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Open Journal of Radiology 2020年第1期10卷 9-15页

作者： t.t.uya hayashi Kei Fukuzawa Hidekazu Yamazaki t.kashi Konno Jun’ichi Kot.ku Sat.shi Sait.h Graduat. School of Medical t.chnology Teikyo University Tokyo Japan Depart.ent.of Radiological t.chnology Toranomon Hospital Tokyo Japan Depart.ent.of Radiological t.chnology Southern TOHOKU General Hospital Fukushima Japan Depart.ent.of Hepat.logy Toranomon Hospital Tokyo Japan

Purpose: t. evaluat. t.e influence of gadolinium et.oxybenzyl diet.ylenet.iamine pent.acet.c acid (Gd-EOB-Dt.A) on prot.n densit. fat.fract.on (PDFF) using mult.ple vendors’ DIXON met.ods in a mult.cent.r, mult.vendor phant.m st.dy. Mat.rials and Met.ods: Pairs of phant.ms wit. varying fat.volume percent.ges (0, 5, 10, 15, 20, 30, 40, and 50) and Gd-EOB-Dt.A concent.at.ons (0 and 0.4 mM) were const.uct.d. t.e phant.m wit.out.Gd-EOB-Dt.A in each pair was defined as t.e precont.ast.phant.m, and t.e corresponding phant.m wit. Gd-EOB-Dt.A in each pair was defined as t.e post.ont.ast.phant.m. t.e phant.ms were scanned via t.ree vendors’ DIXON t.chniques t. det.rmine PDFFs. Agreement.bet.een PDFFs det.rmined in precont.ast.and post.ont.ast.phant.ms was evaluat.d via Bland–Alt.an analysis. Result.: Mean differences (precont.ast.PDFF - post.ont.ast.PDFF) and limit. of agreement.were Philips 5.1% (−0.8% t. 11.0%), Siemens 6.1% (−0.9% t. 13.1%), and GE 1.3% (−1.2% t. 3.9%). Conclusions: PDFFs measured using t.e t.ree vendors’ DIXON t.chniques were smaller in t.e post.ont.ast.phant.ms t.an in t.e corresponding precont.ast.phant.ms regardless of different.scanning paramet.rs, because t. bias was improved by Gd-EOB-Dt.A.

关键词： Dixon Fat Liver MRI Phant.m Quant.ficat.on

Clinical ut.lit. of t.e plat.let.lymphocyt. rat.o as a predict.r of post.perat.ve complicat.ons aft.r radical gast.ect.my for clinical t.-4 gast.ic cancer

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World Journal of Gast.oent.rology 2017年第14期23卷 2519-2526页

作者： Kenichi Inaoka Mit.uro Kanda Hiroaki Uda Yuri t.naka Chie t.naka Daisuke Kobayashi Hideki t.kami Naoki Iwat. Masamichi hayashi Yukiko Niwa Suguru Yamada t.ut.mu Fujii Hiroyuki Sugimot. Kent. Murot.ni Michit.ka Fujiwara Yasuhiro Kodera Depart.ent.of Gast.oent.rological Surgery (Surgery II) Nagoya University Graduate School of Medicine Division of Biost.t.st.cs Clinical Research Center Aichi Medical University Hospital

AIMt. ident.fy simple and sensit.ve markers for post.perat.ve complicat.ons aft.r gast.ect.my, t.e predict.ve values were compared among candidat. preoperat.ve ***-hundred and t.elve pat.ent. wit. previously unt.eat.d clinical t.-4 gast.ic cancer who underwent.a D2 st.ndard gast.ect.my (dist.l gast.ect.my or t.t.l gast.ect.my) were included in t.e analysis. Correlat.ons bet.een 21 paramet.rs t.at.can be det.rmined by preoperat.ve rout.ne blood t.st. and clinically relevant.post.perat.ve complicat.ons (grade II or higher according t. t.e Clavien-Dindo classificat.on) were evaluat.d. t.e opt.mal cut.ff values and clinical significance of t.e select.d markers were furt.er evaluat.d by subgroup analyses according t. age, body mass index, operat.ve procedure and clinical disease ***-six pat.ent. (21.1%) experienced grade II or higher post.perat.ve complicat.ons. t.e plat.let.lymphocyt. rat.o (PLR, t.t.l lymphocyt. count.plat.let.count.× 100) exhibit.d t.e highest.area under t.e curve value (0.639) for predict.ng post.perat.ve complicat.ons among t.e 21 paramet.rs, and t.e opt.mal cut.ff value was det.rmined t. be 0.71 (sensit.vit. = 70%, specificit. = 56%). In t.e univariat. analysis, t.e odds rat.o of a low PLR for t.e occurrence of post.perat.ve complicat.ons was 2.94 (95%CI: 1.66-5.35, P t.variat. binomial logist.c analysis involving ot.er pot.nt.al risk fact.rs ident.fied a low PLR as an independent.risk fact.r for post.perat.ve complicat.ons (OR = 3.32, 95%CI: 1.82-6.25, P t. age, body mass index, operat.ve procedure and clinical disease st.ge, t.e low PLR group exhibit.d an increased incidence of post.perat.ve *** preoperat.ve PLR is a simple and useful predict.r of complicat.ons aft.r curat.ve gast.ect.my in pat.ent. wit. clinical t.-4 gast.ic cancer.

关键词： Gast.ic cancer Gast.ect.my Plat.let.lymphocyt. rat.o Post.perat.ve complicat.on Predict.on

ZEffect. of Prolonged Muscle St.et.hing Bot. St.diesin vivo and in Vit.o

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ZEffects of Prolonged Muscle Stretching Both Studiesin vivo ...

Sphingosine-1-phosphat. recept.r t.pe 1 regulat.s glioma cell proliferat.on and correlat.s wit. pat.ent.survival

中国康复医学会首届儿童康复学术会议暨中国残疾人康复协会第八届小儿脑瘫学术会议

作者： Inui KimiharulR.P.Ph.Dt.Mukai KoujiR.P.t.M.S. Oht. Makot.R.P.M.S. t.ayase t.kahideR.P.t. hayashi MasanoriR.P.t. Nakazawa KazuyaR.P.t. Ido HisanoriR.P.t. Mat.uura ShihoR.P.t. Uchida AyakoR.P.t. Kozuka NaokilR.P.t.Ph.D. School of Healt. Sciences Sapporo Medical UniversitySapporoJapan Depat.ent.of Physical t.erapy Nippon Welfare & Rehabilitation SchoolEniwaJapan Division of Rehabilit.t.on Hakodate Goryoukaku HospitalHakodateJapan Division of Rehabilit.t.on Shin-Sapporo Brain Surgery HospitalSapporoJapan Division of Rehabilit.t.on Maruyama Orthopedic HospitalSapporoJapan

[Previous St.dy] t.ere are many st.dies about.effect. of muscle st.et.hing and t.e result. are improvement.of R.O.M., circulat.on and performance, prevent.on of muscle cont.act.re and muscle or t.ndon injury during performance and recovery from fat.gue. We also st.died t.e effect. of prolonged muscle st.et.hing bot. of in vivo and in vit.o since 1996. [Met.od & Result. in vivo] t.e phot.-st.mulat.on response t.me of knee ext.nsion has been measured before and aft.r 60sec quadriceps femoris st.et.hing. t.e result.was t.at.only mot.on t.me was significant.y delayed. t.e st.dy of a-mot.r neuron excit.t.on has been done on soleus muscle for different.st.et.hing t.me. t.e result.was t.at.H-wave amplit.des aft.r 30 and 60sec st.et.hing were smaller t.an it. of cont.ol and 5 sec st.et.hing. t.ere are t.o EMG st.dies of effect. of muscle st.et.hing. Aft.r muscle st.et.hing for 60sec, t.e lat.ncy of knee ext.nsion reflex was significant.y delayed comparat.ve t. t.e value of cont.ol and t.e durat.on t.me of muscle act.vit. aft.r 30sec st.et.hing was significant.y short.r t.an it.of cont.ol. t.e st.dy of st.et.hing on fat.gue muscle has been done using surface EMG power spect.al analysis. t.e result. were t.at.t.e beginning of low frequency appearance was delayed and mean int.grat.ve value increasing t.ming was delayed. [Conclusion in vivo st.dy] t.ese result. from in vivo st.dies suggest.t.at.prolonged st.et.hing inhibit. muscle excit.bilit. and cont.ibut. t.e recovery from fat.gue. [Met.od & Result. in vit.o] On t.e ot.er hand, muscle force, miniat.re end plat. pot.nt.al (MEPP) and end plat. pot.nt.al (EPP) were st.died in vit.o before and aft.r prolonged muscle st.et.hing. On soleus muscle of rat. muscle force significant.y increased aft.r st.et.hing but.EDL (ext.nsor digit.rum longus) force did not.change. t.o minut.s st.et.hing t. fat.gued rat.soleus muscle was effect.veness for recovery. t.e values of amplit.de and frequency of MEPP were no-significant.difference bet.een

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Sphingosine-1-phosphate receptor type 1 regulates glioma cel...

Lit.ium Ion t.ansport.Environment.by Molecular Vibrat.ons in Ion-Conduct.ng Glasses

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Yuya Yoshida Mit.ut.shi Nakada Naot.shi Sugimot. t.moya Harada Yasuhiko hayashi Daisuke Kit. Naoyuki Uchiyama Yut.ka hayashi Akihiro Yachie Yoh t.kuwa Jun-ichiro Hamada Depart.ent.of Neurosurgery Graduate School of Medical ScienceKanazawa University Depart.ent.of Physiology Graduate School of Medical ScienceKanazawa UniversityKanazawaJapan Depart.ent.of Pediat.ics Graduate School of Medical ScienceKanazawa UniversityKanazawaJapan

Sphingosine-1-phosphat.（S1P） is a bioact.ve lipid t.at.signals t.rough a family of G prot.in-coupled recept.rs consist.ng of 5 members t.rmed S1P1-5,and it.regulat.s cellular proliferat.on,migrat.on and *** invest.gat.d t.e expression and role of S1P recept.rs in *** glioma expressed S1P1,S1P2,S1P3,and S1P5 by quant.t.t.ve real-t.me PCR *** of t.e S1P1 was significant.y lower in glioblast.ma t.an in t.e normal brain（p ＜ 0.01） and diffuse ast.ocyt.ma（p ＜ 0.05）.Immunoblot.ing showed t.at.normal brain expressed more S1P1 prot.in t.an did *** showed t.at.S1P1 was localized predominant.y in t.e ast.ocyt.s in t.e normal brain,but.no st.ining was observed in *** of S1P1 expression correlat.d wit. poor survival of pat.ent. wit. glioblast.ma（p ＜ 0.05）.S1P1 small int.rfering RNA promot.d cell proliferat.on in high-expressor glioma cell lines（t.8G,G112）.Cell proliferat.on was promot.d by t.e pert.ssis t.xin,which deact.vat.s Gi/o t.pe of G prot.ins;t.e S1P1 is exclusively coupled t. t.ese *** expression of t.e S1P1 in low-expressor cell lines（U87,U251） result.d in decreased cell growt. and led t. suppressed t.mor growt. in t.ansplant.d gliomas in ***,we found a significant.associat.on bet.een t.e S1P1 expression and early growt. response-1,a t.anscript.onal fact.r t.at.exhibit. t.mor suppression in glioblast.ma cells（p ＜ 0.05）.t.ese dat. indicat. t.at.t.e downregulat.on of S1P1 expression enhances t.e malignancy of glioblast.ma by increasing cell proliferat.on and correlat.s wit. t.e short.r survival of pat.ent. wit. glioblast.ma.

关键词： glioblast.ma S1P recept.rs S1P1 recept.r proliferat.on survival

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Energy & Environment.l Mat.rials 2024年第3期7卷 133-142页

作者： Hiroki Yamada Koji Ohara Sat.shi Hiroi At.ushi Sakuda Kazut.ka lkeda t.kahiro Ohkubo Kengo Nakada Hirofumi t.ukasaki Hiroshi Nakajimai Laszlo t.mleit.er Laszlo Puszt.i Shunsuke Ariga Aot. Mat.uo Jiong Ding t.kumi Nakano t.kuya Kimura Ryo Kobayashi t.keshi Usuki Shut. t.hara Koji Amezawa Yoshit.ka t.t.yama Shigeo Mori Akit.shi hayashi Diffract.on and Scat.ering Division Japan Synchrotron Radiation Research Institute(JASRI)1-1-1 KoutoSayo-choSayo-gun Hyogo 679-5198Japan Facult. of Mat.rials for Energy Shimane University1060Nishi-Kawatsu-ChoMatsue Shimane 690-8504Japan Depart.ent.of Applied Chemist.y Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Inst.t.t. of Mat.rials St.uct.re Science High Energy Accelerator Research Organization(KEK)203-1 ShirakataTokai-muraNaka-gunlbaraki 319-1106Japan Graduat. School of Engineering Chiba Universit. 1-33 Yayoi-cho Inage-kuChiba 263-8522Japan Depart.ent.of Mat.rials Science Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Wigner Research Cent.e for Physics Konkoly Thegeút 29-33 H-1121Budapest Hungary Int.rnat.onal Research Organisat.on of Advanced Science and t.chnology(IROASt. Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Depart.ent.of Applied Physics Nagoya Institute of TechnologyGokisoShowaNagoya 466-8555Japan Facult. of Science Yamagata University1-4-12 KojirakawaYamagata-shiYamagata 990-5860Japan Facult. of Science University of the Ryukyus1 SenbaruNishihara-choOkinawa 903-0213Japan Inst.t.t. of Mult.disciplinary Research for Advanced Mat.rials Tohoku University2-1-1 KatahiraAoba-kuSendai 980-8577Japan Cent.r for Green Research on Energy and Environment.l Mat.rials(GREEN)and Int.rnat.onal Cent.r for Mat.rials Nanoarchit.ct.nics(MANA) National Institute for Materials Science(NIMS)TsukubaIbaraki 305-0044Japan

Cont.olling Li ion t.ansport.in glasses at.at.mic and molecular levels is key t. realizing all-solid-st.t. bat.eries,a promising t.chnology for elect.ic *** t.is cont.xt.Li_(3)PS_(4)glass,a promising solid elect.olyt. candidat.,exhibit. dynamic coupling bet.een t.e Li^(+)cat.on mobilit. and t.e PS_(4)^(3-)anion librat.on,which is commonly referred t. as t.e paddlewheel *** addit.on,it.exhibit. a concert.d cat.on diffusion effect.i.e.,a cat.on-cat.on int.ract.on),which is regarded as t.e essence of high Li ion ***,t.e correlat.on bet.een t.e Li^(+)ions wit.in t.e glass st.uct.re can only be vaguely det.rmined,due t. t.e limit.d experiment.l informat.on t.at.can be ***,t.is st.dy report. t.at.t.e Li ions present.in glasses can be classified by evaluat.ng t.eir valence oscillat.ons via Bader analysis t. t.pologically analyze t.e chemical *** is found t.at.t.ree t.pes of Li ions are present.in Li_(3)PS_(4)glass,and t.at.t.e more mobile Li ions(i.e.,t.e Li3-t.pe ions)exhibit.a charact.rist.c correlat.on at.relat.vely long dist.nces of ***,reverse Mont. Carlo simulat.ons combined wit. deep learning pot.nt.als t.at.reproduce X-ray,neut.on,and elect.on diffract.on pair dist.ibut.on funct.ons showed an increase in t.e number of Li3-t.pe ions for part.ally cryst.llized glass st.uct.res wit. improved Li ion t.ansport.*** result. show order wit.in t.e disorder of t.e Li ion dist.ibut.on in t.e glass by a t.pological analysis of t.eir ***,considering t.e molecular vibrat.ons in t.e glass during t.e evaluat.on of t.e Li ion valences is expect.d t. lead t. t.e development.of new solid elect.olyt.s.

关键词： elect.olyt.s ionic conduct.rs modeling molecular dynamics

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在国际人工器官学会(ISAO)第四届学术会上对人工器官及其材料的调查

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生物医学工程学杂志 1985年第4期 299-302页

作者： H.Yoshida,t.Kishimot.,t.hayashi,N.Yamamot.,t.Mat.uda,M.Nishimura,I.Yamashit.,S.Yoshihawa,刘青医学技术委员会大阪科技研究中心医学技术委员会大阪科技研究中心医学技术委员会大阪科技研究中心医学技术委员会大阪科技研究中心医学技术委员会大阪科技研究中心医学技术委员会大阪科技研究中心医学技术委员会大阪科技研究中心医学技术委员会大阪科技研究中心

日本也与世界各地一样,为了取得更好的医疗保健和幸福,对人工器官的研制正在进行着。在大阪科技研究中心,来自各个领域的专家们组成了医学技术委员会,努力地工作,以满足医学和社会的需要。参加第四届ISAO大会代表们对我

关键词：人工肾血液透析回答低温过滤除法透析疗法血浆交换 ISAO 人工器官血液净化疗法血液过滤全人工心脏

Malignant.pheochromocyt.ma:Hepat.ct.my for liver met.st.ses

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World Journal of Gast.oint.st.nal Surgery 2013年第11期5卷 309-313页

作者： t.mohide Hori Kent.ro Yamagiwa t.dat.ka hayashi Shint.ro Yagi t.ku Iida Kent.ro t.niguchi Yoshifumi Kawarada Shinji Uemot. Divisions of Hepat.-Pancreat.-Biliary Transplant and Pediatric SurgeryDepartment of SurgeryKyoto University HospitalKyoto 606-8507Japan First.Depart.ent.of Surgery Mie University HospitalTsuMie Prefecture514-8507Japan Second Depart.ent.of Surgery Hamamatsu University HospitalHamamatsuShizuoka431-3192Japan

Malignant.pheochromocyt.ma account. for approximat.ly 10% of pheochromocyt.ma cases. t.e main sit. of dist.nt.met.st.sis is t.e liver. Hypert.nsive crisis due t. cat.cholamine oversecret.on is pot.nt.ally fat.l. We present.a case of malignant.pheochromocyt.ma wit. mult.ple liver met.st.ses. A 60-year-old female wit. repeat.d hypert.nsive episodes was diagnosed wit. malignant.pheochromocyt.ma. She underwent.a left.adrenalect.my and part.al hepat.ct.my wit. resect.on of segment.6. Cat.cholamine levels remained high aft.r surgery and she received repeat.d cycles of chemot.erapy. Four mont.s aft.r surgery, mult.ple liver met.st.ses were det.ct.d. In spit. of ongoing chemot.erapy, cat.cholamine levels event.ally became uncont.ollable. Serum and urine noradrenaline andvanillylmandelic acid levels increased, but.adrenaline and dopamine levels st.yed wit.in t.e normal range. Preoperat.ve liver imaging revealed mult.ple met.st.ses in all segment. except.segment.4. Percut.neous t.anshepat.c port.l vein embolizat.on(Pt.E) of t.e right.and lat.ral branches of t.e port.l vein was performed. t.e funct.onal liver volume of segment.4 increased aft.r Pt.E. Right.hepat.ct.my, lat.ral segment.ct.my and part.al resect.on of segment.1 were performed 10 mo aft.r t.e init.al surgery. Int.aoperat.ve ult.asonography det.ct.d t.o small t.mors in segment.4, which were t.eat.d wit. int.aoperat.ve microwave coagulat.on t.erapy. Noradrenaline levels normalized immediat.ly aft.r t.e second hepat.ct.my. As t.ere was increased t.lomerase act.vit. in t.e resect.d specimen, she received adjuvant.chemot.erapy. She remained in good healt. for 2 years. However, furt.er met.st.ses event.ally occurred and she subsequent.y died due t. a brain hemorrhage. Hepat.ct.my may be a t.erapeut.c opt.on for reduct.on of t.mor mass in pheochromocyt.ma wit. liver met.st.ses.

关键词： Malignant pheochromocyt.ma Liver met.st.sis Mass reduct.on Percut.neous t.anshepat.c port.l vein embolizat.on Hepat.ct.my

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舌鳞状细胞癌浸润深度预测颈部淋巴结转移

临床与实验病理学杂志 2016年第8期32卷 923-923页

作者： Mit.ni S t.mioka t.hayashi R 刘仙花(摘译) 余英豪(审校) 不详南京军区福州总医院病理科福州350025

舌鳞状细胞癌（SCC）的5年生存率为50%～60%,其中延迟颈部淋巴结转移（CLNM）是舌SCC最重要的负相关预后因素。本研究选取212例已接受部分舌截除术且临床无淋巴结转移（cN 0）的SCC患者为研究对象分析解剖学浸润深度（AID）与延迟CLNM... 详细信息

舌鳞状细胞癌（SCC）的5年生存率为50%～60%,其中延迟颈部淋巴结转移（CLNM）是舌SCC最重要的负相关预后因素。本研究选取212例已接受部分舌截除术且临床无淋巴结转移（cN 0）的SCC患者为研究对象分析解剖学浸润深度（AID）与延迟CLNM间的相关性。

关键词：舌鳞状细胞癌颈部淋巴结转移浸润深度舌下间隙无淋巴结转移对象分析舌内肌截除术颈部淋巴结清扫负相关

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经皮血管成形术对高血压合并肾动脉狭窄患者左心室质量的影响

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中华高血压杂志(中英文) 2021年第6期29卷 598-598页

作者： Iwashima Y Fukuda t.Horio t.Kusunoki H hayashi SI Kamide K Kawano Y Ishimit.u t.Yoshihara F 刘青

研究者研究了经皮肾血管成形术对左心室质量的影响,以及左心室质量减少对预后的影响。方法:共有144例高血压合并肾动脉狭窄(renal art.ry st.nosis, RAS)的患者接受了血管成形术,平均年龄69岁,22.2%为肌纤维发育不良(fibromuscular dysp...

研究者研究了经皮肾血管成形术对左心室质量的影响,以及左心室质量减少对预后的影响。方法:共有144例高血压合并肾动脉狭窄(renal art.ry st.nosis, RAS)的患者接受了血管成形术,平均年龄69岁,22.2%为肌纤维发育不良(fibromuscular dysplasia, FMD)。在基线和1年后进行超声心动图检查,此后对患者进行中位数5.6年的随访,以获得主要终点事件:首次发生心血管事件,包括全因死亡、心肌梗死、

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4例日本青少年视网膜劈裂症患者中3例存在RS1基因突变

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世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 21-21页

作者： hayashi t. Omot. S. t.keuchit.张少娟

t. describe t.e clinical phenot.pes of four unrelat.d Japanese male pat.ent. w it. juvenile ret.noschisis and t. invest.gat. occurrences of mut.t.ons in t.e RS 1 gene. Observat.onal case series and experiment.l st.dy. Fundus examinat.ons, f luorescein angiography, and single flash elect.oret.nography (ERG) were carried out. In one pat.ent. opt.cal coherence t.mography (OCt. was performed. t.e codi ng regions of t.e RS1 gene t.at.encodes ret.noschisin were amplified by polymera se chain react.on (PCR). t.e PCR product. were purified and direct.y sequenced. t.e four affect.d pat.ent. showed cyst.id or wheel like foveal changes wit. a lit.le or no fluorescein leakage and negat.ve b wave pat.erns in bot. eyes. t.e OCt.images of foveal ret.noschisis disclosed t.at.split.ing occurs in t.e put.t.ive fibers of Henle. In t.ree pat.ent., we ident.fied t.ree different.missense m ut.t.ons (p.S73P, p.Y89C, p.R209C) in t.e funct.onally import.nt.discoidin domai n of t.e RS1 gene. t.e p.S73P mut.t.on has not.been previously report.d. In cont.rast. no nucleot.de subst.t.t.ons were det.ct.d in t.e fourt. pat.ent.whose pare nt. were unrelat.d and asympt.mat.c. No ot.er member of t.is family for t.ree ge nerat.ons has had juvenile ret.noschisis. Because serine 73 is conserved in t.e mouse ort.olog and ot.er discoidin prot.ins, t.e proline 73 allele is t.erefore very likely t. encode a defect.ve ret.noschisin. Alt.ough t.e inherit.nce pat.er n is uncert.in in t.e pat.ent.wit.out.t.e RS1 mut.t.on, t.e clinical and ERG fin dings were indist.nguishable from t.ose of pat.ent. wit. RS1 mut.t.ons. t.is fin ding point. t. t.e genet.c het.rogeneit. of juvenile ret.noschisis.

关键词：视网膜劈裂症 RS1 基因突变荧光渗漏闪光视网膜电图眼底检查纤维层聚合酶链反应黄斑中心凹直接测序

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