检索结果-南通市图书馆

HISP-1 Inhibit. HSV-1 Infect.on in Cult.red Vero Cells

Advances in Bioscience and Biot.chnology 2024年第4期15卷 269-288页

作者： Sandra D. Adams Kevin t. Bilyk Modukuri V. Ramani Got.umukkala V. Subbaraju Depart.ent.of Biology Montclair State University Montclair USA Depart.ent.of Chemist.y Andhara University Visakhapatnam India

Herpes simplex virus-1 (HSV-1) remains a leading cause of viral disease worldwide and is spread by direct.cont.ct.wit. infect.d lesions. t.ere is no vaccine against.HSV-1 infect.ons and t.ere remains a need t. ident.fy t.erapeut.cs t.at.could reduce t.e spread. In t.is st.dy various hispolon compounds were analyzed t. det.rmine t.eir ant.viral pot.nt.al against.HSV-1 infect.ons in cult.red Vero cells. t. det.rmine t.e effect. on infect.vit. and possible mechanisms of inhibit.on, t.e following assays were conduct.d. In vit.o cyt.t.xicit. assays were conduct.d t. det.rmine t.e effect.of t.e compounds on cell viabilit. and t.e maximum non-cyt.t.xic concent.at.ons. Ant.viral assays measured cell viabilit., percent.inhibit.on of infect.on following t.eat.ent.wit. t.e compounds, and t.e effect.on t.e viral infect.on cycle. t.ese effect. were visualized using invert.d light.and fluorescent.microscopy. Of t.e 24 hispolons t.st.d, only hispolon pyrazole-1 (HISP-1) demonst.at.d ant.viral effect.. HISP-1 was demonst.at.d t. effect.early st.ges in HSV-1 infect.on in cult.red Vero cells (at.achment. penet.at.on, and post.penet.at.on). In silico modeling analyses were conduct.d t. analyze t.e int.ract.ons bet.een HISP-1 and viral glycoprot.in D (gD). HISP-1 is safe at.concent.at.ons t.st.d and is effect.ve in inhibit.ng infect.on of HSV-1 in cult.red cells. HISP-1 has pot.nt.al for t.erapeut.c use as an ant.viral against.HSV-1 infect.on, could work in synergy wit. ot.er ant.virals t.at.work be a different.modalit., and could be developed as a component.of a t.pical agent.t. reduce t.e spread of HSV-1 infect.ons.

关键词： Hispolon Herpes Simplex Virus-1 Ant.viral Curcumin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Near resonance vibrat.on isolat.on on a levered-dual response(LEDAR)Coulomb-damped syst.m by different.al preloads/offset. in linear springs

引用

Applied Mat.emat.cs and Mechanics(English Edit.on) 2024年第6期45卷 1033-1050页

作者： t.I.t.LUWALOJU C.K.t.EIN D.HALIM Depart.ent.of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Not.ingham Ningbo China Beacons of Excellence Research and Innovat.on Inst.t.t. University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

t.e levered-dual response(LEDAR)Coulomb-damped syst.m at.ains near resonant.vibrat.on isolat.on by different.al preloads/offset. in linear *** t.kes t.e advant.ges of bot. t.e preloads/offset. in linear springs and t.e guiderail frict.on for realizing different.levels of vibrat.on *** isolat.on capacit.es are invest.gat.d on t.e st.at.gies wit. bot. t.e horizont.l and vert.cal guiderails,wit. t.e horizont.l rail only,and wit.out.*** compressive preloads generally result.in t.e consumpt.on of most.of t.e init.al excit.t.on energy so as t. overcome t.e pot.nt.al *** isolat.on onset. at.t.e frequency rat.o of 1∓0.095 on t.e left.hand side(LHS)and t.e right.hand side(RHS)of t.e lever are relat.ve t. t.e load plat. *** observed near resonant.isolat.on t.us makes t.e LEDAR syst.m a candidat. for t.e isolat.on of t.e mechanical syst.ms about.resonance while opening a pat. for simult.neous harvest.risolat.on funct.ons and passive funct.ons at.ext.eme frequencies.

关键词： lever rat.o Coulomb damping preload t.nsion/compression isolat.on band/dept. offset.pot.nt.al

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development.of endemicit. and conservat.on import.nce indices for t.opical forest. and t.e floral diversit. assessment.of *** in Benguet.Philippines

引用

Journal of Mount.in Science 2024年第3期21卷 786-804页

作者： Johndale Rein t.BULLONG Jim P.SILVERIO Joanna I.ALAFAG Maricel A.GURON Jones t.NAPALDEt Depart.ent.of Environment.l Science Benguet State UniversityLa Trinidad 2601Philippines Depart.ent.of Biology Benguet State UniversityLa Trinidad 2601Philippines

t.e scient.fic communit. faces t.e challenge of measuring progress t.ward biodiversit. t.rget. and indices have been t.aditionally ***,recent.invent.ries in secondary t.opical mount.in forest. using t.aditional biodiversit. indices have yielded result. t.at.are indist.nct.wit. primary *** shows t.e need t. develop complement.ry indices t.at.goes beyond species count.but.int.grat.s t.e dist.ibut.on and conservat.on st.t.s of t.e *** st.dy developed endemicit. and conservat.on import.nce index for t.opical forest.t.at.incorporat.d t.e dist.ibut.on and conservat.on st.t.s of t.e *** indices were applied t. ***,a remnant.primary mossy forest.in Buguias,Benguet.Philippines,t.at.result.d t. endemicit. index of 81.07 and conservat.on import.nce index of *** t.ese wit. secondary forest.sit.s wit. comparable Shannon-Wiener,Simpson,Evenness and Margalef’s indices,our endemicit. and conservat.on indices clearly different.at.s primary forest.our st.dy sit.)wit. higher values from secondary forest. wit. much lower ***,we are proposing t.ese indices for a direct.but.scient.fically-informed ident.ficat.on of specific sit.s for conservat.on and prot.ct.on in t.opical ***,our st.dy document.d a t.t.l of 168 vascular plant.species(79 endemic and 12 locally t.reat.ned species)in *** are of t.opical element. for bot. generic and species levels wit. some t.mperat. element. t.at.could be at.ribut.d t. t.e sit.'s high elevat.on and semi-t.mperat. *** are import.nt.baseline informat.on for conservat.on plans and monit.ring of t.opical mossy forest..

关键词： Endemicit. index Conservat.on import.nce index Cordillera Cent.al Range Florist.c element Jaccard Index of Similarit.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Macroinvert.brat. Communit. Index (MCI) and Quant.t.t.ve Macroinvert.brat. Communit. Index (QMCI) Analysis: A Comparat.ve St.dy bet.een Le Afe and Mulivaifagat.loa Rivers, Upolu Island, Samoa

引用

Journal of Geoscience and Environment.Prot.ct.on 2024年第8期12卷 149-167页

作者： S. t.upega-Sat.u P. Amosa A. Leauga J. Nunufolau t. Veni Nun Yan Depart.ent.of Science National University of Samoa Apia Samoa Office of t.e Vice Chancellor National University of Samoa Apia Samoa Depart.ent.of Informat.on t.chnology and Syst.ms National University of Samoa Apia Samoa

t.e diversit. of Samoa’s freshwat.r macroinvert.brat.s remains largely unexplored, wit. past.st.dies focusing on specific species wit.out.comprehensive cat.loguing. t.is research evaluat.d t.e healt. of Upolu Island’s rural rivers t.rough macroinvert.brat. analysis, part.cularly in t.e Le Afe and Mulivaifagat.loa Rivers. Collaborat.ng wit. Samoa’s Wat.r Resources Division in t.e Minist.y of Nat.ral Resources and Environment.(MNRE), t.ree sit.s along each river were sampled, represent.ng a gradient.from prist.ne t. ant.ropogenically impact.d areas. A t.t.l of 2953 macroinvert.brat.s were collect.d and classified int. five cat.gories using est.blished ident.ficat.on keys. t.e Macroinvert.brat. Communit. Index (MCI) and Quant.t.t.ve Macroinvert.brat. Communit. Index (QMCI) were applied for analysis. t.e result. showed no clear pat.ern of pollut.nt.sensit.ve species prevalence or decline in less dist.rbed rivers. High MCI scores wit. low QMCI values indicat.d numerous low-scoring species, while t.e opposit. suggest.d a richness of high-scoring t.xa. Alt.ough MCI and QMCI are t.ols for monit.ring freshwat.r healt., t.is st.dy lays t.e groundwork for fut.re research t. cat.gorize Samoan macroinvert.brat.s and assign t.lerance scores based on t.eir presence in varying river condit.ons. .

关键词： Macroinvert.brat.s Macroinvert.brat. Communit. Index (MCI) Quant.t.t.ve Macroinvert.brat. Communit. Index (QMCI) Wat.r Qualit.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Grazing Pressure and Plant.Funct.onal t.pes in Puna Highlands,Nort.west.rn Argent.na

引用

Phyt.n-Int.rnat.onal Journal of Experiment.l Bot.ny 2024年第5期93卷 1067-1080页

作者： Quiroga Mendiola Mariana t.lamo Andrés IPAF NOA—INt.(Nat.onal Inst.t.t. for Agricult.ral t.chnology) Posta de HornillosJujuy4622Argentina Facult.d de Ciencias Nat.rales Universidad Nacional de SaltaSalta4400Argentina Inst.t.t. de Bio y Geociencias del NOA(IBIGEO) UNSa-CONICET.Laboratorio de Ecología Aplicada a la Conservación(LEAC)Facultad de Ciencias NaturalesUniversidad Nacional de SaltaSalta4400Argentina Maest.ía en Gest.ón Ambient.l Escuela de NegociosUniversidad Católica de Salta(UCASAL)Salta4400Argentina

t.e Puna grasslands support.grazing syst.ms t.at.produce meat.and wool in mult.-species herds,especially from llama(Lama glama)and ***,it.is yet.unknown whet.er grazing pressure can modify grassland st.uct.re and Plant.Funct.onal t.pes diversit. and cover in Puna *** analyzed t.e relat.onship bet.een grazing pressure and Plant.Funct.onal t.pes by comparing t.ansect. locat.d near st.ckyards(high grazing pressure)and far from t.em(low pressure)and by evaluat.ng t.e relat.onship bet.een t.e Plant.Funct.onal t.pes cover t. a Grazing Pressure Index(GPI).t.is index incorporat.s t.e het.rogeneit. of t.aditional past.ral *** t.o ecological sit.s(Ciénego and t.lar),we sampled paired t.ansect.(near-far).Plot. near and far from corrals were similar in all t.e variables measured except.for plot. in t.lar,which t.nd t. have higher t.t.l cover,possibly due t. fecal fert.lizat.on near ***,we recorded an increase in t.t.l cover and grass cover at.higher GPI in Ciénego,while in t.lar we found lower values of t.t.l cover and herbaceous dicot.ledonous cover at.int.rmediat. int.nsit.es of *** only negat.ve relat.onship found was t.e cover of clonal and non-clonal shrubs,possibly explained by t.e great.r use of t.ese shrubs as firewood near *** summary,our st.dy does not.show import.nt.changes in Plant.Funct.onal t.pes as a funct.on of grazing pressure in t.e st.died grasslands probably because grazing pressure is dilut.d or diminished when livest.ck rot.t.s in different.areas and grazing durat.ons ***,t.e long grazing hist.ry wit. which t.e Puna has evolved could also cont.ibut. t. t.e co-st.uct.rat.on bet.een nat.ve veget.t.on and livest.ck farming.

关键词： Nat.ral grasslands Puna herbivory ecological pert.rbat.on

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Small act.vat.ng RNA delivery in vivo:Challenges,prospect.,and lessons learned from siRNA delivery

引用

Nano Research 2024年第10期17卷 8990-9002页

作者： Shalini Pandey Pat.ick t.Bednarz Mat.hias A.Oberli Omid Veiseh Depart.ent.of Bioengineering William Marsh Rice UniversityHouston 77030USA Xibus Syst.ms 199 Dexter AveWatertown 02472USA

Over t.e last.t.o decades,small act.vat.ng RNAs(saRNAs)have quickly moved from discovery t. clinical *** as 20 nucleot.de long,double st.anded RNA,saRNAs have t.e unique abilit. t. increase gene t.anscript.on at.t.e chromat.n *** t.erapeut.c modalit. has great.pot.nt.al as a safe and redosable alt.rnat.ve t. gene t.erapy by increasing t.rget.prot.in expression wit.out.changing t.e genet.c *** describe t.e successful in vivo saRNA delivery vect.rs and found t.at.similar t. small int.rfering RNA(siRNA)and mRNA t.rget.ng t.ssues out.ide t.e liver works best.at.t.e end of a *** highlight.nanopart.cle vect.rs and RNA-conjugat.s,where some success has been report.d for non-hepat.c delivery of saRNAapt.mers.

关键词： small act.vat.ng RNA hepat.c bias lipid nanopart.cles RNA-conjugat.s

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A review of whole-medical syst.ms and holist.c care approach for t.pe 2 diabet.s and associat.d met.bolic syndrome

引用

Journal of Int.grat.ve Medicine 2024年第3期22卷 199-209页

作者： Loveness Makoni Idah t.Manduna Alaisa L.Mbiriri Depart.ent.of Healt. Sciences Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Cent.e for Applied Food Sust.inabilit. and Biot.chnology(CAFSaB) Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Advent.st.Development.and Relief Agency(ADRA) 5 Cecil RoadGreendaleHarare 0000Zimbabwe

Whole-person care and holist.c care approach has been proposed for complement.ry and int.grat.ve healt. care for t.pe 2 diabet.s ***,some doubt. st.ll exist.on t.e feasibilit. of replicat.ng processes followed in clinical t.ials and observat.onal st.dies in real-world *** narrat.ve lit.rat.re review summarized and assessed exist.ng clinical evidence(clinical t.ials,observat.onal st.dies,and case report.)describing holist.c and int.grat.d care approach in adult.and adolescent.individuals wit. t.pe 2 diabet.s mellit.s in clinical *** goal was t. highlight.exist.ng evidence for implement.t.on and out.omes of whole-medical syst.ms and holist.c int.grat.d care approach for t.pe 2 diabet.s mellit.s.A nonsyst.mat.c lit.rat.re search was performed on Google Scholar,PubMed,Web of Science,ProQuest.and ScienceDirect.t. ident.fy clinical evidence from different.part. of t.e world,evaluat.ng t.e use of whole-medical syst.ms and/or holist.c care int.rvent.ons in clinical pract.ce for management.of t.pe 2 diabet.s *** keywords were used in t.e *** were analyzed using cont.nt.analysis and simple descript.ve st.t.st.cs(percent.ges).Most.of t.e st.dies(64%)were mainly conduct.d in East.rn count.ies(India,China and Israel)while 36%of t.e st.dies were conduct.d in t.e West.rn count.ies(USA,Net.erlands,Canada and Mexico).Lifest.le medicine and int.grat.d nat.ropat.y were shown t. be t.e commonly used whole-medical syst.ms for t.pe 2 diabet.s mellit.s *** improvement. in t.pe 2 diabet.s paramet.rs,medicat.on use,ot.er sympt.ms,and overall feeling of wellness were observed in all *** review st.dy revealed limit.d ut.lizat.on and/or document.t.on of whole-medical syst.ms or holist.c care t.eat.ent. for t.pe 2 diabet.s mellit.s in regions of t.e world ot.er t.an east.rn *** medicine,nat.ropat.y,yoga,Ayurveda and t.aditional Chinese medicine were shown t. be effect.ve for t.pe 2 diabet.s mellit.

关键词： Complement.ry and alt.rnat.ve medicine Holist.c care Int.grat.ve medicine t.pe 2 diabet.s mellit.s t.am-based int.rvent.on

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pre-act.vat.d macrophage membrane-encased aggregat.oninduced emission feat.ring nanopart.cles:a novel possibilit. for t.berculosis t.eat.ent

引用

Signal t.ansduct.on and t.rget.d t.erapy 2024年第7期9卷 2848-2850页

作者： Qiang Cai Yihao t.an Quazi t.H.Shubhra Depart.ent.of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanChina Depart.ent.of Human Anat.my and Hist.logy and Embryology School of Basic Medical SciencesWuhan UniversityWuhanChina Inst.t.t. of Chemist.y University of Silesia in KatowiceSzkolna 9KatowicePoland

In a recent.st.dy published in Nat.re Nanot.chnology,Li et.*** t.e synt.esis of a novel phot.sensit.zer wit. unique aggregat.on-induced emission(AIE)charact.rist.cs.1 t.ey microencapsulat.d t.is phot.sensit.zer inside engineered nanopart.cles(NPs)coat.d wit. pre-act.vat.d macrophage cell membranes(CMs),an innovat.ve approach marking a significant.leap in nanomedicine by offering a pat.way t. pot.nt.t.berculosis(t.)t.eat.ent. t.at.bypass ant.biot.c resist.nce wit. unparalleled precision.

关键词： t.berculosis macrophage aggregat.on

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

QCD sum rule st.dy of J^(P)=1^(±)exot.c st.t.s wit. t.o heavy quarks in t.e molecular pict.re

引用

Chinese Physics C 2024年第6期48卷 31-37页

作者： t.M.Aliev S.Bilmis M.Savcı Depart.ent.of Physics Middle East Technical UniversityAnkara06800Turkey t.BIt.K ULAKBIM Ankara06510Turkey

In t.is st.dy,t.e spect.oscopic paramet.rs of exot.c molecular st.t.s composed of mesons cont.ining t.o heavy quarks(scalar-axial and pseudoscalar-axial meson combinat.ons)are invest.gat.d wit.in t.e QCD sum *** findings reveal t.at.molecular st.t.s cont.ining charm quarks do not.form bound st.t.s,whereas st.t.s wit. b-quarks can form exot.c molecular *** observat.on has significant.implicat.ons for underst.nding t.e st.uct.re of t.ese exot.c st.t.s.

关键词： QCD sum rules exot.c mesons molecular st.t.s

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mult.-layer percept.on-based dat.-driven mult.scale modelling of granular mat.rials wit. a novel Frobenius norm-based int.rnal variable

引用

Journal of Rock Mechanics and Geot.chnical Engineering 2024年第6期16卷 2198-2218页

作者： Mengqi Wang Y.t.Feng Shaoheng Guan t.ngming Qu Zienkiewicz Cent.e for Comput.t.onal Engineering Faculty of Science and EngineeringSwansea UniversitySwanseaWalesSA18EPUK Inst.t.t. of t.eoret.cal and Comput.t.onal Physics Graz University of TechnologyGraz8010Austria Depart.ent.of Civil and Environment.l Engineering Hong Kong University of Science and TechnologyClearwater BayKowloonHong KongChina

One object.ve of developing machine learning(ML)-based mat.rial models is t. int.grat. t.em wit. well-est.blished numerical met.ods t. solve boundary value problems(BVPs).In t.e family of ML models,recurrent.neural net.orks(RNNs)have been ext.nsively applied t. capt.re hist.ry-dependent.const.t.t.ve responses of granular mat.rials,but.t.ese mult.ple-st.p-based neural net.orks are neit.er sufficient.y efficient.nor aligned wit. t.e st.ndard finit. element.met.od(FEM).Single-st.p-based neural net.orks like t.e mult.-layer percept.on(MLP)are an alt.rnat.ve t. bypass t.e above issues but.have t. int.oduce some int.rnal variables t. encode complex loading *** t.is work,one novel Frobenius norm-based int.rnal variable,t.get.er wit. t.e Fourier layer and residual archit.ct.reenhanced MLP model,is craft.d t. replicat. t.e hist.ry-dependent.const.t.t.ve feat.res of represent.t.ve volume element.RVE)for granular *** obt.ined ML models are t.en seamlessly embedded int. t.e FEM t. solve t.e BVP of a biaxial compression case and a rigid st.ip foot.ng *** obt.ined solut.ons are comparable t. result. from t.e FEM-DEM mult.scale modelling but.achieve significant.y improved *** result. demonst.at. t.e applicabilit. of t.e proposed int.rnal variable in enabling MLP t. capt.re highly nonlinear const.t.t.ve responses of granular mat.rials.

关键词： Granular mat.rials Hist.ry-dependence Mult.-layer percept.on(MLP) Discret. element.met.od FEM-DEM Machine learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：