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Clinicopat.ological feat.res of small t. colorect.l cancers

World Journal of Clinical Cases 2021年第33期9卷 10088-10097页

作者： Yuki t.kashina Shin-Ei Kudo Kat.uro Ichimasa Yut. Kouyama Kenichi Mochizuki Yoshika Akimot. Yasuharu Maeda Yuichi Mori Masashi Misawa Noriyuki Ogat. t.yoki Kudo t.mokazu Hisayuki t.kemasa hayashi Kunihiko Wakamura Naruhiko Sawada t.shiyuki Baba Fumio Ishida Kazunori Yokoyama Mit.uru Dait. t.t.uo Nemot. Hideyuki Miyachi Digest.ve Disease Cent.r Showa University Northern Yokohama HospitalYokohama 224-8503Japan Depart.ent.of Gast.oent.rology Nikko Kinen HospitalMuroran 051-8501Japan Clinical Effect.veness Research Group Institute of Health and SocietyUniversity of OsloOslo 0001Norway Depart.ent.of Pat.ology Showa University Nothern Yokohama HospitalYokohama 224-8503Japan

BACKGROUND Alt.ough small colorect.l neoplasms(<10 mm)are oft.n easily resect.d endoscopically and are considered t. have less malignant.pot.nt.al compared wit. large neoplasms(≥10 mm),some are invasive t. t.e *** t.... 详细信息

BACKGROUND Alt.ough small colorect.l neoplasms(t.n easily resect.d endoscopically and are considered t. have less malignant.pot.nt.al compared wit. large neoplasms(≥10 mm),some are invasive t. t.e *** t. clarify t.e clinicopat.ological feat.res of small t. colorect.l *** Of 32025 colorect.l lesions bet.een April 2001 and March 2018,a t.t.l of 1152 t. colorect.l cancers resect.d endoscopically or surgically were included in t.is st.dy and were divided int. t.o groups by t.mor size:a small group(t.ological fact.rs including lymph node met.st.sis(LNM)bet.een t.e t.o *** t.e incidence of small t. cancers was 10.1%(116/1152).t.e percent.ge of init.al endoscopic t.eat.ent.in small group was significant.y higher t.an in large group(t.e surgical resect.on cohort.n=798),t.e rat. of LNM did not.significant.y differ bet.een t.e t.o groups(small 12.3%vs large 10.9%,P=0.70).In addit.on,t.ere were also no significant.differences bet.een t.e t.o groups in pat.ological fact.rs such as hist.logical grade,vascular invasion,or lymphat.c *** Because t.ere was no significant.difference in t.e rat. of LNM bet.een small and large t. colorect.l cancers,t.e requirement.for addit.onal surgical resect.on should be det.rmined according t. pat.ological findings,regardless of t.mor size.

关键词： Colorect.l neoplasms Lymphat.c met.st.sis Biological phenomena Polyps Colorect.l cancers

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Ossified t.oracic spinal meningioma wit. hemat.poiesis: A case report.and review of t.e lit.rat.re

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Case Report. in Clinical Medicine 2013年第1期2卷 24-28页

作者： Asuka t.neoka t.mayoshi hayashi t.kayuki Mat.uo Kuniko Abe Naoe Kinoshit. Haruna Yasui t.kafumi Fuchino Izumi Nagat. Junya Fukuoka Depart.ent.of Neurosurgery Nagasaki University Hospital Nagasaki Japan Depart.ent.of Pat.ology Nagasaki University Hospital Nagasaki Japan

Meningiomas account.for 25% of spinal t.mors, and t.ey are oft.n locat.d in t.e t.oracic spine. t.e ossified subt.pe is even rarer, and t.ose wit. hemat.poiesis are rarely described. t.e mechanism of bone format.on has not.yet.been clarified. A case of ossified spinal meningioma wit. hemat.poiesis occurring in a 78-year-old woman is described. Magnet.c resonance imaging revealed a lesion wit. a dural t.il sign at.t.e t. level locat.d dorsal t. t.e spinal cord. Comput.rized t.mography revealed a high densit. lesion, as high as t.e bone signal. t.t.l resect.on was performed, and t.e sympt.ms improved. Pat.ological findings revealed many psammoma bodies (PBs), bone format.on, and bone marrow wit. hemat.poiesis. Bot. PBs and bone seemed t. be based on t.e same background of calcified st.uct.res. t.is report.is t.e second dealing wit. ossified spinal meningioma wit. hemat.poiesis. t.e hardness of t.e t.mor can make t.e operat.on more difficult. so t.at.t.e operat.on should be performed carefully t. avoid injuring t.e spinal cord.

关键词： Spinal Cord Meningioma Ossificat.on Ext.amedullary Hemat.poiesis Spinal t.mor

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Plasma levels of cat.cholamine met.bolit.s and serum levels of brain-derived neurot.rophic fact.r in smokers wit. schizophrenia t.eat.d wit. varenicline: A pilot.st.dy

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Open Journal of Psychiat.y 2012年第4期2卷 327-334页

作者： Wakako Umene-Nakano Reiji Yoshimura Hikaru Hori Asuka Kat.uki Kenji hayashi Chiharu Yoshii At.uko Ikenouchi-Sugit. Kiyokazu At.ke Jun Nakamura Depart.ent.of Psychiat.y School of Medicine University of Occupational and Environmental Health Kitakyushu City Japan Depart.ent.of Respirat.ry Medicine Wakamatsu Hospital of University of Occupational and Environmental Health Kitakyushu City Japan

Object.ve: t.e present.st.dy sought.t. det.rmine changes in plasma levels of cat.cholamine met.bolit.s and serum levels of brain-derived neurot.rophic fact.r (BDNF) among smokers wit. schizophrenia who were t.eat.d wit. varenicline. Met.ods: We compared plasma homovanillic acid (HVA) and 3-met.oxy-4-hydroxyphenylglycol (MHPG) levels and serum BDNF levels across 4 groups, divided as follows: smokers wit. schizophrenia (S-Sc), nonsmokers wit. schizophrenia (NS-Sc), smokers who were ot.erwise healt.y (S-HC) and nonsmokers who were ot.erwise healt.y (NS-HC). In addit.on, we also examined plasma HVA and MHPG levels and serum BDNF levels prior t. st.dy init.at.on (t.) and 8 weeks aft.r varenicline t.eat.ent.(t.) in t.e S-Sc and S-HC groups. Result.: Plasma HVA levels in t.e S-Sc group at.t. were significant.y higher t.an in t.e NS-Sc, S-HC and NS-HC groups at.t.e same t.me point.(S-Sc at.t.;7.6 ± 1.6 ng/mL, NS-Sc;4.8 ± 1.0 ng/mL, S-HC;4.3 ± 0.9 ng/mL, NS-HC;3.4 ± 1.4 ng/mL, p t.e S-Sc group at.t. were significant.y higher t.an in t.e NS-Sc and S-HC groups;in addit.on, plasma MHPG levels in t.e NS-HC group were significant.y higher t.an in t.e S-HC group (S-Sc at.t.;5.2 ± 0.7 ng/mL, NS-Sc;2.8 ± 1.2 ng/mL, S-HC;1.9 ± 0.8 ng/mL, NS-HC;3.6 ± 1.3 ng/mL, p t.differ bet.een t.e S-Sc and NS-Sc groups. In cont.ast. no difference in plasma HVA levels, plasma MHPG levels or serum BDNF levels was observed bet.een t. and t.. Conclusions: In conclusion, plasma levels of HVA and MHPG in t.e S-Sc group were significant.y higher t.an in t.e NS-Sc group. Serum BDNF levels did not.differ bet.een t.e S-Sc and NS-Sc groups. Plasma HVA and MHPG levels and serum BDNF levels did not.change aft.r t.eat.ent.wit. varenicline.

关键词： Schizophrenia BDNF HVA MHPG Varenicline Smoking Cessat.on

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Cell Proliferat.on Abilit. of Mouse Fibroblast.Like Cells and Ost.oblast.Like Cells on a t.-6Al-4V Alloy Film Produced by Select.ve Laser Melt.ng

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Mat.rials Sciences and Applicat.ons 2014年第7期5卷 475-483页

作者： Mayu Kawase t.t.uhide hayashi Masaki Asakura Akimichi Mieki Hironari Fuyamada Masahiro Sassa Shizuka Nakano Masashi Hagiwara t.ru Shimizu t.t.ushi Kawai Advanced Laser and Process t.chnology Research Associat.on (ALPROt. Tokyo Japan Laser Sint.ring Depart.ent ASPECT Inc. Tokyo Japan Advanced Laser and Process t.chnology Research Associat.on (ALPROt. Tokyo Japan Low-Formabilit.-Mat.rials Processing Group Advanced Manufacturing Research Institute National Institute of Advanced Industrial Science and Technology Tsukuba Japan Depart.ent.of Dent.l Mat.rials Science Aichi Gakuin University School of Dentistry Nagoya Japan Depart.ent.of Dent.l Mat.rials Science Aichi Gakuin University School of Dentistry Nagoya Japan Advanced Laser and Process t.chnology Research Associat.on (ALPROt. Tokyo Japan Depart.ent.of Gerodont.logy Aichi Gakuin University School of Dentistry Nagoya Japan

Successful regenerat.on of t.ssues and organs relies on t.e applicat.on of suit.ble subst.at.s or scaffolds in scaffold-based regenerat.ve medicine. In t.is st.dy, t.-6Al-4V alloy films (t. alloy film) were produced using a t.ree-dimensional print.ng t.chnique called Select.ve Laser Melt.ng (SLM), which is one of t.e met.l addit.ve manufact.ring t.chniques. t.e t.ickness of produced t. alloy film was approximat.ly 250 μm. t.e laser-irradiat.d surface of t. alloy film had a relat.vely smoot. yet.porous surface. t.e non-irradiat.d surface was also porous but.also ret.ined a lot.of part.ally melt.d t.-6Al-4V powder. Cell proliferat.on abilit. of mouse fibroblast.like cells (L929 cells) and mouse ost.oblast.like cells (MC3t.-E1 cells) on bot. t.e surfaces of t. alloy film was examined using WSt.assay. Bot. L929 and MC3t.-E1 cells underwent.cell proliferat.on during t.e cult.re period. t.ese result. indicat. t.at.select.ve laser melt.ng is suit.ble for producing a cell-compat.ble t.-6Al-4V alloy film for biomat.rials applicat.ons.

关键词： Select.ve Laser Melt.ng (SLM) t.-6Al-4V Film Mouse Fibroblast.Like Cell Mouse Ost.oblast.Like Cell Cell Compat.bilit.

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行对比增强多层螺旋Ct.描的肾功能不全病人与对比剂肾病的关系

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国际医学放射学杂志 2012年第6期 607-608页

作者： R.Murakami H.hayashi K.Sugizaki t.Yoshida E.Okazaki S.Kumit. 陈莉 Depart.ent.of Radiology Graduate School of MedicineNippon Medical School1-1-5 Sendagi BunkyoTokyo 1138602Japan

目的评价在肾功能不全病人中进行对比增强多层螺旋Ct.查的安全性。方法对938例稳定肾功能不全[估计肾小球滤过率(eGFR)为15～60mL/min)]并接受对比增强Ct.查的病人进行回顾性分析。在注射对比剂前和注射后48～72h后分别测定肌酐水平... 详细信息

目的评价在肾功能不全病人中进行对比增强多层螺旋Ct.查的安全性。方法对938例稳定肾功能不全[估计肾小球滤过率(eGFR)为15～60mL/min)]并接受对比增强Ct.查的病人进行回顾性分析。在注射对比剂前和注射后48～72h后分别测定肌酐水平。对对比剂肾病(CIN)在总研究人群中的发病率进行了评估。作为对照组,对1164例未接受注射对比剂Ct.查的肾功能不全病人也进行了回顾。结果有CIN的肾功能不全的病人在研究人群中的总发病率是6.1%;eGFR为45～60、30～45和≤30mL/min病人的发病率分别为4.4%、10.5%、10.0%(Pt.查的病人中没有表现出显著的区别(P=0.82)。结论肾功能不全病人行对比增强多层螺旋Ct.描造成CIN的风险似乎较低,CIN病人与没有接受对比增强Ct.人的发病率相比没有显著差异。

关键词：对比剂对比剂肾病慢性肾脏病肾毒性多层螺旋Ct

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白内障超声乳化术后眼内压的升高和角膜内皮细胞的丢失情况

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世界核心医学期刊文摘（眼科学分册） 2005年第4期1卷 54-55页

作者： Yachimori R. Mat.uura t. hayashiK. hayashiH. 肖颖 hayashi Eye Hospit.l 4- 7- 13 Hakataekimae Hakata- Ku Fukuoka Japan Dr.

BACKGROUND AND OBJECt.VE: t. compare t.e influence of low- molecular- weight.viscoelast.cs on post.perat.ve int.aocular pressure (IOP) and corneal endot.elial cell loss aft.r phacoemulsificat.on surgery. PAt.ENt. AND MEt.ODS: Sixt.- nine eyes undergoing phacoemulsificat.on surgery were randomized t. have eit.er Opegan (Sant.n Pharmaceut.cals, Osaka, Japan) alone or t.e soft. shell t.chnique using Viscoat.(Alcon Surgical, Fort.Wort., t.) during phacoemulsificat.on. t.e IOP was measured preoperat.vely and at.5 and 24 hours post.perat.vely. Int.aoperat.ve fact.rs and corneal endot.elial cell loss were also examined. RESULt.: Mean IOP was increased at.5 hours aft.r surgery but.ret.rned t. preoperat.ve levels at.24 hours in t.e Opegan group, whereas it.remained higher at.24 hours t.an at.preoperat.ve levels in t.e soft. shell group. When comparing groups, IOP at.5 and 24 hours post.perat.vely in t.e Opegan group was significant.y less t.an t.at.in t.e soft. shell group. Corneal endot.elial cell loss was approximat.ly t.e same in t.e t.o groups. CONCLUSION: t.e increase in IOP following phacoemulsificat.on surgery wit. t.e use of Opegan was less t.an t.at.wit. t.e soft. shell t.chnique using Viscoat. alt.ough endot.elial injury was almost.t.e same.

关键词：角膜内皮细胞眼内压超声乳化白内障角膜内皮损伤软壳黏弹剂低分子量于术升高值

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家族性斑纹状视网膜合并夜盲症患者杂合体RDH5的变异

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 19-19页

作者： hayashi t.Got.-Omot. S. t.keuchi t. 王永强 Depart.ent.of Opht.almology Jikei University School of Medicine 3- 25- 8 Nishi-shinbashi Minatoku Tokyo 105- 8461 Japa Dr.

Purpose: t. describe t.e clinical feat.res and genet.c analysis of a 3- year-old boy diagnosed wit. familial fleck ret.na wit. night.blindness. Met.ods: t.e proband and his parent. and grandparent. were included. Hist.ry, visual acuit. and fundus examinat.ons were evaluat.d. Bright.flash (rod-plus-cone)-elect.oret.nograms (ERGs) were recorded aft.r 30mins and 180 mins of dark adapt.t.on. Mut.t.on screening of t.e RDH5 gene encoding 11- cis ret.nol dehydrogenase was performed. Result.: t.e parent. not.ced t.e proband’ s night.blindness when he was 2 years old. Best.correct.d visual acuit. was 1.0 in bot. eyes. Fundus examinat.ons revealed numerous yellow-whit. flecks of varying size and shape t.roughout.t.e midperipheral t. far peripheral ret.na in bot. eyes. t.e dist.ibut.on, size and shape of t.e flecks were comparable t. t.ose seen in familial fleck ret.na wit. night.blindness, rat.er t.an fundus albipunct.t.s. t.e ERGs showed ext.emely diminished responses aft.r 30 mins of dark adapt.t.on, but.t.ere were subst.nt.al increases in t.e amplit.des of bot. a-and b-waves when recorded aft.r 180 mins of dark adapt.t.on. Alt.ough a t.t.l of 19 RDH5 mut.t.ons have been found only in pat.ent. wit. fundus albipunct.t.s, compound het.rozygous mut.t.ons, p.V177G and p.L310delinsEV, whose combinat.on has not.been previously report.d,were found in t.e proband. t.e asympt.mat.c parent. and one of t.e grandparent. each carried one of t.e mut.t.ons, consist.nt.wit. aut.somal recessive t.ansmission. Conclusion: Our st.dy indicat.s t.at.different.mut.t.ons in t.e RDH5 gene can cause phenot.pic variat.ons of eit.er fundus albipunct.t.s or familial fleck ret.na wit. night.blindness.

关键词： RDH5 杂合体变异基因族性眼底检查闪光视网膜电图视黄醛脱氢酶矫正视力暗适应基因分析

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小脑下蚓部的葡萄糖利用和眼肌痉挛

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 19-19页

作者： Yakushiji Y. Ot.ubo R. hayashi t. 郭俊 Dr.Division of Neurology Department of Internal MedicineSaga University Faculty of Medicine5-1-1 NabeshimaSaga 849-8501Japan

In a pat.ent.wit. sympt.mat.c ocular myoclonus,t.e aut.ors observed t.e regional cerebral met.bolic rat. of glucose use(rCMRGlu)before and aft.r successful t.eat.ent.wit. *** aft.r t.e sympt.ms resolved,t.e rCMRGlu in t.e hypert.ophic olive increased persist.nt.y,whereas t.at.in t.e inferior cerebellar vermis cont.alat.ral t. t.e hypert.ophic olive *** inferior cerebellar vermis,belonging t. t.e vest.bulocerebellar syst.m,may be associat.d wit. t.e generat.on of sympt.mat.c ocular myoclonus.

关键词：眼肌痉挛小脑下蚓部症状性

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先天性心脏病术后患者应用小剂量阿托品引起的负性变时效应与副交感神经介导的心血管反应有关

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世界核心医学期刊文摘（心脏病学分册） 2005年第9期1卷 52-52页

作者： Ohuchi H. Hamamichi Y. hayashi t. 陈仆 Depart.ent.of Pediat.ics National Cardiovascular Center 5-7-1 Fujishiro-dai Suita Osaka 565-8565 Japan

Object.ves: t. invest.gat. t.e negat.ve chronot.opic response(NCR) t. low-dose at.opine in post.perat.ve pat.ent. wit. congenit.l heart.disease(CHD). Background: Low-dose at.opine causes a NCR t.rough t.e cent.al nervous syst.m muscarinic recept.r and is at.enuat.d in adult.heart.failure pat.ent.. It.has never been evaluat.d in CHD pat.ent.. Met.ods: NCR correct.d for basal heart.rat.(HR)(minimal HR/-basal HR=cNCR) was det.rmined aft.r low-dose at.opine(3 μg/kg) administ.at.on in 124 post.perat.ve CHD pat.ent.(97 bivent.icular repair and 27 Font.n pat.ent.) and 11 cont.ols and was compared wit. t.e cardiac aut.nomic nervous and funct.onal st.t.s. Result.: t.e cNCR in simple CHD(post.at.ial or vent.icular sept.l defect.closure), complex bivent.icular CHD, and Font.n pat.ent. were 0.92±0.04, 0.94±0.04 and 0.96±0.04, respect.vely, and higher t.an in cont.ols(0.87±0.03, pt.e complex CHD pat.ent., higher cNCR was mainly associat.d wit. t.e lower pharmacologically det.rmined cardiac parasympat.et.c nervous t.ne(PSt., HR variabilit., high at.ial nat.iuret.c pept.de, and lower right.vent.icular eject.on fract.on(pt.n pat.ent., t.e lower βsensit.vit. of t.e sinus node and t.e PSt.mainly det.rmined t.e higher cNCR(pt.e cNCR did not.correlat. wit. eit.er hemodynamics or exercise capacit.. Conclusions: NCR is at.enuat.d in proport.on t. t.e impaired cardiac parasympat.et.c nervous syst.m and hemodynamics in post.perat.ve complex bivent.icular CHD pat.ent.. In addit.on t. PSt. βsensit.vit. of t.e sinus node significant.y influences t.e NCR in Font.n pat.ent..

关键词：心血管反应先天性心脏病室间隔缺损双心室血流动力学基础心率心脏自主神经副交感神经系统窦房结射血分数

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预后良好的近视性脉络膜新生血管患者的特征

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 42-42页

作者： hayashi K. Ohno-Mat.ui K. Yoshida t. 张磊 Dept. of Opht.almol./Visual Science Graduate School Tokyo Medical and Dental University 1- 5- 45 Yushima Bunkyo-ku Tokyo 113- 8519 Japan

Object.ve: t. ident.fy t.e charact.rist.cs of pat.ent. wit. myopic choroidal neovascularizat.on (CNV) who had a favorable visual prognosis wit.out.t.eat.ent. Met.ods: We reviewed t.e medical records of 52 conse cut.ve pat.ent. (57 eyes) wit. myopic CNV who were followed for at.least.5 years aft.r t.e onset.of CNV. Clinical charact.rist.cs (pat.ent.age, CNV size and locat.on, visual acuit. at.onset. chorioret.nal at.ophy development.around CNV, and degree of myopia) were compared bet.een pat.ent. whose visual acuit. 5 years aft.r CNV onset.was bet.er t.an 20/40 and t.ose whose visual acuit. was worse t.an 20/200. Result.: Among 57 eyes, eight.eyes (14.0% ; 8 pat.ent.) had a final visual acuit. bet.er t.an 20/40. On t.e ot.er hand,37 eyes (64.9% ;33 pat.ent.) had a final visual acuit. worse t.an 20/200. St.t.st.cal analysis revealed t.at.t.e pat.ent. wit. a good prognosis (final visual acuit. bet.er t.an 20/40) were significant.y younger, had significant.y smaller CNV, and significant.y bet.er init.al visual acuit. (Mann-Whit.ey U-t.st. P t.foveal CNV was more frequent.y observed in pat.ent. wit. a good prognosis t.an in t.ose wit. a poor prognosis (Fisher’ s exact.probabilit. t.st. P t.ent.(12.5% ) in t.e good prognosis group developed a very limit.d area of chorioret.nal at.ophy around t.e regressed CNV, while 91.9% of t.e pat.ent. in t.e poor prognosis group developed chorioret.nal at.ophy. Refract.ve st.t.s and t.e axial lengt. measurement. did not.differ bet.een t.e t.o groups. Conclusions: Some young pat.ent. wit. myopic CNV ret.in favorable vision over t.e long t.rm wit.out.act.ve t.eat.ent. t.ese informat.onmight.be useful t. predict.t.e visual out.ome of pat.ent. wit. myopic CNV.

关键词：脉络膜新生血管近视性预后良好近视程度屈光状态中心凹精确概率检验轴长较差者统计学分析

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