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A Single Hypoxic Event.Ameliorat.s Pilocarpine Induced Hyperkinet.c Movement. in Planaria

Nat.ral Science 2022年第4期14卷 149-156页

作者： t.agan Neufeld t.evor N. Carniello blake t. Dot.a Behavioural Neuroscience School of Natural Sciences Laurentian University Sudbury ON Canada

Int.rmit.ent.hypoxia or hypoxia t.erapy is exposing an individual t. oxygenat.on condit.ons t.at.are below at.ospheric levels in a planned or acut. t.meframe. Hypoxia t.erapy is a pot.nt.ally novel t.erapeut.c st.at.gy for a variet. of pat.ologies including: mit.chondrial disorders, exercise t.aining, and mild cognit.ve impairment.. Mit.chondrial dysfunct.on, hyperkinet.c movement., and cognit.ve impairment. are hallmarks of seizures and st.t.s epilept.cus (SE). A seizure can be considered uncont.olled elect.ical act.vit. in t.e brain and SE is a seizure last.ng more t.an 30 minut.s, or mult.ple seizures wit.out.regaining consciousness in bet.een. We examined t.e possibilit. of using t.e Pilocarpine model for seizure like act.vit. on brown planaria (Dugesia t.grine). Pilocarpine is a muscarinic acet.lcholine recept.r agonist.capable of creat.ng seizure relat.d brain damage. We ut.lized 5 mM dosages of pilocarpine and t.en measured open field behaviour for 3 minut.s. Mobilit. and aversive hyperkinet.c movement. were observed t.roughout.t.e measurement.phase. Aft.r exposure t. 5 mM pilocarpine, t.e planaria displayed behaviours consist.nt.wit. seizures (e.g. aversive hyperkinet.c movement. and decreased mobilit.). Addit.onally, we measured t.e effect. of an acut. hypoxic event.on Planaria behaviour. We used 25% carbonat.d wat.r t. creat. a hypoxic environment.for t.e planaria and t.en measured mobilit. and hyperkinet.c movement. for 3 minut.s. We not.d t.at.exposure t. t.e hypoxic en-vironment.produced no changes in behaviour. However, t.e aversive hyperkinet.c move-ment. produced wit. pilocarpine administ.at.on were complet.ly absent.when a brief (3 minut.s) hypoxic episode followed t.e pilocarpine exposure (p t.when t.e ordering of pilocarpine and hypoxia were count.rbal-anced. t.is ordering effect.was consist.nt.across 40 t.ials. Furt.er evaluat.on of t.e pilo-carpine seizure model and int.rmit.ent.hypoxia on planarian behaviour is warrant.d.

关键词： Hypoxia Pilocarpine Planaria Hyperkinet.c Movement. Seizure Model

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Shift. in Phot.n Spect.al Power Densit.es wit.in Schumann (7.7 t. 7.8 Hz) Values in Microt.bules during Complex Magnet.c Field Exposures May Reflect.an Informat.on Int.rface wit. Universal Energies

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Open Journal of Biophysics 2015年第3期5卷 84-95页

作者： Michael A. Persinger blake t. Dot.a David A. E. Vares St.nley A. Koren Quant.m Neurobiology Laborat.ry Behavioural Neuroscience Biomolecular Sciences and Human Studies Programs Laurentian University Sudbury Canada

t.e specific diamet.r of microt.bules was shown t. be a primary solut.on when magnet.c energy was set.equal t. Casimir energy. t. discern if t.is spat.al cont.inment.could be foci for informat.on phot.n emissions were measured from preparat.ons of microt.bules (Mt.) while t.ey were exposed in sequent.al 4 min int.rvals t. various pat.erns of weak magnet.c fields whose int.nsit.es ranged from 3 t. 10 μt. Calculat.ons from t.e median mass of a t.bulin dimer, it. summed charges and t.e applied magnet.c field as well as t.e change in magnet.c moment.derived from t.e energy of t.e hydrogen line when applied t. our experiment.l fields predict.d a dynamic shift.(Δf) bet.een 0.03 and 0.21 Hz. Spect.al power densit.es (SPD) indicat.d marked enhancement. in phot.n numbers during periods of magnet.c field exposures wit.in t.e 7.6 t. 7.8 Hz increment. t.e t.t.l SPD unit. for t.e shift.were 10-18 t. 10-17 J per s. Five of t.e eight.pat.erns elicit.d a split.spect.um of power wit.in t.is range. Separat. fact.r analyses of t.e SPDs of t.e serial values t.at.composed t.e point. of t.e act.al field pat.erns indicat.d t.ose t.at.evoked t.e split.spect.um (Δf = 0.05 t. 0.13 Hz) displayed significant.y higher loadings on t.e same fact.r compared t. t.ose t.at.did not. If t.is shift.in phot.n energy reflect. a phase modulat.on of t.e coherence frequency (8 MHz) of Mt., t.e increment.of energy per MHz frequency would be wit.in t.e energy of t.e neut.al hydrogen line. t.ese result. suggest.t.at.t.e int.insic st.uct.re or informat.on from specific int.nsit. magnet.c fields when applied t. Mt. is reflect.d in phot.n energy densit.es vacillat.ng around t.e fundament.l Schumann Resonance t.at.could be an int.rface bet.een Casimir and magnet.c sources.

关键词： Microt.bules Casimir Energy Magnet.c Energy Phot.n Emissions Schumann Resonance Phase Modulat.on Split.Spect.um

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微软开启“未来之家”之门软件公司将产品引入现实生活

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英语自学 2005年第12期 17-20页

作者： ScoT. Blake Wayne t. Price 陈健

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Design of molecule-based magnet.c conduct.rs

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Nano Research 2014年第12期7卷 1832-1842页

作者： Naureen Akht.r Graeme R. blake Robert. Felici Heinz Amenit.ch t.omas t. M. Palst.a Pet.a Rudolf Zernike Inst.t.t. for Advanced Mat.rials University of Groningen Nijenborgh 4 NL-9747AG Groningen The Netherlands ESRF BP 220 F-38043 Grenoble Cedex 9 France Inst.t.t. of Inorganic Chemist.y Graz University of Technology Stremayerg. 9/IV A-8010 Graz Austria

在工艺的设备启用讲道理地设计的薄电影的使用是在材料科学的一个公认的目标。然而，与控制得好的尺寸和生长方向用高度订的超分子的体系结构构造如此的薄电影留下了一逃犯目标。这里，我们介绍一个 layer-by-layer 协议种包括 arachid... 详细信息

在工艺的设备启用讲道理地设计的薄电影的使用是在材料科学的一个公认的目标。然而，与控制得好的尺寸和生长方向用高度订的超分子的体系结构构造如此的薄电影留下了一逃犯目标。这里，我们介绍一个 layer-by-layer 协议种包括 arachidic 酸和施主二度(et.ylenedioxy ) 的基于分子的磁性的售票员的混合薄电影 t.t.at.iafulvalene (BEDO-t.F ) 作为器官的部件和 Cu/Gd 建筑群作为无机的部件。分层的混合薄电影的构造被采用 Langmuir-Blodget. 方法以周围的条件完成，它在电影厚度上提供好控制并且在单层分子收拾行李。是由 X 光检查衍射示威了，这些电影与不同器官、无机的 sublat.ices 是水晶的，在 BEDO-t.F 分子的层与无机的层被连接的地方。由于 Langmuir-Blodget. 免职技术的灵活性，这结果与各种各样的功能向秩序井然的电影的准备显示一条线路，自愿与 BEDO-t.F 的单位被相结合的无机的混合物的决定了。而且，在许多底层上扔电影的能力在便宜底层上为降低费用的设备制造建立潜力。

关键词：超分子结构设计导体杂化薄膜磁性无机成分有序薄膜四硫富瓦烯

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Magnet.c Field Configurat.ons Corresponding t. Elect.ic Field Pat.erns t.at.Evoke Long-t.rm Pot.nt.at.on Shift.Power Spect.a of Light.Emissions from Microt.bules from Non-Neural Cells

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Open Journal of Biophysics 2014年第4期4卷 112-118页

作者： blake t. Dot.a David A.E. Vares Carly A. Buckner Robert.M. Lafrenie Michael A. Persinger Biomolecular Sciences and Behavioural Neuroscience Programs Laurentian University Sudbury Canada

Phot.n count. were measured every 15 ms for 75 s from microt.bule-enriched preparat.ons (and nuclei) from mouse melanoma cells during baseline and aft.r 2 min exposures t. 1 μt.magnet.c fields. t.e magnet.c fields were generat.d from a circular array of solenoids and present.d wit. accelerat.ng or decelerat.ng rot.t.on velocit.es. t.e range of phot.n radiant.flux densit. was in t.e order of 10-12 W·m-2. Microt.bules preparat.ons t.at.had been exposed for only 2 min t. a magnet.c field configurat.on corresponding t. t.e elect.ic field pat.ern t.at.induced long-t.rm pot.nt.at.on in neural t.ssue when applied as elect.ic current.displayed peaks of spect.al power densit.es wit.in 7 - 8 Hz, 9.5 Hz, 14 - 15 Hz, and 22 Hz bands. t.e major peak (9.4 Hz) bandwidt. was approximat.ly 0.1 Hz. While microt.bule preparat.ons exposed for 2 min t. a 7 Hz sine-wave or in t.e absence of a field emit.ed an overall similar level of spect.al power densit., t.e peaks in power densit. were not.present. t.eat.ent.wit. t.e Lt. pat.erned fields, compared t. t.e baseline or sine-wave fields primarily alt.red t.e frequency band in which t.e amplit.de of t.e phot.n field was expressed. t.ese result. suggest.t.at.t.e phot.n emissions from microt.bule preparat.ons have t.e capacit. t. respond t. specifically-pat.erned or geomet.ic shapes of magnet.c fields by alt.ring spect.al configurat.ons rat.er t.an t.e absolut. numbers of phot.ns.

关键词： Microt.bules Phot.n Emissions Spect.al Densit. Shift. Physiologically-Pat.erned Magnet.c Fields

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“Doubling” of local phot.n emissions when t.o simult.neous, spat.ally-separat.d, chemiluminescent.react.ons share t.e same magnet.c field configurat.ons

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Journal of Biophysical Chemist.y 2012年第1期3卷 72-80页

作者： blake t. Dot.a Michael A. Persinger Biomolecular Sciences Program Laurentian University Sudbury Canada

t.e aim of t.e present.experiment. was t. discern if t.e “ent.nglement.-like phot.n emissions from pairs of cell cult.res or human brains separat.d by significant.dist.nces but.sharing t.e same circling magnet.c field could be demonst.at.d wit. a classic chemiluminescent.react.on produced by hydrogen peroxide and hypochlorit.. Simult.neous inject.on of t.e same amount.of peroxide int. a local dish (above a phot.mult.plier t.be) and a dish 10 m away in a closed chamber produced a “doubling” of t.e durat.ons of t.e phot.n spikes only when t.e t.o react.ons were placed in t.e cent.r of separat. spaces around each of which magnet.c fields were generat.d as accelerat.ng group velocit.es cont.ining decreasing phase modulat.ons followed by decelerat.ng group velocit.es embedded wit. increasing phase modulat.ons. t.e durat.on of t.is “ent.nglement. was about.8 min. t.ese result. suggest.t.at.separat. dist.nces behave as if t.ey were “t.e same space” if t.ey are exposed t. t.e same precise t.mporal configurat.on of magnet.c fields wit. specific angular velocit.es.

关键词： Phot.n Emission Ent.nglement Angularly Accelerat.ng Magnet.c Fields Hydrogen Per-oxide/Hypochlorit. React.on

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Seed Germinat.on and t.eir Phot.n Emission Profile Following Exposure t. a Rot.t.ng Magnet.c Field

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Open Journal of Biophysics 2019年第4期9卷 254-266页

作者： Vict.ria L. Hossack Michael A. Persinger blake t. Dot.a Behavioural Neuroscience and Biology Programs Laurentian University Sudbury Ontario Canada

A mult.t.de of experiment. have applied magnet.c fields t. plant. or seeds and found a variet. of different.and somet.mes cont.adict.ng result.. A magnet.c field generat.ng device called t.e Chrysalis resonat.r has been shown t. influence t.e brain act.vit. of human part.cipant., t.e phot.n emissions from bact.ria, mammalian cell cult.res and wat.r. In t.is experiment.sunflower seeds (Heliant.us annus) were allowed t. begin germinat.on and t.en exposed t. eit.er t.e field generat.d by t.e Chrysalis resonat.r or a sham condit.on. t.eir growt. and phot.n emissions were t.ken over t.e next.5 days. It.was found t.at.t.e seeds showed less germinat.on 48 hours aft.r exposure and significant.y higher phot.n emissions when 3 seeds were measured t.get.er in a dish, but.not.if 2 seeds or 1 seed were measured. t.ere were no significant.differences in t.e phot.n measurement. from t.e wat.r t.e seeds were germinat.ng in. t.ese result. may indicat. t.at.t.e seeds became more sensit.ve t. t.e presence of neighbouring seeds. t.e phot.n emissions result. were also significant.y impact.d by ext.rnal weat.er condit.ons.

关键词： Seed Germinat.on Phot.n Communicat.on Magnet.c Field

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Power St.ipping of Asbest.s-Cont.ining Insulat.on from Elect.ical Cable

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Occupat.onal Diseases and Environment.l Medicine 2019年第3期7卷 65-74页

作者： Charles L. blake Giffe t. Johnson Raymond D. Harbison Bureau Verit.s Kennesaw GA USA Cent.r for Environment.l and Occupat.onal Risk Analysis and Management College of Public Health University of South Florida Tampa FL USA

Effort. t. recycle copper from elect.ical conduct.rs have led t. t.e development.of specialized machines, which aut.mat.cally remove insulat.ng covers from wires and cable product.. In t.e past. cert.in wire and cable product. were insulat.d using chrysot.le asbest.s. t.is research was undert.ken t. det.rmine t.e asbest.s fiber exposure risks associat.d wit. power st.ipping machinery t. remove asbest.s-cont.ining insulat.on mat.rials from elect.ical wire or cable. A Rigby Machinery, Inc., Model 4H elect.ic powered wire/cable insulat.on st.ipping machine was acquired along wit. approximat.ly 42 m of asbest.s insulat.d cable. During t.o separat., but.nearly ident.cal, t.st.sessions, a laborer used t.e wire st.ipper t. remove t.e asbest.s-cont.ining insulat.on from t.e subject.cable. t.is work t.ok place wit.in a closed met.l building wit. a t.t.l int.rior volume of 2500 m3. Indust.ial hygiene personal and area air samples were collect.d for airborne fibers t.roughout.all wire st.ipping periods. Collect.d air samples were analyzed using phase cont.act.microscopy (PCM) and t.ansmission microscopy (t.M). t.e result. of analysis using PCM for personal samples (n = 3) t.ken during periods of cont.nuous cable st.ipping act.vit. showed t.st.period airborne fiber exposures ranging from 0.034 t. 0.068 (mean 0.056 f/cc). Follow-up analysis of t.ese personal samples using t.M indicat.d asbest.s adjust.d PCM exposures ranging from 0.017 t. 0.045 (mean 0.033 f/cc). Area air samples t.ken at.dist.nces ranging from 2 t. 9 met.rs from t.e wire st.ipper (n = 16) showed asbest.s adjust.d PCM concent.at.ons ranging from less t.an 0.0001 t. 0.041 f/cc (mean 0.007 f/cc). t.e process of power st.ipping asbest.s-cont.ining insulat.on from elect.ical wires and cables can cause exposure t. airborne asbest.s fibers. However, t.e levels of such exposure are not.expect.d t. exceed t.e current.occupat.onal exposure limit. for asbest.s of 0.1 f/cc as an 8-hr t.A or 1.0 f/cc averaged over a 30-minut. exposure period.

关键词： Asbest.s Exposure Insulat.ng Covers Power St.ipping Elect.ical Wire Chrysot.le Asbest.s Asbest.s Fibers Asbest.s-Relat.d Disease Asbest.s-Cont.ining Mat.rial

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Exposure of Weak t.me-Invariant.Elect.omagnet.c Fields t. B16-BL6 Cell Cult.res Alt.r Biophot.n Emission Profile as a Funct.on of Dist.nce

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Open Journal of Biophysics 2020年第2期10卷 47-53页

作者： Billy C. S. Yearingt.n Vict.ria L. Hossack blake t. Dot.a Behavioural Neuroscience and Biology Programs Laurentian University Sudbury Canada

Biophot.n emission is produced by all living syst.ms;t.is emission pat.ern has been shown t. be alt.red by t.e presence of an elect.omagnet.c field (EMF). Cult.res of B16-BL6 cells were exposed t. a weak EMF produced by a specially const.uct.d EM generat.r, called t.e “Resonat.r”, for one hour. t.is EM generat.r incorporat.s mult.ple geomet.ic rat.os in it. design, including t.e golden rat.o (phi), pi, root.2, root.3, and root.5. It.has been used previously t. purify wat.r of t.xins. t.ere was a significant.decrease in mean phot.n count. from B16-BL6 cells exposed at.a dist.nce of 1 m compared t. t.ose exposed at.0 m. Alt.rat.ons in t.e spect.al power densit. variabilit. were also observed in t.e 8 - 10 Hz range. t.e EM generat.r may have an impact.on t.e viabilit. of t.e exposed cell cult.res, but.only at.specific dist.nces.

关键词： Elect.omagnet.c Fields B16-BL6 Cells Spect.al Power Densit. Biophot.n Emission

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QX-314抑制细菌穿孔毒素和神经元t.PV1介导的金黄色葡萄球菌引发的疼痛

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中国疼痛医学杂志 2019年第3期25卷 163-166页

作者： blake KJ Baral P Voisin t.贾欣同济大学医学院附属第一康复医院

许多细菌感染的特征是疼痛,但活性病原菌入侵机体时产生疼痛的潜在机制目前还不清楚。本研究阐明了耐甲氧西林金黄色葡萄球菌(MRSA)感染过程中产生疼痛的关键分子机制。研究发现自发性疼痛依赖于细菌毒性决定因子agr和细菌穿孔毒素PFt.... 详细信息

许多细菌感染的特征是疼痛,但活性病原菌入侵机体时产生疼痛的潜在机制目前还不清楚。本研究阐明了耐甲氧西林金黄色葡萄球菌(MRSA)感染过程中产生疼痛的关键分子机制。研究发现自发性疼痛依赖于细菌毒性决定因子agr和细菌穿孔毒素PFt.。MRSA的三种PFt.:alpha-溶血素(Hla)、酚溶性调质(PSMs)和双组份白介素(HlgAB),可直接引发神经元放电并产生自发性疼痛。背根神经节神经元的阳离子通道t.PV1特异性介导MRSA所致的热痛敏。在MRSA作用下神经元形成的穿孔允许QX-314进入伤害性感受器,从而在感染期间缓解疼痛。QX-314在MRSA感染时可以即刻并且长时程阻断疼痛,其镇痛效果明显优于临床广泛应用的利多卡因和布洛芬两种镇痛药。

关键词：细菌感染分子机制热痛敏机械痛敏感染过程神经元 QX-314 t.PV1 自发痛金黄色葡萄球菌伤害性感受器穿孔毒素

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