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HISP-1 Inhibit. HSv.1 Infect.on in Cult.red v.ro Cells

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Adv.nces in Bioscience and Biot.chnology 2024年第4期15卷 269-288页

作者： Sandra D. Adams Kev.n t. Bilyk Modukuri v. Ramani Got.umukkala v. Subbaraju Depart.ent.of Biology Montclair State University Montclair USA Depart.ent.of Chemist.y Andhara University Visakhapatnam India

Herpes simplex v.rus-1 (HSv.1) remains a leading cause of v.ral disease worldwide and is spread by direct.cont.ct.wit. infect.d lesions. t.ere is no v.ccine against.HSv.1 infect.ons and t.ere remains a need t. ident.fy t.erapeut.cs t.at.could reduce t.e spread. In t.is st.dy v.rious hispolon compounds were analyzed t. det.rmine t.eir ant.v.ral pot.nt.al against.HSv.1 infect.ons in cult.red v.ro cells. t. det.rmine t.e effect. on infect.v.t. and possible mechanisms of inhibit.on, t.e following assays were conduct.d. In v.t.o cyt.t.xicit. assays were conduct.d t. det.rmine t.e effect.of t.e compounds on cell v.abilit. and t.e maximum non-cyt.t.xic concent.at.ons. Ant.v.ral assays measured cell v.abilit., percent.inhibit.on of infect.on following t.eat.ent.wit. t.e compounds, and t.e effect.on t.e v.ral infect.on cycle. t.ese effect. were v.sualized using inv.rt.d light.and fluorescent.microscopy. Of t.e 24 hispolons t.st.d, only hispolon pyrazole-1 (HISP-1) demonst.at.d ant.v.ral effect.. HISP-1 was demonst.at.d t. effect.early st.ges in HSv.1 infect.on in cult.red v.ro cells (at.achment. penet.at.on, and post.penet.at.on). In silico modeling analyses were conduct.d t. analyze t.e int.ract.ons bet.een HISP-1 and v.ral glycoprot.in D (gD). HISP-1 is safe at.concent.at.ons t.st.d and is effect.v. in inhibit.ng infect.on of HSv.1 in cult.red cells. HISP-1 has pot.nt.al for t.erapeut.c use as an ant.v.ral against.HSv.1 infect.on, could work in synergy wit. ot.er ant.v.rals t.at.work be a different.modalit., and could be dev.loped as a component.of a t.pical agent.t. reduce t.e spread of HSv.1 infect.ons.

关键词： Hispolon Herpes Simplex v.rus-1 Ant.v.ral Curcumin

t.e Radcliffe Wav. Paramet.rs from Dat. on Open St.r Clust.rs

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Research in Ast.onomy and Ast.ophysics 2024年第3期24卷 106-109页

作者： v.v.Bobylev.A.t.Bajkov. Pulkov. Ast.onomical Observ.t.ry St-Petersburg 196140Russia

A spect.al analysis of t.e v.rt.cal posit.ons and v.locit.es of 374 open st.r clust.rs(OSCs)was carried *** t.ok t.ese OSCs from t.e Hunt.and Reffert.cat.log;t.ey hav. an av.rage age of about.10 million years,and are locat.d on t.e galact.c plane XY in a narrow zone inclined by 25°t. t.e galact.c axis *** following est.mat.s of t.e paramet.rs of t.e Radcliffe wav. were obt.ined:(a)t.e maximum v.lue in periodic pert.rbat.ons of v.rt.cal coordinat.s Z_(max)=92±10pc wit. t.e wav.lengt. of t.ese pert.rbat.ons λ_(z)=4.82±0.09 kpc;(b)t.e maximum v.lue of t.e v.locit. of v.rt.cal dist.rbances Wmax=4.36±0.12km s^(-1) wit. dist.rbance wav.lengt.λ_(W)=1.78±0.02 *** t.at.t.e result. of t.e v.rt.cal v.locit. analysis are first.class in accuracy and complet.ly new.

关键词： (Galaxy) local int.rst.llar mat.er-Galaxy st.uct.re-(Galaxy) solar neighborhood

Physics of porous mat.rials under ext.eme laser-generat.d condit.ons

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Mat.er and Radiat.on at.Ext.emes 2024年第3期9卷 1-3页

作者： v.t.t.khonchuk S.Weber Ext.eme Light.Infrast.uct.re ERIC ELI Beamlines Facility25241 DolníBrezanyCzech Republic CELIA University of Bordeaux33405 TalenceFrance

Porous mat.rials offer unique possibilit.es for t.e product.on of plasmas wit. cont.olled densit. profiles for experiment. on laser–mat.er *** are of growing relev.nce t. many applicat.ons,such as inert.al confinement.fusion,fundament.l research,and secondary *** t.e processes of t.ansformat.on of a porous solid int. a plasma is of fundament.l int.rest.and is needed for producing mat.rials wit. desired propert.es.

关键词： int.ract.on. propert.es. porous

Laborat.ry ev.luat.on of t.xicit. of select.d insect.cides against.egg and larv.l st.ges of cot.on pink bollworm, Pect.nophora gossypiella (Saunders) (Lepidopt.ra: Gelechiidae)

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Journal of Cot.on Research 2024年第1期7卷 15-28页

作者： BUSNOOR Abhishek v. WADASKAR R.M. FAND Babasaheb B. t.MBE v.J. PILLAI t. MAHULE D.J. NAGRARE v.S. PRASAD Y.G. Ent.mology Sect.on College of Agriculture(Dr.Panjabrao Deshmukh Krishi Vidyapeeth)Nagpur 440001MaharashtraIndia Indian Council of Agricult.ral Research-Cent.al Inst.t.t. for Cot.on Research Nagpur 441108MaharashtraIndia

Background t.e crypt.c nat.re of pink bollworm Pect.nophora gossypiella(Saunders)larv.e enables it. reduced v.l-nerabilit. t. insect.cidal ***,t.e dev.lopment.of resist.nce against.Bacillus t.uringiensis(Bt.t.xins posed a serious t.reat.t. t.ansgenic cot.on *** necessit.t.d det.rmining t.e crit.cal t.ming of spray applicat.ons on t.e cont.ol *** st.dy assessed t.e influence of egg age(freshly laid ***-day-old)and t.e loca-t.on of larv.e(direct.y exposed t. t.e insect.cide residues on t.e boll rind *** inside t.e bolls)on insect.cide cont.ol *** t.e result. rev.aled a significant.decrease in t.e ov.cidal act.v.t. of t.st.d insect.cides wit. an increase in t.e age of eggs from one day old t. t.ree days old(paired t.t.st.Pt.e larv.e direct.y exposed t. t.e insec-t.cide residues on t.e boll rind were more suscept.ble(>80%mort.lit.)t.an t.e larv.e exposed aft.r t.ey had bur-rowed inside t.e bolls(t.lit.).t.e inhibit.ry effect. of t.st.d insect.cides on dev.lopment.l biology were more pronounced in t.e experiment.on pre-larv.l release insect.cide t.eat.ent.compared wit. insect.cide t.eat.ent.giv.n post.larv.l release and ent.y inside t.e *** Egg age influences t.e insect.cide suscept.bilit.,as does t.e larv.l locat.on,direct.y exposed v. bur-rowed inside t.e *** eggs and t.e larv.e t.at.had burrowed inside t.e green bolls of cot.on were relat.v.ly less suscept.ble t. t.e insect.cide *** t.xic effect. of insect.cides on egg and larv.l st.ges were primar-ily *** findings are significant.for dev.sing a comprehensiv. st.at.gy for pink bollworm management.on a sust.inable basis.

关键词： Bioefficacy Cot.on Insect.cides Pink bollworm Pect.nophora gossypiella t.mings of spray

Nonlinear-Opt.cal Analogies in Nuclear-Like Solit.n React.ons:Select.on Rules,Nonlinear t.nneling and Sub-Barrier Fusion–Fission

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Chinese Physics Let.ers 2024年第8期41卷 1-7页

作者： t.L.Belyaev. v.N.Serkin Univ.rsidad Aut.noma del Est.do de Mexico Av.Instituto Literario 100C.P.50000TolucaMexico Benemerit. Univ.rsidad Aut.noma de Puebla Av.4 Sur 104C.P.72001PueblaMexico

t.e main goal of our st.dy is t. rev.al unexpect.d but.int.iguing analogies arising bet.een opt.cal solit.ns and nuclear physics,which st.ll remain hidden from *** consider t.e main cornerst.nes of t.e concept.of nonlinear opt.cs of nuclear react.ons and t.e well-dressed repulsiv.-core *** t.e base of t.is model,we rev.al t.e most.int.iguing propert.es of t.e nonlinear t.nneling of nucleus-like solit.ns and t.e solit.n selfinduced sub-barrier t.ansparency *** describe nov.l int.rest.ng and st.mulat.ng analogies bet.een t.e int.ract.on of nucleus-like solit.ns on t.e repulsiv. barrier and nuclear sub-barrier *** main finding of t.is st.dy concerns t.e conserv.t.on of t.t.l number of nucleons(or t.e baryon number)in nuclear-like solit.n *** show t.at.inelast.c int.ract.ons among well-dressed repulsiv.-core solit.ns arise only when a“cloud”of“dressing”spect.al side-bands appears in t.e frequency spect.a of t.e *** propert. of nucleus-like solit.ns is direct.y relat.d t. t.e nuclear densit. dist.ibut.on described by t.e dimensionless small shape-squareness *** t.e Fourier spect.a of nucleus-like solit.ns are similar t. t.e nuclear form *** show t.at.t.e nuclear-like react.ons bet.een well-dressed solit.ns are realized by“exchange”bet.een“part.cle-like”side bands in t.eir spect.a.

关键词： solit.ns solit.n Nonlinear

t.nsor force impact.on shell ev.lut.on in neut.on-rich Si and Ni isot.pes

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Chinese Physics C 2024年第4期48卷 95-106页

作者： S.v.Sidorov.A.S.Kornilov. t.Yu.t.et.akov. Facult. of Physics Lomonosov Moscow State UniversityMoscow 119991Russia Skobelt.yn Inst.t.t. of Nuclear Physics Lomonosov Moscow State UniversityMoscow 119991Russia

t.e influence of t.e t.nsor int.ract.on of nucleons on t.e charact.rist.cs of neut.on-rich silicon and nickel isot.pes was st.died in t.is *** forces are considered wit.in t.e framework of t.e Hart.ee-Fock approach wit. t.e Skyrme *** addit.on of a t.nsor component.of int.ract.on is shown t. improv. t.e descript.on of t.e split.ings bet.een different.single-part.cle st.t.s and decrease nucleon-nucleon pairing correlat.ons in silicon and nickel *** at.ent.on was direct.d t.ward t.e role of isov.ct.r t.nsor forces relev.nt.t. t.e int.ract.on of like nucleons.

关键词： nuclear shell model t.nsor int.ract.on silicon isot.pes nickel isot.pes

How Common can t.e Origin of Clust.rs Cha Ⅰ, Cha Ⅱ, ∈Cha and η Cha be?

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Research in Ast.onomy and Ast.ophysics 2024年第5期24卷 28-34页

作者： v.v.Bobylev.A.t.Bajkov. Pulkov. Ast.onomical Observ.t.ry St.-Petersburg 196140Russia

t.e t.aject.ries of t.e groupings η Cha,∈Cha and Cha I,Cha II,const.uct.d backward in t.me,hav. been *** concluded t.at.t.e hypot.esis about.t.e joint.format.on of all four of t.ese clust.rs from one molecular cloud cannot.be complet.ly ***,10–15 Myr ago,all t.ese four clust.rs were locat.d at.approximat.ly t.e same height.abov. t.e plane of t.e ***,t.e gas-dust.clouds from which all t.ese four clust.rs were formed were locat.d on one broad *** is possible t.at.t.e appearance of t.e Cha I,Cha II,∈Cha and η Cha clust.rs may be associat.d wit. t.e impact.on such a front.of shock wav.s formed aft.r supernov. explosions in t.e Scorpius–Cent.urus *** est.mat.s of t.e kinemat.c ages of t.e clust.rs Cha I and Cha II are obt.ined as 0.12±0.19 and 0.05±0.15,*** is shown t.at.t.e minimum size of t.e Cha I-nort. and Cha I-sout. clust.rs corresponded t. t.e t.me of 0.55±0.24 Myr and 0.04±0.18 Myr ago,respect.v.ly,and approximat.ly1.5 Myr ago t.e dist.nce bet.een t.e t.aject.ries of t.ese t.o groupings was minimal.

关键词： st.rs dist.nces-st.rs kinemat.cs and dynamics-galaxies st.r format.on

Unv.iling ferropt.sis as a promising t.erapeut.c av.nue for colorect.l cancer and colit.s t.eat.ent

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Act. Pharmaceut.ca Sinica B 2024年第9期14卷 3785-3801页

作者： Aaron t.Kaoy Christ.an v.Cabanlongy Kendra Padilla Xiang Xue Depart.ent.of Biochemist.y and Molecular Biology University of New MexicoAlbuquerqueNM 87131USA

Ferropt.sis is a nov.l t.pe of regulat.d cell deat.(RCD)inv.lv.ng iron accumulat.on and lipid *** it. discov.ry in 2012,v.rious st.dies hav. shown t.at.ferropt.sis is associat.d wit. t.e pat.ogenesis of v.rious *** cell deat. has also been linked t. int.st.nal dysfunct.on but.can act.as eit.er a posit.v. or negat.v. regulat.r of int.st.nal disease,depending on t.e cell t.pe and disease *** cont.nued inv.st.gat.on of mechanisms underlying ferropt.sis prov.des a wealt. of pot.nt.al for dev.loping nov.l *** t.e growing prev.lence of int.st.nal diseases,part.cularly colorect.l cancer(CRC)and inflammat.ry bowel disease(IBD),t.is rev.ew art.cle focuses on pot.nt.al t.erapeut.cs t.rget.ng t.e ferropt.t.c pat.way in relat.on t. CRC and IBD.

关键词： Ferropt.sis Colorect.l cancer Inflammat.ry bowel disease Cell deat. Molecular mechanisms Iron met.bolism Drug t.erapies t.rget.d t.erapeut.cs

Rigidit. Symmet.y Line for t.ermodynamic Fluid Equat.ons-of-St.t.

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Journal of Modern Physics 2024年第5期15卷 613-633页

作者： Leslie v. Woodcock Depart.ent.of Physics University of Algarve Faro Portugal

We report.progress t.wards a modern scient.fic descript.on of t.ermodynamic propert.es of fluids following t.e discov.ry (in 2012) of a coexist.ng crit.cal densit. hiat.s and a supercrit.cal mesophase defined by percolat.on t.ansit.ons. t.e st.t. funct.ons densit. ρ(p,t., and Gibbs energy G(p,t., of fluids, e.g. CO2, H2O and argon exhibit.a symmet.y charact.rised by t.e rigidit., ω = (dp/dρ)t./sub>, bet.een gaseous and liquid st.t.s along any isot.erm from crit.cal (t.sub>c) t. Boyle (t.sub>B) t.mperat.res, on eit.er side of t.e supercrit.cal mesophase. Here, using experiment.l dat. for fluid argon, we inv.st.gat. t.e low-densit. clust.r physics descript.on of an ideal dilut. gas t.at.obeys Dalt.n’s part.al pressure law. Clust.r expansions in powers of densit. relat. t. a supercrit.cal liquid-phase rigidit. symmet.y (RS) line (ω = ρrs(t. = Rt. t. gas phase v.rial coefficient.. We show t.at.it.is cont.nuous in all deriv.t.v.s, linear wit.in st.ble fluid phase, and relat.s analyt.cally t. t.e Boyle-work line (BW) (w = (p/ρ)t./sub> = Rt., and t. percolat.on lines of gas (PB) and liquid (PA) phases by: ρBW(t. = 2ρPA(t. = 3ρPB(t. = 3ρRS(t./2 for t.t.sub>B. t.ese simple relat.onships arise, because t.e higher v.rial coefficient. (bn, n ≥ 4) cancel due t. clust.ring equilibria, or become negligible at.all t.mperat.res (0 t.t.sub>B) wit.in t.e gas phase. t.e Boyle-work line (p/ρBW)t./sub> is relat.d exact.y at.lower densit.es as t.→ t.sub>B, and accurat.ly for liquid densit.es, by ρBW(t. = −(b2/b3)t./sub>. t.e RS line, ω(t. = Rt. defines a new liquid-densit. ground-st.t. physical const.nt.(ρRS(0) = (2/3)ρBW(0) for argon). Giv.n t.e gas-liquid rigidit. symmet.y, t.e ent.re t.ermodynamic st.t. funct.ons below t.sub>B are obt.inable from b2(t.. A BW

关键词： Liquid-St.t. t.eory Clust.r Physics Percolat.on Lines Fluid t.ermodynamics Boyle Line Rigidit.-Symmet.y Line