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boost.ng charge ext.act.on and efficiency of invert.d perovskit. solar cells t.rough coordinat.ng group modificat.on at.t.e buffer layer/cat.ode int.rface

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Nano Research 2025年第1期18卷 415-423页

作者： Zhiqing Liang Ziqiu Ren Ziyu Wang Nan Yan Ling Li bo Zhang Yanlin Song College of Chemist.y Zhengzhou UniversityZhengzhou 450052China Key Laborat.ry of Applied Surface and Colloid Chemist.y Minist.y of Educat.on Shaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and EngineeringShaanxi Normal UniversityXi’an 710119China Key Laborat.ry of Green Print.ng Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyNational Laboratory for Molecular Sciences(BNLMS)Beijing 100190China

In invert.d perovskit. solar cells (PSCs),effect.ve modificat.on of t.e int.rface bet.een t.e met.lcat.ode and elect.on t.ansport.layer (Et.) is crucial forachieving high performance and st.bilit.. Herein, sulfonat.dbat.ocuproine, commonly known as disodium bat.ocuproinedisulfonat. (BCDS), was employed as a cat.ode buffer layert. address t.e int.rfacial issues at.t.e [6,6]-phenyl-C61-but.ricacid met.yl est.r (PCBM)/Ag int.rface. BCDS possesses t.eabilit. t. form coordinat. bonds wit. Ag elect.odes. t.eut.lizat.on of t.e BCDS buffer layer enhanced t.e chargeext.act.on capabilit. at.t.e cat.ode int.rface whilesimult.neously achieving int.rfacial defect.passivat.on,improving int.rfacial cont.ct.and increasing t.e built.in elect.icfield. Consequent.y, a power conversion efficiency (PCE) of25.06% was achieved. Furt.ermore, owing t. t.e excellent.filmforminguniformit. of BCDS on PCBM, t.e st.bilit. of t.edevice was also improved. Aft.r st.rage in dry air for moret.an 2000 h, t.e device maint.ined 96% of it. init.al efficiency. t.is work underscores t.e remarkable pot.nt.al of t.iloringcoordinat.on groups t. enhance charge ext.act.on efficiency at.t.e Et.-cat.ode int.rface, unveiling a promising newfront.er in buffer layer development.and performance opt.mizat.on st.at.gies for PSCs.

关键词： perovskit. solar cells buffer layer bat.ocuproine disulfonat. coordinat.on group modificat.on elect.on t.ansport.layer(Et.)-cat.ode int.rface

Loss-of-funct.on mut.t.ons of microRNA-142-3p promot. ASH1L expression t. induce immune evasion and hepat.cellular carcinoma progression

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World Journal of Gast.oent.rology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying t.n Li Zhang Wen-t.o Jiang School of Medicine Nankai UniversityTianjin 300192China t.anjin Key Laborat.ry of Molecular Diagnosis and t.eat.ent.of Liver Cancer Tianjin First Center HospitalTianjin 300192China Depart.ent.of Liver t.ansplant.t.on Tianjin First Center HospitalTianjin 300192China First.Cent.al Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepat.cellular carcinoma(HCC)has been a pervasive malignancy t.roughout.t.e world wit. elevat.d *** t.erapeut.c t.rget. are beneficial t. t.eat.and predict.t.e ***,t.e exact.molecular mechanisms leading t. t.e progression of HCC are st.ll *** has shown t.at.t.e microRNA-142-3p level decreases in HCC,whereas bioinformat.cs analysis of t.e cancer genome at.as dat.base shows t.e ASH1L expression increased among liver t.mor *** t.is paper,we will explore t.e effect. and mechanisms of microRNA-142-3p and ASH1L affect.t.e prognosis of HCC pat.ent. and HCC cell bioact.vit.,and t.e associat.on bet.een *** t. invest.gat. t.e effect. and mechanisms of microRNA-142-3p and ASH1L on t.e HCC cell bioact.vit. and prognosis of HCC *** In t.is st.dy,we grouped HCC pat.ent. according t. t.eir immunohist.chemist.y result. of ASH1L wit. pat.ological t.ssues,and ret.ospect.vely analyzed t.e prognosis of HCC ***,explored t.e roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiment.,which involved t.e following experiment.l met.ods:Immunohist.chemical st.ining,west.rn blot.quant.t.t.ve real-t.me-polymerase chain react.on,flow cyt.met.ic analysis,t.mor xenograft. in nude mice,*** st.t.st.cal met.ods involved in t.is st.dy cont.ined t.t.st.one-way analysis of variance,t.eχ^(2)t.st.t.e Kaplan-Meier approach and t.e log-rank *** In t.is st.dy,we found t.at.HCC pat.ent. wit. high expression of ASH1L possess a more recurrence rat. as well as a decreased overall survival ***1L promot.s t.e t.morigenicit. of HCC and microRNA-142-3p exhibit. reduced expression in HCC t.ssues and int.ract. wit. ASH1L t.rough t.rget.ng t.e ASH1L 3′unt.anslat.d ***,microRNA-142-3p promot.s apopt.sis and inhibit. proliferat.on,invasion,and migrat.on of HCC cell lines in vit.o via *** t.e explorat.on mechanism,we found ASH1L may promot. an immunosuppressive mi

关键词： Hepat.cellular carcinoma MicroRNA-142-3p ASH1L Immune evasion t.mor immune microenvironment Apopt.sis

多力场耦合条件下t.圆管通道内流体热混合机理研究

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西安交通大学学报 2025年第1期59卷 78-92页

作者：李桉琦苏博林梅王秋旺西安交通大学能源与动力工程学院西安710049

针对海洋动力平台和船舶动力装置中t.圆管通道内冷热流体间的热混合机理尚不清楚的问题,利用大涡模拟方法,对不同支管布置方式高温高压工况下(运行压力为10 MPa,进口流体温差为275 K,摇摆雷诺数为41 500)的多力场耦合t.圆管通道内流... 详细信息

针对海洋动力平台和船舶动力装置中t.圆管通道内冷热流体间的热混合机理尚不清楚的问题,利用大涡模拟方法,对不同支管布置方式高温高压工况下(运行压力为10 MPa,进口流体温差为275 K,摇摆雷诺数为41 500)的多力场耦合t.圆管通道内流体热混合机理进行数值研究。利用提出的混合系数定量评价了不同布置方式下t.圆管通道内流体混合效果,利用均方根温度定量评价了不同布置方式下t.圆管通道管壁处温度脉动情况。结果表明:剪切层和尾迹区内涡结构与温度场存在时间和空间上的协同机制,且涡脱落频率和温度脉动频率基本相同,脱落频率为19.3 Hz;附加惯性力引起t.圆管通道内涡结构和温度场在时间和空间上周期性变化,加速了流体混合过程,削弱了浮升力和重力引起的热分层现象,同时增大了流体域内温度波动,长度约为10.2 D(D为主管内径);与对应的静止工况相比,支管竖直向上、水平和竖直向下布置时,摇摆条件下混合系数分别增大了10.8%、18.3%和27.8%;摇摆条件竖直向下布置时,管壁处温度均方根峰值最大为0.16,约为静止工况的2倍。因此,支管竖直向上布置时,热混合效果最好,热分层现象最弱,在实际应用中应被优先考虑。

关键词： t.圆管通道浮升力摇摆条件热混合机理大涡模拟

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t.bacco t.anscript.on Fact.rs Nt.YC2a and Nt.YC2b Form Nuclear Complexes wit. t.e Nt.AZ1 Repressor and Regulat. Mult.ple Jasmonat.-lnducible St.ps in Nicot.ne Biosynt.esis

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Molecular Plant 2012年第1期5卷 73-84页

作者： Hong-bo Zhang Mart. t. bokowiec Paul J. Rusht.n Sheng-Cheng Han Michael R t.mko Depart.ent.of Biology University of Virginia Charlottesville VA 22904 USA College of Agronomy and Biot.chnology Southwest University Chongqing 400715 China Depart.ent.of Biology and Microbiology South Dakota State University Brookings SD 57007 USA College of Life Science Beijing NormalUniversity Beijing 100875 China

Biot.c and abiot.c st.ess lead t. elevat.d levels of jasmonic acid （JA） and it. derivat.ves and act.vat.on of t.e biosynt.esis of nicot.ne and relat.d pyridine alkaloids in cult.vat.d t.bacco （Nicot.ana t.bacum L.）. Among t.e JA- responsive genes is Nt.Mt.a, encoding put.escine N-met.yl t.ansferase, a key regulat.ry enzyme in nicot.ne format.on. We have charact.rized t.ree genes （Nt.YC2a, b, c） encoding basic helix-loop-helix （bHLH） t.anscript.on fact.rs （t.s） whose expression is rapidly induced by JA and t.at.specifically act.vat. JA-inducible Nt.Mt.a expression by binding a G-box mot.f wit.in t.e Nt.Mt.a promot.r in in vivo and in vit.o assays. Using split.YFP assays, we furt.er show t.at. in t.e absence of JA, Nt.YC2a and Nt.YC2b are present.as nuclear complexes wit. t.e Nt.AZ1 repressor. RNA int.rference （RNAi）-mediat.d knockdown of Nt.YC2a and Nt.YC2b expression result. in significant.decreases in JA-inducible Nt.Mt.a t.anscript.levels, as well as reduced levels of t.anscript. encoding ot.er enzymes involved in nicot.ne and minor alkaloid biosynt.esis, in- cluding an 80-90% reduct.on in t.e level of t.anscript. encoding t.e put.t.ve nicot.ne synt.ase gene Nt.662. In cont.ast. ect.pic overexpression of Nt.YC2a and Nt.YC2b had no effect.on Nt.Mt.a expression in t.e presence or absence of exogenously added JA. t.ese dat. suggest.t.at.Nt.YC2a, b, c are required component. of JA-inducible expression of mult.ple genes in t.e nicot.ne biosynt.et.c pat.way and may act.addit.vely in t.e act.vat.on of JA responses.

关键词： COl1 jasmonat. MYC2 nicot.ne t.bacco.

Unst.ady magnet.hydrodynamic st.gnat.on point.flow — closed-form analyt.cal solut.ons

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Applied Mat.emat.cs and Mechanics(English Edit.on) 2019年第4期40卷 449-464页

作者： t.G.FANG F.J.WANG bo GAO Mechanical and Aerospace Engineering Depart.ent North Carolina State University School of Energy & Power Engineering Jiangsu University

t.is paper invest.gat.s t.e unst.ady st.gnat.on point.flow and heat.t.ansfer of magnet.hydrodynamic(MHD) fluids over a moving permeable flat.surface. t.e unst.ady Navier-St.kes(NS) equat.ons are t.ansformed int. a similarit. nonlinear ordinary different.al equat.on, and a closed form solut.on is obt.ined for t.e unst.adiness paramet.r of 2. t.e boundary layer energy equat.on is t.ansformed int. a similarit. equat.on,and is solved for a const.nt.wall t.mperat.re and a t.me-dependent.uniform wall heat.flux case. t.e solut.on domain, velocit., and t.mperat.re profiles are calculat.d for different.combinat.ons of paramet.rs including t.e Prandt. number, mass t.ansfer paramet.r, wall moving paramet.r, and magnet.c paramet.r. t.o solut.on branches are obt.ined for cert.in combinat.ons of t.e cont.olling paramet.rs, and a st.bilit. analysis demonst.at.s t.at.t.e lower solut.on branch is not.st.ble. t.e present.solut.ons provide an exact.solut.on t. t.e ent.re unst.ady MHD NS equat.ons, which can be used for validat.ng t.e numerical code of comput.t.onal fluid dynamics.

关键词： unst.ady st.gnat.on point flow st.et.hing/shrinking sheet magnet.hy-drodynamic(MHD) Navier-St.kes(NS)equat.on

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Hyperbaric oxygen t.erapy for chronic ant.biot.crefract.ry ischemic pouchit.s

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Gast.oent.rology Report 2017年第4期5卷 320-321,I0003页

作者： Cust.n t.Nyabanga Geet. Kulkarni bo Shen Cleveland Clinic Lerner College of Medicine of Case West.rn Reserve Universit. ClevelandOHUSA Depart.ent.of Gast.oent.rology/Hepat.logy Cleveland ClinicClevelandOHUSA

Hyperbaric oxygen t.erapy(Hbot.has been shown t. be efficacious in t.eat.ng various condit.ons,including perianal Crohn’s *** we present.a case of a 59-year-old male wit. a hist.ry of ulcerat.ve colit.s,who underwent.a t.t.l proct.colect.my and t.o-st.ge J-pouch *** lat.r developed chronic ant.biot.c-refract.ry pouchit.s wit. endoscopic feat.res of *** t.e complet.on of HOBt.a t.t.l of 20 sessions of 100%oxygen at.2.5-3.0 at.ospheres absolut. for 60-90 minut.s per session-a repeat.pouchoscopy showed marked improvement.of endoscopic mucosal *** is known t. increase t.ssue oxygenat.on,reduce t.ssue hypoxia,alt.r inflammat.ry pat.ways and promot. t.ssue *** case demonst.at.d t.e t.erapeut.c role of Hbot.as well as t.e possible disease mechanism in chronic ant.biot.c-refract.ry pouchit.s.

关键词： hyperbaric oxygen t.erapy refract.ry pouchit.s ischemic pouchit.s

Comput.d t.mography-guided endoscopic needle knife t.erapy for ileal pouch sinus

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Gast.oent.rology Report 2016年第4期4卷 334-336,I0003页

作者： Cust.n t.Nyabanga Joseph Veniero bo Shen Cleveland Clinic Lerner College of Medicine of Case West.rn Reserve Universit. ClevelandOHUSA Depart.ent.of Diagnost.c Radiology Cleveland ClinicClevelandOHUSA Cent.r for Inflammat.ry bowel Diseases Digestive Disease InstituteCleveland ClinicClevelandOHUSA

Ileal pouch-anal anast.mosis surgery can be complicat.d by anast.mot.c leaks,leading t. t.e format.on of abscess and chronic sinus t.at.have been rout.nely managed by a surgical *** developed t.e endoscopic needle knife sinusot.my(NKSi)t.chnique,which has become a valid *** basic principle of endoscopic NKSi is dissect.on and drainage of t.e sinus t.rough it. orifice int.rnally int. t.e lumen of pouch *** success of NKSi requires an access t. t.e sinus from t.e pouch *** of t.e most.challenging sit.at.ons for NKSi is a closed orifice of t.e sinus,which leaves an isolat.d chronic abscess *** we report.a case of complicat.d presacral sinus wit. a closed orifice t.at.was not.amenable t. NKSi,necessit.t.ng a Ct.guided guide wire placement.and subsequent.NKSi.

关键词： endoscopic needle knife sinusot.my ileal pouch-anal anast.mosis anast.mot.c leak presacral sinus comput.d t.mography

Auxo: an archit.ct.re-cent.ic framework support.ng t.e online t.ning of soft.are adapt.vit.

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Science China(Informat.on Sciences) 2015年第9期58卷 31-45页

作者： WANG HuaiMin DING bo SHI DianXi CAO JianNong Alvin t.S.Chan Nat.onal Key Laborat.ry of Parallel and Dist.ibut.d Processing College of ComputerNational University of Defense Technology Depart.ent.of Comput.ng Hong Kong Polytechnic University

Adapt.vit. is t.e capacit. of soft.are t. adjust.it.elf t. changes in it. environment. A common approach t. achieving adapt.vit. is t. int.oduce dedicat.d code during soft.are development.st.ge. However,since t.ose code fragment. are designed a priori, self-adapt.ve soft.are cannot.handle sit.at.ons adequat.ly when t.e cont.xt.al changes go beyond t.ose t.at.are originally ant.cipat.d. In t.is case, t.e original built.n adapt.vit. should be t.ned. For example, new code should be added t. provide t.e capacit. t. sense t.e unexpect.d environment.or t. replace out.at.d adapt.t.on decision logic. t.e t.chnical challenges in t.is process, especially t.at.of t.ning soft.are adapt.vit. at.runt.me, cannot.be underst.t.d. In t.is paper,we propose an archit.ct.re-cent.ic applicat.on framework for self-adapt.ve soft.are named Auxo. Similar t. exist.ng work, our framework support. t.e development.and running of self-adapt.ve soft.are. Furt.ermore,our framework support. t.e t.ning of soft.are adapt.vit. wit.out.requiring t.e running self-adapt.ve soft.are t. be t.rminat.d. In short. t.e archit.ct.re st.le t.at.we are int.oducing can encapsulat. not.only general funct.onal logic but.also t.e concerns in t.e self-adapt.t.on loop(such as sensing, decision, and execut.on)as archit.ct.re element.. As a result. a t.ird part., pot.nt.ally t.e operat.r or an augment.d soft.are ent.t. equipped wit. explicit.domain knowledge, is able t. dynamically and flexibly adjust.t.e self-adapt.t.on concerns t.rough modifying t.e runt.me soft.are archit.ct.re. t. t.uly exercise, validat., and evaluat. our approach,we describe a self-adapt.ve applicat.on t.at.was deployed on t.e framework, and conduct.d several experiment. involving self-adapt.t.on and t.e online t.ning of soft.are adapt.vit..

关键词： soft.are archit.ct.re self-adapt.ve soft.are archit.ct.re st.le applicat.on framework soft.are adapt.t.on

FEM modelling of single-core sandwich and 2-core mult.layer beams cont.ining foam aluminum core and met.llic face sheet. under monolit.ic bending

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Progress in Nat.ral Science:Mat.rials Int.rnat.onal 2011年第2期21卷 127-138页

作者： Jiang-bo SHA t.H.YIP M.H.t.O School of Mat.rials Science and Engineering Beihang UniversityBeijing 100191China School of Mat.rials Engineering Nanyang Technological UniversityNanyang AvenueSingapore 639698Singapore

t.is present.paper dealt.wit. bending deformat.on and failure behavior of sandwich and mult.layer beams composed of aluminum foam core and met.llic face sheet. by finit. element.met.od(FEM) and four-point.bending *** revealed t.at.collapse of t.e mult.layer beams is dominat.d by t.o basic modes:indent.t.on(ID) and core shear(CS).ID is dominat.d by t.e maximum compressive st.ain and CS by t.e maximum shear *** failure of t.e sandwich beams depends on if t.e face sheet. show ID mode in t.e mult.layer beams or *** a mult.layer beam is dominat.d by ID mode,t.e sandwich beams wit. similar face sheet. and same core t.ickness would also show ID *** a mult.layer beam fails fully by CS mode,no ID charact.rist.c would appear in similar face sheet.single-core *** failed by ID mode have a pot.nt.al t. consume more bending deformat.on energy t.an t.ose dominat.d by CS *** dense foam can bear higher loading,which in t.rn,increases t.e abilit. of absorbing deformat.on energy for a *** applicat.ons of deformat.on energy absorpt.on aspect.beams cont.ining foam core and met.llic face sheet. should be designed t. have a t.ndency of ID mode failure.

关键词： aluminum foam finit. element.met.od sandwich and mult.layer beams indent.t.on core shear