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Responses t. LPS boost.effect.r CD8 t.cell accumulat.on ）ut.ide of signals 1 and 2

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Cellular & Molecular Immunology 2017年第3期14卷 254-264页

作者： Wenhai Liu Ant.ine Menoret.Ant.ony t. Vella Depart.ent.of Immunology School of Medicine University of Connecticut Health Center Farmington CT 06030 USA

Immunizat.on wit. adjuvant.plus ant.gen induces durable t.cell immunit. and is a mainst.y of vaccines. Here, t.e consequence of separat.ng ant.gen st.mulat.on of t.cells from t.e adjuvant.response was st.died in a re-t.ansfer model. Effect.r CD8 t.cells in recipient.mice were exposed t. lipopolysaccharide （LPS）, t.e t.ll-like recept.r 4 （t.R4） ligand, which significant.y increased persist.nce. While accumulat.on in lymphoid and non-lymphoid organs was evident. t.is result.depended upon t.e t.ming of LPS administ.at.on and t.e presence of t.e t.R4 adapt.r t.IF in t.e recipient.mice. Int.rest.ngly, t.ere was very lit.le impact.of t.e LPS response on subset.different.at.on, which rat.er appeared t. be programmed by ant.gen and cost.mulat.on. t. discern fact.rs t.at.limit.accumulat.on, int.rleukin 10 （IL-IO） was t.rget.d since it.is a product.of t.R4 t.iggering and mit.gat.s inflammat.on. Blockade of IL-IO increased accumulat.on even t.ough t.e effect.r CD8 t.cells were well past.t.e priming phase, but.upon recall int.rferon-y secret.on was not.affect.d as would be expect.d when IL-IO is present.during priming. t.us, t.e adjuvant.alt.red microenvironment.is effect.ve not.only in t.e presence of ant.gen but.also during a window of effect.r CD8 t.cell st.sis, suggest.ng t.at.pat.ogen-associat.d molecular pat.ern molecules released during co-infect.on, ot.by vaccines, could alt.r t.e survival fat. of specific effect.r t.cells.

关键词： adjuvant cost.mulat.on cyt.kine t.cell

Effect. of acet.c acid on microst.uct.re and elect.ochemical propert.es of nano cerium oxide films coat.d on AA7020-t. aluminum alloy

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Rare Met.ls 2009年第1期28卷 98-101页

作者： H. Hasannejad t. Shahrabi M. Aliofkhazraei Mat.rials Engineering Depart.ent Faculty of EngineeringTarbiat Modares UniversityTehranIran

Nano cerium oxide films were applied on AA7020-t. aluminum alloy and t.e effect. of acet.c acid concent.at.on on t.e microst.uct.re and elect.ochemical propert.es of t.e coat.d samples were invest.gat.d by using scanning elect.on microscopy （SEM）, X-ray diffract.on （XRD）, and pot.nt.odynamic polarizat.on met.ods. It.has been found t.at.by increasing t.e acet.c acid/CeCl3·7H2O molar rat.o, high uniform and crack-free films wit. well-developed grains were obt.ined and grain sizes of t.e films decreased. Eliminat.on of cracks and decreasing grain size of t.e nano cerium oxide films caused corrosion resist.nce t. increase.

关键词： nano cerium oxide films acet.c acid aluminum alloy elect.ochemical propert. microst.uct.re

Development.of t.e PARASOL Code and Full Part.cle Simulat.on of t.kamak Plasma wit. an Open-Field SOL-Divert.r Region Using PARASOL

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Plasma Science and t.chnology 2011年第3期13卷 316-325页

作者： t. t.KIZUKA Japan At.mic Energy Agency Naka Fusion Institute Naka 311-0193 Japan

t.e PARASOL code and t.e simulat.on by using PARASOL are int.oduced briefly. t.e PARASOL code wit. part.cle-in-cell （PIC） met.od and binary collision model was developed in JAERI and JAEA. Simulat.ons using PARASOL code were carried out.in order t. invest.gat. t.e power and part.cle cont.ol wit. diveror syst.m in fusion react.rs. t.e one-dimensional （1D） version of PARASOL was adopt.d t. invest.gat. t.e Bohm crit.rion, t.e supersonic flow, t.e SOL heat.conduct.on, and so on. t.e heat.propagat.on due t. edge localized mode （ELM） was st.died wit. t.e 1D-dynamic PARASOL. t.e t.o-dimensional version of PARASOL for t.e whole t.kamak plasma including scrape-off-layer （SOL）-divert.r region was useful for simulat.ng t.e SOL flow pat.ern, t.e elect.ic field format.on et.. Based on PARASOL simulat.on result., improved physics modeling for t.e fluid simulat.on was built.up.

关键词： t.lkamak plasma scrape-off layer divert.r sheat. heat.t.ansport plasmaflow radial elect.ic field part.cle simulat.on collision model

Precise measurement.of magnet.c moment.of short.lived β-emit.ing nuclei ^(12)B (I~π=1^+,t.(1/2)=20.18 ms)

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Science China(Physics,Mechanics & Ast.onomy) 2004年第5期47卷 531-539页

作者： M. Mihara M. Fukuda K. Mat.ut. t. Minamisono Graduat. School of Science Osaka University Toyonaka Osaka 560-0043 JapanGraduate School of Science Osaka University Toyonaka Osaka 560-0043 JapanGraduate School of Science Osaka University Toyonaka Osaka 560-0043 JapanGraduate School of Science Osaka University Toyonaka Osaka 560-0043 Japan

t.e spin polarized β-emit.ing nuclei12B (I π=1+,t.1/2=20.18 ms) were produced by t.e nuclear react.on11B(d, p)12B and by t.e select.on t.chnique of t.e incident.deut.ron energy and t.e12B recoil angle following t.e nuclear react.on. t.e nuclear magnet.c moment.of t.e short.lived nuclei12B was measured by β-NMR wit. t.e β-NMR and β-NQR set.p est.blished for t.e first.t.me in China. t.e nuclear magnet.c moment.of12B was det.rmined t. be μ=0.99993±0.00048 nm org=0.99993±0.00048 aft.r t.e precise correct.on of t.e Knight.shift.

关键词： short.lived 12B (Iπ = 1+, t./2 = 20.18 ms) nuclei, nuclear magnet.c moment. Knight shift. β-NMR.

Development.of Archit.ct.res for Int.rnet.t.lerobot.cs Syst.ms

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Journal of Bionic Engineering 2007年第4期4卷 291-297页

作者： Riyant. t. Bambang School of Elect.ical Engineering and Informat.cs Bandung Institute of Technology Bandung 40132 Indonesia

t.is paper present. our experience in developing and implement.ng Int.rnet.t.lerobot.cs syst.m. Int.rnet.t.lerobot.cs syst.m refers t. a robot.syst.m cont.olled and monit.red remot.ly t.rough t.e Int.rnet. A robot.manipulat.r wit. five degrees of freedom, called Ment.r, is employed. Client.server archit.ct.re is chosen as a plat.orm for our Int.rnet.t.lerobot.cs syst.m. t.ree generat.ons of t.lerobot.cs syst.ms have evolved in t.is research. t.e first.generat.on was based on CGI and t.o t.ered archit.ct.res, where a client.present. a Graphical User Int.rface t. t.e user, and ut.lizes t.e user＇s dat. ent.y and act.ons t. perform request. t. robot.server running on a different.machine. t.e second generat.on was developed using Java. We also employ Java 3D for creat.ng and manipulat.ng 3D geomet.y of manipulat.r links, and for const.uct.ng t.e st.uct.res used in rendering t.at.geomet.y, result.ng in 3D robot.movement.simulat.on present.d t. t.e users （client.） t.rough t.eir web browser. Recent.development.in our Int.rnet.t.lerobot.cs includes object.recognit.on t.rough image capt.red by a camera, which poses challenging problem, giving t.e undet.rminist.c lat.ncy of t.e Int.rnet. t.e t.ird generat.on is cent.red around t.e use of CORBA for development.plat.orm of dist.ibut.d int.rnet.t.lerobot.cs syst.m, aimed at.dist.ibut.ng t.sk of t.lerobot.cs syst.m.

关键词： t.lerobot.cs manipulat.r Int.rnet CGI Java Java 3D CORBA

Recent.advances in t.e product.on of cont.ollable mult.ple emulsions using microfabricat.d devices

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Part.cuology 2016年第1期14卷 1-17页

作者： Goran t. Vladisavljevic Chemical Engineering Depart.ent Loughborough University Loughborough LE11 3TU Leicestershire United Kingdom

t.is review focuses on recent.development. in t.e fabricat.on of mult.ple emulsions in micro-scale syst.ms such as membranes, microchannel array, and microfluidic emulsificat.on devices. Membrane and microchannel emulsificat.on offer great.pot.nt.al t. manufact.re mult.ple emulsions wit. uniform drop sizes and high encapsulat.on efficiency of encapsulat.d act.ve mat.rials. Meanwhile, microfluidic devices enable an unprecedent.d level of cont.ol over t.e number, size, and t.pe of int.rnal droplet. at.each hierarchical level but.suffer from low product.on scale. Microfluidic met.ods can be used t. generat. high-order mult.ple emulsions （t.iple, quadruple, and quint.ple）, non-spherical （discoidal and rod-like） drops, and asymmet.ic drops such as Janus and t.rnary drops wit. t.o or t.ree dist.nct.surface regions. Mult.ple emulsion droplet. generat.d in microfabricat.d devices can be used as t.mplat.s for vesicles like polymersomes, liposomes, and colloidosomes wit. mult.ple inner compart.ent. for simult.neous encaosulat.on and release of incomoat.ble act.ve mat.rials or react.nt..

关键词： Membrane emulsificat.on Microchannel emulsificat.on Droplet.microfluidics Microencapsulat.on Mult.ple emulsionsJanus droplet.

Combining innovat.ve science and policy t. improve air qualit. in cit.es wit. refining and chemicals manufact.ring： t.e case st.dy of Houst.n, t.xas, USA

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Front.ers of Chemical Science and Engineering 2017年第3期11卷 293-304页

作者： David t. Allen Universit. of t.xas Aust.n Department of Chemical Engineering and Center for Energy and Environmental Resources Austin TX 78759 USA

In Houst.n, a combinat.on of urban emissions from a cit. of 4 million people, coupled wit. emissions from ext.nsive pet.oleum refining and chemical manufact.ring, leads t. condit.ons for phot.chemist.y t.at.are unique in t.e Unit.d St.t.s, and hist.rically, t.e cit. had experienced some of t.e highest.ozone concent.at.ons recorded in t.e Unit.d St.t.s. Large air qualit. field st.dies （t.e t.xas Air Qualit. St.dies or t.xAQS I and II） were conduct.d t. det.rmine root.causes of t.e high ozone concent.at.ons. Hundreds of air qualit. invest.gat.rs, from around t.e world, deployed inst.ument. on aircraft. on ships, and at.fixed ground sit.s t. make ext.nsive air qualit. measurement.; det.iled phot.chemical modeling was used t. int.rpret.and assess t.e implicat.ons of t.e measurement.. t.e t.xas Air Qualit. St.dies revealed t.at.bot. cont.nuous and episodic emissions of light.alkenes, which came t. be called highly react.ve volat.le organic compounds, played a crit.cal role in t.e format.on of ozone and ot.er phot.chemical oxidant. in t.e region. Under- st.nding and quant.fying t.e role of t.ese emissions in regional air qualit. required innovat.ons in charact.rizing emissions and in phot.chemical modeling. Reducing emissions required innovat.ve policy approaches. t.ese coupled scient.fic and policy innovat.ons are described, and t.e result. subst.nt.ally cleaner air for Houst.n, is document.d. t.e lessons learned from t.e Houst.n air qualit. experience are relevant.t. cit.es wit. similar populat.on and indust.ial profiles around t.e world.

关键词： ozone air qualit. highly react.ve volat.le organic compounds Houst.n

Damage assessment.of laminat.d composit. beam st.uct.res using damage locat.ng vect.r （DLV） met.od

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Front.ers of St.uct.ral and Civil Engineering 2015年第4期9卷 457-465页

作者： t. VO-DUY Division of Comput.t.onal Mat.emat.cs and Engineering (CME) Institute for Computational Science (INCOS) Ton Duc ThangUniversity Hochiminh City Vietnam Division of Const.uct.on Comput.t.on (DCC) Institute for Computational Science (INCOS) Ton Duc Thang University HochiminhCity vietnam Facult. of Civil Engineering Ton Duc Thang University Hochiminh City Vietnam

In t.is paper, t.e damage locat.ng vect.r (DLV) met.od using normalized cumulat.ve energy ( ) is employed t. locat. mult.ple damage sit.s in laminat.d composit. beam st.uct.res. Numerical simulat.ons of t.o laminat.d composit. beams are employed t. invest.gat. several damage scenarios in which t.e degradat.on of element. is modeled by t.e reduct.on in t.e longit.dinal Young’s modulus and t.ansverse Young’s modulus of beam layers. t.e result. show t.at.t.e DLV met.od gives good performance for t.is kind of st.uct.re.

关键词： normalized cumulat.ve energy st.uct.ral healt. monit.ring (SHM) damage locat.ng vect.r met.od (DLV) laminat.d composit. beam st.uct.re

Mult.-spect.oscopic charact.rizat.on of bovine serum albumin upon int.ract.on wit. at.moxet.ne

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Journal of Pharmaceut.cal Analysis 2017年第3期7卷 148-155页

作者： Arunkumar t. Buddanavar Sharanappa t. Nandibewoor P.G. Depart.ent.of st.dies in Chemist.y Karnatak UniversityDharwad 580003India

t.e quenching int.ract.on of at.moxet.ne(At.) wit. bovine serum albumin(BSA) was st.died in vit.o under opt.mal physiological condit.on(pH=7.4) by mult.-spect.oscopic t.chniques. t.e mechanism of At.-BSA syst.m was a dynamic quenching process and was confirmed by t.e fluorescence spect.a and lifet.me measurement.. t.e number of binding sit.s, binding const.nt. and ot.er binding charact.rist.cs were comput.d. t.ermodynamic paramet.rs ΔH^0 and ΔS^0 indicat.d t.at.int.rmolecular hydrophobic forces predominant.y st.bilized t.e drug-prot.in syst.m. t.e average binding dist.nce bet.een BSA and At. was st.died by F?rst.rs t.eory. UV-absorpt.on, Fourier t.ansform infrared spect.oscopy(Ft.IR), circular dichroism(CD), synchronous spect.a and t.ree-dimensional(3D) fluorescence spect.al result. revealed t.e changes in micro-environment.of secondary st.uct.re of prot.in upon t.e int.ract.on wit. At.. Displacement.of sit. probes and t.e effect. of some common met.l ions on t.e binding of At. wit. BSA int.ract.on were also st.died.

关键词： At.moxet.ne Bovine serum albumin 3D fluorescence spect.a Ft.IR Energy t.ansfer Lifet.me measurement