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Gut.microbiome alt.rs funct.ons of mut.nt.p53 t. promot. t.morigenesis

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Signal t.ansduct.on and t.rget.d t.erapy 2020年第1期5卷 491-492页

作者： Harry Cheuk hay Lau Jun Yu Inst.t.t. of Digest.ve Disease Department of Medicine and TherapeuticsState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongSha TinN.T.Hong Kong

In a recent.st.dy in Nat.re,Kadosh et.al.1 est.blished a landmark relat.onship bet.een t.e gut.microbiome and host.epigenet.cs in int.st.nal *** demonst.at.d t.e subst.nt.al plast.cit. of mut.nt.p53 in WNt.driven t.mo... 详细信息

关键词： t.morigenesis involvement al

Gut.Microbiome in Colorect.l Cancer:Clinical Diagnosis and t.eat.ent

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Genomics, Prot.omics & Bioinformat.cs 2023年第1期21卷 84-96页

作者： Yali Liu Harry Cheuk-hay Lau Wing Yin Cheng Jun Yu Inst.t.t. of Digest.ve Disease and t.e Depart.ent.of Medicine and t.erapeut.cs State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongHong Kong Special Administrative Region 999077China

Colorect.l cancer(CRC)is one of t.e most.frequent.y diagnosed cancers and t.e leading cause of cancer-associat.d *** st.dies have shown t.at.bot. genet.c and environment.l risk fact.rs cont.ibut. t. t.e development.of *** met.genomic st.dies of CRC have ident.fied gut.dysbiosis as a fundament.l risk fact.r in t.e evolut.on of colorect.l *** enormous effort. and subst.nt.al progresses have been made in underst.nding t.e relat.onship bet.een human gut.microbiome and CRC,t.e precise mechanisms involved remain *** dat. have shown a direct.causat.ve role of t.e gut.microbiome in DNA damage,inflammat.on,and drug resist.nce in CRC,suggest.ng t.at.modulat.on of gut.microbiome could act.as a powerful t.ol in CRC prevent.on and ***,we provide an overview of t.e relat.onship bet.een gut.microbiome and CRC,and explore relevant.mechanisms of colorect.l *** next.highlight.t.e pot.nt.al of bact.rial species as clinical biomarkers,as well as t.eir roles in t.erapeut.c *** limit.ng t.e clinical t.anslat.on of gut.microbiome and st.at.gies for resolving current.challenges are furt.er discussed.

关键词： Gut.microbiome Colorect.l cancer Diagnost.c biomarker Immunot.erapy Chemot.erapy

具有再生能力和交配型稳定性的香菇原生质体的高产制备

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国外生物科技 1989年第1期 52-56页

作者： kawa.,t. 周伏忠

Phosphat. Rock Fert.lizer in Acid Soils: Comparing Phosphat. Ext.act.on Met.ods for Measuring Dissolut.on

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Pedosphere 1998年第3期8卷 273-279页

作者： t. S. ANSUMANA kawa and WANG GUANGHUO Depart.ent.of Soil Science and Applied Chemist.y, College of Nat.ral Resources and Environment.l Sciences, Zhejiang Agricult.ral Universit., Hangzhou 310029 (China) (Received March 13, 1998 revised April 22, 199 Depart.ent.of Soil Science and Applied Chemist.y College of Natural Resources and Environmental Sciences Zhejiang Agricultural University Hangzhou 310029 China

t.ree phosphat. ext.act.on met.ods were used t. invest.gat. t.e dissolut.on, availabilit. and t.ansformat.on of Kunyang phosphat. rock (KPR) in t.o surface acid soils. Dissolut.on was det.rmined by measuring t.e increase in t.e amount. of soluble and adsorbed inorganic phosphat. fract.ons, and did not.differ significant.y among t.e t.ree met.ods. Significant.correlat.ons were obt.ined among P fract.ons got.by t.e t.ree ext.act.on met.ods. Dissolut.on cont.nued unt.l t.e end of t.e 90 day incubat.on period. At.t.e end of t.e period, much of t.e applied phosphat. recovered in bot. soils were in t.e Al and Fe P or in t.e hydroxide and bicarbonat. ext.act.ble inorganic P fract.ons. t.e dissolut.on of KPR in t.e t.o soils was also similar: increased addit.on of phosphat. rock result.d in decreased dissolut.on. t.e similarit. in t.e order and ext.nt.of dissolut.on in t.e t.o soils was probably due t. t.e similarit. in each soil of several fact.rs t.at.are known t. influence phosphat. rock dissolut.on, namely low CEC, pH, P level, and base st.t.s; and high clay and free iron and aluminum oxide cont.nt.. t.e result. suggest.d t.at.KPR could be an alt.rnat.ve P source in t.e long, if not.t.e short. t.rm in t.e soils, provided t.at.t.ose fact.rs influencing P availabilit. in t.e soils are not.limit.ng.

关键词： alt.rnat.ve source of phosphat. fract.onat.on phosphat. rock

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分离遗传与环境对儿童发展的影响:介绍一个新颖的研究方法(英文)

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心理学报 2008年第10期40卷 1124-1134页

作者： Gordon t. Harold Kat.erine H. Shelt.n Frances Rice Jacky Boivin Dale hay Marianne Van Den Bree Anit. t.apar School of Psychology Cardiff UniversityUnited Kingdom Depart.ent.of Psychological Medicine School of MedicineCardiff UniversityUnited Kingdom

本文介绍一个可以用于研究遗传与环境互动的新颖方法。此研究收集了上千个4～10岁儿童的数据。这些儿童的出生都借助于不同的辅助受孕技术（Assist.d Reproduct.ve t.chnologies），包括试管婴儿、精子捐赠、卵子捐赠、胚胎捐赠及代孕... 详细信息

本文介绍一个可以用于研究遗传与环境互动的新颖方法。此研究收集了上千个4～10岁儿童的数据。这些儿童的出生都借助于不同的辅助受孕技术（Assist.d Reproduct.ve t.chnologies），包括试管婴儿、精子捐赠、卵子捐赠、胚胎捐赠及代孕技术。本项目通过妇科（助孕）医院收集被试的行为数据，包括家庭互动、养育方式、父母婚姻质量、家庭成员的心理健康及经济状况等。本文选择性地介绍一些分析的结果，以彰显这种设计在分离遗传和产前产后环境对儿童发展的贡献。首先，我们比较了“助孕”儿童与“自然孕”儿童在父母冲突、父母对子女敌意以及儿童抑郁症状之间关系的异同。其次，我们比较了这两组儿童在父母抑郁症状、家庭关系质量以及儿童抑郁症状之间关系的异同。再次，本文介绍了这一可分离遗传与环境因素的研究设计。最后，我们讨论了这一设计对发展心理病干预及预防的意义。

关键词：辅助受孕技术家庭关系遗传与环境互动

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自身免疫性胰腺炎中发现的皮质激素反应性胰腺囊肿

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世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 29-30页

作者： Muraki t. Hamano H. Ochi Y. S. kawa 赵萌 Depart.ent.of Medicine Gastroenterology Shinshu University School of Medicine 3- 1- 1 Asahi Matsumoto 390- 8621 Japan

t.ere have been only a few report. of aut.immune pancreat.t.s complicat.d wit. pancreat.c cyst.and such cyst. are rare, probably due t. t.e absence of severe t.ssue necrosis and/or lack of st.sis of t.e pancreat.c juice in t.is condit.on. However, during a follow- up of 48 pat.ent. wit. t.is disease, we found 3 pat.ent. wit. pancreat.c cyst., and t.is enabled us t. evaluat. t.eir clinicopat.ological findings. Bet.een Sept.mber 1994 and July 2003, we t.eat.d and followed 48 pat.ent. wit. aut.immune pancreat.t.s, and found 3 pat.ent. wit. pancreat.c cyst.format.on t.at.was responsive t. cort.cost.roid t.erapy. All of t.e pat.ent. wit. cyst. had high serum IgG4 concent.at.ons. Aft.r cort.cost.roid t.erapy, rapid resolut.on of t.e pancreat.c cyst. was observed. Immunost.ining wit. goat.polyclonal ant.body for each IgG subclass showed severe infilt.at.on of IgG4- posi- t.ve plasma cells in t.e cyst.wall in one pat.ent. t.e high serum IgG4 concent.at.on and favorable response t. cort.cost.roid t.erapy suggest. t.at.a highly act.ve st.t. of t.e inflammat.ry process is closely associat.d wit. cyst.format.on, and t.at.a cort.cost.roid- responsive pancreat.c cyst.is a charact.rist.c feat.re of aut.immune pancreat.t.s.

关键词：胰腺囊肿皮质激素囊肿壁 IgG 免疫染色病理检查活性状态

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Sequent.al Remediat.on Processes for a Low Level Pest.cide Wast.wat.r

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Journal of Environment.l Prot.ct.on 2012年第2期3卷 150-163页

作者： Mariam t. Al hat.ab Abdel E. Ghaly Depart.ent.of Process Engineering and Applied Sciences Faculty of Engineering Dalhousie University Halifax Canada

t.e aim of t.is st.dy was t. develop a remediat.on syst.m for t.e t.eat.ent.of a low-level pest.cide wast.wat.r t.at.uses available onfarm organic mat.er as an absorpt.on media, is capable of reducing t.e concent.at.on of t.e pest.cide t. a safe level and is economically viable for implement.t.on by farmers. t.e absorpt.on capacit. of chopped hay and soybean t. t.e fungicide capt.n was evaluat.d under bat.h condit.ons and t.e effect.veness of t.e compost.ng process in depredat.ng capt.n in cont.minat.d organic mat.rials was evaluat.d. t.e result. showed t.at.bot. hay and soybean plant.residues were very effect.ve in absorbing 99.2% and 98.5% of capt.n form t.e wast.wat.r aft.r 4 hours, respect.vely. Because of it. availabilit., hay can be used in an onfarm pest.cide immobilizat.on syst.m t.at.consist. of shallow reinforced concret. pit.(filled wit. hay) wit. st.el bars across t.e t.p for machinery t. roll ont. and be washed. t.e wast.wat.r can be ret.ined for 24 hours which is a sufficient.t.me for hay t. absorb t.e capt.n. t.e cont.minat.d hay can t.en be compost.d. t.e addit.on of used cooking oil raised t.e t.mperat.re of t.e compost.ng mixt.re t. 63?C. Small reduct.ons in moist.re cont.nt.(from 60% t. 58.9 %) and C:N rat.o (from 30:1 t. 28:1) were observed while reduct.ons of 18.92%, 15.56% and 4.8% in t.e volat.le solids, t.t.l carbon t.t.l Kjeldahl nit.ogen were achieved aft.r 10 d of compost.ng, respect.vely. About.92.4% of t.e capt.n was degraded in t.e first.4 days of compost.ng. Most.of capt.n (92.4%) was degraded during t.e mesophilic st.ge (first.3 days). t.e degradat.on rat. const.nt.for t.e mesophilic st.ge (0.724 d-1) was 2.74 t.mes t.e degradat.on rat. const.nt.for t.e t.ermophilic st.ge (0.264 d-1). An onfarm windrow compost.ng process would be very effect.ve in degrading capt.n cont.minat.d hay. t.e capt.n cont.minat.d hay could be mixed wit. equal amount.poult.y manure or dairy manure t. provide t.e required bioavailable carbon and nut.ient. for t

关键词： Pest.cide Capt.n Soybeans hay Absorpt.on Immobilizat.on Degradat.on Compost.ng

Carboxyl Est.r Lipase Prot.ct. Against.Met.bolic Dysfunct.on-Associat.d St.at.hepat.t.s by Binding t. Fat.y Acid Synt.ase

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Engineering 2024年第10期41卷 204-215页

作者： Yang Song Wei Zhong Harry Cheuk-hay Lau Yat.ng Zhang Huayu Guan Mingxu Xie Suki Ha Diwen Shou Yongjian Zhou Hongzhi Xu Jun Yu Xiang Zhang Depart.ent.of Medicine and t.erapeut.cs Institute of Digestive DiseaseState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong 999077China Shenzhen Research Inst.t.t. The Chinese Unviersity of Hong KongShenzhen 518057China Depart.ent.of Gast.oent.rology&Inst.t.t. for Microbial Ecology&Xiamen Key Laborat.ry of Int.st.nal Microbiome and Human Healt.&Clinical Research Cent.r for Gut.Microbiot. and Digest.ve Diseases of Fujian Province Zhongshan Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361004China Division of Gast.oent.rology and Hepat.logy Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200025China Depart.ent.of Gast.oent.rology and Hepat.logy Guangzhou Digestive Disease CenterGuangzhou First People’s HospitalGuangzhou 510180China

Carboxyl est.r lipase(CEL),a pivot.l enzyme involved in lipid met.bolism,is recurrent.y mut.t.d in obese ***,we aimed t. elucidat. t.e funct.onal significance,molecular mechanism,and t.erapeut.c pot.nt.al of CEL in met.bolic dysfunct.on-associat.d st.at.hepat.t.s(MASH).Hepat.cyt.-specific carboxyl est.r lipase gene(Cel)knockout.Cel^(DHEP))and wildt.pe(Wt.lit.ermat.s were fed wit. cholinedeficient.high-fat.diet.CD-HFD)for 16 weeks,or met.ionine-and choline-deficient.diet.MCD)for t.ree weeks t. induce *** chromat.graphy–mass spect.omet.y and co-immunoprecipit.t.on were employed t. ident.fy t.e downst.eam t.rget. of ***-HFD/MCD-fed Wt.mice received int.avenous inject.ons of CEL-adeno-associat.d viral,serot.pe 8(AAV8)t. induce specific overexpression of CEL in t.e *** observed a decrease in CEL prot.in levels in MASH induced by CD-HFD or MCD in ***^(DHEP) mice fed wit. CD-HFD or MCD exhibit.d pronounced hepat.c st.at.sis,inflammat.on,lipid peroxidat.on,and liver injury compared t. Wt.lit.ermat.s,accompanied by increased hepat.c nuclear fact.r kappa-light.chain-enhancer of act.vat.d B cell(NF-jB)***,Cel knockdown in mouse primary hepat.cyt.s and AML12 cells aggravat.d lipid accumulat.on and inflammat.on,whereas CEL overexpression exert.d t.e opposit. ***,CEL direct.y bound t. fat.y acid synt.ase(FASN),result.ng in reduced FASN SUMOylat.on,which in t.rn promot.d FASN degradat.on t.rough t.e prot.asome ***,inhibit.on of FASN ameliorat.d hepat.cyt. lipid accumulat.on and inflammat.on induced by Cel knockdown in vivo and in ***-specific CEL overexpression using AAV8-Cel significant.y mit.gat.d st.at.hepat.t.s in mice fed wit. CD-HFD or *** prot.ct. against.st.at.hepat.t.s development.by direct.y int.ract.ng wit. FASN and suppressing it. expression for de novo *** overexpression confers a t.erapeut.c benefit.in st.at.hepat.t.s.

关键词： Met.bolic dysfunct.on-associat.d st.at.hepat.t.s Carboxyl est.r lipase Fat.y acid synt.ase De novo lipogenesis t.eat.ent

t.me Est.mat.on in Development.l Dyslexia: An Experiment.l Invest.gat.on

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Open Journal of Medical Psychology 2014年第5期3卷 373-381页

作者： Azizuddin Khan Abdalla Abdal-hay t.bassum Qazi Claudio López Calle Rut. Clavijo Cast.llo Psychophysiology Laborat.ry Department of Humanities and Social Sciences Indian Institute of Technology Bombay Mumbai India Facult.d de Psicología Universidad de Cuenca Cuenca Ecuador Engineering Mat.rials and Mechanical Design Faculty of Engineering South Valley University Qena Egypt Depart.ent.of Psychology S.N.D.T University Churchgate Mumbai India

t.me est.mat.on is t.e abilit. t. judge t.e durat.on or apprehend t.e passage of t.me by t.e order of occurrence of experience or by physiological rhyt.m (Fraisse, 1984). It.plays quit. a significant.role in language disorder especially development.l dyslexia. It.is charact.rized by deficit. in phonological processing abilit.es. However, it.is unclear what.t.e underlying fact.rs for poor phonological abilit.es or speech sound represent.t.ons are. t.e deficit.in phonological processes has been for t.e processing of paired t.nes or t.mporal sequences different.when relat.vely short.t.me int.rvals are used in individuals wit. dyslexia compared t. t.pical readers. t.is paper present. t.e result. of a st.dy t.at.was undert.ken t. det.rmine t.e effect. of met.od of t.me judgment. and paradigm on dyslexic and at.pical readers. An experiment.was conduct.d using 115 children (age: M = 12.23 years, SD = 1.30), 51 dyslexics and 64 t.pical readers. t.e dat. were obt.ined t.rough t.e met.od of verbal est.mat.on and reproduct.on. Analysis of variance was used t. analyse t.e dat.. t.me judgment. dat. were analyzed using direct.onal error. For direct.onal error, all t.e main effect. and few int.ract.ons were significant. Children wit. dyslexia showed more errors in t.me est.mat.on (M = 0.59, SD = 0.52) as compared t. t.pical readers (M = 0.83, SD = 0.74). Est.mat.on of durat.on under t.e prospect.ve paradigm was more accurat. t.an under t.e ret.ospect.ve paradigm for bot. dyslexics and t.pical readers. However, dyslexics were more error prone as compared t. t.pical readers. t.me judgment.was accurat. under verbal t.me est.mat.on as compared t. reproduct.on met.od.

关键词： Durat.on Language Disorder Phonological Deficit t.pical Reader