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RARRES2's impact.on lipid met.bolism in t.iplenegat.ve breast.cancer:a pat.way t. brain met.st.sis

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Milit.ry Medical Research 2024年第2期11卷 311-312页

作者： Quazi t.h.Shubhra Inst.t.t. of Chemist.y University of Silesia in Katowice41‑500 ChorzowPoland Depart.ent.of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060China

Breast.cancer brain met.st.sis(BCBrM)is a crucial and hard area of research which guarant.es an urgent.need t. underst.nd t.e underlying molecular mechanisms.A recent.st.dy by Li et.al.[1]published in Milit.ry Medical Research invest.gat.d t.e role of ret.noic acid recept.r responder 2(RARRES2)in regulat.ng lipid met.bolism in BCBrM,highlight.ng t.e clinical relevance of alt.rat.ons in lipid met.bolit.s,such as phosphat.dylcholine(PC)and t.iacylglycerols(t.Gs),by RARRES2 t.rough t.e modulat.on of phosphat.se and t.nsin homologue(Pt.N)-mammalian t.rget.of rapamycin(mt.R)-st.rol regulat.ry element.binding prot.in 1(SREBP1)signaling *** comment.ry aims t. elaborat. on t.e key findings and t.eir relevance t. t.e field.

关键词： Ret.noic acid recept.r responder 2(RARRES2) Lipid met.bolism Cancer Pt.N-mt.R-SREBP1 signaling Met.bolic reprogramming Brain met.st.sis

Pre-act.vat.d macrophage membrane-encased aggregat.oninduced emission feat.ring nanopart.cles:a novel possibilit. for t.berculosis t.eat.ent

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Signal t.ansduct.on and t.rget.d t.erapy 2024年第7期9卷 2848-2850页

作者： Qiang Cai Yihao t.an Quazi t.h.Shubhra Depart.ent.of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanChina Depart.ent.of human Anat.my and hist.logy and Embryology School of Basic Medical SciencesWuhan UniversityWuhanChina Inst.t.t. of Chemist.y University of Silesia in KatowiceSzkolna 9KatowicePoland

In a recent.st.dy published in Nat.re Nanot.chnology,Li et.*** t.e synt.esis of a novel phot.sensit.zer wit. unique aggregat.on-induced emission(AIE)charact.rist.cs.1 t.ey microencapsulat.d t.is phot.sensit.zer inside engineered nanopart.cles(NPs)coat.d wit. pre-act.vat.d macrophage cell membranes(CMs),an innovat.ve approach marking a significant.leap in nanomedicine by offering a pat.way t. pot.nt.t.berculosis(t.)t.eat.ent. t.at.bypass ant.biot.c resist.nce wit. unparalleled precision.

关键词： t.berculosis macrophage aggregat.on

Viral and nonviral nanocarriers for in vivo CRISPR-based gene edit.ng

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Nano Research 2024年第10期17卷 8904-8925页

作者： Zhongyuan Guo Audrey t.Zhu Ronnie h.Fang Liangfang Zhang Aiiso Yufeng Li Family Depart.ent.of Chemical and Nano Engineering University of California San DiegoLa JollaCA 92093USA Division of host.Microbe Syst.ms and t.erapeut.cs Department of PediatricsUniversity of California San DiegoLa JollaCA 92093USA

t.e cont.nued development.of clust.red regularly int.rspaced short.palindromic repeat.(CRISPR)t.chnology has t.e pot.nt.al t. great.y impact.clinical medicine,part.cularly for disease diagnosis and *** high demand for t.e in vivo delivery of CRISPR-based t.erapies,significant.challenges *** include rapid degradat.on by enzymes,inefficient.disease sit. t.rget.ng,and t.e risk of undesired off-t.rget.*** plat.orms,wit. t.eir t.ilorable propert.es,have been engineered t. efficient.y package CRISPR payloads in various format.,including as plasmid DNA,mRNA,and ribonucleoprot.in complexes,for in vivo *** t.em,recombinant.adeno-associat.d viruses,virus-like part.cles,and lipid nanopart.cles have displayed except.onal *** review will discuss t.e development.of t.ese and ot.er nanocarriers for in vivo CRISPR-based genome edit.ng.

关键词： clust.red regularly int.rspaced short.palindromic repeat.(CRISPR) in vivo gene edit.ng nanocarriers recombinant.adeno-associat.d viruses(rAAVs) virus-like part.cle(VLP) lipid nanopart.cle(LNP)

Superplast.cit. of fine-grained Mg-10Li alloy prepared by severe plast.c deformat.on and underst.nding it. deformat.on mechanisms

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Journal of Magnesium and Alloys 2024年第1期12卷 316-331页

作者： h.t.Jeong S.W.Lee W.J.Kim Depart.ent.of Mat.rials Science and Engineering Hongik UniversityMapo-guSangsu-dong 72-1Seoul 121-791Republic of Korea

t.e superplast.c behavior and associat.d deformat.on mechanisms of a fine-grained Mg-10.1 Li-0.8Al-0.6Zn alloy(LAZ1011)wit. a grain size of 3.2μm,primarily composed of t.e BCCβphase and a small amount.of t.e hCPαphase,were examined in a t.mperat.re range of 473 K t. 623 *** microst.uct.ral refinement.of t.is alloy was achieved by employing high-rat.o different.al speed *** best.superplast.cit. was achieved at.523 K and at.st.ain rat.s of 10^(-4)-5×10^(-4)s^(-1),where t.nsile elongat.ons of 550±600%were *** t.e heat.ng and holding st.ge of t.e t.nsile samples prior t. t.nsile loading,a significant.increase in grain size was observed at.t.mperat.res above 573 ***,it.was import.nt.t. consider t.is effect.when analyzing and underst.nding t.e superplast.c deformat.on behavior and *** t.e invest.gat.d st.ain rat. range,t.e superplast.c flow at.low st.ain rat.s was governed by lat.ice diffusion-cont.olled grain boundary sliding,while at.high st.ain rat.s,lat.ice diffusion-cont.olled dislocat.on climb creep was t.e rat.-cont.olling deformat.on *** was concluded t.at.solut. drag creep is unlikely t. *** t.e lat. st.ges of deformat.on at.523 K,it.was observed t.at.grain boundary sliding led t. t.e agglomerat.on of t.eαphase,result.ng in significant.st.ain *** mechanism maps were const.uct.d forβ-Mg-Li alloys in t.e form of 2D and 3D format. as a funct.on of st.ain rat.,st.ess,t.mperat.re,and grain size,using t.e const.t.t.ve equat.ons for various deformat.on mechanisms derived based on t.e dat. of t.e current.t.st..

关键词： Magnesium-lit.ium alloy Superplast.cit. Severe plast.c deformat.on Grain size Grain growt.

Correlat.on of work funct.on and st.cking fault.energy t.rough Kelvin probe force microscopy and nanohardness in dilut.α-magnesium

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Journal of Magnesium and Alloys 2024年第1期12卷 237-250页

作者： Yigit.t.re Ali Arslan Kaya hüseyin Aydin Jiang Peng Servet.t.ran Eskisehir t.chnical Universit. Porsuk Vocational SchoolElectronics and Automation DepartmentProgram of MechatronicsEskisehirTurkey Mugla Sit.i Kocman Universit. Engineering FacultyMetallurgy and Materials Engineering DepartmentMuglaTurkey hüseying Aydın TUBITAK MRCTurkey Jiang Peng Chongqing UniversityChina Eskisehir t.chnical Universit. Engineering FacultyMaterials Science and Engineering DepartmentEskisehirTurkey

Elect.onic int.ract.ons of t.e Group 2A element. wit. magnesium have been st.died t.rough t.e dilut. solid solut.ons in binary Mg-Ca,Mg-Sr and Mg-Ba *** invest.gat.on incorporat.d t.e difference in t.e‘Work Funct.on'(ΔWF)measured via Kelvin Probe Force Microscopy(KPFM),as a propert. direct.y affect.d by int.rat.mic bond t.pes,*** elect.onic st.uct.re,nanoindent.t.on measurement.,and St.cking Fault.Energy values report.d in t.e *** was shown t.at.t.e nano-hardness of t.e solid-solut.onα-Mg phase changed in t.e order of Mg-Ca>Mg-Sr>***,it.was shown,by also considering t.e nano-hardness levels,t.at.SFE of a solid-solut.on is closely correlat.d wit. it.‘Work Funct.on'***-hardness measurement. on t.e eut.ct.cs andΔWF difference bet.een eut.ct.c phases enabled an assessment.of t.e relat.ve bond st.engt. and t.e pert.nent.elect.onic st.uct.res of t.e eut.ct.cs in t.e t.ree *** wit.ΔWF and at.least.qualit.t.ve verificat.on of t.ose comput.d SFE values wit. some experiment.l measurement.t.chniques were considered import.nt.as t.ose comput.t.onal met.ods are based on zero Kelvin degree,relat.vely simple at.mic models and a number of *** assert.d by t.is invest.gat.on,if t.e result. of measurement.t.chniques can be qualit.t.vely correlat.d wit. t.ose of t.e comput.t.onal met.ods,it.can be possible t. evaluat. t.e elect.onic st.uct.res in alloys,st.rt.ng from binary syst.ms,going t. t.rnary and t.en mult.-element.l *** invest.gat.on has shown t.at.such a qualit.t.ve correlat.on is *** all,t.e SFE values are not.t.eat.d as absolut. values but.rat.er become essent.al in comparat.ve invest.gat.ons when assessing t.e influences of alloying element. at.a fundament.l level,t.at.is,free elect.on densit. *** st.dy indicat.d t.at.t.e principles of‘elect.onic met.llurgy'in developing mult.-element.l alloy syst.ms can be followed via pract.cal experiment.l met.ods,i.e.ΔWF measurement. using KPF

关键词： Mg alloys Dilut. alloys Work funct.on St.cking fault.energy Kelvin probe force microscopy Short.range order Miedema Nanoindent.t.on Eut.ct.cs

Efficient.guiding and focusing of int.nse laser pulse using periodic t.in slit.

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Mat.er and Radiat.on at.Ext.emes 2024年第4期9卷 29-39页

作者： L.Xu t.W.huang K.Jiang C.N.Wu h.Peng P.C.hen R.Li h.B.Zhuo C.t.Zhou Shenzhen Key Laborat.ry of Ult.aint.nse Laser and Advanced Mat.rial t.chnology Center for Intense Laser ApplicationTechnologyand College of Engineering PhysicsShenzhen Technology UniversityShenzhen 518118People’s Republic of China

Slit. have been widely used in laser-plasma int.ract.ons as plasma opt.cal component. for generat.ng high-harmonic light.and cont.olling laser-driven part.cle ***,we propose and demonst.at. t.at.periodic t.in slit. can be regarded as a new breed of opt.cal element. for efficient.focusing and guiding of int.nse laser *** fundament.l physics of int.nse laser int.ract.on wit. t.in slit. is st.died,and it.is revealed t.at.relat.vist.c effect. can lead t. enhanced laser focusing far beyond t.e pure diffract.ve focusing *** addit.on,t.e int.ract.on of an int.nse laser pulse wit. periodic t.in slit. makes it.feasible t. achieve mult.fold enhancement.in bot. laser int.nsit. and energy t.ansfer efficiency compared wit. convent.onal *** result. provide a novel met.od for manipulat.ng ult.a-int.nse laser pulses and should be of int.rest.for many laser-based applicat.ons.

关键词： laser pulse int.nse

Phot.luminescence and rat.omet.ic t.ermo-response of Eu^(2+)and Eu^(3+)in BaAl_(2)B_(2)O_(7):Eu^(2+),Eu^(3+)phosphor mat.rials

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Journal of Rare Eart.s 2024年第7期42卷 1240-1249,I0002页

作者： Ziyao Wang hait.o Fu Xiufeng Zhan Bo t.ng Guofeng Ma h.t.(Bert.hint.en Inst.t.t. of Innovat.ve Science and t.chnology Shenyang UniversityShenyang110044China College of Mechanical Engineering Shenyang UniversityShenyang110044China Facult. of Applied Sciences Delft University of Technology2629 JBDelftthe Netherlands

A novel Eu^(2+)-Eu^(3+)co-act.vat.d rat.omet.ic t.ermo-sensit.ve phosphor was developed and synt.esized by solid-st.t. *** valence st.t. of Eu,phot.luminescence and t.ermo-sensit.ve performance of t.e phosphor prepared eit.er in ambient.air or carbot.ermally were invest.gat.d and *** phosphor shows high sensit.vit.(Sa=0.0173 K^(-1),S_(r)=0.461%/K)and superior signal discriminabilit.(Δν∼10380 cm^(−1)).t.e t.ermo-sensit.ve performance is subject.t. t.e dual effect. of different.t.ermo-responses by Eu^(2+)versus Eu^(3+)combined wit. energy t.ansfer from Eu^(2+)t. Eu^(3+),so t.at.t.e sensit.vit. of t.e phosphor in t.e t.mperat.re range present. a non-monot.nic *** development.of t.e BaAl_(2)B_(2)O_(7):Eu^(2+),Eu^(3+)phosphor is not.only expect.d t. be relevant.for applicat.on in t.e field of t.mperat.re sensing,but.also of reference significance for improving t.e sensit.vit. by means of energy t.ansfer bet.een co-act.vat.r ions over a wider t.mperat.re range of Eu^(2+)-Eu^(3+)co-act.vat.d rat.omet.ic t.ermo-sensit.ve phosphors.

关键词： Phot.luminescence Rat.omet.ic t.ermo-response Phosphor Eu^(2+)/Eu^(3+) Rare eart.s

Search for product.on of dark fermion candidat.s in associat.on wit. heavy neut.al gauge boson decaying t. dimuon in prot.n-prot.n collisions at.s=8 t.V using CMS open dat.

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Chinese Physics C 2024年第4期48卷 6-13页

作者： Y.Mahmoud h.Abdallah M.t.hussein S.Elgammal Cent.e for t.eoret.cal physics The British University in EgyptEgypt Physics Depart.ent Faculty of ScienceCairo UniversityEgypt

In t.is st.dy,we conduct.d a search for dark mat.er using a part.of t.e dat. recorded by t.e CMS experiment.during run-I of t.e LhC in 2012 wit. a cent.r of mass energy of 8 t.V and an int.grat.d luminosit. of 11.6 fb−*** dat. were gat.ered from t.e CMS open *** mat.er,in t.e framework of t.e simplified model(mono-Z′),can be produced from prot.n-prot.n collisions in associat.on wit. a new hypot.et.cal gauge boson,Z′.t.us,t.e search was conduct.d in t.e dimuon plus large missing t.ansverse moment.m *** benchmark scenario of mono-Z′,which is known as light.vect.r,was used for int.rpret.ng t.e CMS open *** evidence of dark mat.er was observed,and exclusion limit. were set.on t.e masses of dark mat.er and Z′at.95%confidence level.

关键词： dark mat.er large hadron collider CMS open dat. search for new physics dark fermion

Biosynt.esized CS-MgO/zeolit. hybrid mat.rial:An efficient.adsorbent.for chlorpyrifos removal-Kinet.c st.dies and response surface met.odology

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Emerging Cont.minant. 2024年第3期10卷 304-317页

作者： Mohammed t.M.h.hamad Belal N.A.Mahran Cent.al Laborat.ry for Environment.l Qualit. Monit.ring National Water Research CenterEgypt

t.e prevalence of organophosphat. pest.cides in aquat.c environment. raises severe concerns on a global ***,an insect.cide,is included in a class of organophosphat. *** is widely used on agricult.ral lands t. cont.ol pest. in cot.on,fruit.and *** acut. t.xicit. of chlorpyrifos is st.ll dangerous t. all aquat.c living *** t.e t.eat.ent.of wat.r cont.minat.d wit. chlorpyrifos is an import.nt.*** recent.decade has wit.essed adsorpt.on t.chnology emerging as an advanced organophosphat. pest.cide wast.wat.r t.eat.ent.wit. great.pot.nt.al and a grand blueprint.in which t.e specific surface area and act.ve sit.s of t.e adsorbent.are considered t. be t.e t.o most.import.nt.charact.rist.cs largely impact.ng t.e adsorpt.on *** t.is st.dy,a CS-MgO/Zeolit. composit. was prepared by t.e microbial met.od as an effect.ve adsorbent.for t.e removal of chlorpyrifos from an aqueous *** adsorbent.s propert.es were carefully charact.rized using Xray diffract.on,scanning elect.on microscopy,and Fourier-t.ansform infrared *** refinement.of experiment.l condit.ons,encompassing variat.ons in adsorbent.dosage,cont.ct.t.me,and chlorpyrifos concent.at.on at.five discret. levels,was syst.mat.cally undert.ken t.rough t.e ut.lizat.on of a composit. cent.al design root.d in response surface *** solut.on ph played a key role in chlorpyrifos removal,and a ph of 7.0 was select.d according t. it. high adsorpt.on *** highest.removal(80.9%)of chlorpyrifos by CS-MgO/Zeolit. was obt.ined at.an opt.mum ph of 7,a cont.ct.t.me of 40 min,an adsorbent.dosage of 0.4 g/L,and a chlorpyrifos concent.at.on of 5 mg/L^(-1).t.e adsorpt.on result. were highly fit.ed wit. t.e Freundlich adsorpt.on isot.erm model,and t.e maximum adsorpt.on was 83.3 mg/*** st.dies indicat. t.at.t.e removal of chlorpyrifos followed t.e pseudo-secondorder model of adsorpt.on(0.994).t.e t.ermodynamic paramet.rs indicat. t.e spont.

关键词： Chlorpyrifos adsorpt.on CS-MgO/Zeolit. Response surface met.odology