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t.e CUL4A ubiquit.n ligase is a pot.nt.al t.erapeut.c t.rget.in skin cancer and ot.er malignancies

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Chinese Journal of Cancer 2013年第9期32卷 478-482页

作者： Jeffrey Hannah Peng-bo Zhou Depart.ent.of Pat.ology and Laborat.ry Medicine Weill Cornell Medical College and Weill Cornell Graduate School of Medical Sciences Depart.ent.of Pat.ology and Laborat.ry Medicine Weill Cornell Medical College

Cullin 4A(CUL4A)is an E3 ubiquit.n ligase t.at.direct.y affect. DNA repair and cell cycle progression by t.rget.ng subst.at.s including damage-specific DNA-binding prot.in 2(DDB2),xeroderma pigment.sum complement.t.on group C(XPC),chromat.n licensing and DNA replicat.on fact.r 1(Cdt.),and *** work from our laborat.ry has shown t.at.Cul4a-deficient.mice have great.y reduced rat.s of ult.aviolet.induced skin *** a cellular level,Cul4a-deficient.cells have great.capacit. for DNA repair and demonst.at. a slow rat. of proliferat.on due primarily t. increased expression of DDB2 and p21,*** suggest. t.at.CUL4A promot.s t.morigenesis(as well as accumulat.on of skin damage and subsequent.premat.re aging)by limit.ng DNA repair act.vit. and expedit.ng S phase *** addit.on,CUL4A has been found t. be up-regulat.d via gene amplificat.on or overexpression in breast.cancers,hepat.cellular carcinomas,squamous cell carcinomas,adrenocort.cal carcinomas,childhood medulloblast.mas,and malignant.pleural *** of it. oncogenic act.vit. in skin cancer and up-regulat.on in ot.er malignancies,CUL4A has arisen as a pot.nt.al candidat. for t.rget.d t.erapeut.c *** t.is review,we out.ine t.e est.blished funct.ons of CUL4A and discuss t.e E3ligase’s emergence as a pot.nt.al driver of t.morigenesis.

关键词：泛素连接酶恶性肿瘤皮肤癌治疗 DNA修复 DNA结合蛋白靶点细胞水平

内蒙古农牧交错区典型黑土坡耕地土壤侵蚀空间分布特征

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水土保持研究 2025年第1期32卷 13-20页

作者：邹惠杰刘刚舒成博孙波刘亚张琼郭珍中国科学院教育部水土保持与生态环境研究中心黄土高原土壤侵蚀与旱地农业国家重点实验室中国科学院水利部水土保持研究所中国科学院大学西北农林科技大学黄土高原土壤侵蚀与旱地农业国家重点实验室四川华标测检测技术有限公司

[目的]定量了解内蒙古典型黑土区土壤侵蚀速率，探究该区域土壤侵蚀空间分布特征，阐明土壤侵蚀坡面和区域空间分布规律，以期为区域水土流失治理提供参考。[方法]采集内蒙古农牧交错区（海拉尔区、额尔古纳市和牙克石市）典型黑土坡耕... 详细信息

[目的]定量了解内蒙古典型黑土区土壤侵蚀速率，探究该区域土壤侵蚀空间分布特征，阐明土壤侵蚀坡面和区域空间分布规律，以期为区域水土流失治理提供参考。[方法]采集内蒙古农牧交错区（海拉尔区、额尔古纳市和牙克石市）典型黑土坡耕地的土壤样品，利用137Cs示踪技术计算各采样点土壤侵蚀速率，结合小波分析的方法研究土壤侵蚀在坡面的分布特征。[结果]（1） 3个坡面所有采样点137Cs含量均小于背景值（1 984.24 Bq/m2）,表现为所有坡面土壤流失。（2） 3个地区的采样坡面平均侵蚀速率表现为：海拉尔[6 533.37 t.（km2·a）]>额尔古纳[4 174.35 t.（km2·a）]>牙克石[2 765.87 t.（km2·a）]。相同坡面的3个纵向断面的平均侵蚀速率相近，同一断面侵蚀速率的变异程度较高。（3）土壤侵蚀速率沿坡长呈强弱交替的周期性变化，但周期长度并不固定。大部分纵向断面存在周期长度为80～160 m和160～200 m的大小两个周期。部分纵向断面只存在一个周期长度为100～120 m的周期。[结论]该地区土壤侵蚀在坡面尺度表现为全坡面侵蚀且在纵向呈现周期性特征，在区域尺度呈现从东到西逐渐增加趋势。

关键词：土壤侵蚀典型黑土农牧交错带小波分析

Est.mat.ng aboveground biomass in Mu Us Sandy Land using Landsat.spect.al derived veget.t.on indices over t.e past.30 years

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Journal of Arid Land 2013年第4期5卷 521-530页

作者： Feng YAN bo WU YanJiao WANG Inst.t.t. of Desert.ficat.on St.dies Chinese Academy of Forestry Nat.onal Climat. Cent.r China Meteorological Administration

Remot. sensing is a valuable and effect.ve t.ol for monit.ring and est.mat.ng aboveground biomass （AGB） in large *** current.int.rnat.onal research on biomass est.mat.on by remot. sensing t.chnique mainly focused on forest.,grasslands and crops,wit. relat.vely few applicat.ons for desert.*** t.is paper,Landsat.t.emat.c Mapper （t.）/Enhanced t.emat.c Mapper Plus （Et.＋） images from 1988 t. 2007 and t.e dat. of 283 AGB samples in August.2007 were used t. est.mat. t.e AGB for Mu Us Sandy Land over t.e past.30 ***,t.mporal and spat.al dist.ibut.on charact.rist.cs of AGB and influencing fact.rs of climat. and underlying surface were also *** show t.at.（1） Differences of correlat.ons exist.in t.e fit.ed equat.ons bet.een AGB and different.veget.t.on indices in desert.*** modified soil adjust.d veget.t.on index （MSAVI） and soil adjust.d veget.t.on index （SAVI） show relat.vely higher correlat.ons wit. AGB,while t.e correlat.on bet.een normalized difference veget.t.on index （NDVI） and AGB is relat.vely *** t.st.ng shows t.at.t.e AGB-MSAVI model est.blished can be used t. accurat.ly est.mat. AGB of Mu Us Sandy Land in August.（2） AGB in Mu Us Sandy Land shows t.e fluct.ant.charact.rist.cs over t.e past.30 years,which decreased from t.e 1980s t. t.e 1990s,and increased from t.e 1990s t. *** in 2007 had t.e highest.value,wit. a t.t.l AGB of 3.352×106 ***,in t.e 1990s,AGB had t.e lowest.value wit. a t.t.l AGB of 2.328×106 t.（3） AGB wit. relat.vely higher values was mainly locat.d in t.e middle and sout.ern part. of Mu Us Sandy Land in t.e *** was low in t.e whole area in t.e1990s,and relat.vely higher AGB values were mainly locat.d in t.e sout.ern part. of *** 2007,AGB in t.e whole area was relat.vely higher t.an t.ose of t.e last.t.ent. years,and higher AGB values were mainly locat.d in t.e nort.ern,west.rn and middle part. of Mu Us Sandy Land.

关键词： aboveground biomass (AGB) linear regression veget.t.on indices Mu Us Sandy Land

Recent.advances in organic pressure-responsive luminescent.mat.rials

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Chinese Chemical Let.ers 2019年第11期30卷 1883-1894页

作者： Zhiyuan Fu Kai Wang bo Zou St.t. Key Laborat.ry of Superhard Mat.rials College of PhysicsJilin University

Organic luminescent.mat.rials are very sensit.ve t. ext.rnal st.muli,such as pressure,t.mperat.re,and elect.ic *** luminescent.propert.es of some organic luminescent.mat.rials significant.y change under high *** mat.rials may show luminescence discolorat.on,whereas some may exhibit.luminescence *** propert.es have many pot.nt.al applicat.ons in ant.count.rfeit.ng,force sensor,dat. recording and st.rage,and luminescent.devices,t.ereby great.y at.ract.ng t.e at.ent.on of *** t.is review,t.e progress of research on t.ese mat.rials at.high pressure in recent.years is summarized.

关键词： Pressure-responsive Piezochromic Diamond anvil cell Pressure-induced enhanced emission Organic luminescent

Experiment.l evidence of coupling int.ract.on bet.een charge ordering and spin ordering

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Science China(Physics,Mechanics & Ast.onomy) 2010年第7期53卷 1255-1260页

作者： HONG bo CAO GuangHan XU ZhuAn College of Mat.rials Science and Engineering China Jiliang UniversityHangzhou 310018China Depart.ent.of Physics Zhejiang UniversityHangzhou 310027China

In order t. experiment.lly probe int. t.e complicat.d int.ract.on bet.een charge ordering and spin ordering in manganit.s,t.o set. of samples Nd0.5Sr0.5Mn1-xGaxO3(NSMGO) and Nd 0.5Sr0.5Mn1-y CryO3(NSMCO)(0.0 x,y 0.075),have been st.died by means of elect.ical t.ansport.magnet.zat.on,elect.on spin resonance and t.ansmission elect.on microscopy *** comparing t.e influence of Cr-doping and Ga-doping in t.e Nd0.5Sr0.5MnO3(NSMO) syst.m,large difference bet.een t.e evolut.on of charge ordering t.mperat.re t.co in t.e Cr-doping and t.e Ga-doping cases is *** t.e NSMCO syst.m,t.e CE-t.pe ant.ferromagnet.c(AFM)/charge ordering(CO) phase disappears wit. only 2.5 percent.Cr doping;but.in t.e NSMGO syst.m,t.e CE-t.pe AFM/CO phase always *** phenomenon indicat.s t.at.t.e charge ordering format.on is dominat.d by t.e spin *** a result.it.is experiment.lly proved t.at.t.ere is st.ong coupling int.ract.on bet.een charge ordering and spin ordering in NSMO syst.m.

关键词： perovskit. manganit.s phase t.ansit.ons order-disorder effect.

Design of new t.adit.onal Chinese medicine herbal formulae for t.eat.ent.of t.pe 2 diabet.s mellit.s based on net.ork pharmacology

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Chinese Journal of Nat.ral Medicines 2017年第6期15卷 436-441页

作者： HU Rui-Feng SUN Xiao-bo Beijing Key Laborat.ry oflnnovat.ve Drug Discovery of t.adit.onal Chinese Medicine (Nat.ral Medicine) and t.anslat.onal Medicine Institute of Medicinal Plant Development Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100193 China Key Laborat.ry of Bioact.ve Subst.nces and Resource Ut.lizat.on of Chinese Herbal Medicine Ministry of Education Beijing100193 China Zhongguancun Open Laborat.ry of t.e Research and Development.of Nat.ral Medicine and Healt. Product. Beijing 100193 China

In t.e present.st.dy, 28 Chinese medicinal herbs belonging t. t.adit.onal Chinese medicine(t.M) for t.e t.eat.ent.of t.pe 2 diabet.s were select.d t. explore t.e applicat.on of net.ork pharmacology in developing new Chinese herbal medicine formulae for t.e t.eat.ent.of t.pe 2 diabet.s mellit.s(t.DM). t.ese herbs have t.e highest.appearance rat. in t.e lit.rat.re, and t.eir compounds are list.d. t.e human prot.in–prot.in int.ract.on net.ork and t.e t.DM disease prot.in int.ract.on net.ork were const.uct.d. t.en, t.e relat.d algorit.m for net.ork t.pology was used t. perform int.rvent.ons on t.e int.ract.on net.ork of disease prot.ins and normal human prot.ins t. t.st.different.Chinese herbal medicine compound combinat.ons, according t. t.e informat.on on t.e int.ract.on of compounds–t.rget. in t.o dat.bases, namely t.rN et.and t.e Medicinal Plant. Dat.base. Result. of t.e int.rvent.on scores indicat. t.at.t.e met.od proposed in t.is st.dy can provide new effect.ve combinat.ons of Chinese herbal medicines for t.DM. Net.ork pharmacology can effect.vely promot. t.e modernizat.on and development.of t.M.

关键词： Net.ork pharmacology t.M formulae Prot.in–prot.in int.ract.on net.ork t.pe 2 diabet.s mellit.s Nework int.rvent.on

St.nding Waves for Periodic Discret. Nonlinear Schrdinger Equat.ons wit. Asympt.t.cally Linear t.rms

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Act. Mat.emat.cae Applicat.e Sinica 2012年第2期28卷 351-360页

作者： Wen-xiong Chen Min-bo Yang School of Mat.emat.cal Science Huaqiao UniversityQuanzhou 362021FujianChina Depart.ent.of Mat.emat.cs Zhejiang Normal University321004 JinhuaChina

In t.is paper we st.dy t.e exist.nce of nont.ivial solut.ons for t.e periodic discret. nonlinear equat.on Lun-un=ωfn（un）,where Lun=an＋1un＋an-1un-1＋bnunis t.e discret. Laplacian in one spat.al dimension. t.e given real-valued sequences an, bn are assumed t. be N-periodic in n, i.e., an＋N =an, bn＋N = bn. t.e nonlinearit. fn（t. is N-periodic in n and asympt.t.cally linear at.infinit.. We show t.at. if ω is in t.e spect.um gap of L, t.ere is a nont.ivial solut.on. t.e proof is based on t.e st.ongly indefinit. funct.onal crit.cal point. t.eorem developed recent.y.

关键词： discret. Schrodinger equat.on crit.cal point linking

Biogenesis,act.on and biological funct.ons of an Arabidopsis 5' t.RF,5' t. R-Ala

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Science China(Life Sciences) 2022年第5期65卷 1050-1052页

作者： Chunyan Liu bo Cao Xiaofeng Cao St.t. Key Laborat.ry of Plant.Genomics and Nat.onal Cent.r for Plant.Gene Research(Beijing) Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China St.t. Key Laborat.ry of Microbial Met.bolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200030China Cent.r for Excellence in Molecular Plant.Sciences Chinese Academy of SciencesBeijing 100101China Universit. of Chinese Academy of Sciences Beijing 100049China

t.ansfer RNAs(t.NAs) are one class of most.conserved and abundant.RNA species wit. 76–90 nucleot.des(nt. in *** const.t.t. approximat.ly 4%–15% of t.t.l cellular RNAs and are well known for t.anslat.ng t.e codons on... 详细信息

关键词： act.on t.anslat.ng t.ll

High Accuracy Calculat.on for Excit.d-St.t. Energies of H At.ms in a Magnet.c Field

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Communicat.ons in t.eoret.cal Physics 2009年第8期52卷 339-345页

作者： ZHAO Li-bo DU Meng-Li Depart.ent.of Physics College of William ＆ Mary Williamsburg VA 23187-8795 USA Inst.t.t. of t.eoret.cal Physics Chinese Academy of Sciences P.O. Box 2735 Beijing 100190 China

Using t.e recent.y developed finit.-basis-set.met.od wit. B splines, excit.d st.t.s of H at.ms in a magnet.c field have been calculat.d. Energy levels are present.d for t.e t.n excit.d st.t.s, 2so, 3d＇0, 3po, 3p-1, 3d_1, 4d-1, 3d-2, 4d-2, 4f-2 , and 5f-2 as a funct.on of magnet.c field st.engt.s wit. a range from zero up t. 2.35 × 10^6 t. t.e obt.ined result. are compared wit. available high accuracy t.eoret.cal dat. report.d in t.e lit.rat.re and found t. be in excellent.agreement. t.e comparison also shows t.at.t.e current.met.od can produce energy levels wit. an accuracy higher t.an t.e exist.ng high accuracy met.od [Phys. Rev. A 54 （1996） 287]. Here high accuracy energy levels are for t.e first.t.me report.d for t.e 3d＇0, 4d-1, 4d-2, 4f-2, and 5f-2 st.t.s.

关键词： H at.ms st.ong magnet.c fields whit. dwarf st.rs