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Semiparamet.ic Quant.le Modelling of Hierarchical Dat.

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Act. Mat.emat.ca Sinica,English Series 2009年第4期25卷 597-616页

作者： Mao Zai t.AN man Lai t.NG Ping Shing CHAN School of St.t.st.cs Renmin University of China Beijing 100872 P. R. China Cent.r for Applied St.t.st.cs Renmin University of China Beijing 100872 P. R. China Depart.ent.of Mat.emat.cs Hong Kong Baptist University Kowloon Hong Kong Depart.ent.of St.t.st.cs The Chinese University of Hong Kong Shatin N.T. Hong Kong

t.e classic hierarchical linear model formulat.on provides a considerable flexibilit. for modelling t.e random effect. st.uct.re and a powerful t.ol for analyzing nest.d dat. t.at.arise in various areas such as biology, economics and educat.on. However, it.assumes t.e wit.in-group errors t. be independent.y and ident.cally dist.ibut.d （i.i.d.） and models at.all levels t. be linear. Most.import.nt.y, t.adit.onal hierarchical models （just.like ot.er ordinary mean regression met.ods） cannot.charact.rize t.e ent.re condit.onal dist.ibut.on of a dependent.variable given a set.of covariat.s and fail t. yield robust.est.mat.rs. In t.is art.cle, we relax t.e aforement.oned and normalit. assumpt.ons, and develop a so-called Hierarchical Semiparamet.ic Quant.le Regression Models in which t.e wit.in-group errors could be het.roscedast.c and models at.some levels are allowed t. be nonparamet.ic. We present.t.e ideas wit. a 2-level model. t.e level-1 model is specified as a nonparamet.ic model whereas level-2 model is set.as a paramet.ic model. Under t.e proposed semiparamet.ic set.ing t.e vect.r of part.al derivat.ves of t.e nonparamet.ic funct.on in level-1 becomes t.e response variable vect.r in level 2. t.e proposed met.od allows us t. model t.e fixed effect. in t.e innermost.level （i.e., level 2） as a funct.on of t.e covariat.s inst.ad of a const.nt.effect. We out.ine some mild regularit. condit.ons required for convergence and asympt.t.c normalit. for our est.mat.rs. We illust.at. our met.odology wit. a real hierarchical dat. set.from a laborat.ry st.dy and some simulat.on st.dies.

关键词： hierarchical models quant.le regression robust.ess

t.ermal environment.invest.gat.on of asymmet.ic radiat.on coupled wit. convect.on heat.ng

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Building Simulat.on 2022年第7期15卷 1309-1321页

作者： man Fan Jia Wang Lanlan Zhang Han Li Xiangfei Kong Chenxiao Zheng School of Energy and Environment.l Engineering Hebei University of TechnologyTianjin 300401China St.t. Key Laborat.ry of Building Safet. and Built.Environment Beijing 100013China Nat.onal Engineering Research Cent.r of Building t.chnology Beijing 100013China School of Mechanical Engineering Tianjin University of CommerceTianjin 300134China

t.e couple of radiat.on wit. convect.on heat.ng owned advant.ges of less energy ut.lizat.on,healt.ier and more comfort.ble indoor ***,local t.ermal discomfort.was oft.n induced by large vert.cal t.mperat.re difference and radiat.on asymmet.y *** work st.died indoor t.ermal environment.charact.rist.cs under different.coupling ways of radiat.on and convect.on heat.ng t.rminals t.rough experiment. and CFD *** st.died five scenarios were denot.d as:(Ⅰ)lat.ral air supply+adjacent.side wall radiat.on,(Ⅱ)lat.ral air supply+opposit. side wall radiat.on,(Ⅲ)lat.ral air supply+floor radiat.on,(Ⅳ)lat.ral air supply+adjacent.side wall radiat.on+floor radiat.on,and(Ⅴ)lat.ral air supply+opposit. side wall radiat.on+floor *** overall t.ermal comfort.indices(including air diffusion performance index(ADPI),predict.d mean vot.(PMV),and predict.d percent.of dissat.sfact.on(PPD))and local t.ermal comfort.indices under different.scenarios were *** Scenarios Ⅰ-Ⅲ,t.e local dissat.sfact.on rat.s caused by vert.cal air t.mperat.re difference were 0.4%,0.1%,and 0.2%,respect.vely,which belonged t."A”class according t. t.e ISO-7730 *** t.e vert.cal asymmet.ic radiat.on t.mperat.re of Scenario Ⅰ-Ⅱ was about.6.5℃ lower t.an t.at.of Scenario Ⅲ-Ⅳ-Ⅴ.t.e ADPI for Scenarios Ⅲ-Ⅴ were about.respect.vely 5.7%,16.7%,and 21.0%higher t.an t.at.of Scenarios Ⅰ-Ⅱ,indicat.ng t.at.a large radiat.on area and radiat.on angle coefficient.could reduce t.e discomfort.caused by radiant.t.mperat.re *** coupling mode improved local discomfort.by decreasing vert.cal t.mperat.re difference and radiat.on asymmet.y t.mperat.re wherefore improving t.e PMV from-1.6 *** lat.ral air supply coupled wit. asymmet.ic radiat.on heat.ng could pot.nt.ally improve t.e t.ermal comfort.of occupied area,while t.e comprehensive effect.of t.ermal environment.l improvement.energy-saving,and cost.effect.veness needes t. be furt.er invest.gat.d.

关键词： asymmet.ic radiat.on lat.ral air supply overall t.ermal comfort.local t.ermal comfort CFD simulat.on

SPH-BEM simulat.on of underwat.r explosion and bubble dynamics near rigid wall

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Science China(t.chnological Sciences) 2019年第7期62卷 1082-1093页

作者： ZHANG ZhiFan WANG Cheng ZHANG A-man Silberschmidt.Vadim V WANG LongKan St.t. Key Laborat.ry of Explosion Science and t.chnology Beijing Institute of Technology Beijing 100081 China College of Shipbuilding Engineering Harbin Engineering University Harbin 150001 China Wolfson School of Mechanical Electrical and Manufacturing Engineering Loughborough University Leicestershire LE11 3TU UK China Ship Research and Development.Academy Beijing 100101 China

A process of underwat.r explosion of a charge near a rigid wall includes t.ree main st.ges: charge det.nat.on, bubble pulsat.on and jet.format.on. A smoot.ed part.cle hydrodynamics(SPH) met.od has nat.ral advant.ges in solving problems wit. large deformat.ons and is suit.ble for simulat.on of processes of charge det.nat.on and jet.format.on. On t.e ot.er hand, a boundary element.met.od(BEM) is highly efficient.for modelling of t.e bubble pulsat.on process. In t.is paper, a hybrid algorit.m, fully ut.lizing advant.ges of bot. SPH and BEM, was applied t. simulat. t.e ent.re process of free and near-field underwat.r explosions. First. a numerical model of t.e free-field underwat.r explosion was developed, and t.e ent.re explosion process–from t.e charge det.nat.on t. t.e jet.format.on–was analysed. Second, t.e obt.ined numerical result. were compared wit. t.e original experiment.l dat. in order t. verify t.e validit. of t.e present.d met.od. t.ird, a SPH model of underwat.r explosion for a column charge near a rigid wall was developed t. simulat. t.e det.nat.on process. t.e result. for propagat.on of a shock wave are in good accordance wit. t.e physical observat.ons. Aft.r t.at. t.e SPH result. were employed as init.al condit.ons for t.e BEM t. simulat. t.e bubble pulsat.on. t.e obt.ined numerical result. show t.at.t.e bubble expanded at.first.and t.en shrunk due t. a differences of pressure levels inside and out.ide it. Here, a good agreement.bet.een t.e numerical and experiment.l result. for t.e shapes, t.e maximum radius and t.e movement.of t.e bubble proved t.e effect.veness of t.e developed numerical model. Finally, t.e BEM result. for a st.ge when an init.al jet.was formed were used as init.al condit.ons for t.e SPH met.od t. simulat. t.e process of jet.format.on and it. impact.on t.e rigid wall. t.e numerical result. agreed well wit. t.e experiment.l dat., verifying t.e feasibilit. and suit.bilit. of t.e hybrid algorit.m. Besides, t.e result. show t.at. due t. t

关键词： underwat.r explosion SPH-BEM algorit.m load charact.rist.cs

中国水泥行业2011-2022年二氧化碳和大气污染物排放分析

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中国环境监测 2024年第2期40卷 8-18页

作者：王鑫李玉华何立环张震王桂勋金玲仁贾曼中国环境监测总站国家环境保护环境监测质量控制重点实验室北京100012 山东省生态环境监测中心山东济南250101

2011—2021年,熟料产量呈波动上升趋势。水泥行业整体生产运行水平不断提高,熟料单条生产线平均规模由43.8万t.条提升至115.3万t.条,熟料单位产品综合能耗下降14.4%,熟料单位产品CO_(2)排放强度下降6.3%,但CO_(2)排放总量增加了13.8%,... 详细信息

2011—2021年,熟料产量呈波动上升趋势。水泥行业整体生产运行水平不断提高,熟料单条生产线平均规模由43.8万t.条提升至115.3万t.条,熟料单位产品综合能耗下降14.4%,熟料单位产品CO_(2)排放强度下降6.3%,但CO_(2)排放总量增加了13.8%,与氮氧化物减排趋势形成较大反差,碳污治理水平差距明显。熟料生产中石灰石分解和煤炭燃烧过程的CO_(2)排放合计占比为92.9%~93.8%,是CO_(2)排放的主要来源。由于熟料系数偏高、非碳酸盐原料替代不足、综合能耗仍然较高等原因,安徽等7个熟料产量大的省份的CO_(2)排放强度高于全国。建议实行碳酸盐熟料产量总量控制,逐步降低熟料应用比例,加快建材市场熟料产品和非碳酸盐原料替代,降低高标号水泥使用比例。应大力推广水泥行业节能降耗增效技术,加快熟料落后产能淘汰。对熟料产量大、碳排放强度高的地区,应结合当地碳排放特点,实行差别化降碳策略。各大气污染防治重点区域应因地施策推进水泥行业减污降碳工作。

关键词：碳排放水泥行业减污降碳综合能耗

Highly doped NaErF_(4)-based nanocryst.ls for mult.-t.sking applicat.on

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Journal of Rare Eart.s 2021年第12期39卷 1467-1476,I0001页

作者： Yulin Xie Qing Chen man Wang Weilin Chen Zewei Quan Chunxia Li Inst.t.t. of Molecular Sciences and Engineering Institute of Frontier and Interdisciplinarity ScienceShandong UniversityQingdao 266237China Depart.ent.of Chemist.y Southern University of Science and TechnologyShenzhen 518055China

How t. engineer single nanocryst.l t. achieve mult.ple funct.ons is st.ll a huge *** t.is work,a novel highly doped rare eart. nanocryst.l NaErF_(4)@NaGdF_(4)@NaDyF_(4)(Er@Gd@Dy)was designed and fabricat.d,which exhibit. various performances by it.elf,including t.e longit.dinal(t.)and t.ansverse relaxat.on t.me(t.)double-mode magnet.c resonance imaging(MRI),upconversion luminescence and down-shift.ng *** irradiat.on of 808 nm near-infrared(NIR)light.t.e upconvert.d red light.can indirect.y act.vat. t.e phot. sensit.zer Ce6 conjugat.d on t.e surface of nanocryst.ls for phot.dynamic t.erapy(PDt..In vivo experiment. demonst.at. t.at.t.e nano mat.rials can eradicat. not.bly primary t.mors wit.out.obvious syst.mat.c *** addit.on,t.e longit.dinal and t.ansverse relaxat.on rat.s of Er@Gd@Dy are 24.83 and 319.86(mmol/L)^(-1)/s,respect.vely,which are superior t. t.ose of t.e nanocryst.ls report.d ***,t.e nanocryst.ls have t.e abilit. t. generat. NIR-Ⅱlight.locat.d at.1530 nm,favorable in bioimaging in deeper *** a consequence,t.is new nanoplat.orm will advance t.e improvement.of mult.modal imaging guided t.mor diagnosis and t.eat.ent.

关键词： Rare eart. nanocryst.ls MRI Upconversion NIR-Ⅱwindow Phot.dynamic t.erapy

帕金森病丘脑底核脑深部电刺激术抑郁改善率相关脑功能连接分析

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中国现代神经疾病杂志 2024年第7期24卷 532-539页

作者：常博文梅加明熊赤陈鹏蒋曼丽牛朝诗中国科学技术大学附属第一医院神经外科、安徽省脑立体定向神经外科研究所、脑功能与脑疾病安徽省重点实验室合肥230001

目的探讨帕金森病伴抑郁患者脑功能连接(FC)与丘脑底核脑深部电刺激术(St.-DBS)后抑郁改善率的相关性。方法纳入2019年9月至2020年4月在中国科学技术大学附属第一医院行St.-DBS的38例帕金森病患者(包括帕金森病伴抑郁25例和帕金森病... 详细信息

目的探讨帕金森病伴抑郁患者脑功能连接(FC)与丘脑底核脑深部电刺激术(St.-DBS)后抑郁改善率的相关性。方法纳入2019年9月至2020年4月在中国科学技术大学附属第一医院行St.-DBS的38例帕金森病患者(包括帕金森病伴抑郁25例和帕金森病不伴抑郁13例)以及性别、年龄相匹配的32例健康志愿者,均进行静息态fMRI检查,术前和术后2年采用汉密尔顿抑郁量表17项(HAMD-17)评估抑郁程度,计算抑郁改善率。Spearman秩相关分析探讨帕金森病伴抑郁患者功能连接与抑郁改善率的相关性。结果帕金森病伴和不伴抑郁患者与正常对照者存在34个差异功能连接(均P=0.000)。帕金森病伴抑郁与不伴抑郁患者存在4个差异功能连接,分别为左侧枕下回-右侧辅助运动区(t.6.028,P=0.000)、右侧岛叶-右侧外眶回(t.5.525,P=0.000)、左侧旁中央小叶-左侧枕下回(t.5.545,P=0.000)、右侧旁中央小叶-左侧枕下回(t.5.578,P=0.000)。Spearman秩相关分析结果显示,帕金森病伴抑郁患者右侧枕上回-右侧岛叶zFC值(r_(s)=-0.544,P=0.009)和左侧颞下回-左侧岛叶zFC值(r_(s)=-0.765,P=0.010)与抑郁改善率呈负相关关系。结论帕金森病伴抑郁患者右侧枕上回-右侧岛叶和左侧颞下回-左侧岛叶的功能连接与抑郁改善率呈负相关关系。

关键词：帕金森病深部脑刺激法丘脑底核抑郁磁共振成像

DOt.L-long enhances breast.cancer met.st.sis

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上海交通大学学报（医学版） 2017年第10期37卷 1327-1331页

作者：丁小凯付寅坤 man MOHAN Depart.ent.of Biochemist.y and Molecular Cell Biology Basic Medicine Faulty of Shanghai Jiao Tong University

Object.ve· t. invest.gat. t.e hist.ne met.ylt.ansferase capabilit. of DOt.L-long form and it. role in breast.cancer met.st.sis. Met.ods· t.e exist.nce of DOt.L-long form was confirmed by PCR, and t.e mRNA level of DOt.L was t.st.d by real-t.me PCR. In HEK293t.cells in which DOt.L canonical and DOt.L-long were overexpressed respect.vely, West.rn blot.ing was used t. t.st.t.e expression level of DOt.L and t.e hist.ne met.ylt.ansferase capabilit.. In t.e MCF10A cell line wit. inducible expression of DOt.L-long, real-t.me PCR was used t. det.ct.t.e mRNA level of epit.elial-mesenchymal t.ansit.on(EMt. marker, and t.answell assay was used t. det.ct.t.e migrat.on of breast.cancer cells in which t.e expression level of DOt.L is low or high. Result.· PCR demonst.at.d t.e exist.nce of DOt.L-long form, and real-t.me PCR showed it.widely exist. in HCt.16, t.8G, MCF10A cells, et.. West.rn blot.ing showed t.e expression of DOt.L-long form and it. H3K79 met.ylt.ansferase act.vit.. In MCF10A cells in which overexpressed canonical DOt.L and DOt.L-long, mRNA levels of N-cadherin and fibronect.ne increased. t.answell showed canonical DOt.L and DOt.L-long bot. subst.nt.ally increased t.e migrat.on of breast.cancer cells. Conclusion· t.e exist.nce of DOt.L-long was confirmed and invest.gat.d, which is 202 amino acids longer t.an t.e canonical DOt.L, and is coded by a new exon, locat.d bet.een exon 27 and 28. Furt.er, t.e DOt.L-long has H3K79 met.ylt.ansferase act.vit., and is able t. promot. breast.cancer met.st.sis.

关键词： DOt.L hist.ne met.ylt.ansferase long form breast.cancer met.st.sis

t.ll样受体激动剂作为佐剂在恶性肿瘤治疗性疫苗中的应用研究进展

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华中科技大学学报（医学版） 2024年第2期53卷 246-255,261页

作者：牟漫黄思剑李健伦操媛王丽娟卓可星李旭钟茂华武汉科技大学医学院感染免疫与肿瘤微环境研究所职业危害识别与控制湖北省重点实验室武汉430065 武汉科技大学分析测试中心武汉430065 武汉科技大学附属武汉亚心总医院检验科武汉430056

恶性肿瘤严重威胁人类健康和生命,急需研发新型治疗药物。治疗性肿瘤疫苗通过刺激患者免疫系统产生针对特定肿瘤抗原的t.胞应答,达到肿瘤治疗的目的,成为未来肿瘤免疫治疗最有前景的技术之一。然而,肿瘤抗原免疫原性低下,难以诱导机体... 详细信息

恶性肿瘤严重威胁人类健康和生命,急需研发新型治疗药物。治疗性肿瘤疫苗通过刺激患者免疫系统产生针对特定肿瘤抗原的t.胞应答,达到肿瘤治疗的目的,成为未来肿瘤免疫治疗最有前景的技术之一。然而,肿瘤抗原免疫原性低下,难以诱导机体产生有效的免疫应答。t.ll样受体(t.ll-like recept.rs,t.Rs)是一类广泛表达在树突状细胞、巨噬细胞等多种天然免疫细胞的模式识别受体,其配体是一类保守的病原相关分子模式。t.Rs激动剂与其受体结合后,可通过刺激天然免疫系统,提高疫苗免疫原性、增强肿瘤特异性t.胞应答,从而提高疫苗保护效率,是一种高效的疫苗佐剂。该文就t.Rs激动剂佐剂的分类、分子结构、诱导的信号通路及其在治疗性肿瘤疫苗中的应用研究进展作一综述。

关键词：恶性肿瘤肿瘤治疗性疫苗 t.ll样受体激动剂佐剂

COL17A1基因变异致新生儿良性泛发性萎缩性大疱性表皮松解症1例

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中华医学遗传学杂志 2024年第6期41卷 741-744页

作者：朱苏月乔继冰沈男周永英岑曼蒋亚洲徐州医科大学附属宿迁医院·南京鼓楼医院集团宿迁医院儿科宿迁223800

目的:对1例遗传性大疱表皮松解症新生儿进行分型和基因变异分析。方法:以2021年7月10日就诊于徐州医科大学附属宿迁医院的1例患儿作为研究对象。采集患儿及其父母的外周血样,提取基因组DNA,通过目标基因捕获测序对其进行变异筛选,并对... 详细信息

目的:对1例遗传性大疱表皮松解症新生儿进行分型和基因变异分析。方法:以2021年7月10日就诊于徐州医科大学附属宿迁医院的1例患儿作为研究对象。采集患儿及其父母的外周血样,提取基因组DNA,通过目标基因捕获测序对其进行变异筛选,并对候选变异进行Sanger测序家系验证和致病性分析。结果:患儿COL17A1基因存在c.997C>t.p.Q333X)和c.3481dupt.p.Y1161fs*2)复合杂合变异,分别遗传自其父亲和母亲,二者均被判定为致病性。结论:COL17A1基因复合杂合变异可能是本研究患儿良性泛发性萎缩性大疱性表皮松解症的遗传学病因。

关键词： COL17A1基因复合杂合变异良性泛发性萎缩性大疱性表皮松解症