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Eviden.e-Based Complemen.0}ry an. Alt.rn.t.ve Medicin. Effect. of Capybara Oil on.Cardiac Remodelin. of C57bl/6 Mice

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Journ.l of Bioscien.es an. Medicin.s 2024年第5期12卷 213-232页

作者： Rafael M. Almeida Wagn.r D. Gian.et.i Guilherme R. Silveira Carolin. R. Cast.lho Ren.t. V. Lisboa Bian.a t. Ciambarella Rodrigo n. Ferreira Jorge José de Carvalho Laborat.ry of Ult.ast.uct.re an. t.ssue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher Educat.on.Cen.0}r of Valen.#231 a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Cardiovascular diseases are t.e main.cause of morbidit. an. mort.lit. in.t.e world, an. obesit. an. t.e met.bolic syn.rome are risk fact.rs for it. developmen.0} On. of t.e t.erapies t. reduce cardiovascular risk is t.e use of polyun.at.rat.d fat.y acids. In.Brazil, a source of such acid is t.e oil ext.act.d from t.e fat.of t.e capybara. t.e object.ve of t.is work is t. st.dy t.e effect. of t.e capybara oil on.lipid an. glucose met.bolism, as well as it. effect. on.t.e adipose t.ssue an. cardiac remodelin.. We assessed t.e effect. of capybara oil t.eat.en.0}on.body mass, lipid an. carbohydrat. met.bolism, syst.lic blood pressure, adipose t.ssue an. cardiac remodelin., an. performed an.ult.ast.uct.ral evaluat.on.of t.e myocardium in.C57Bl/6 mice t.eat.d wit. high-fat.diet. t.eat.en.0}wit. capybara oil reduced t.t.l cholest.rol an. t.iglyceride levels, syst.lic blood pressure, visceral an. subcut.n.ous adipose t.ssue, an. adipocyt. diamet.r. In.addit.on. cardiac remodelin. was at.en.at.d, preservin. cardiomyocyt.s, in.reasin. vascularizat.on. reducin. cardiomyocyt. hypert.ophy an. t.e ext.acellular mat.ix, an. preservin. t.e morphological in.0}grit. of mit.chon.ria. Capybara oil has several ben.ficial effect. on.t.e cardiovascular an. met.bolic syst.m, an. furt.er st.dies are n.eded t. bet.er un.erst.n. it. role in.t.e preven.0}on.or t.eat.en.0}of cardiovascular diseases.

关键词： Capybara Oil Cardiac Remodelin. Polyun.at.rat.d Fat.y Acids Obesit. Met.bolic Syn.rome

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Compression.propert.es of cost.efficien.0}porous expan.ed clay rein.orced AA7075 syn.0}ct.c foams fabricat.d by in.ust.ial-orien.0}d die cast.n. t.chn.logy

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Chin. Foun.ry 2024年第1期21卷 60-70页

作者： İsmail Cem Akgün.Çağın.Bolat.Ali Gökşen.i Facult. of Mechan.cal En.in.erin. Istanbul Technical University34437İstanbulTurkey Facult. of En.in.erin. Samsun University55420SamsunTurkey

In.t.day’s man.fact.rin. in.ust.ies,hard compet.t.on.bet.een.rival firms makes it.compulsory for researchers t. design.light.r an. cheaper machin. compon.n.0} due t. t.e megat.en.s of cost.effect.ven.ss an. *** t.is poin.0}alumin.m syn.0}ct.c foams(ASFs)are n.w-gen.rat.on.en.in.erin. composit.s an. come in.0} t.e upfron.0}as a *** t. t.eir feat.res like low den.it.,sufficien.0}elon.at.on.an. perfect.en.rgy absorpt.on.abilit.,t.ese advan.ed foams have been.con.iderably seduct.ve for man. in.ust.ial sect.rs *** t.is st.dy,an.in.ust.ial-orien.0}d aut.mat.c die cast.n. t.chn.logy was used for t.e first.t.me t. man.fact.re t.e combin.t.on.of AA7075/porous expan.ed clay(PEC).Micro evaluat.on.(opt.cal an. FESEM)reveal t.at.t.ere is a homogen.us part.cle dist.ibut.on.in.t.e foam samples,an. in.pect.on. are compat.ble wit. t.e ot.er ASF ***,t. agin. heat.t.eat.en.0}was operat.d on.on. half of t.e produced foams t. explore t.e probable impact.of agin. on.t.e compressive *** result. show t.at.PEC part.cles can.be an.alt.rn.t.ve t. expen.ive hollow spheres used in.t.e previous ***,a favorable relat.on.hip is ascert.in.d bet.een.t.e agin. t.eat.en.0}an. mechan.cal propert.es such as compression.st.en.t. an. plat.au st.en.t..

关键词： die cast.n. porous mat.rials met.l mat.ix syt.n.t.c foams expan.ed clay compressive deformat.on

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A n.n.-plasmon.c HMIM waveguide based con.urren.0}dual-ban. BPF usin. circular rin. reson.t.r

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Opt.elect.on.cs Let.ers 2024年第3期20卷 152-156页

作者： Miriyala Sridhar Suren.ra Kumar Bit.a t. n.Murt.y Koppireddi Padmaraju Depart.en.0}of Elect.on.cs an. Commun.cat.on.En.in.erin. Koneru Lakshmaiah Education FoundationGunturIndia Ast.a Microwave Product. Lt.. HyderabadIndia Depart.en.0}of Elect.on.cs an. Commun.cat.on.En.in.erin. JNTU-GV College of EngineeringVizianagaramIndia Depart.en.0}of Elect.on.cs an. Commun.cat.on.En.in.erin. Jawaharlal Nehru Technological University KakinadaKakinadaIndia

t.is art.cle an.lyzes t.e t.an.mission.lin. charact.rist.cs of plasmon.c hybrid met.l in.ulat.r met.l(HMIM) wave-guide, circular rin. reson.t.r(CRR) based dual-ban. ban.-pass filt.rs wit. t.o t.an.mission.poles in.bot. pass-ban.s in.t.e opt.cal regime usin. coupled lin. feed. t.e t.an.mission.lin. charact.rist.cs of an.HMIM waveguide, such as charact.rist.c impedan.e(Z_(PV)), effect.ve refract.ve in.ex(n.(eff)) an. propagat.on.len.t.(L_(spp)), have been.obt.in.d by usin. full wave simulat.on.

关键词： waveguide reson.t.r circular

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Human.Eosin.phil Cell Man.pulat.on.by Opt.cal t.eezers

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Open.Journ.l of Biophysics 2024年第3期14卷 330-338页

作者： Pavel Yale Jean.Michel Edoukoua Kon.n.Abadê An.e-Boris n.guessan.Michel Abaka Kouacou Jérémie t. Zoueu Laborat.ire dIn.t.umen.0}t.on Image et Spectroscopie (L2IS) Institut National Polytechnique Houphout-Boigny (INPHB) Yamoussoukro Cte dIvoire Laborat.ire de Chimie et.de Physique Appliques Sciences et Techniques Universit Alassane Ouattara Bouak Cte dIvoire

In.t.is work, lat.ral deformat.on.of human.eosin.phil cell durin. t.e lat.ral in.en.0}t.on.by an.opt.cally t.apped microbead of diamet.r 4.5 µm is st.died. t.e images were capt.red usin. a CCD camera an. t.e Bolt.man. st.t.st.cs met.od was used for force calibrat.on. Usin. t.e Hert. model, we calculat.d an. compared t.e elast.c moduli result.n. from t.e lat.ral force, showin. t.at.t.e differen.es are import.n.0}an. t.e force should be con.idered. Besides t.e lat.ral compon.n.0} t.e set.p also allows us t. examin. t.e lat.ral cell-bead in.0}ract.on. t.e mean.values of t.e propert.es obt.in.d, in.part.cular t.e elast.c st.ffn.ss an. t.e shear st.ffn.ss, were Eh = (37.76 ± 2.85) µn.m an. Gh = (12.57 ± 0.32) µn.m. t.ese result. show t.at.t.e lat.ral in.en.0}t.on.can.t.erefore be used as a rout.n. met.od for cell st.dy, because it.en.bled us t. man.pulat. t.e cell wit.out.con.0}ct.wit. t.e laser.

关键词： Opt.cal t.eezers Human.Eosin.phil Cell In.en.0}t.on Shear St.ffn.ss

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Secure an. En.rgy-Efficien.0}Mult.-Fact.r-Based Resource Allocat.on.in.A Cloud En.iron.en.

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Journ.l of Harbin.In.t.t.t. of t.chn.logy(n.w series) 2024年

作者： Sureshbabu n.Pragaladan.R Kan.adasan.t Depart.en.0}of Comput.r Scien.e Rajah Serfoji Govern.en.0}College Depart.en.0}of Comput.r Scien.e Sri Vasavi College Depart.en.0}of Comput.r Scien.e t.an.0}ai Periyar Govern.en.0}Art. an. Scien.e College (Aut.n.mous)

t.e dat. cen.0}e’s en.rgy-efficien.0}an. safe dist.ibut.on.of virt.al machin.s is crucial t. en.ble cloud users t. profit.from flexible an. cost.effect.ve comput.n.. Due t. t.e expon.n.0}al growt. in.deman. for cloud services， man. physical servers have been.deployed， leadin. t. excessive en.rgy con.umpt.on.an. in.fficien.0}use of resources. Opt.mizin. resource use an. reducin. power usage have emerged as crit.cal issues in.an. dat. cen.0}e. Cloud service providers use VM allocat.on.st.at.gies t. maximize t.e ut.lizat.on.of dist.ibut.d physical resources in.t.e cloud. t.is paper proposes secure an. en.rgy-efficien.0}Mult.-fact.r-based Resource Allocat.on.(MFRA) in.t.e cloud. By maximizin. resource use， t.e suggest.d framework guaran.0}es an.en.rgy-efficien.0}dist.ibut.on.of physical resources across virt.al machin.s an. priorit.zes t.e safe an. prompt.execut.on.of user applicat.on.. t.e suggest.d work has been.implemen.0}d in.0} pract.ce usin. t.e CloudSim simulat.on.t.ol kit. an. a comparison.wit. ot.er well-kn.wn.virt.al machin. allocat.on.st.at.gies in.t.e cloud comput.n. in.ust.y is don. t. verify t.e algorit.m’s viabilit.. Accordin. t. t.e experimen.0}l simulat.on.result.， t.e suggest.d VM allocat.on.policy out.erformed exist.n. VM allocat.on.t.chn.ques.

关键词：

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Crit.cal con.iderat.on. for t.e man.gemen.0}of acut. abdomen.in.t.an.plan.0}pat.en.0}

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World Journ.l of t.an.plan.0}t.on 2024年第2期14卷 8-12页

作者： Efst.t.ios t.Pavlidis Georgios Kat.an.s At.an.sios Kofin.s Georgios t.oulfas Ioan.is n.Galan.s t.eodoros E Pavlidis t.e 2^(n.)Depart.en.0}of Propaedeut.c Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece Depart.en.0}of t.an.plan.0}t.on.Surgery Center for Research and Innovation in Solid Organ TransplantationAristotle University of ThessalonikiSchool of MedicineThessaloniki 54642Greece

t.e n.mber of solid organ.t.an.plan.0}t.on. performed an.ually is in.reasin. an. are in.reasin. in.t.e followin. order:Kidn.y,liver,heart.lun.,pan.reas,small bowel,an. ut.rin. ***,t.e out.omes of t.an.plan.0} are impro-vin.(organ.survival>90%aft.r t.e 1st.year).t.erefore,t.ere is a high probabilit. t.at.a gen.ral surgeon.will be faced wit. t.e man.gemen.0}of a t.an.plan.0}pat.en.0}wit. acut. *** problems in.immun.compromised pat.en.0} may n.t.on.y in.lude graft.relat.d problems but.also n.n.raft.relat.d *** perioperat.ve regulat.on.of immun.suppression.t.e t.eat.en.0}of accompan.in. problems of immun.suppression.t.e admin.st.at.on.of cort.sol an.,above all,t.e realizat.on.of a rapidly det.riorat.n. sit.at.on.an. t.e accurat. evaluat.on.an. in.0}rpret.t.on.of clin.cal man.fest.t.on. are part.cularly import.n.0}in.t.ese *** perioperat.ve assessmen.0}an. preparat.on.in.ludes evaluat.on.of t.e pat.en.0}s cardiovascular syst.m an. det.rmin.n. if t.e pat.en.0}has hypert.n.ion.or suppression.of t.e hypot.alamic-pit.it.ry-adren.l axis,or if t.e pat.en.0}has had an. coagulat.on.mechan.sm abn.rmalit.es or t.romboembolic *** in.t.an.plan.0}pat.en.0} is associat.d wit. t.e use of calci-n.urin.in.ibit.rs,cort.cost.roids,an. an.0}proliferat.on.*** t.mes,t.e clin.cal pict.re is at.pical,result.n. in.delays in.diagn.sis an. t.eat.en.0}an. leadin. t. in.reased morbidit. an. *** comput.d t.mo-graphy is of ut.ost.import.n.e for early diagn.sis an. *** recipien.0} are pron. t. in.ect.on.,especially specific in.ect.on. caused by cyt.megalovirus an. Clost.idium difficile,an. t.ey are predisposed t. in.0}aop-erat.ve or post.perat.ve complicat.on. t.at.require great.care an. *** is n.cessary t. follow eviden.e-based t.erapeut.c ***,it.is required t.at.t.e clin.cian.choose t.e correct.t.erapeut.c plan.for t.e pat.en.0}con.ervat.ve,emergen.y open.surgery or min.mally in.asive s

关键词： Acut. abdomen Abdomin.l emergen.y surgery t.an.plan.0}t.on Immun.compromised pat.en.0} Immun.-suppression Post.ran.plan.0}t.on.surgery

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Promot.on.of st.uct.ral plast.cit. in.area V2 of visual cort.x preven.0} again.t.object.recogn.t.on.memory deficit. in.agin. an. Alzheimer's disease roden.0}

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n.ural Regen.rat.on.Research 2024年第8期19卷 1835-1841页

作者： Iren. n.varro-Lobat. Mariam Masmudi-Mart.n.Man.el F.López-Aran.a Juan.F.López-t.llez Gloria Delgado Pablo Gran.dos-Durán.Celia Gaon.-Romero Mart. Carret.ro-Rey Sin.orian. Posadas María E.Quiros-Ort.ga Zafar U.Khan Laborat.ry of n.urobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Depart.en.0}of Medicin. Faculty of MedicineUniversity of MalagaMalagaSpain Cen.0}o de In.est.gación.Biomédica en.Red de En.ermedades n.urodegen.rat.vas(CIBERn.D) Institute of Health Carlos IIIMadridSpain t.e Don.ers In.t.t.t. for Brain.Cogn.t.on.an. Behaviour Radboud UniversityNijmegenThe Netherlands t.e Brain.Met.st.sis Group National Cancer Research Centre(CNIO)MadridSpain t.e Depart.en.0}of n.urobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit.which is oft.n.associat.d wit. agin. an. man. psychiat.ic,n.urological,an. n.urodegen.rat.ve diseases,has been.a challen.in. issue for *** t.ll n.w,all pot.n.0}al drug can.idat.s have failed t. produce sat.sfa ct.ry ***,in.t.e search for a solut.on.we foun. t.at.a t.eat.en.0}wit. t.e gen. correspon.in. t. t.e RGS14414prot.in.in.visual area V2,a brain.area con.ect.d wit. brain.circuit. of t.e ven.0}al st.eam an. t.e medial t.mporal lobe,which is crucial for object.recogn.t.on.memory(ORM),can.in.uce en.an.emen.0}of *** t.is st.dy,we demon.t.at.d t.at.t.e same t.eat.en.0}wit. RGS14414in.visual area V2,which is relat.vely un.ffect.d in.n.urodegen.rat.ve diseases such as Alzheimer s disease,produced lon.last.n. en.an.emen.0}of ORM in.youn. an.mals an. preven.0}ORM deficit. in.roden.0}models of agin. an. Alzheimer’s ***,we foun. t.at.t.e preven.0}on.of memory deficit. was mediat.d t.rough t.e upregulat.on.of n.uron.l arbo rizat.on.an. spin. den.it.,as well as an.in.rease in.brain.derived n.urot.ophic fact.r(BDn.).A kn.ckdown.of BDn. gen. in.RGS14414-t.eat.d agin. rat. an. Alzheimer s disease model mice caused complet. loss in.t.e upregulat.on.of n.uron.l st.uct.ral plast.cit. an. in.t.e preven.0}on.of ORM *** fin.in.s suggest.t.at.BDn.-mediat.d n.uron.l st.uct.ral plast.cit. in.area V2 is crucial in.t.e preven.0}on.of memory deficit. in.RGS14414-t.eat.d roden.0}models of agin. an. Alzheimer’s ***,our fin.in.s of RGS14414gen.-mediat.d act.vat.on.of n.uron.l circuit. in.visual area V2 have t.erapeut.c relevan.e in.t.e t.eat.en.0}of memory deficit..

关键词： behavioral performan.e brain.derived n.urot.ophic fact.r cogn.t.ve dysfun.t.on episodic memory memory circuit.act.vat.on memory deficit. memory en.an.emen. object.recogn.t.on.memory preven.0}on.of memory loss regulat.r of G prot.in.sign.lin.

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First.prin.iples calculat.on. t. in.est.gat. st.uct.ral,elect.on.c,magn.t.c,opt.cal an. t.ermodyn.mic propert.es of RE_(2)Rh_(3)Ge(RE=Pr,Sm)

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Journ.l of Rare Eart.s 2024年第7期42卷 1385-1393,I0007页

作者： A.Ezaier R.Masrour M.Hamedoun.J.Kharbach A.Rezzouk A.Hourmat.llah n.Ben.akour K.Bouslykhan. Laborat.ry of Solid Physics Faculty of Sciences Dhar El MehrazSidi Mohamed Ben Abdellah UniversityBP 1796FezMorocco Equipe de Physique du Solide LaboratoiresLIPIEcole Normale SupérieureBensoudaFèsMorocco

In.t.is paper,we an.lyzed t.e physical charact.rist.cs of t.e t.rn.ry alloys RE_(2)Rh_(3)Ge(RE=Pr an. Sm)usin. t.e first.prin.iples calculat.on.based on.fun.t.on.l den.it. t.eory in.0}grat.d in.t.e Wien.k *** calculat.d format.on.en.rgies of Pr_(2)Rh_(3)Ge an. Sm_(2)Rh_(3)Ge are−5.3827 an.−5.2782 eV/at.m,respect.vely,showin. t.at.t.ese alloys may exist.*** result. of t.e ban. st.uct.re an. den.it. of st.t.s in.icat. t.at.all of t.e compoun.s t.st.d are magn.t.c met.ls,an. t.eir magn.t.sm is most.y relat.d t. t.e con.0}ibut.on.of Pr an. Sm *** t.t.l magn.t.c momen.0} of Pr_(2)Rh_(3)Ge an. Sm_(2)Rh_(3)Ge are 4.07245 an. 11.16161μB/f.u,*** paramet.rs such as heat.capacit. at.con.t.n.0}pressure,en.0}opy,Debye t.mperat.re,lat.ice volume,compressibilit. coefficien.0},an. Grün.isen.paramet.r alloys were calculat.d usin. t.e Gibbs algorit.m an. st.died in.dept. over a large t.mperat.re ran.e of 0-900 *** Debye t.mperat.re in.reases wit. in.reasin. pressure an. decreases wit. decreasin. ***,t.e Debye t.mperat.res calculat.d at.p=0 GPa an. t.300 K are equal t. be 342 an. 322 K for Pr_(2)Rh_(3)Ge an. Sm_(2)Rh_(3)Ge,*** opt.cal charact.rist.cs such as t.e real an. imagin.ry port.on. of t.e dielect.ic fun.t.on.t.e absorpt.on.coefficien.0}t.e en.rgy-loss fun.t.on.an. t.e refract.ve in.ex were in.est.gat.d an. discussed in.more dept..

关键词： Magn.t.c met.ls Fun.t.on.l den.it. t.eory Den.it. of st.t.s Magn.t.c momen. Opt.cal an. t.ermodyn.mic propert.es Rare eart.s

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Double-Blin., Parallel Group St.dy t. Compare t.e Clin.cal Effect.ven.ss of Calcium Dobesilat. 500 mg BID vs. Calcium Dobesilat. LP 1 g OD, in.Pat.en.0} wit. Chron.c Ven.us In.ufficien.y of t.e Lower Limbs

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In.0}rn.t.on.l Journ.l of Clin.cal Medicin. 2024年第5期15卷 211-223页

作者： Ramón.t.llez Mén.ez Maria Gon.ález Yibirin.David Rin.ón.Mat.t. Cen.0}o Cln.co Prevaler Pampatar Nueva Esparta Venezuela Grupo Let. Guarenas Miranda Venezuela

Backgroun.: Chron.c ven.us in.ufficien.y (CVI) describes a con.it.on.t.at.affect. t.e ven.us syst.m of t.e lower ext.emit.es due t. ven.us hypert.n.ion.(VH. t.e prevalen.e is bet.een.5% - 30%. CVI is associat.d wit. older age, smokin., lower ext.emit. t.auma, presen.e of an.art.rioven.us shun.0} an. elevat.d est.ogen.levels. All pat.en.0} should be in.t.ally t.eat.d wit. con.ervat.ve man.gemen.0} Ven.act.ve drugs like calcium dobesilat. are useful. Object.ves: t.e primary object.ve compared t.e clin.cal improvemen.0}in.pat.en.0} wit. CVI, grades 0 - 3 of t.e CEAP classificat.on.of chron.c ven.us disease, produced by t.o formulat.on. of calcium dobesilat.: calcium dobesilat. LP 1 g OD vs calcium dobesilat. 500 mg BID, immediat. release. t.e secon.ary object.ve assessed t.e side effect. of bot. formulat.on.. Met.od: All pat.en.0} t.ok on. t.blet.an. on. capsule at.7 am, an. on. capsule at.7 pm, for 8 weeks. On. group received dobesilat. 1 g OD an. t.e ot.er group received dobesilat. 500 md BID. t.ey were evaluat.d aft.r 15, 30 an. 60 days of t.eat.en.0} usin. t.e sympt.m evaluat.on.scale. Result.: In.bot. groups, t.ere was a sign.fican.0}decrease in.t.e sympt.m score aft.r 15 days. Four pat.en.0} in.t.e Dobesilat. OD group: had adverse effect., which did n.t.require suspen.ion.of t.eat.en.0} In.t.e BID dobesilat. group, t.ere was on. t.erapeut.c failure, an. on. case of gast.ic discomfort. Con.lusion.: Prolon.ed-release Calcium dobesilat. 1 g OD is as effect.ve as calcium dobesilat. 500 mg BID for t.e t.eat.en.0}of pat.en.0} wit. chron.c ven.us in.ufficien.y.

关键词： Chron.c Ven.us In.ufficien.y (CVI) Calcium Dobesilat. CEAP Classificat.on Adverse Effect. t.eat.en.0}Adheren.e

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Omics-based biomarkers as useful t.ols in.met.bolic dysfun.t.on.ssociat.d st.at.t.c liver disease clin.cal pract.ce:How far are we?

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World Journ.l of Gast.oen.0}rology 2024年第14期30卷 1982-1989页

作者： Juliet. t.in.s María F Mascardi Adrián.Gadan. Sebast.án.Marcian. In.t.t.t. de Medicin. t.aslacion.l e In.en.ería Biomédica-Con.ejo n.cion.l de In.est.gacion.s Cien.0}ficas y t.cn.cas-In.t.t.t. Un.versit.rio del Hospit.l It.lian.-Hospit.l It.lian. de Buen.s Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina Con.ejo n.cion.l de In.est.gacion.s Cien.0}ficas y t.cn.cas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Un.t Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Depart.en.0}of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Un.et.n.eds exist.in.met.bolic dysfun.t.on.associat.d st.at.t.c liver disease(MASLD)risk *** abilit. t. iden.0}fy pat.en.0} wit. MASLD wit. advan.ed fibrosis an. at.higher risk for adverse out.omes is st.ll *** n.vel biomarkers could represen.0}a mean.n.ful improvemen.0}t. curren.0}risk *** t.is aim,omics t.chn.logies have revolut.on.zed t.e process of MASLD biomarker discovery over t.e past.*** t.e research in.t.is field is t.rivin.,much of t.e publicat.on.has been.haphazard,oft.n.usin. sin.le-omics dat. an. specimen.set. of con.en.en.e,wit. man. iden.0}fied can.idat. biomarkers but.lackin. clin.cal validat.on.an. *** we in.orporat. t.ese biomarkers t. direct.pat.en.0}’man.gemen.0}it.should be con.idered t.at.t.e roadmap for t.an.lat.n. a n.wly discovered omics-based sign.t.re t. an.act.al,an.lyt.cally valid t.st.useful in.MASLD clin.cal pract.ce is rigorous an.,t.erefore,n.t.easily *** art.cle presen.0} an.overview of t.is area’s curren.0}st.t.,t.e con.eivable opport.n.t.es an. challen.es of omics-based laborat.ry diagn.st.cs,an. a roadmap for improvin. MASLD biomarker research.

关键词： Met.bolic dysfun.t.on.associat.d st.at.t.c liver disease n.n.alcoholic st.at.hepat.t.s Biomarker Risk st.at.ficat.on Omics

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