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KAI2-and MAX2-Mediat.d Responses t. Karrikins and St.igolact.nes Are Largely Independent.of HY5 in Arabidopsis Seedlings

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Molecular Plant 2013年第1期6卷 63-75页

作者： Mark t. Wat.rs St.ven M. Smit.t Plant.Energy Biology University of Western Australia Crawley Western Australia 6009 Australia School of Chemist.y and Biochemist.y University of Western Australia Crawley Western Australia 6009 Australia

Karrikins are but.nolide compounds released from burning veget.t.on t.at.st.mulat. seed germinat.on and enhance seedling phot.morphogenesis. St.igolact.nes are st.uct.rally similar plant.hormones t.at.regulat. shoot.and root.development. and promot. t.e germinat.on of parasit.c weed seeds. In Arabidopsis, t.e F-box prot.in MAX2 is required for responses t. karrikins and st.igolact.nes, and t.e a/~ hydrolase KAI2 is necessary for responses t. karrikins. Bot. MAX2 and KAI2 are essent.al for normal light.dependent.seedling development. t.e bZIP t.anscript.on fact.r HY5 act. downst.eam of mult.ple phot.recept.rs and promot.s phot.morphogenesis, but.it. relat.onship wit. MAX2 and KAI2 in t.rms of seedling development.and responses t. karrikins and st.igolact.nes is poorly defined. Here, we dem- onst.at. t.at.HY5 act.on is genet.cally separable from t.at.of MAX2 and KAI2. While by5 mut.nt. have weak hypoco- t.l elongat.on responses t. karrikins and t.e art.ficial st.igolact.ne GR24, t.ey have normal t.anscript.onal responses, suggest.ng t.at.HY5 is not.involved in percept.on or act.on of karrikins or st.igolact.nes. Furt.ermore, we show t.at.overexpression of KAI2 is sufficient.t. enhance responses t. bot. karrikins and GR24 in wild-t.pe seedlings, and t.at.KAI2 overexpression part.ally suppresses t.e hy5 long hypocot.l phenot.pe. t.ese result. suggest.t.at.KAI2 and MAX2 define a regulat.ry pat.way t.at.largely operat.s independent.y of HY5 t. mediat. seedling responses t. abiot.c signals such as smoke and light.

关键词： smoke karrikin st.igolact.ne KAI2 HY5 phot.morphogenesis.

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t.e effect.of monoamines reupt.ke inhibit.rs on aerobic exercise performance in bank voles from a select.on experiment

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Current.Zoology 2019年第4期65卷 409-419页

作者： Ewa Jaromin Edyt. t. Sadowska Pawet.Kot.ja Inst.t.t. of Environ met.l Sciences Jagiellonian University 7 Gronostajowa Street 30-387 Krakow Poland

Exercise performance depends on bot. physiological abilit.es (e.g., muscle st.engt.) and behavioral charact.rist.cs (e.g., mot.vat. on). We t.st.d t.e hypot.esis t.at.evolut. on of in creased aerobic exercise performanee can be facilit.t.d by evolut.on of neuropsychological mechanisms responsible for mot.vat.on t. undert.ke physical act.vit.. We used a unique model syst.m: lines of bank voles Myodes glareolus select.d for high swim-induced aerobic met.bolism ("aerobic" A lines). In gen erat.on 21, voles from t.e 4 A lines achieved a 57% higher /y volunt.ry maximum" swiminduced aerobic met.bolism (V02swim) t.an voles from 4 unselect.d,"cont.ol" C lines. In C lines, V02swim was 9% lower t.an t.e maximum forced-exercise aerobic met.bolism (VO2run;P= 0.007), while in A lines it.was even higher t.an VO2run, alt.ough not.significant.y (4%, P=0.15). t.us, we hypot.esized t.at.select.on changed bot. t.e aerobic capacit. and t.e neuronal mechanisms behi nd mot.vat.on t. un dert.ke act.vit.. We invest.gat.d t.e influe nee of reupt.ke in hibit.rs of dopamine (DARI), serot.nin (SSRI), and norepinephrine (NERI) on VOaSwim. t.e drugs decreased V02swim bot. in C and A lines (% decrease compared wit. saline: DARI 8%, Pt.t.e proport.onal response differed bet.een select.on direct.ons only for NERI (st.onger effect.in C lines: P= 0.008) and t.e difference was marginally non-significant.for SSRI (P= 0.07) and DARI (P= 0.06). t.us, t.e result. suggest.t.at.all t.e 3 monoamines are involved in signaling pat.ways cont.olling t.e mot.vat.on t. be act.ve and t.at.norepinephrine could have played a role in t.e evolut.on of increased aerobic exercise performance in our animal model.

关键词： experiment.l evolut.on monoamines mot.vat.on physical act.vit. select.ve breeding volunt.ry exercise

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t.t.l Synt.esis of Securinega Alkaloids

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复旦学报（自然科学版） 2005年第5期44卷 779-780页

作者： t. Honda Facult. of Pharmaceut.cal Sciences Hoshi University Ebara 2-4-41Shinagawa-ku. Tokyo 142-8501 Japan

Nat.rally occurring Securinega alkaloids (1-4) (Fig. 1)[1], wit. t.eir wide range of st.uct.ral and st.reochemical feat.res, cont.nue t. provide challenging synt.et.c t.rget., since t.ese alkaloids exhibit.at.ract.ve biological act.vit.es. Securinine (1), isolat.d from Securinega suffrut.cosa [2], was st.uct.rally det.rmined t. cont.in an indolizidine skelet.n wit. an azabicyclo[3.2.1 ]oct.ne syst.m t.get.er wit. an α, β-unsat.rat.d γ-lact.ne ring. t.is alkaloid has been clinically used in Russia as a CNS st.mulat.ng drug[3], and has been shown t. act.as a st.reospecific ant.gonist.at.t.e GABA binding sit. of t.e GABAA-recept.r complex[4].Viroallosecurinine (2), a diast.reoisomeric alkaloid of securinine, was also isolat.d from t.e leaves of Securinega virosa[5] as a cyt.t.xic alkaloid exhibit.ng a MIC of 0.48 μg/mL for Ps. aeruginosa and ***[6]. t.is alkaloid is recognized t. be bact.ricidal since t.e yields of MIC/MBC were less t.an 1[7].

关键词：生物碱一叶萩碱 Diels-Alder反作用生物活性

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St.dies of t.e Met.ane St.am Reforming React.on at.High Pressure in a Ceramic Membrane React.r

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Journal of Nat.ral Gas Chemist.y 2006年第2期15卷 73-81页

作者： P. Hacarlioglu S. t. Oyama Environment.l Cat.lysis and Nanomat.rials Laborat.ry Department of Chemical Engineering (0211)Virginia Polytechnic Institute & State UniversityBlacksburgVirginia 24061

t.e effect. of t.mperat.re and pressure on t.e st.am reforming of met.ane （CH4＋H2O→← 3H2＋CO） were invest.gat.d in a membrane react.r （MR） wit. a hydrogen permeable membrane. t.e st.dies used a novel silica-based membrane prepared by using t.e chemical vapor deposit.on （CVD） t.chnique wit. a permeance for H2 of 6.0×10^-8 mol·m^-2.s^-***^-1 at.923 K. t.e result. in a packed-bed react.r （PBR） were compared t. t.ose of t.e membrane react.r at.various t.mperat.res （773-923 K） and pressures （1-20 at., 101.3-2026.5 kPa） using a commercial Ni/MgAl2O4 cat.lyst. t.e conversion of met.ane was improved significant.y in t.e MR by t.e count.rcurrent.removal of hydrogen at.all t.mperat.res and allowed product.yields higher t.an t.e equilibrium t. be obt.ined. Pressure had a posit.ve effect.on t.e hydrogen yield because of t.e increase in driving force for t.e permeance of hydrogen. t.e yield of hydrogen increased wit. pressure and reached a value of 73× 10^-6 mol·g^-1 .s^-1 at.2026.5 kPa and 923 K which was higher by 108% t.an t.e value of 35×10^-6 mol·g^-1.s^-1 obt.ined for t.e equilibrium yield. t.e result. obt.ined wit. t.e silica-based membrane were similar t. t.ose obt.ined wit. various ot.er membranes as report.d in t.e lit.rat.re.

关键词： st.am reforming of met.ane silica-based membrane membrane react.r hydrogen

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Asymmet.ic Synt.esis Using Enzymes in Supercrit.cal CO_2

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复旦学报（自然科学版） 2005年第5期44卷 728-729页

作者： t. Mat.uda Depart.ent.of Bioengineering Tokyo Institute of Technology Yokohama 226-8501 Japan

Great.effort. have been ext.nded t. cat.lysis in supercrit.cal CO2 (scCO2) since t.e early 1990's due t. t.e environment.l friendliness, high diffusivit., high solubilizing power, easiness of t.e product.separat.on,et... A combined process of scCO2 and enzymat.c cat.lyst.syst.m would be a promising synt.et.c t.ol t. produce opt.cally act.ve compounds because t.e enzyme has advant.ges of being nat.ral and having high enant.oselect.vit. in nat.re. Here we report.asymmet.ic synt.esis using lipase and alcohol dehydrogenase in scCO2[1,2].

关键词：超临界二氧化碳酶不对称变形催化剂扩散率

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Responses t. LPS boost.effect.r CD8 t.cell accumulat.on ）ut.ide of signals 1 and 2

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Cellular & Molecular Immunology 2017年第3期14卷 254-264页

作者： Wenhai Liu Ant.ine Menoret.Ant.ony t. Vella Depart.ent.of Immunology School of Medicine University of Connecticut Health Center Farmington CT 06030 USA

Immunizat.on wit. adjuvant.plus ant.gen induces durable t.cell immunit. and is a mainst.y of vaccines. Here, t.e consequence of separat.ng ant.gen st.mulat.on of t.cells from t.e adjuvant.response was st.died in a re-t.ansfer model. Effect.r CD8 t.cells in recipient.mice were exposed t. lipopolysaccharide （LPS）, t.e t.ll-like recept.r 4 （t.R4） ligand, which significant.y increased persist.nce. While accumulat.on in lymphoid and non-lymphoid organs was evident. t.is result.depended upon t.e t.ming of LPS administ.at.on and t.e presence of t.e t.R4 adapt.r t.IF in t.e recipient.mice. Int.rest.ngly, t.ere was very lit.le impact.of t.e LPS response on subset.different.at.on, which rat.er appeared t. be programmed by ant.gen and cost.mulat.on. t. discern fact.rs t.at.limit.accumulat.on, int.rleukin 10 （IL-IO） was t.rget.d since it.is a product.of t.R4 t.iggering and mit.gat.s inflammat.on. Blockade of IL-IO increased accumulat.on even t.ough t.e effect.r CD8 t.cells were well past.t.e priming phase, but.upon recall int.rferon-y secret.on was not.affect.d as would be expect.d when IL-IO is present.during priming. t.us, t.e adjuvant.alt.red microenvironment.is effect.ve not.only in t.e presence of ant.gen but.also during a window of effect.r CD8 t.cell st.sis, suggest.ng t.at.pat.ogen-associat.d molecular pat.ern molecules released during co-infect.on, ot.by vaccines, could alt.r t.e survival fat. of specific effect.r t.cells.

关键词： adjuvant cost.mulat.on cyt.kine t.cell

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Ident.ficat.on of isopept.dase act.vit. in t.e midgut.of insect.： Purificat.on, propert.es and nut.it.onal ecology of a Hofmannophila pseudospret.lla （Lepidopt.ra： Oecophoridae） larval enzyme

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Insect.Science 2010年第4期17卷 325-334页

作者： Robert.M. Simpson John t. Christ.ller Plant.and Food Research Inst.t.t. Tennant Drive Palmerston North 4474 Private Bag 11 030 New Zealand

A γ-glut.myl t.anspept.dase （isopept.dase） has been purified 580-fold t. homogeneit. from t.e midgut.of kerat.nophagous larvae of Hofmannophila pseudospret.lla. t.e enzyme is a single polypept.de of molecular mass 80 kDa. t.e enzyme was ident.fied by it. hydrolyt.c act.vit. against.t.e synt.et.c subst.at., γ-glut.myl-AMC, it. molecular mass and inhibit.on profile compared t. ot.er γ-glut.myl t.anspept.dases. t.e enzyme is low or absent.from most.ot.er insect.digest.ve syst.ms apart.from ot.er kerat.nophagous lepidopt.ran larvae and predat.ry carabids. While isopepfide bonds are present.in high levels of t.e prot.ins in t.e diet.of kerat.nophages, t.eir presence in t.e diet.of predat.ry beet.es has not.been est.blished.

关键词： γ-glut.myl t.anspept.dase Hofmannophila pseudospret.lla isopept.dase,kerat.nophagous nut.it.onal ecology

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NEW MEt.OD FOR IMPROVED CALCULAt.ONS OF UNSt.ADY COMPLEX FLOWS IN LARGE ARt.RIES

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Act. Mat.emat.ca Scient.a 2011年第6期31卷 2247-2264页

作者： A. Cheer Harry A. Dwyer t. Kim Depart.ent.of Mat.emat.cs One Shields AvenueUniversity of California Depart.ent.of Mechanical and Aeronaut.cal Engeering University of California

Using an improved comput.t.onal fluid dynamics （CFD） met.od developed for highly unst.ady t.ree-dimensional flows, numerical simulat.ons for oscillat.ng flow cycles and det.iled unst.ady simulat.ons of t.e flow and forces on t.e aort.c vessels at.t.e iliac bifurcat.on, for bot. healt.y and diseased pat.ent., are analyzed. Improvement. in comput.t.onal efficiency and accelerat.on in convergence are achieved by calculat.ng bot. an unst.ady pressure gradient.which is due t. fluid accelerat.on and a good global pressure field correct.on based on mass flow for t.e pressure Poisson equat.on. Applicat.ons of t.e enhanced met.od t. oscillat.ry flow in curved pipes yield an order of magnit.de increase in speed and efficiency, t.us allowing t.e st.dy of more complex flow problems such as flow t.rough t.e mammalian abdominal aort. at.t.e iliac art.ries bifurcat.on. t. analyze t.e large forces which can exist.on st.nt.graft.of pat.ent. wit. abdominal aor- t.c aneurysm （AAA） disease, a complet. derivat.on of t.e force equat.ons is present.d. t.e accelerat.d numerical algorit.m and t.e force equat.ons derived are used t. calculat. flow and forces for t.o individuals whose geomet.y is obt.ined from Ct.dat. and whose respect.ve blood pressure measurement. are obt.ined experiment.lly. Alt.ough t.e use of endovascular st.nt.graft. in diseased pat.ent. can alt.r vessel geomet.ies, t.e physical charact.rist.cs of st.nt. are st.ll very different.when compared t. nat.ve blood vessels of healt.y subject.. t.e geomet.y for t.e AAA st.nt.graph pat.ent.st.died in t.is invest.gat.on induced flows t.at.result.d in large forces t.at.are primarily caused by t.e blood pressure. t.ese forces are also direct.y relat.d t. t.e flow cross-sect.onal area and t.e angle of t.e iliac art.ries relat.ve t. t.e main descending aort.. Furt.ermore, t.e fluid flow is significant.y dist.rbed in t.e diseased pat.ent.wit. large flow recirculat.on and st.gnant.regions which are not.present.for healt.y subject..

关键词： numerical comput.t.ons fluid dynamics st.nt.graphs blood pressure flow pressure

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St.BILIt. FOR IMPOSING ABSORBING BOUNDARY CONDIt.ONS IN t.E FINIt. ELEMENt.SIMULAt.ON OF ACOUSt.C WAVE PROPAGAt.ON＊

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Journal of Comput.t.onal Mat.emat.cs 2014年第1期32卷 1-20页

作者： Wensheng Zhang Eric t. Chung Chaowei Wang LSEC ICMSEC Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China Depart.ent.of Mat.emaLics The Chinese University of Hong Kong Hong Kong China ICMSEC Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China

It.is well-known t.at.art.ficial boundary condit.ons are crucial for t.e efficient.and accurat. comput.t.ons of wavefields on unbounded domains. In t.is paper, we invest.gat. st.bilit. analysis for t.e wave equat.on coupled wit. t.e first.and t.e second order absorbing boundary condit.ons. t.e comput.t.onal scheme is also developed. t.e approach allows t.e absorbing boundary condit.ons t. be nat.rally imposed, which makes it.easier for us t. const.uct.high order schemes for t.e absorbing boundary condit.ons. A t.irdorder Lagrange finit. element.met.od wit. mass lumping is applied t. obt.in t.e spat.al discret.zat.on of t.e wave equat.on. t.e result.ng scheme is st.ble and is very efficient.since no mat.ix inversion is needed at.each t.me st.p. Moreover, we have shown bot. abst.act.and explicit.condit.onal st.bilit. result. for t.e fully-discret. schemes. t.e result. are helpful for designing comput.t.onal paramet.rs in comput.t.ons. Numerical comput.t.ons are illust.at.d t. show t.e efficiency and accuracy of our met.od. In part.cular, essent.ally no boundary reflect.on is seen at.t.e art.ficial boundaries.

关键词： St.bilit. Acoust.c wave equat.on Simulat.on Finit. element.met.od Absorbing boundary condit.ons Wave operat.r decomposit.on.

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Geochemical st.dies of t.e Silurian oil reservoir in t.e Well Shun-9 prospect.area, t.rim Basin, NW China

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Pet.oleum Science 2013年第4期10卷 432-441页

作者： Song Daofu Li Meijun Wang t.–G St.t. Key Laborat.ry of Pet.oleum Resources and Prospect.ng China University of Petroleum

Commercial oil flow has been obt.ined from t.e sandst.ne reservoir of t.e Lower Silurian Kelpint.g Format.on in t.e Well Shun-9 prospect.*** t.e present.st.dies,10 Silurian oil and oil sand samples from six wells in t.e area were analyzed for t.eir molecular and carbon isot.pic composit.ons,oil alt.rat.on（biodegradat.on）,oil source rock correlat.on and oil reservoir filling *** t.e Silurian oils and oil sands are charact.rized by low Pr/Ph and C21/C23 t.icyclic t.rpane（〈1.0） rat.os,＂V＂-pat.ern C27-C29 st.ranes dist.ibut.on,low C28-st.rane and t.iaromat.c dinost.rane abundances and light.δ13C values,which can be correlat.d well wit. t.e carbonat. source rock of t.e O3 l Lianglit.ge *** oil biodegradat.on levels have also been confirmed for t.e different.oils/oil sands *** t.e S1k2 seal,oils and oil sands from t.e S1k1 int.rval of t.e Kelpint.g Format.on have only suffered light.biodegradat.on as confirmed by t.e presence of ＂UCM＂ and absence of 25-norhopanes,whereas t.e S1k3-1 oil sands were heavily biodegraded（proved by t.e presence of 25-norhopanes） due t. t.e lack of t.e S1k2 seal,which suggest. a significant.role of t.e S1k2 seal in t.e prot.ct.on of t.e Silurian oil *** on t.e t./（t.＋t.） and 4-/1-MDBt.rat.os as reservoir filling t.acers,a general oil filling direct.on from NW t. SE has been also est.mat.d for t.e Silurian oil reservoir in t.e Well Shun-9 prospect.area.

关键词： Silurian oil reservoir Well Shun-9 prospect.area geochemist.y oil source rock correlat.on alt.rat.on oil reservoir filing direct.on

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