as detected using *** serum metabolites were found to discriminate between tumor grades and nine metabolites between tumor *** results from three different analytical platforms demonstrate that the identified distinct serum metabolites and metal elements have potential to be used for noninvasive detection,staging,and grading of bC.

关键词： bladder cancer biomarkers Human serum Metallomics Metabolomics

Long-term adenosine A1 receptor activation-induced sortilin expression promotes α-synuclein upregulation in dopaminergic neurons

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Neural Regeneration Research 2020年第4期15卷 712-723页

作者： Yun-Cheng Lv An-bo Gao Jing Yang Li-Yuan Zhong bo Jia shu-Hui Ouyang Le Gui tian-Hong Peng sha sun Francisco s.Cayabyab Clinical Anatomy&Reproductive Medicine Application Institute Hengyang Medical CollegeUniversity of South ChinaHengyangHunan ProvinceChina department of surgery College of MedicineUniversity of SaskatchewanSaskatoonCanada Institute of Pharmacy and Pharmacology School of Pharmaceutical ScienceUniversity of South ChinaHengyangHunan ProvinceChina department of Metabolism&Endocrinology the First Affiliated HospitalHengyang Medical CollegeUniversity of South ChinaHengyangHunan ProvinceChina

Prolonged activation of adenosine A1 receptor likely leads to damage of dopaminergic neurons and subsequent development of neurodegenerative ***,the pathogenesis underlying long-term adenosine A1 receptor activation-induced neurodegeneration remains *** this study,rats were intraperitoneally injected with 5 mg/kg of the adenosine A1 receptor agonist N6-cyclopentyladenosine(CPA)for five *** mobility of rats was evaluated by forced swimming test,while their cognitive capabilities were evaluated by Y-maze *** of sortilin,α-synuclein,p-JUN,and c-JUN proteins in the substantia nigra were detected by western blot *** addition,immunofluorescence staining of sortilin andα-synuclein was performed to detect expression in the substantia *** results showed that,compared with adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine(5 mg/kg)+CPA co-treated rats,motor and memory abilities were reduced,surface expression of sortin andα-synuclein in dopaminergic neurons was reduced,and total sortilin and totalα-synuclein were increased in CPA-treated ***9d cells were incubated with 500 nM CPA alone or in combination with 10μM sP600125(JNK inhibitor)for 48 *** real-time polymerase chain reaction analysis of sortilin andα-synuclein mRNA levels in MN9d cells revealed upregulated sortilin expression in MN9d cells cultured with CPA alone,but the combination of CPA and sP600125 could inhibit this *** made using Jasper,PROMO,and Alibaba online databases identified a highly conserved sequence in the sortilin promoter that was predicted to bind JUN in both humans and rodents.A luciferase reporter assay of sortilin promoter plasmid-transfected HEK293t cells confirmed this *** sortilin expression was inhibited by sh-sORt1,expression of p-JUN and c-JUN was detected by western blot ***-term adenosine A1 receptor activation levels upregulatedα-synuclein expression at the pos

关键词： cognitive dysfunction dopaminergic neuron dyskinesia JNK/c-JUN pathway long-term adenosine A1 receptor activation neural regeneration neurodegenerative diseases sortilin α-synuclein

A Cyborg Insect Reveals a Function of a Muscle in Free Flight

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Cyborg and bionic systems 2022年第1期2022卷 98-108页

作者： t.thang Vo-doan V.than dung Hirotaka sato Nanyang technological University School of Mechanical and Aerospace EngineeringSingapore University of Freiburg Institute of biology I Germany

While engineers put lots of effort,resources,and time in building insect scale micro aerial vehicles(MAVs)that fly like insects,insects themselves are the real masters of *** if we would use living insect as platform for MAV instead?Here,we reported a flight control via electrical stimulation of a flight musde of an insect-computer hybrid robot,which is the interface of a mountable wireless backpack controller and a living *** beetle uses indirect flight muscles to drive wing flapping and three major direct flight muscles(basalar,subalar,and third axilliary(3Ax)muscles)to control the kinematics of the wings for flight *** turning control was already achieved by stimulating basalar and 3Ax muscles,electrical stimu lation of subalar musdes resulted in braking and elevation control in *** also demonstrated around 20 degrees of contralateral yaw and roll by stimulating individual subalar *** both subalar muscles lead to an increase of 20 degrees in pitch and decelerate the flight by 1.5 m/s2 as well as an induce in elevation of 2m/s.

关键词： robot computer mount

Level structure of 116sb

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Level structure of 116Sb

评《欧洲霸权之前:公元1250—1350年的世界体系》

第十三届全国核结构研讨会暨第九次全国“核结构与量子力学”专题讨论会

作者： d.P.sun,~(1 1)) s.Y.Wang,~1 b.Qi,~1 L.W.duan,~1 G.Wang,~1 X.L.Ren,~1 b.t.duan,~1 X.X.Zhu,~1 F.Z.Lv,~1 C.Liu,~1 C.J.Xu,~1 H.Hua,~2 s.Q.Zhang,~2 Z.Y.Li,~2 J.M.Yao,~2 L.H.Zhu~3 X.G.Wu,~3 G.s.Li,~3 Y.Liu,~3 X.Q.Li,~3 Y.Zheng,~3 L.L.Wang,~3 L.Wang,~3 1(school of space science and Physics,shandong University at Weihai,Weihai 264209,China) 2(school of Physics,and state-Key Lab.Nucl.Phys.& tech.,Peking University,beijing 100871,China) 3(China Institute of Atomic Energy,beijing 102413,China)

the odd-odd nucleus sb was populated using the reaction Cd（Li,5n） at a beam energy of 48 *** previously known rotational bands have been observed up to high spins.A new△I = 1 band were identified,and were suggested as a magnetic rotational *** rotor model calculations show reasonably good agreement with the *** the spherical discrete levels were also *** 30 newγ—rays were added in the level scheme of sb.

关键词： odd-odd nucleus magnetic rotational band level scheme

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世界社会科学 1991年第8期 77-78页

作者： d.切罗特 ,戴昭

世界历史——用全球性比较的手段对非常长期的、大范围的社会变化进行解释——是一个重大的、独特的领域。尽管这个领域很难归入某个社会科学学科,但它却包含了所有这些学科中一些最能引发争论,最具有创新性的人物。因此对它不能忽视。... 详细信息

世界历史——用全球性比较的手段对非常长期的、大范围的社会变化进行解释——是一个重大的、独特的领域。尽管这个领域很难归入某个社会科学学科,但它却包含了所有这些学科中一些最能引发争论,最具有创新性的人物。因此对它不能忽视。历史学中的W.麦克内尔、E.霍布斯鲍姆和F.布劳代尔,社会学中的I.沃勒斯坦、C.梯利和b.莫尔,政治学中的t.斯考克波和s.亨丁顿,经济学中的d.诺斯和W.罗斯托,人类学中的E.沃尔夫和s.明茨,只是提出这个领域的理论讨论日程的许多重要人物中的一小部分。尽管正规社会科学中的“学科论者”力图将这种探索贬低为不科学的和浅薄的东西,但它仍然增进了我们对过去和现在的了解。

关键词：欧洲霍德世界体系社会科学阿布沃勒斯坦蒙古帝国霸权

Growth and spectroscopic properties of Ho3+doped sr3Y2(bO3)4 crystal

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Growth and spectroscopic properties of Ho3+doped Sr3Y2(BO3)4...

中国化学会第五届全国结构化学学术会议

作者： Qian Wei~(a,b) Xiuzhi Li~a Guojian Wang~(a,b) Mingjun song~(a,b) Zujian Wang~(a,b) Guofu Wang~a Xifa Long~(a*) a Fujian Institute of Research on the structure of Matter,Chinese Academy of sciences,Fuzhou,Fujian 350002,China b Graduate school of the Chinese Academy of sciences,beijing 100039,China

the single crystal of Hodoped srY(bO) has been grown by the Czochralski method. the absorption spectrum,fluorescence spectrum,and fluorescence decay curve of the crystal were measured at room *** fluorescence spectrum in the range of 450-800 nm is dominated by F→I and s,F→I *** to the Judd-Ofelt theory,the intensity parameters Ω(t=2,4,6)were calculated,and the spontaneous transition probabilities, fluorescence branching ratios and radiative lifetimes were *** fluorescence lifetime of the F→I transition for Ho:srY(bO) crystal is about 57 ns.

关键词：

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软骨肉瘤的影像学诊断

中国医学影像技术 2011年第5期27卷 1025-1029页

作者： b.Kirankumar Reddy 陈铟铟王希明李勇刚郭亮苏州大学附属第一医院放射科江苏苏州215006

目的探讨不同分型软骨肉瘤的影像学表现。方法回顾性分析手术病理证实的26例软骨肉瘤的影像学资料。结果①普通髓腔型:X线平片检查6例,表现为溶骨与硬化混合的外观,位于长管状骨者可见骨内膜的扇贝样改变。Ct检查8例,7例示膨胀性骨质破... 详细信息

目的探讨不同分型软骨肉瘤的影像学表现。方法回顾性分析手术病理证实的26例软骨肉瘤的影像学资料。结果①普通髓腔型:X线平片检查6例,表现为溶骨与硬化混合的外观,位于长管状骨者可见骨内膜的扇贝样改变。Ct检查8例,7例示膨胀性骨质破坏,5例钙化明显,3例钙化轻微。MR检查9例,t1WI为等、低信号,t2WI 8例呈明显高信号,其中6例可见低信号分隔。②间叶型:X线平片检查2例,1例肿瘤位于骨内,呈轻度膨胀性改变,1例位于骨外,病灶密集钙化。Ct检查7例,6例位于骨骼系统外,4例钙化明显,1例钙化局限,1例未见明显钙化。MR检查5例,4例骨外型t2信号特点取决于瘤体内钙化的形态及范围,或呈胡椒面样表现或表现为高信号包绕低信号。③去分化型:Ct检查3例,均示钙化,2例尚可见絮状成骨样改变。MR检查2例,t2WI上均为高低混杂信号。④皮质旁型:X线平片检查2例,1例可见相应部位异常钙化。Ct检查3例,均显示分叶状外形的软组织肿块贴近骨皮质,2例见基质轻微钙化。MR检查3例,2例可见髓腔侵犯。增强扫描普通髓腔型及皮质旁型呈边缘及间隔强化,间叶型呈弥漫性强化,去分化型则同时可见边缘强化及弥漫性强化。结论普通髓腔型软骨肉瘤影像学表现较具特征性。结合钙化特点、信号特征及增强后表现可提示诊断间叶型及去分化型软骨肉瘤。

关键词：软骨肉瘤体层摄影术,X线计算机磁共振成像

Crystal structure of 〔PrAl（CF3COO）2（CF3CHOO）(C2H5)2（C4H8O）2〕2

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Chinese Journal of structural Chemistry 1999年第1期 49-52页

作者： tONG Yue Jin a CHENG Yan Xiang b GUAN Huai Min a LIN Yong Hua c JIN Ying tai c a (department of Chemistry, Fujian Normal University, Fuzhou, 350007, China) b (department of Chemistry, Henan University, Kaifeng, 475001, C

１ＩＮＴＲＯＤＵＣＴＩＯＮＩｎｒｅｃｅｎｔｙｅａｒｓ，ａｓｅｒｉｅｓｏｆｌａｎｔｈａｎｉｄｅａｌｕｍｉｎｉｕｍｃｏｍｐｌｅｘｅｓｗｈｉｃｈａｒｅａｃｔｉｖｅｆｏｒｐｏｌｙｍｅｒｉｚａｔｉｏｎｏｆｏｌｆｉｎｓ〔１〕... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＩｎｒｅｃｅｎｔｙｅａｒｓ，ａｓｅｒｉｅｓｏｆｌａｎｔｈａｎｉｄｅａｌｕｍｉｎｉｕｍｃｏｍｐｌｅｘｅｓｗｈｉｃｈａｒｅａｃｔｉｖｅｆｏｒｐｏｌｙｍｅｒｉｚａｔｉｏｎｏｆｏｌｆｉｎｓ〔１〕ｈａｖｅｂｅｅｎｒｅｐｏｒｔｅｄ．...

关键词： crystal structure mixed ligand lanthanoid complex aluminium

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汉斯·克雷布斯与谷氨酰胺在临床营养的应用

中华临床营养杂志 2014年第1期22卷 1-8页

作者： Malcolm Watford John t. brosnan 李娟(译) 赵维纲(校) department of Nutritional sciences School of Environmental and Biological Sciences Rutgers The State University New Brunswick NJ 08901 USA department of biochemistry Memorial University of Newfoundland St. John's NL A1B 3X9 Canada 不详

汉斯·阿道夫·克雷布斯（Hans Adolf Krebs）（1953年诺贝尔奖获得者）为谷氨酰胺在临床营养的应用开创了新的舞台,本文对其在谷氨酰胺代谢方面的研究贡献进行阐述.本文两位作者在谷氨酰胺代谢方面也进行了多年研究,并在克雷布斯教授... 详细信息

汉斯·阿道夫·克雷布斯（Hans Adolf Krebs）（1953年诺贝尔奖获得者）为谷氨酰胺在临床营养的应用开创了新的舞台,本文对其在谷氨酰胺代谢方面的研究贡献进行阐述.本文两位作者在谷氨酰胺代谢方面也进行了多年研究,并在克雷布斯教授指导下完成了牛津大学哲学博士学位训练.1923年,克雷布斯成为一名医生,并参加了3年的临床培训.1926年,他进入奥托·沃伯格（Otto Warburg）（1931年诺贝尔奖获得者）实验室开始了他的科研生涯.克雷布斯利用沃伯格测压法等技术对肿瘤相关蛋白降解代谢进行相关研究.1931年克雷布斯开始研究合成反应,并于1932年描述了第一个生化循环路径——尿素循环.1933年克雷布斯移居英格兰,同时将研究集中于氨基酸代谢,从分子水平阐述动物组织谷氨酰胺代谢,为临床营养应用谷氨酰胺奠定了基础.其研究以谷氨酰胺异常代谢为起点,之后,他将注意力转移到谷氨酰胺水解产生谷氨酸与氨的过程.克雷布斯于1935年发表文章阐述谷氨酰胺代谢的重要酶学研究,如谷氨酰胺的合成是一个吸热反应,需要能量供应.同时,他鉴定了谷氨酰胺酶对谷氨酰胺的水解作用,且不同组织含有不同亚型的谷氨酰胺酶.此外,他还阐述了分布最广泛的“脑型”谷氨酰胺酶的基本调节特点,证实其受谷氨酸负反馈调节,而“肝型”谷氨酰胺酶则不受此调节.1935年的文章发表后,克雷布斯仍致力于应用当时最先进的技术方法对氨基酸代谢进行各种研究,并将注意力转移到谷氨酰胺其他代谢过程.20世纪70年代,克雷布斯与其同事合作,发现谷氨酰胺是肝糖异生与尿素合成的底物,肾糖异生与氨的产物,且是小肠上皮细胞的代谢底物.此外,克雷布斯团队还发现骨骼肌可以释放大量谷氨酰胺,同时阐述了肝在谷氨酰胺利用与合成中的作用.直到克雷布斯去世（1981年）前,他仍致力于支链氨基酸与谷氨酰胺代谢关系的研究.在过去的20-30年大量研究中,威尔莫（Wilmor）与弗斯特（Furst）团队最先发表文章描述谷氨酰胺在临床肠外营养中的补充应用.关于在临床营养中补充谷氨酰胺,已发表了大量研究文章与综述,一些研究展示了其非常显著的有效性,更多的研究显示它具有一定效果,也有研究发现它在某些人群中会产生不良反应.总而言之,谷氨酰胺在临床营养的运用在很大程度上应归功于克雷布斯与他的同事和实习生所做的大量工作.描述与克雷布斯工作“个人追忆”的本文作者,非常感谢作为谷氨酰胺之父的汉斯·阿道夫·克雷布斯教授对他们科学研究技术的培养.

关键词：谷氨酰胺三羧酸循环临床应用