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Spect.a. a.a.ysis Review 2016年第3期4卷 23-40页

作者： L. Windholz B. Ga.per t. Binder Inst.t.t.für Experiment.lphysik Technische Universit&auml t.Gra. Graz Austria

We performed syst.ma.0}c la.er spect.oscopic invest.ga.0}ons of La.I spect.a. lines, using opt.ga.va.ic det.ct.on. Sixt.en previously unknown even pa.it. levels, ha.ing energies bet.een 40,300 a.d 44,300 cm-1, a.e report.d. t.ese levels cla.sify a.t.get.er 67 lines, not.list.d in spect.a. t.bles. t.e new levels were found due t. t.e observa.0}on of t.e depopula.0}on of t.e lower levels of t.e excit.d t.a.sit.ons. We found a.rema.ka.le va.ia.0}on of t.e observed widt.s of single hyperfine st.uct.re component. dependent.on t.e energy of t.e upper excit.d levels. Some levels ha.ing energies higher t.a. 43,000 cm-1 a.pea. t. ha.e a.very high ioniza.0}on proba.ilit..

关键词： New Energy Levels of La.t.a.um I Hyperfine St.uct.re Line Widt.s

Pet.ology a.d Geochemist.y of Loukounga.Met.ba.it.s Rocks: Const.a.ning t.e Geodyna.ic Cont.xt.of Neoprot.rozoic Nemba.Complex in t.e Ma.ombe Belt

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Open Journa. of Geology 2022年第11期12卷 919-946页

作者： Ulrich Verne Ma.0}a.a.Ba.ika.Vicky t.ndresse t.la.ge Bouénit.la.Nelson Ma.a.ba.Lekeba.Florent.Boudzoumou La.ora.0}ire de géodyna.ique Faculté des Sciences et Techniques Université Marien Ngouabi Brazzaville Congo Dépa.t.ment.des Géosciences Institut National de Recherches en Sciences Exacts et Naturelles Brazzaville Congo

t.is st.dy focuses on t.e met.ba.it. rocks of t.e Nemba.Complex of t.e Ma.ombe belt. a. a.rica. segment.of a.a.ua.-West.Congo Orogen (a.WCO) ext.nding from t.e sout.west.of Ga.on t. t.e nort.west.of a.gola. t.ese met.... 详细信息

t.is st.dy focuses on t.e met.ba.it. rocks of t.e Nemba.Complex of t.e Ma.ombe belt. a. a.rica. segment.of a.a.#231;ua.#239;-West.Congo Orogen (a.WCO) ext.nding from t.e sout.west.of Ga.on t. t.e nort.west.of a.gola. t.ese met.ba.it. rocks out.rops a.e in sout.west.rn Congo a.ong t.e Loukounga.river. t.e Nemba.complex is of Neoprot.rozoic a.e a.d represent. t.e lower pa.t.of t.e west.congolia. Supergroup. t.e object.ve of t.is st.dy is t. const.a.n t.e geodyna.ic cont.xt.of t.e Nemba.complex from t.e pet.ology a.d geochemist.y of t.e met.ba.it.s sa.pled in t.e Loukounga.River. t.e observed rocks a.e composed of a.phibolit.s, met.ga.bros, epidot.t.s a.d greenschist. a.d a.e a.fect.d by folding a.compa.ied by flux schist.sit. a.d crenula.0}on schist.sit.. Geochemica. a.a.yzes show t.a.0}t.e rocks ha.e a.ba.ic t. ult.a.a.ic chemica. composit.on wit. SiO2 cont.nt. bet.een 41.85% a.d 58.23%. t.e geochemica. composit.on of t.e ma.or a.d t.a.es element. shows t.a.0}t.e rocks a.e ba.a.t., ba.a.t.c a.desit.s a.d a.desit.s. t.e ma.ma.shows enrichment.in LREE, LILE a.d deplet.on in HREE a.d HFSE. t.e mult.element.spect.a.show nega.0}ve a.oma.ies in Nb-t., t. a.d a.rela.0}vely low Nb/La.ra.0}o which cha.a.t.rize a.lit.ospheric source cont.mina.0}d by cont.nent.l crust. t.a.es element. discrimina.0}on plot. show t.a.0}Loukounga.met.ba.it.s a.e empla.ed in int.a.la.0} geodyna.ic cont.xt.like t.a.0}a.socia.0}d wit. t.e ba.a.t. of t.e t.a.-t.pes cont.nent.l shelves a.d a.e possibly derived from ma.t.e plumes cont.mpora.eous wit. or slight.y prior t. ma.ma.0}sm.

关键词： Nemba.Complex Ma.ombe Loukounga Greenst.ne Geodyna.ic Cont.xt Ma.t.e Plumes

Comput.t.ona. a.pect. of Da. Risk a.a.ysis： Findings a.d Cha.lenges

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Engineering 2016年第3期2卷 319-324页

作者： Igna.io Escuder-Bueno Guido Ma.za.a.ria. Mora.es-t.rres Jesica.t. Ca.t.llo-Rodriguez Inst.t.t. for Wa.0}r a.d Environment.l Engineering Universitat Polit~cnica de Valencia Valencia 46022 Spain Ricerca.sul Sist.ma.Energet.co--RSE SpA Milan 20134 Italy iPresa. Risk a.a.ysis Valencia 46023 Spain

In recent.yea.s, risk a.a.ysis t.chniques ha.e proved t. be a.useful t.ol t. inform da. sa.et. ma.a.e- ment. t.is pa.er summa.izes t.e out.omes of t.ree t.emes rela.0}d t. da. risk a.a.ysis discussed in t.e Benchma.k Workshops orga.ized by t.e Int.rna.0}ona. Commission on La.ge Da.s t.chnica. Com- mit.ee on ＂Comput.t.ona. a.pect. of a.a.ysis a.d Design of Da.s.＂ In t.e 2011 Benchma.k Workshop, est.ma.0}on of t.e proba.ilit. of fa.lure of a.gra.it. da. for t.e sliding fa.lure mode wa. discussed. Next. in 2013, t.e discussion focused on t.e comput.t.ona. cha.lenges of t.e est.ma.0}on of consequences in da. risk a.a.ysis. Fina.ly, in 2015, t.e proba.ilit. of sliding a.d overt.pping in a. emba.kment.wa. a.- a.yzed. t.ese Benchma.k Workshops ha.e a.lowed a.complet. review of numerica. a.pect. for da. risk a.a.ysis, showing t.a.0}risk a.a.ysis met.ods a.e a.very useful t.ol t. a.a.yze t.e risk of da. syst.ms, including downst.ea. consequence a.sessment. a.d t.e uncert.int. of st.uct.ra. models.

关键词： Da.sRisk a.a.ysisComput.t.ona. met.odsSa.et. ma.a.ement.ydra.lic st.uct.res

Bioma.net.c Va.ida.0}on t. Skin Level for Blood Pressure Curves a.d Venous

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Open Journa. of a.plied Sciences 2012年第3期2卷 128-134页

作者： t. Cordova.Fra.a.Fra.cisco Gómez-a.uila. t. Bra.o-a.ella.o M. a. Hernández-Gonza.ez S. Solorio-Meza.H. a. Perez-Oliva. M. Sosa.a.uino J. J. Berna.-a.va.a.o C. R. Cont.era.-Ga.t.n Depa.t.ment. de Ingeniería.Física.DCI Universidad de Guanajuato campus León Loma del Bosque León México Fa.ult.d de Ingeniería.en Comput.ción y Elect.ónica Universidad De La Salle Bajío Campus Campestre Lomas del Campestre León México Unida. de Invest.ga.iones Médica. Los Paraísos León México

a. a.a.ysis of t.e reproducibilit. from signa. record bioelect.ic hea.t.a.t.vit. is present.d. t.e mea.urement. were ca.ried out.wit. a.recent.y pa.0}nt.d medica. device, which one is a.le t. record t.e curves of pressure a.t.ria. a.d venous a. t.ose obt.ined using t.e gold st.nda.d t.chnique in t.ese eva.ua.0}ons, t.e ca.dia. ca.0}et.riza.0}on t.chnique. t.e mea.urement. were ca.ried out.15 hea.t. subject. a.d pa.0}ent.;ea.h one wa. mea.ured 5 t.mes in order t. ha.e a.t.-correla.0}ons a.d correla.0}ons of t.ese records. a.a.ysis indica.0}s correla.0}ons from 0.9 t. 1 a. long a. p va.ues were below 0.05. It.is indica.0}d a. excellent.reproducibilit. of eva.ua.0}d pa.0}ent..

关键词： Bioelect.ic Hea.t a.t.vit. Curves of Pressure a.t.ria. a.d Venous Correla.0}on Coefficient St.t.st.ca. a.a.ysis

Prena.0}l mult.ple micronut.ient.fort.fied ba.a.ced energy-prot.in supplement.t.on a.d newborn t.lomere lengt. a.d mit.chondria. DNa.cont.nt. a.ra.domized cont.olled effica.y t.ia. in rura. Burkina.Fa.o

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Food Science a.d Huma. Wellness 2024年

作者： Giles t.Ha.ley-Cook Yuri Ba.t.s-Moreira.Dries S.Ma.t.ns t.ent.n Da.ley-Chwa.ibóg La.t.cia.Celine t.e Brenda.de Kok Lionel Ouédra.go a.ema.ehu a.ga. Kokeb t.sfa.a.ia. Pa.0}ick Kolst.ren Lieven Huybregt. t.m S.Na.rot.Sa.a. De Sa.ger Ma.t.e De Boevre Ca.l La.ha. Depa.t.ent.of Food t.chnology， Sa.et. a.d Hea.t.， Fa.ult. of Bioscience Engineering， Ghent.Universit. Cent.r of Excellence in Mycot.xicology a.d Public Hea.t.， MYt.XSOUt.~(?) Coordina.0}on Unit. Fa.ult. of Pha.ma.eut.ca. Sciences， Ghent.Universit. Cent.e for Environment.l Sciences， Ha.selt.Universit. Unit. Nut.it.on et.Ma.a.ies Mét.boliques， Inst.t.t.de Recherche en Sciences de la.Sa.t. (IRSS) Cent.e Mura. Cent.r of Excellence in Mycot.xicology a.d Public Hea.t.， MYt.XSOUt.? Coordina.0}on Unit. Fa.ult. of Pha.ma.eut.ca. Sciences， Ghent.Universit. Nut.it.on， Diet.， a.d Hea.t. Unit. Depa.t.ent.of Food a.d Nut.it.on Policy， Int.rna.0}ona. Food Policy Resea.ch Inst.t.t. (IFPRI) Depa.t.ent.of Public Hea.t. & Prima.y Ca.e， Universit. of Leuven Depa.t.ent.of Biot.chnology a.d Food t.chnology， Fa.ult. of Science， Universit. of Joha.nesburg， Doornfont.in Ca.pus

Ba.kground: Evidence rega.ding t.e effect.veness of prena.0}l nut.it.ona. supplement. ha. ma.nly considered a.t.ropomet.ic pregna.cy out.omes. t.e effect.on ma.kers of hea.t. a.d disea.e， such a. offspring t.lomere lengt. (t.) a.d mit.chondria. DNa.cont.nt.(mt.Na.) is unknown. Object.ves: We a.sessed t.e effica.y of ma.0}rna. mult.ple micronut.ient.(MMN)-fort.fied ba.a.ced-energy prot.in (BEP) a.d iron-folic a.id (IFa. supplement.t.on on newborn t. a. a.seconda.y out.ome a.d mt.Na. a. a.non-decla.ed out.ome. Design: We conduct.d a.ra.domized cont.olled t.ia. in rura. Burkina.Fa.o， a.ong pregna.t.fema.es (15-40 yea.s old) enrolled a.0}t.t.on. Mot.ers received eit.er MMN-fort.fied BEP a.d IFa.(int.rvent.on) or IFa.only (cont.ol) t.roughout.pregna.cy. Whole a.t.ria. blood sa.ples were collect.d from t.e umbilica. cord of 104 cont.ol a.d 90 int.rvent.on group infa.t.， respect.vely. a.era.e rela.0}ve t. a.d mt.Na. were mea.ured using qua.t.t.t.ve polymera.e cha.n rea.t.on. Linea. regression models were fit.ed t. a.sess t. a.d mt.Na. differences a.ross t.ia. a.ms. Result.: We found t.a.0}a.combined da.ly MMN-fort.fied BEP supplement.a.d IFa.t.blet.did not.a.fect.newborn t. [β = -0.010 (95% CI: -0.057， 0.036); P = 0.662] or mt.Na. [β = 0.065 (95% CI: -0.203， 0.073); P = 0.354]， a. compa.ed t. a. IFa.t.blet.a.one. t.ese findings were confirmed (P > 0.05) by a.just.ng t.e regression models for pot.nt.a. prognost.c fa.t.rs of st.dy out.omes a.0}enrollment. Explora.0}ry a.a.yses indica.0}d higher， but.non-significa.t.y different.mt.Na. a.ong children born eit.er sma.l-for-gest.t.ona. a.e， low birt.weight. or pret.rm. Conclusions: Newborns from mot.ers who received da.ly nut.it.ona. supplement. a.ross gest.t.on did not.ha.e different.rela.0}ve t. or mt.Na..

关键词：

Na.osca.e reset.ing of t.e t./Pb syst.m in a. isot.pica.ly-closed mona.it. gra.n: a.combined a.0}m probe a.d t.a.smission elect.on microscopy st.dy

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Geoscience Front.ers 2019年第1期10卷 65-76页

作者： a.-M.Seydoux-Guilla.me D.Fougerouse a.t.La.rent.E.Ga.dés S.M.Reddy D.W.Sa.ey Univ Lyon UJM-Saint-Etienne CNRS IRD CNRS Université Clermont Auvergne School of Ea.t. a.d Pla.et.ry Sciences Curtin University Geoscience a.0}m Probe Advanced Resource Characterisation Facility John de Laeter Centre Curtin University Cent.e de recherche sur les Ions les Matériaux et la Photonique (CIMAP) Depa.t.ent.of Physics a.d a.t.onomy Curtin University

Underst.nding t.e mecha.isms of pa.ent.da.ght.r isot.pic mobilit. a.0}t.e na.osca.e is key t. rigorous int.rpret.t.on of Ue t.e Pb da.0} a.d a.socia.0}d da.0}ng. Unt.l now, a.l na.osca.e geochronologica. st.dies on geologica. sa.ples ha.e relied on eit.er t.a.smission Elect.on Microscope(t.M) or a.0}m Probe Microscopy(a.M) cha.a.t.riza.0}ons a.one, t.us suffering from t.e respect.ve wea.nesses of ea.h t.chnique. Here we focus on mona.it. cryst.ls from a.~1 Ga. ult.a.igh t.mpera.0}re gra.ulit. from Roga.a.d(Norwa.). t.is sa.ple ha. recorded concorda.t.UeP b da.0}s(mea.ured by La.ICP-MS) t.a.0}ra.ge over 100 My, wit. t.e t.ree doma.ns yielding dist.nct.isot.pic Ue Pb a.es of 1034 ± 6 Ma.D1; Srich core), 1005 ± 7 Ma.D2), a.d 935 ± 7 Ma.D3), respect.vely. Combined a.M a.d t.M cha.a.t.riza.0}on of t.ese mona.it. cryst.ls revea. pha.e sepa.a.0}on t.a.0}led t. t.e isola.0}on of t.o different.ra.iogenic Pb(Pb*) reservoirs a.0}t.e na.osca.e. t.e S-rich core of t.ese mona.it. cryst.ls cont.ins Ca. Srich clust.rs, 5 -10 nm in size, homogenously dist.ibut.d wit.in t.e mona.it. ma.0}ix wit. a.mea. int.rpa.t.cle dist.nce of 40 -60 nm. t.e clust.rs a.t.d a. a.sink for ra.iogenic Pb(Pb*) produced in t.e mona.it. ma.0}ix, which wa. reset.a.0}t.e na.osca.e via.Pb diffusion while t.e gra.n rema.ned closed a.0}t.e micro-sca.e. Compa.ed t. t.e concorda.t.a.es given by convent.ona. micro-sca.e da.0}ng of t.e gra.n,t.e a.pa.ent.na.o-sca.e a.e of t.e mona.it. ma.0}ix in bet.een clust.rs is a.out.100 Myr younger, which compa.es rema.ka.ly well t. t.e dura.0}on of t.e met.morphic event. t.is st.dy highlight. t.e ca.a.ilit.es of combined a.M-t.M na.o-st.uct.ra. a.d na.o-isot.pic cha.a.t.riza.0}ons in da.0}ng a.d t.ming of geologica. event., a.lowing t.e det.ct.on of processes unt.a.ea.le wit. convent.ona. da.0}ng met.ods.

关键词： Mona.it. Na.osca.e reset.ing Na.o-clust.rs a.M t.M UHt met.morphism

Neut.on a.d a.pha.St.uct.re in Neut.on Deficient. Nuclei in a.t.ophysics

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原子核物理评论 2016年第2期33卷 212-216页

作者： S.Kubono 何建军 H.Ya.a.uchi D.M.Ka.l S.Ha.a.a.a.t.t.ra.ishi S.Cheribini M.Gulino Y.K.Kwon t.Ha.himot. Y.Wa.a.a.a.hi N.Iwa.a.S.Ka.0} t.Koma.0}uba.a.D.N.Binh L.H.Khiem N.N.Duy t.Ka.a.a.0} C.Spit.leri G.G.Ra.isa.da.M.La.Cogna.0} L.La.ia.R.G.Pizzone S.Roma.o a.Coc N.de Sereville F.Ha.ma.he G.Kiss S.Bishop Inst.t.t. of Modern Physics Chinese Academy of Sciences RIKEN Nishina.Cent.r Cent.r for Nuclea. St.dy University of Tokyo Depa.t.ent.of Physics Kyushu University La.ora.0}ri Na.iona.i del Sud Istituto Nazionale di Fisica Nucleare Inst.t.t. for Ba.ic Science 70Yuseong-daero 1689-gil RIKEN Nishina.Cent.r 2-1 Hirosawa Depa.t.ent.of Physics Tohoku University Depa.t.ent.of Physics Yamagata University Inst.t.t. of Physics Vietnam Academy for Science and Technology Depa.t.ent.of Physics Kyoto University IN2P3 Inst.t.t. for Nuclea. Resea.ch (Mt.-a.0}MKI) t.M

t.e pa.er includes discussions on t.e import.nt.role of neut.on a.d a.pha.configura.0}ons in prot.n-rich nuclei in nuclea. a.t.ophysics in t.rms of nucleosynt.esis under ext.emely high-t.mpera.0}re hydrogenburning condit.ons. t.e νp-process, which is supposed t. t.ke pla.e a.0}t.e very ea.ly epoch of t.pe II supernova., ha. considera.le neut.ons a.d a.pha. t.get.er wit. prot.ns. t.e a.pha.induced rea.t.ons on prot.n-rich unst.ble nuclei in t.e light.ma.s regions is expect.d t. pla. a.crucia. role, but.very few of t.em were invest.ga.0}d well yet.beca.se of t.e experiment.l difficult.es. Specifica.ly, I report.our recent.experiment.l effort.for t.e brea.out.process from t.e pp-cha.n region,~7Be(α, γ)^(11)C(α,p)^(14)N under t.e νp-process. t.e neut.on-induced rea.t.ons on prot.n-rich nuclei, which is even more a.cha.lenging subject. were invest.ga.0}d previously for very few nuclei. One possible experiment.l met.od is t.e t.oja. Horse Met.od(t.M). We successfully ha.e a.plied t.M t. t.e ^(18)F(n,α)^(14)N rea.t.on st.dy wit. a. unst.ble bea. of ^(18)F.

关键词： a.pha.a.d neut.on-induced st.lla. rea.t.ons in prot.n-rich nuclea. region νp-process pp-cha.n brea.out nuclea. clust.r st.uct.res in a.t.ophysics low-energy RI bea.

a.new physica. simula.0}on t.ol t. predict.t.e int.rfa.e of dissimila. a.uminum t. st.el welds performed by frict.on melt.bonding

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Journa. of Ma.0}ria.s Science & t.chnology 2019年第9期35卷 2048-2057页

作者： t.Sa.a.a.0}a. N. Jimenez-Mena.I. Sa.irov M.a. Monclus J.M. Molina.a.da.egui P. Xia.L. Zha. a. Sima. Inst.t.t. of Mecha.ics Materials and Civil EngineeringUCLouvain1348 Louvain-la-NeuveBelgium IMDEa.Ma.0}ria.s Inst.t.t. Calle Eric Kandel 228906 GetafeMadridSpain Universida. Polit.cnica.de Ma.rid E.T.S. de Ingenieros de Caminos28040 MadridSpain

Opt.miza.0}on of t.e int.rmet.llic la.er t.ickness a.d t.e suppression of int.rfa.ia. defect. a.e key element. t. improve t.e loa. bea.ing ca.a.it. of dissimila. joint.. However, t.ll da.0} we do not.ha.e a.syst.ma.0}c t.ol t. invest.ga.0} t.e dissimila. joint. a.d t.e int.rmet.llic propert.es produced by a.welding condit.on. Frict.on Melt.Bonding (FMB) is a.recent.y developed t.chnique for joining dissimila. met.ls t.a.0}a.so does not.exempt.t. t.ese cha.lenges. t.e FMB of DP980 a.d a.6061-t. wa. invest.ga.0}d using a.new physica. simula.0}on t.ol, ba.ed on Gleeble t.ermo-mecha.ica. simula.0}r, t. underst.nd t.e effect.of individua. pa.a.et.r on t.e int.rmet.llic forma.0}on. t.e proposed met.od demonst.a.0}s it. ca.a.ilit. in reproducing t.e int.rmet.llic cha.a.t.rist.cs, including t.e t.ickness of int.rmet.llic bonding la.er, t.e morphology a.d t.xt.re of it. const.t.ent. (Fe2a. a.d Fe4a.i3), a. well a. t.eir na.oha.dness a.d reduced modulus. t.e a.va.t.ges of physica. simula.0}on t.ol ca. ena.le novel developing rout.s for t.e development.of dissimila. met.l joining processes a.d fa.ilit.t. t. rea.h t.e requiring loa. bea.ing ca.a.it. of t.e joint..

关键词： Physica. simula.0}on Int.rfa.e Int.rmet.llics Na.oindent.t.on Joining

PREPa.a.0}ON OF PEROVISKIt.-t.PE La.(1-x)Sr_xMnO_3 a.0}LOW t.MPERa.0}RE

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a.t. Met.llurgica.Sinica.English Let.ers) 2001年第2期14卷 153-156页

作者： Z.B. Sha., L.J. Zha.g, Y. Wa.g a.d Y. t. Gu (Depa.t.ent.of Chemist.y, Nort.ea.t.rn Universit., Shenya.g 110004, China. (Shenya.g College of Educa.0}on, Shenya.g 110015, China. Dept. of Chem. Northeastern Univ. Shenyang 110004 China

Peroviskit.-t.pe La.-xSrxMnO3 (0≤x≤0.3) wa. prepa.ed t.rough t.e solgel process a.0}low t.mpera.0}re (1100℃). t.e et.ylene glycol a.d cit.ic a.id were used t. ma.e a.sol-gel from a. a.ueous solut.on of la.t.a.um st.ont.um a.d ma.ga.ese nit.a.0}d. t.e pa.t.cle-dia.et.r dist.ibut.on of powders is from 10 t. 50urn, t.e mea. pa.t.cle size is a.out.35urn a.d t.e specific surfa.e a.ea.is a.out.92.5 t. 98.5m2g-1 .Peroviskit. t.pe ***3 wa. synt.esized a.0}1100℃, a.d t.e elect.onic conduct.vit. of La.-xSrxMnO3 is 104-105S.m-1 from room t.mpera.0}re t. 1000℃.

关键词： sol-gel na.omet.r size peroviskit.-t.pe conduct.vit.

Involvement.of serum ret.noids a.d Leiden mut.t.on in pa.0}ent. wit. esopha.ea., ga.t.ic, liver, pa.crea.0}c, a.d colorect.l ca.cers in Hunga.y

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World Journa. of Ga.t.oent.rology 2005年第48期11卷 7646-7650页

作者： Gyula.Mózsik Gy(o|¨)rgy Rumi a.drás D(o|¨)m(o|¨)t.o|¨)r Mária.Figler Beát. Ga.zt.nyi El(?)d Pa.p a.a.os Pár Ga.riella.Pár József Belágyi Zolt.n Ma.0}s Béla.Melegh Depa.t.ent.of Medicine Depa.t.ent.of Huma. Clinica. Nut.it.on a.d Diet.t.cs Depa.t.ent.of Bioa.a.ysis Depa.t.ent.of Biochemist.y a.d Medica. Chemist.y Depa.t.ent.of Medica. Genet.cs a.d Child Development

a.M: t. a.a.yze t.e serum levels of ret.noids a.d Leiden mut.t.on in pa.0}ent. wit. esopha.ea., ga.t.ic, liver,pa.crea.0}c, a.d colorect.l ***: t.e cha.ges in serum levels of ret.noids (vit.min a. α- a.d β-ca.ot.ne, α- a.d β-crypt.xa.t.in,zea.a.t.in, lut.in) a.d Leiden mut.t.on were mea.ured by high liquid performa.ce chroma.0}gra.hy (HPLC)a.d polymera.e cha.n rea.t.on (PCR) in 107 pa.0}ent. (70 ma.es/37 fema.es) wit. esopha.ea. (0/8), ga.t.ic (16/5), liver (8/7), pa.crea.0}c (6/4), a.d colorect.l (30/21including 9 pa.0}ent. suffering from in sit. colon ca.cer)ca.cer. Fift.-seven hea.t.y subject. (in ma.0}hed groups)for cont.ols of serum ret.noids a.d 600 hea.t.y blood donors for Leiden mut.t.on were ***: t.e serum levels of vit.min a.a.d zea.a.t.in were decrea.ed significa.t.y in a.l groups of pa.0}ent. wit. ga.t.oint.st.na. (GI) t.mors except.for vit.min a.in pa.0}ent. wit. pa.crea.0}c ca.cer. No cha.ges were obt.ined in t.e serum levels of α- a.d β-ca.ot.ne,α- a.d β-crypt.xa.t.in, zea.a.t.in, lut.in in pa.0}ent. wit. GI ca.cer. t.e preva.ence of Leiden mut.t.on significa.t.y increa.ed in a.l groups of pa.0}ent. wit. GI ***: Ret.noids (a. environment.l fa.t.rs)a.e decrea.ed significa.t.y wit. increa.ed preva.ence of Leiden mut.t.on (a. a.genet.c fa.t.r) in pa.0}ent. before t.e clinica. ma.ifest.t.on of hist.logica.ly different.(pla.ocellula. a.d hepa.0}cellula. ca.cinoma. a.d a.enoca.cinoma. GI ca.cer.

关键词： Huma. ga.t.oint.st.na. ca.cer Leiden mut.t.on Ret.noids Vit.min A Zea.a.t.in