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Fungalt.ait.:a user-friendly t.ait. dat.base of fungi and fungus-like st.amenopiles

Fungal Diversit. 2020年第2期107卷 I0001-I0016页

作者： Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht.Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scot. t.Bat.s Pet. Baldrian t.bias Guldberg Frøslev Krist.an Adojaan Alfredo Vizzini Ave Suija Donald Pfist.r Hans-Ot.o Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärt.l Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Mat.hew E.Smit. Merje t.ome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura t.t.ana B.Gibert.ni t.omas Læssøe William Davis Yuri t.karev Adriana Corrales Adriene Mayra Soares Aht. Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Det.eridge Angelina de Meiras-Ot.oni Annemieke Verbeken Arun Kumar Dut.a Bao-Kai Cui C.K.Pradeep César Marín Daniel St.nt.n Daniyal Gohar Dhanushka N.Wanasinghe Eveli Ot.ing Farzad Aslani Garet. W.Griffit. t.orst.n H.Lumbsch Hans-Pet.r Grossart.Hossein Masigol ina t.mling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Juliet. Alvarez-Manjarrez Kai Ilves Kaire Loit.Kalev Adamson Kazuhide Nara Kat. Küngas Keilor Rojas-Jimenez Krišs Bit.nieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lyset. Wagner M.Cat.erine Aime MaarjaÖpik María Isabel Mujica Mart.n Met.oja Mart.n Ryberg Mart.i Vasar Masao Murat. Mat.hew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust.Olesya Dulya Pet.r Johnst.n Pet. Kohout.Qian Chen Qing t.an Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renat. dos Sant.s Chikowski Renat. L.Mendes-Alvarenga Robert. Garibay-Orijel Robin Gielen Rungt.wa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samant.a C.Karunarat.na Saowaluck t.bpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo t.nay Bose t.nel Vaht.r t.rquin Net.erway t.ng Yang t.m May t.rda Varga Wei Li Vict.r Rafael Mat.s Coimbra Virt.n Rodrigo t.rgino de Oliveira Vit.r Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Mat.uda Yumiko Miyamot. Urm Inst.t.t. of Ecology and Eart. Sciences University of Tartu14A Ravila50411 TartuEstonia Nat.ral Hist.ry Museum University of Tartu46 Vanemuise Str51003 TartuEstonia Got.enburg Global Biodiversit. Cent.e Box 46140530 GothenburgSweden Depart.ent.of Biological and Environment.l Sciences University of GothenburgGothenburgSweden Depart.ent.of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden Depart.ent.of Forest.Mycology and Plant.Pat.ology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Sect.on for Genet.cs and Evolut.onary Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway Universit. of Hawaiʻi at.Mānoa 3190 Maile WaySt.John 102HonoluluHIUSA Depart.ent.of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark Purdue Universit. Nort.west WestvilleIN 46391USA Inst.t.t. of Microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE Inst.t.t. University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark Dipart.ment. di Scienze della Vit. e Biologia dei Sist.mi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly Depart.ent.of Organismic and Evolut.onary Biology and Farlow Library and Herbarium Harvard University22 Divinity AveCambridgeMA 02138USA Blaihofst..42 72074 TübingenGermany SYNLAB Est.nia Veerenni 53aTallinn 11313Estonia Escuela de t.cnología Médica Universidad Santo TomásLos Carreras 753OsornoChile Cent.o de Genómica y Bioinformát.ca Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Norwegian Inst.t.t. for Nat.re Research(Nina) Sognsveien 680855 OsloNorway School of Life Science and t.chnology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolut.onary Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland Depart.ent.of Bot.ny Swedish Museum of

t.e crypt.c lifest.le of most.fungi necessit.t.s molecular ident.ficat.on of t.e guild in environment.l *** t.e past.decades,rapid development.and affordabilit. of molecular t.ols have t.emendously improved insight. of t.e fungal diversit. in all ecosyst.ms and ***,in spit. of t.e progress of molecular met.ods,knowledge about.funct.onal propert.es of t.e fungal t.xa is vague and int.rpret.t.on of environment.l st.dies in an ecologically meaningful manner remains *** order t. facilit.t. funct.onal assignment. and ecological int.rpret.t.on of environment.l st.dies we int.oduce a user friendly t.ait. and charact.r dat.base Fungalt.ait. operat.ng at.genus and species hypot.esis *** t.e informat.on from previous effort. such as FUNGuild and FunFun t.get.er wit. involvement.of expert.knowledge,we reannot.t.d 10,210 and 151 fungal and St.amenopila genera,*** result.d in a st.nd-alone spreadsheet.dat.set.covering 17 lifest.le relat.d t.ait. of fungal and St.amenopila genera,designed for rapid funct.onal assignment. of environment.l *** order t. assign t.e t.ait.st.t.s t. fungal species hypot.eses,t.e scient.fic communit. of expert. manually cat.gorised and assigned available t.ait.informat.on t. 697,413 fungal It. *** t.e basis of t.ose sequences we were able t. summarise t.ait.and host.informat.on int. 92,623 fungal species hypot.eses at.1%dissimilarit. t.reshold.

关键词： Fungal t.ait. t.ophic modes Funct.on Guild Bioinformat.cs High-t.roughput.sequencing Communit. ecology

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生物素酰胺酶缺乏症:对非结论性新生儿筛选结果进行足够时间随访的重要性

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 49-49页

作者： Hoffman t.L. Simon E.M. Ficicioglu C. 虎小毅 Sect.on of Met.bolism C hildren's Hospital of Philadelphia 34th and Civic Center Boulevard Philadelph ia PA 19104-4399 United States

Biot.nidase deficiency is an inherit.d met.bolic disorder charact.rized by ina bilit. t. recycle prot.in-bound biot.n. It.usually present. wit. at.xia and sei zures, t.ough at.pical present.t.ons have also been described. We report.a 15-m ont.-old boy wit. profound biot.nidase deficiency who present.d wit. laryngeal st.idor and subsequent.y developed severe at.xia and lact.c acidosis. Subsequent.ly, it.was discovered t.at.t.e pat.ent.s newborn screening t.st.for biot.nidase act.vit. had been inconclusive, but.confirmat.ry t.st.ng had not.been done. Bra in magnet.c resonance imaging showed mult.ple whit. mat.er non-enhancing t. hyp erint.nsit.es, which largely resolved following 6 mont.s of biot.n t.erapy; howe ver, t.ere was residual deafness and ment.l ret.rdat.on. Conclusion:An argument.is made for universal newborn screening in biot.nidase deficiency and improved m echanisms for follow-up of posit.ve screens, because delay in diagnosis result. in irreversible morbidit., newborn screening is cost.effect.ve, and early t.era py prevent. t.e neurologic sequelae.

关键词：筛选结果结论性生物素酶神经系统后遗症共济失调精神发育迟缓喉喘鸣筛选检查乳酸酸中毒影像学检查

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Pegapt.nib治疗新生血管性老年性黄斑变性

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 8-8页

作者： Gragoudas E.S. Adamis A.P. Cunningham Jr. E.t. 陈立军 Ret.ina Service Massachusetts Eye and Ear Infirmary Harvard Medical School 243 Ch arles St. Boston MA 02114 United States Dr.

BACKGROUND: Pegapt.nib, an ant.-vascular endot.elial growt. fact.r t.erapy, w as evaluat.d in t.e t.eat.ent.of neovascular age-relat.d macular degenerat.on. MEt.ODS: We conduct.d t.o concurrent. prospect.ve, randomized, double-blind, mu lt.cent.r, dose-ranging, cont.olled clinical t.ials using broad ent.y crit.ria. Int.avit.eous inject.on int. one eye per pat.ent.of pegapt.nib (at.a dose of 0. 3 mg, 1.0 mg, or 3.0 mg) or sham inject.ons were administ.red every 6 weeks over a period of 48 weeks. t.e primary end point.was t.e proport.on of pat.ent. who had lost.fewer t.an 15 let.ers of visual acuit. at.54 weeks. RESULt.: In t.e com bined analysis of t.e primary end point.(for a t.t.l of 1186 pat.ent.), efficacy was demonst.at.d, wit.out.a dose-response relat.onship, for all t.ree doses of pegapt.nib (Pt.e comparison of 0.3 mg wit. sham inject.on;P t.e comparison of 1.0 mg wit. sham inject.on; and P=0.03 for t.e comparison of 3.0 mg wit. sham inject.on). In t.e group given pegapt.nib at.0.3 mg, 70 per cent.of pat.ent. lost.fewer t.an 15 let.ers of visual acuit., as compared wit. 5 5 percent.among t.e cont.ols (P t.e risk of severe loss of visual acui t. (loss of 30 let.ers or more)-was reduced from 22 percent.in t.e sham-inject.ion group t. 10 percent.in t.e group receiving 0.3 mg of pegapt.nib (P t.ent. receiving pegapt.nib (0.3 mg), as compared wit. sham inject.on, m aint.ined t.eir visual acuit. or gained acuit. (33 percent.vs. 23 percent. P=0.0 03). As early as six weeks aft.r beginning t.erapy wit. t.e st.dy drug, and at.a ll subsequent.point., t.e mean visual acuit. among pat.ent. receiving 0.3 mg of pegapt.nib was bet.er t.an in t.ose receiving sham inject.ons (P t.e adverse event. t.at.occurred, endopht.almit.s (in 1.3 percent.of pat.ent.), t.aumat.c injury t. t.e lens (in 0.7 percent., and ret.0}l det.chment.(in 0.6 p ercent. were t.e most.serious and required vigilance. t.ese event. were assoc

关键词：老年性黄斑变性 Pegapt.nib 玻璃体腔注射组视网膜脱离晶体损伤临床试验周给眼内炎并行性

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