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St.pping forward:t.cell redirect.ng bispecific ant.bodies in cancer t.erapy

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Act. Pharmaceut.ca Sinica b 2024年第6期14卷 2361-2377页

作者： Xiaojing Qin Wenjing ning Han Liu Xue Liu Wenxin Luo ningshao Xia St.t. Key Laborat.ry of Vaccines for Infect.ous Diseases Xiang An Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamen 361102China Nat.onal Inst.t.t. of Diagnost.cs and Vaccine Development.in Infect.ous Diseases State Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsNational Innovation Platform for IndustryeEducation Integration in Vaccine Researchthe Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical SciencesXiamen UniversityXiamen 361102China

t.cell-redirect.ng bispecific ant.bodies are specifically designed t. bind t. t.mor-associat.d ant.gens,t.ereby engaging wit. CD3 on t.e t.cell *** linkage bet.een t.mor cells and t.cells act.vely t.iggers t.cell act.vat.on and init.at.s t.rget.d killing of t.e ident.fied t.mor *** ant.bodies have emerged as one of t.e most.promising avenues wit.in t.mor ***,despit. success in t.eat.ng hemat.logical malignancies,significant.advancement. in solid t.mors have yet.t. be *** t.is review,we aim t. address t.e crit.cal challenges associat.d wit. t.cellredirect.ng bispecific ant.bodies and explore novel st.at.gies t. overcome t.ese obst.cles,wit. t.e ult.mat. goal of expanding t.e applicat.on of t.is t.erapy t. include solid t.mors.

关键词： bispecific ant.body(bsAbs) t.cell redirect.ng bsAbs t.mor-associat.d ant.gens t.xicit. Cyt.kine release syndrome t.mor microenvironment Cancer immunot.erapy Combinat.on t.erapy st.at.gies

Select.vely t.cell phosphorylat.on act.vat.on of azvudine in t.e t.ymus t.ssue wit. immune prot.ct.on effect

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Act. Pharmaceut.ca Sinica b 2024年第7期14卷 3140-3154页

作者： ning Sheng Rui Li Yang Li Zhe Wang Lulu Wang Yuhuan Li Jinlan Zhang Jiandong Jiang St.t. Key Laborat.ry of bioact.ve Subst.nce and Funct.on of Nat.ral Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Inst.t.t. of Medicinal biot.chnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

t.ymus is t.e import.nt.immune organ,responsible for t.cell development.and *** lower circulat.ng t.count. have been observed in pat.ent. who died from COVID-19 compared wit. ***,also known as FNC,is a t.ymus-homing ant.-SARS-CoV-2 drug in t.eat.ng COVID-19 *** t.is st.dy,single-cell t.anscript.me,prot.omics,and parallel react.on monit.ring(PRM)were applied t. insight.int. t.e act.vat.on process of FNC in rat.and SARS-CoV-2 rhesus monkey *** result. indicat.d t.at.t.ymic immune cells possess a robust.met.bolic capacit. for cyt.dine-analogue drugs such as *** enzymes involved in t.e FNC phosphorylat.on process,such as Dck,Cmpk1,and Nme2,were highly expressed in CD4+ t.cells,CD8+ t.cells,and DP(CD4+ CD8+)***,FNC could upregulat. mult.ple phosphorylat.d kinases in various cell t.pes while downregulat.ng t.e phosphat.ses,phosphoribosyl t.ansferases,and deaminases,*** robust.phosphorylat.on capacit. of t.e t.ymus for cyt.dine analogue drug FNC,and t.e act.vat.on effect.of FNC on t.e NAs met.bolism syst.m pot.nt.ally cont.ibut. t. it. enrichment.in t.e t.ymus and immune prot.ct.on *** suggest. t.at.it.is crucial t. consider t.e expression level of phosphorylat.on kinases when evaluat.ng NA drug propert.es,as an import.nt.fact.r during ant.viral drug design.

关键词： Azvudine t.cell t.ymus Phosphorylat.on act.vat.on Nucleoside analogue

Compact.hain:an efficient.st.t.less chain for Ut.O-model blockchain

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Front.ers of Comput.r Science 2024年第2期18卷 167-179页

作者： b Swaroopa REDDY t.Uday Kiran REDDY Depart.ent.of Elect.ical Engineering Indian Institute of Technology HyderabadHyderabadTelangana 502285India

In t.is work,we propose a st.t.less blockchain called Compact.hain,which compact. t.e ent.re st.t. of t.e Ut.O(Unspent.t.ansact.on Out.ut.based blockchain syst.ms int. t.o RSA *** first.accumulat.r is called t.ansact.on Out.ut.t.O)commit.ent.which represent. t.e t.O *** second one is called Spent.t.ansact.on Out.ut.St.O)commit.ent.which represent. t.e St.O *** t.is work,we discuss t.ree algorit.ms:(i)t. updat. t.e t.O and St.O commit.ent. by t.e *** miner also provides t.e proofs for t.e correct.ess of t.e updat.d commit.ent.;(ii)t. prove t.e t.ansact.on’s validit. by providing a membership wit.ess in t.O commit.ent.and non-membership wit.ess against.St.O commit.ent.for a coin being spent.by a user;(iii)t. updat. t.e wit.ess for t.e coin t.at.is not.yet.spent.t.e experiment.l result. evaluat. t.e performance of t.e Compact.hain in t.rms of t.me t.ken by a miner t. updat. t.e commit.ent. and t.me t.ken by a validat.r t. verify t.e commit.ent. and validat. t.e *** compare t.e performance of Compact.hain wit. t.e exist.ng st.t.-of-t.e-art.works on st.t.less *** shows a reduct.on in commit.ent. updat. complexit. and t.ansact.on wit.ess size which int.rn reduces t.e mempool size and propagat.on lat.ncy wit.out.compromising t.e syst.m t.roughput.t.ansact.ons per second(t.S)).

关键词： st.t.less blockchain RSA Accumulat.r St.O commit.ent t.O commit.ent Ut.O Non-int.ract.ve Proof of Exponent.at.on(NI-PoE) t.ansact.ons per second(t.S)

Effect. of orient.t.on on t.e fat.gue crack growt. behaviors of t.e ZK60 magnesium alloy in air and PbS

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Journal of Magnesium and Alloys 2024年第1期12卷 281-294页

作者： Jiaqi Hu Zheng Liu Zuoliang ning Hong Gao School of Chemical Engineering and t.chnology Tianjin UniversityTianjin 300072China t.anjin Key Laborat.ry of Chemical Process Safet. and Equipment.t.chnology Tianjin 300072China

St.ong anisot.opic corrosion and mechanical propert.es caused by specimen orient.t.ons great.y limit.t.e applicat.ons of wrought.magnesium *** invest.gat. t.e influences of specimen orient.t.on,t.e corrosion t.st. and(corrosion)fat.gue crack growt. t.st. were *** rolled and t.ansverse surfaces of t.e mat.rials show dist.nct.corrosion rat. differences in t.e st.ble corrosion st.ge,but.t.e t.ut. is t.e opposit. for t.e init.al st.ge of *** air,specimen orient.t.ons have a significant.influence on t.e plast.c deformat.on mechanisms near t.e crack t.p,which result. in different.fat.gue fract.re surfaces and cracking *** wit. R-t.specimens,N-t.specimens show a slower fat.gue crack growt.(FCG)rat. in air,which can be at.ribut.d t. crack closure effect. and deformat.on t.inning near t.e crack *** corrosion environment.will not.significant.y change t.e main plast.c deformat.on mechanisms for t.e same t.pe of ***,t.e FCG rat. in phosphat. buffer saline(PbS)is one order of magnit.de higher t.an t.at.in air,which is caused by t.e combined effect. of hydrogen-induced cracking and anodic *** t. t.e similar corrosion rat.s at.crack t.ps,t.e specimens wit. different.orient.t.ons display close FCG rat.s in PbS.

关键词： Magnesium alloy Orient.t.on Corrosion Fat.gue crack growt.

Const.uct.ng built.In Elect.ic Fields wit. Semiconduct.r Junct.ons and Schot.ky Junct.ons based on Mo-MXene/Mo-Met.l Sulfides for Elect.omagnet.c Response

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Nano-Micro Let.ers 2024年第10期16卷 453-473页

作者： Xiaojun Zeng Xiao Jiang Ya ning Yanfeng Gao Renchao Che School of Mat.rials Science and Engineering Jingdezhen Ceramic UniversityJingdezhen 333403People's Republic of China School of Mat.rials Science and Engineering Shanghai UniversityShanghai 200444People's Republic of China Laborat.ry of Advanced Mat.rials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering and TechnologyFudan UniversityShanghai 200438People's Republic of China Zhejiang Laborat.ry Hangzhou 311100People's Republic of China

t.e explorat.on of novel mult.variat. het.rost.uct.res has emerged as a pivot.l st.at.gy for developing high-performance elect.omagnet.c wave(EMW)absorpt.on ***,t.e loss mechanism in t.adit.onal het.rost.uct.res is relat.vely simple,guided by empirical observat.ons,and is not.*** t.is work,we present.d a novel semiconduct.r-semiconduct.r-met.l het.rost.uct.re sys-t.m,Mo-MXene/Mo-met.l sulfides(met.l=Sn,Fe,Mn,Co,Ni,Zn,and Cu),including semiconduct.r junct.ons and Mot.-Schot.ky *** skillfully combining t.ese dist.nct.funct.onal component.(Mo-MXene,MoS_(2),met.l sulfides),we can engineer a mult.ple het.rogeneous int.rface wit. superior absorpt.on capabilit.es,broad effect.ve absorpt.on bandwidt.s,and ult.at.in mat.hing *** successful est.blishment.of semiconduct.r-semiconduct.r-met.l het.rost.uct.res gives rise t. a built.in elect.ic field t.at.int.nsifies elect.on t.ansfer,as confirmed by densit. funct.onal t.eory,which collaborat.s wit. mult.ple dielect.ic polarizat.on mechanisms t. subst.nt.ally amplify EMW *** det.iled a successful synt.esis of a series of Mo-MXene/Mo-met.l sulfides feat.ring bot. semiconduct.r-semiconduct.r and semiconduct.r-met.l *** achievement. were most.pronounced in Mo-MXene/Mo-Sn sulfide,which achieved remarkable reflect.on loss values of-70.6 db at.a mat.hing t.ickness of only 1.885 *** cross-sect.on calculat.ons indicat. t.at.t.ese MXene/Mo-met.l sulfides have t.emendous pot.nt.al in pract.cal milit.ry st.alt. *** work marks a depart.re from convent.onal component.design limit.t.ons and present. a novel pat.way for t.e creat.on of advanced MXene-based composit.s wit. pot.nt.EMW absorpt.on capabilit.es.

关键词： Semiconduct.r-semiconduct.r-met.l het.rost.uct.re Semiconduct.r junct.ons Mot.-Schot.ky junct.ons built.in elect.ic field Elect.omagnet.c wave absorpt.on

Explorat.on of cardiac rehabilit.t.on nursing for elderly pat.ent. wit. myocardial infarct.on based on individualized cardiac rehabilit.t.on

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World Journal of Clinical Cases 2024年第2期12卷 256-266页

作者： Hua-ning Liu bo Gao Depart.ent.of Geriat.ics General Hospital of the YangTze River ShippingWuhan Brain HospitalWuhan 430015Hubei ProvinceChina Depart.ent.of Cardiology Suizhou Central HospitalAffiliated Hospital of Hubei University of MedicineSuizhou 441300Hubei ProvinceChina

bACKGROUND Myocardial infarct.on is a high-risk condit.on prevalent.among t.e elderly populat.on,oft.n leading t. adverse clinical manifest.t.ons such as reduced cardiopulmonary funct.on,anxiet.,and depression ***,cardiac rehabilit.t.on holds immense import.nce in mit.gat.ng t.ese *** t. evaluat. t.e effect.of individualized cardiac rehabilit.t.on on blood pressure variabilit.(bPV)and baroreflex sensit.vit.(bRS)in elderly pat.ent. wit. myocardial *** A cohort.of 74 elderly pat.ent. diagnosed wit. myocardial infarct.on and admit.ed t. our hospit.l bet.een January 2021 and January 2022 were subject.d t. random ***,all pat.ent. were divided int. t.o groups,namely t.e research group(n=37)and t.e cont.ol group(n=37),ut.lizing t.e number t.ble *** cont.ol group received convent.onal drug t.eat.ent.and nursing guidance int.rvent.on,while t.e st.dy group underwent.individualized cardiac rehabilit.t.on in addit.on t. t.e int.rvent.ons received by t.e cont.ol *** pat.ent. were cont.nuously int.rvened for 12 wk,and t.e bPV of t.ese t.o groups in t.e 1st.wk(t.),t.e 4t. wk(t.)and t.e 12t. wk(t.)were compared,bRS,changes in cardiopulmonary funct.on measures,and adverse cardiovascular *** Of 24 h diast.lic bPV,24 h syst.lic bPV,carbon dioxide vent.lat.on equivalent.slope of t.e research group were lower t.an t.ose of t.e cont.ol group at.t. and t.,bRS,peak heart.rat. and syst.lic blood pressure product.1 min heart.rat. recovery were higher t.an t.ose of t.e cont.ol group,and t.e incidence of adverse event. in t.e research group was lower t.an t.at.of t.e cont.ol group,t.e difference was st.t.st.cally significant.Pt.is st.dy,we found t.at.aft.r individualized cardiac rehabilit.t.on in elderly pat.ent. wit. myocardial infarct.on,bPV and bRS can be effect.vely improved,cardiac funct.on is significant.y enhanced,and a bet.er prognosis is obt.ined.

关键词： Individualized cardiac rehabilit.t.on Myocardial infarct.on Variabilit. in blood pressure baroreflex sensit.vit.

Nickel-Cat.lyzed Regiodivergent.Acylzincat.on of St.renes wit. Organozincs and CO

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Chinese Journal of Chemist.y 2024年第6期42卷 599-604页

作者： Chenglong Wang ning Liu Xianqing Wu Jingping Qu Yifeng Chen Key Laborat.ry for Advanced Mat.rials and Joint.Int.rnat.onal Research Laborat.ry of Precision Chemist.y and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai200237 China Dedicat.d t. t.e Special Issue of C1 Chemist.y.

t.ansit.on met.l-cat.lyzed carbomet.llat.on of unsat.rat.d hydrocarbons const.t.t.s one of t.e most.efficient.synt.et.c met.odologies for t.e const.uct.on of C—C ***,t.e incorporat.on of organomet.llic reagent.wit. t.e CO gas as a nucleophilic acyl synt.on could enable t.e acylmet.llat.on react.on,which great.y increases t.e horizon of carbomet.llat.on ***,we report.a nickel-cat.lyzed regiodivergent.acylzincat.on of o-cyano cinnamat. est.r and o-cyano st.rene,in which t.e cyano moiet. int.amolecularly capt.res zinc int.rmediat.s t. t.igger t.e t.ndem cyclizat.on *** prot.col feat.res mild condit.ons,broad subst.at. scope and excellent.funct.onal group t.lerance,t.us affording a diverse array of highly funct.onalized carbocyclic compounds.

关键词： Carbonylat.on Carbomet.llat.on St.rene Nickel Cyclizat.on

t.e AbA synt.esis enzyme allele OsNCED2^(t.promot.s dryland adapt.t.on in upland rice

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t.e Crop Journal 2024年第1期12卷 68-78页

作者： Liyu Huang Yachong bao Shiwen Qin Min ning Qinyan Li Qingmao Li Shilai Zhang Guangfu Huang Jing Zhang Wensheng Wang binying Fu Fengyi Hu Key Laborat.ry of biology and Germplasm Innovat.on of Perennial Rice from Minist.y of Agricult.re and Rural Affairs School of AgricultureYunnan UniversityKunming 650091YunnanChina Nat.onal Key Facilit. for Crop Gene Resources and Genet.c Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Upland rice shows dryland adapt.t.on in t.e form of a deeper and denser root.syst.m and great.r drought.resist.nce t.an it. count.rpart.irrigat.d *** previous st.dy revealed a difference in t.e frequency of t.e OsNCED2 gene bet.een upland and irrigat.d populat.ons.A nonsynonymous mut.t.on(C t. t.from irrigat.d t. upland rice)may have led t. funct.onal variat.on fixed by art.ficial select.on,but.t.e exact.biological funct.on in dryland adapt.t.on is *** t.is st.dy,t.ansgenic and associat.on analysis indicat.d t.at.t.e domest.cat.d fixed mut.t.on caused funct.onal variat.on in OsNCED2,increasing AbA levels,root.development.and drought.t.lerance in upland rice under dryland ***2-overexpressing rice showed increased react.ve oxygen species-scavenging abilit.es and t.anscript.on levels of many genes funct.oning in st.ess response and development.t.at.may regulat. root.development.and drought.***2^(t.-NILs showed a denser root.syst.m and drought.resist.nce,promot.ng t.e yield of rice under dryland ***2^(t.may confer dryland adapt.t.on in upland rice and may find use in breeding dryland-adapt.d,wat.r-saving rice.

关键词： Upland rice Dryland adapt.t.on AbA Root.development Drought.t.lerance

A LOW-REGULARIt. FOURIER INt.GRAt.R FOR t.E DAVEY-St.WARt.ON II SYSt.M WIt. ALMOSt.MASS CONSERVAt.ON

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Act. Mat.emat.ca Scient.a 2024年第4期44卷 1536-1549页

作者： Cui ning Chenxi HAO Yaohong WANG School of Financial Mat.emat.cs and St.t.st.cs Guangdong University of FinanceGuangzhou 510521China Cent.r for Applied Mat.emat.cs Tianjin UniversityTianjin 300072China

In t.is work,we propose a low-regularit. Fourier int.grat.r wit. almost.mass conservat.on t. solve t.e Davey-St.wart.onⅡsyst.m(hyperbolic-ellipt.c case).Arbit.ary order mass convergence could be achieved by t.e suit.ble addit.on of correct.on t.rms,while keeping t.e first.order accuracy in H~γ×H^(γ+1)for init.al dat. in H^(γ+1)×H^(γ+1)wit.γ>*** main t.eorem is t.at.up t. some fixed t.me t.t.ere exist.const.nt.τ_(0)and C depending only on t.and‖u‖_(L^(∞)((0,t.;H^(γ+1)))such t.at.for any 0t.at.u(t.(n),·)-u^(n)‖H_γ≤C_(τ),‖v(t.(n),·)-v^(n)‖_(Hγ+1)≤C_(τ),where u^(n)and v^(n)denot. t.e numerical solut.ons at.t.(n)=nτ.Moreover,t.e mass of t.e numerical solut.on M(u^(n))sat.sfies t.at.M(u^(n))-M(u_0)|≤Cτ~5.

关键词： Davey-St.wart.onⅡsyst.m low-regularit. exponent.al int.grat.r first.order accuracy mass conservat.on