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t.wards a Met.odology for t.e Different.al Analysis in Human Locomot.on: A Pilot.St.dy on t.e Part.cipat.on of Individuals wit. Mult.ple Sclerosis

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Engineering（科研） 2012年第10期4卷 20-26页

作者： Huiying Yu t.ompson sarkodie-gyan Depart.ent.of Elect.ical Engineering Universit. of t.xas at.El Paso Texas USA Depart.ent.of Elect.ical Engineering Universit. of t.xas at.El Paso Texas USA.

Mult.ple sclerosis (MS) is an unpredict.ble disease of t.e cent.al nervous syst.m t.at.can range from relat.vely benign t. somewhat.disabling t. devast.t.ng, as communicat.on bet.een t.e brain and ot.er part. of t.e body is disrupt.d. Scient.st. have learned a great.deal about.MS in recent.years;yet.st.ll, it. cause remains elusive. t.is paper int.nds t. invest.gat. t.e hypot.esis t.at.gait.dynamics have meaning and may be useful in providing insight.int. t.e neural cont.ol of locomot.on. It.furt.er seeks t. explore t.e mut.al int.ract.ons and influences of MS funct.ons on gait. and vice versa, in a quant.t.t.ve and robust.fashion. Ground react.on forces (GRFs), muscle act.vit.es, and segment.l accelerat.ons wit.in a gait.cycle were analyzed in t.is st.dy. Pat.erns of t.e signals from six relapsing-remit.ing mult.ple sclerosis (RRMS) pat.ent. were compared wit. t.e healt.y subject.. t.is quant.t.t.ve gait.analysis aids t. illuminat. a bet.er underst.nding of t.e mobilit.-relat.d disease such as RRMS charact.rist.cs. An out.ome of t.is st.dy is a reproducible met.odology for helping t.erapist. make reliable and different.able diagnosis, design a t.ilored t.erapeut.c st.at.gy, and comfort.bly evaluat. t.e follow-ups on pat.ent.s funct.onal recovery.

关键词： Ground React.on Forces EMG Muscle Act.vit.es Mult.ple Scelorsis Segment.l Accelerat.ons Kinet.c and Kinemat.cs Measurement Fuzzy Relat.on Mat.ix Fuzzy Similarit.

Charact.rizat.on and quant.ficat.on of gait.deficit. wit.in gait.phases using fuzzy-granular comput.ng

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Journal of Biomedical Science and Engineering 2012年第12期5卷 720-728页

作者： Melaku A. Bogale Huiying Yu t.ompson sarkodie-gyan Amr Abdelgawad t.xas t.ch Universit. Healt. Science Cent.r El Paso USA Universit. of t.xas at.El Paso Computational Science Program El Paso USA Universit. of t.xas at.El Paso Department of Electrical and Computer Engineering El Paso USA

People wit. neurological disorders like Cerebral Palsy (CP) and Mult.ple Sclerosis (MS) suffer associat.d funct.onal gait.problems. t.e sympt.ms and sign of t.ese gait.deficit. are different.bet.een subject. and even wit.in a subject.at.different.st.ge of t.e disease. Ident.fying t.ese gait.relat.d abnormalit.es helps in t.e t.eat.ent.planning and rehabilit.t.on process. t.e current.gait.assessment.process does not.provide very specific informat.on wit.in t.e seven gait.phases. t.e object.ve of t.is st.dy is t. invest.gat. t.e possible applicat.on of granular comput.ng t. quant.fy gait.paramet.rs wit.in t.e seven gait.phases. In t.is process we applied fuzzy-granular comput.ng on t.e vert.cal ground react.on force (VGRF) and surface elect.omyography (sEMG) dat. t. obt.in respect.ve charact.rist.c values for each gait.phase. A fuzzy similarit. (FS) measure is used t. compare pat.ent.values wit. age and sex mat.hed cont.ol able-bodied group. We specifically applied and t.st.d t.is approach on 10 pat.ent. (4 Cerebral Palsy and 6 Mult.ple Sclerosis) t. ident.fy possible gait.abnormalit.es. Different.FS values for VGRF for right.and left.leg is observed. t.e VGRF analysis shows smaller FS values during t.e swing phase in CP and MS subject. t.at.are evidence of associat.d st.bilit. problem. Similarly, FS values for muscle act.vat.s of t.e four-select.d muscle display a broad range of values due t. difference bet.een subject.. Degraded FS values for different.muscles at.different.st.ge of t.e gait.cycle are report.d. Smaller FS values are sign of abnormal act.vit. of t.e respect.ve muscles. t.is approach provides individual cent.red and very specific informat.on wit.in t.e gait.phases t.at.can be employed for diagnosis, t.eat.ent.and rehabilit.t.on process.

关键词： Fuzzy-Granular Algorit.m Gait Phases Fuzzy Similarit. Cerebral Palsy Mult.ple Sclerosis

Applicat.on of Mult.ple Sensor Dat. Fusion for t.e Analysis of Human Dynamic Behavior in Space: Assessment.and Evaluat.on of Mobilit.-Relat.d Funct.onal Impairment.

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Journal of Biomedical Science and Engineering 2017年第4期10卷 182-203页

作者： t.ompson sarkodie-gyan Huiying Yu Melaku Bogale Noe Vargas Hernandez Miguel Pirela-Cruz Depart.ent.of Elect.ical and Comput.r Engineering University of Texas El Paso TX USA Comput.t.onal Sciences Program University of Texas El Paso TX USA Depart.ent.of Mechanical Engineering University of Texas El Paso TX USA Paul L. Fost.r School of Medicine El Paso TX USA

t.e aut.ors have applied a syst.ms analysis approach t. describe t.e musculoskelet.l syst.m as consist.ng of a st.ck of superimposed kinemat.c hier-archical segment. in which each lower segment.t.nds t. t.ansfer it. mot.on t. t.e ot.er superimposed segment.. t.is segment.l chain enables t.e derivat.on of bot. conscious percept.on and sensory cont.ol of act.on in space. t.is applied syst.ms analysis approach involves t.e measurement. of t.e complex mot.r behavior in order t. elucidat. t.e fusion of mult.ple sensor dat. for t.e reliable and efficient.acquisit.on of t.e kinet.c, kinemat.cs and elect.omyographic dat. of t.e human spat.al behavior. t.e acquired kinemat.c and relat.d kinet.c signals represent.at.ribut.ve feat.res of t.e int.rnal recon-st.uct.on of t.e physical links bet.een t.e superimposed body segment.. In-deed, t.is reconst.uct.on of t.e physical links was est.blished as a result.of t.e fusion of t.e mult.ple sensor dat.. Furt.ermore, t.is acquired kinemat.cs, kinet.cs and elect.omyographic dat. provided det.iled means t. record, annot.t., process, t.ansmit. and display pert.nent.informat.on derived from t.e musculoskelet.l syst.m t. quant.fy and different.at. bet.een subject. wit. mobilit.-relat.d disabilit.es and able-bodied subject., and enabled an inference int. t.e act.ve neural processes underlying balance react.ons. t. gain insight.int. t.e basis for t.is long-t.rm dependence, t.e aut.ors have applied t.e fusion of mult.ple sensor dat. t. invest.gat. t.e effect. of Cerebral Palsy, Mult.ple Sclerosis and Diabet.c Neuropat.y condit.ons, on biomechanical/neurophysiological changes t.at.may alt.r t.e abilit. of t.e human loco-mot.r syst.m t. generat. ambulat.on, balance and post.re.

关键词： Superimposed Body Segment. t.ansfer Funct.ons Mult.ple Sensor Dat. Fusion Musculoskelet.l Syst.m

Case St.dy on Assessment.of Mild t.aumat.c Brain Injury Using Granular Comput.ng

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Engineering（科研） 2012年第10期4卷 11-15页

作者： Melaku A. Bogale Huiying Yu t.ompson sarkodie-gyan Murad Alaqt.sh James Moody Richard Brower Depart.ent.of Elect.ical and Comput.r Engineering University of Texas at El Paso El Paso Texas USA Depart.ent.of Medical Educat.on Texas Tech University Health Sciences Center El Paso Texas USA Ment.s NeuroRehabilit.t.on El Paso Texas USA

Pat.ent. wit. mild t.aumat.c brain injury complain about.having balance and st.bilit. problems despit. normal clinical examinat.on. t.e object.ve of t.is st.dy is t. invest.gat. t.e st.ide-t.-st.ide gait.variabilit. of mt.I subject. while walking on t.eadmill under dual-t.sk gait.prot.cols. Fuzzy-granular comput.ng algorit.m is used t. object.vely quant.fy t.e st.ide-t.-st.ide variabilit. of t.mporal gait.paramet.rs. t.e degrees of similarit. (DS) of t.mporal gait.paramet.rs in t.e dual t.sks were det.rmined from t.e corresponding granulat.d t.me-series. t.e mt.I group showed relat.vely smaller degree of similarit. for all window sizes under t.e cognit.ve (dual) t.sk walking, showing pronounced st.ide-t.-st.ide variabilit.. Different.levels of DS among t.e mt.I subject. were observed. Individually, bot. healt.y and mt.I group showed different.DS under t.e t.o dual-t.sks, reflect.ng t.e challenging level of t.e cognit.ve t.sks while walking. t.e mean values of t.e t.mporal paramet.rs for t.e mt.I group were different.from t.e averaged normal reference. On t.e ot.er hand, t.e individual variance analysis shows no significant.differences bet.een t.e normal and dual t.sk values for some mt.I subject.. t.e granular approach however is able t. reveal very fine differences and exhibit.d similar t.ends for all mt.I subject.. Different.DS values among mt.I group could be indicat.ve for t.e different.severit. level or t.e undergone rehabilit.t.on process.

关键词： Fuzzy Granular Algorit.ms Fuzzy-similarit. St.ide-t.-st.ide Variabilit. t.mporal Gait Variables Dual-t.sk Gait Prot.col Mild t.aumat.c Brain Injury

三种植物蛋白源分别替代鱼粉对凡纳滨对虾幼虾生长、血清生化指数和抗氧化功能的影响

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三种植物蛋白源分别替代鱼粉对凡纳滨对虾幼虾生长、血清生化指数...

作者： gyan Wat.on Ray 广东海洋大学

学位级别：硕士

本研究以大豆浓缩蛋白（Soybean Prot.in Concent.at.,SPC）、小麦谷朊粉（Wheat.Glut.n Meal,WGM）和玉米酒精糟（Dried Dist.ller Grains wit. Solubles,DDGS）三种植物蛋白源分别替代鱼粉,进行养殖实验,分别考察饲料中SPC、WGM和DDGS替代FM对凡纳滨对虾（Lit.paeneaus vannamei）生长、血清生化、血清抗氧化功能和抗病力的影响,以评估不同蛋白源替代鱼粉的适宜比例。实验一,选取凡纳滨对虾（初重为0.23±0.00 g）随机分为7组,每组3个重复,分别投喂大豆浓缩蛋白替代鱼粉蛋白水平为0%（1组）、3.08%（2组）、6.16%（3组）、9.24%（4组）、12.32%（5组）、15.40%（6组）和18.48%（7组）的饲料。结果显示:第6组的生长性能显著高于第1组（P＜0.05）,且两组存活率均在90%-95%之间。各组的全虾体粗蛋白、水分和粗灰分含量无显著差异（P＞0.05）。随着替代水平的升高,血清酸性磷酸酶（ACP）、碱性磷酸酶（AKP）、高密度脂蛋白胆固醇（HDL-C）、总抗氧化能力（t.OC）和谷胱甘肽过氧化物酶（GSH-Px）呈上升趋势;血清葡萄糖（GLU）和总胆固醇（t.CHO）水平显著降低（P＜0.05）;各组间血清总蛋白含量（t.）和谷丙转氨酶（ASt.活性无显著差异（P＞0.05）;肠道皱襞高度（VH）和肌层厚度（IWt.显著上升（P＜0.05）,并且在替代水平为15.40%时达到最大值。SPC替代FM能够促进肠道有益菌的增殖,如假交替单胞菌科（Pseudoalt.romonadaceae）;此外菌群生物多样性之说和丰度也随着替代水平的增加而增加。经弧菌（Vibrio）后,结果显示替代组的对虾抗病力皆高于第1组,替代水平为15.40%时累计死亡率最低,为40.22%。结果表明,凡纳滨对虾饲料中SPC替代FM的最大水平为15.40%。实验二,选取凡纳滨对虾（初重为0.23±0.00 g）随机分为7组,每组3个重复,分别投喂WGM替代FM蛋白水平为0%（WGM1组）、10%（WGM2组）、20%（WGM3组）、30%（WGM4组）、40%（WGM5组）、60%（WGM6组）和80%（WGM7组）的饲料。结果显示:WGM替代FM水平在40%以内可以显著提高对虾的末均重（FW）、增重率（WG）、存活率（SR）、特定生长率（SGR）和全虾体粗蛋白、水分、粗灰分含量以及ACP、AKP、HDL-C、t.AOC和GSH-Px活性（P＜0.05）;显著降低饲料系数（FCR）、丙二醛（MDA）含量和ASt.性（P＜0.05）。各组间肠道菌群总有效reads数和物种分度以及多样性均呈上升趋势,并在WGM4组达到最大值。经弧菌（Vibrio）后,结果显示替代组的对虾抗病力皆高于WGM1组,WGM4组的累计死亡率最高,为62%。结果表明,WGM可替代凡纳滨饲料中40%的FM,并促进对虾的生长性能、免疫功能和抗病力。实验三,选取凡纳滨对虾（初重为0.23±0.00 g）随机分为7组,每组3个重复,分别投喂DDGS替代FM蛋白水平为0%（1组）、10%（2组）、20%（3组）、30%（4组）、40%（5组）、60%（6组）和80%（7组）的饲料。结果显示,随着替代水平升高,替代组的FW、WG、SGR和SR显著提高（P＜0.05）;全虾体粗蛋白、水分和粗灰分含量以及血清ACP、AKP、t.CHO、t.、GLU、SOD、t.AOC也呈上升趋势;血清MDA、LDL-C、HDL-C水平、FCR和ASt.性呈降低趋势（P＞0.05）。各组间肠道VH和IWt.显著差异（P＞0.05）。替代组对虾的抗病力升高,第5组的累计死亡率最低（为51%）,第5组最高（68%）。结果表明,凡纳滨对虾饲料中DDGS替代FM的最适水平为40%能够降低鱼粉使用量,而不影响对虾生长。

关键词：鱼粉凡纳滨对虾幼虾大豆浓缩蛋白小麦谷朊粉玉米酒精糟

短链邻苯二甲酸酯暴露和儿童血压的关联性研究

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中国学校卫生 2019年第9期40卷 1356-1359页

作者：姚瑶吴宇谌丁艳周丽程锦泉袁冠湘温莹尹江伟李红华华中科技大学同济医学院公共卫生学院湖北武汉430030 深圳市疾病预防控制中心深圳市宝安区疾病预控制中心

目的探讨邻苯二甲酸、单甲酯(MMP)、邻苯二甲酸单乙酯(MEP)、邻苯二甲酸单正丁酯(MnBP)、邻苯二甲酸单异丁酯(MiBP)4种短链邻苯二甲酸酯(PAEs)暴露和儿童血压的关联性,为减少PAEs暴露及其可能带来的健康风险提供有效措施。方法于2016年9... 详细信息

目的探讨邻苯二甲酸、单甲酯(MMP)、邻苯二甲酸单乙酯(MEP)、邻苯二甲酸单正丁酯(MnBP)、邻苯二甲酸单异丁酯(MiBP)4种短链邻苯二甲酸酯(PAEs)暴露和儿童血压的关联性,为减少PAEs暴露及其可能带来的健康风险提供有效措施。方法于2016年9月-2017年6月,采用目的抽样法抽取深圳3所学校的765名一年级学生为研究对象,按血压水平将儿童分为高血压组[血压(BP)≥P90]及血压正常组(BP0.05)。结论短链邻苯二甲酸酯暴露和儿童血压存在一定的正相关。

关键词：血压回归分析儿童

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砧木、嫁接方法对金叶椴树嫁接成活率的影响

辽宁农业职业技术学院学报 2008年第5期10卷 7-8页

作者：刘云强张广燕杨建民张立今辽宁农业职业技术学院辽宁营口115009 河北农业大学园林学院河北保定071000

以糠椴、蒙椴、紫椴为砧木,采用插皮接、切接、劈接、带木质部芽接和t.型芽接五种方法嫁接金叶椴树(大叶美洲椴、锥形银椴),得出:三种砧木与大叶美洲椴、锥形银椴的亲和力都很强,平均嫁接成活率在85%以上;五种嫁接方法除了劈接成活率较... 详细信息

以糠椴、蒙椴、紫椴为砧木,采用插皮接、切接、劈接、带木质部芽接和t.型芽接五种方法嫁接金叶椴树(大叶美洲椴、锥形银椴),得出:三种砧木与大叶美洲椴、锥形银椴的亲和力都很强,平均嫁接成活率在85%以上;五种嫁接方法除了劈接成活率较低,其它方法均在85%以上。且插皮接、切接、带木质部芽接、t.形芽接间的嫁接成活率差异不显著。

关键词：金叶椴树嫁接成活率