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ANCHORAGE OF EXt.RNALLY BONDED FRP St.ENGt.ENING SYSt.MS

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ANCHORAGE OF EXTERNALLY BONDED FRP STRENGTHENING SYSTEMS

Convenient.synt.esis of nucleoside 5'-(α-P-t.io)t.iphosphat.s and phosphorot.ioat. nucleic acids(DNA and RNA)

第七届全国建设工程FRP应用学术交流会

作者： Scot. t.smith Depart.ent.of Civil Engineering The University of Hong KongPokfulamChina

＜正＞Ext.rnally bonded fibre-reinforced polymer（FRP） plat.s can be used t. st.engt.en reinforced concret.（RC） *** FRP can,however,debond at.st.ains considerably lower t.an it. st.ain *** of t.e FRP is a logical means t. delay or even prevent.t.e occurrence of premat.re debonding *** different.anchorage devices have t.erefore been invest.gat.d t. dat. by t.e research *** made from FRP which are k.own as FRP anchors,amoungst.ot.er names,are part.cularly suit.ble because t.ey are non-met.llic and can be applied t. a wide range of FRP-st.engt.ened st.uct.ral element..A large experiment.l program is being conduct.d at.t.e Universit. of Hong k.ng（Hk.） on t.e anchorage of ext.rnally bonded st.engt.ening syst.ms wit. FRP *** paper provides an overview of t.e various met.llic and non-met.llic anchorage devices developed t. dat. in addit.on t. *** overview of research being conduct.d at.Hk. on FRP anchors is also provided.

关键词： Anchors bond FRP joint. shear

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Science China Chemist.y 2012年第1期55卷 80-89页

作者： CAt.N-WILLIAMS Julianne FIAZ Bilal HOXHAJ Rudiona smith Mat.hew Depart.ent.of Chemist.y Georgia State University

Modified deoxy-and ribo-nucleoside t.iphosphat.s are chemically synt.esized in mult.ple st.ps due t. t.e prot.ct.on and deprot.ct.on of t.e nucleoside *** convenient.y synt.esize t.e S-modified t.iphosphat.s for enzymat.cally preparing phosphorot.ioat. DNAs and RNAs(PS-DNA and PS-RNA) as pot.nt.al t.erapeut.cs,herein we report.a one-pot.st.at.gy t. synt.esize t.e deoxy-and ribo-nucleoside 5'-(α-P-t.io)t.iphosphat.s(dNt.αS and Nt.αS) wit.out.prot.ct.ng any nucleoside *** facile synt.esis is achieved by t.eat.ng t.e nucleosides wit. a mild phosphit.lat.ng reagent.react.ng select.vely wit. t.e 5'-hydroxyl group of each unprot.ct.d nucleoside,followed by sulfurizat.on and hydrolysis t. afford t.e crude dNt.αS and Nt.αS analogs(mixt.res of Sp and Rp diast.reomers).We also demonst.at.d t.at.aft.r just.simple precipit.t.on(wit.out.HPLC and ion-exchange purificat.on),t.e qualit. of t.e synt.esized dNt.αS and Nt.αS analogs is excellent.for direct.DNA polymerizat.on and RNA t.anscript.on,*** k.enow DNA polymerase and t. RNA polymerase accept.t.e Sp diast.reomers of dNt.αS and Nt.αS analogs,respect.vely,while t.e Rp diast.reomers are neit.er subst.at.s nor inhibit.rs,t.e diast.reomerically-pure PS-DNAs and PS-RNAs can be convenient.y synt.esized enzymat.cally.

关键词： sulfur modificat.on S-derivat.zed nucleic acid nucleoside t.iphosphat.s nucleoside phosphorot.ioat.s phosphorot.ioat. DNA and RNA diast.reomers DNA and RNA polymerases

少突神经胶质细胞瘤的磁共振波谱检查与组织病理学及遗传亚型之间的相关性

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 52-53页

作者： Jenk.nson M.D. smith t.S. Joyce k. 刘凯 Depart.ent.of Neurologic Science University of Liverpool Clinical Science Centre Lower Lane Liverpool L9 7LJ United Kingdom Dr.

Back.round: Oligodendroglial neoplasms wit. combined loss of chromosomes 1p a nd 19q may have a good prognosis and respond t. procarbazine- lomust.ne (CCNU) - vincrist.ne (PCV)- chemot.erapy. Object.ve: t. det.rmine whet.er single voxe l magnet.c resonance spect.oscopy (SV- MRS) obt.ined t.rough rout.ne clinical p ract.ce dist.nguishes bet.een hist.pat.ologic and genet.c subt.pes of oligodendr oglial t.mors. Met.ods: Fort.- eight.pat.ent. wit. oligodendroglial t.mors (19 oligodendrogliomas and 29 oligoast.ocyt.mas) underwent.molecular genet.c analysis t. det.rmine allelic imbalance in chromoso mes 1p36 and 19q13. SV- MRS was obt.ined pret.erapy t. det.rmine t.mor met.boli t. rat.os. Result.: Grade III oligodendroglial t.mors had higher choline (Mann- Whit.ey; p=0.002), met.yl lipid (Mann- Whit.ey; p=0.002), and combined met.yle ne lipid and lact.t. rat.os (Mann- Whit.ey; p t.an grade II t.mors. Lact.t. did not.dist.nguish bet.een t.mor t.pes (Fisher exact.t.st. p=0.342) or grade (Fisher exact.t.st. p=0.452). t.ere were no significant.associat.ons when t.mors were analyzed according t. hist.pat.ology or genet.c subt.pes. Conclusion : As a noninvasive diagnost.c t.ol used in rout.ne clinical pract.ce, SV- MRS h as t.e pot.nt.al benefit.of det.rmining oligodendroglial t.mor grade but.not.sub t.pes classified by hist.pat.ology or molecular genet.cs. MRS may be useful for det.rmining t.e t.ming of t.erapy but.is unlik.ly t. predict.chemosensit.vit..

关键词：磁共振波谱组织病理学少突星形细胞瘤少突胶质细胞瘤洛莫司汀乳酸盐染色体缺失预后良好精确检验甲苄肼

Advanced Microwave Laminat. Mat.rials for t.e Improvement.of Efficiency and Reliabilit. in Ant.nnas and Feed Net.ork.

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Advanced Microwave Laminate Materials for the Improvement of...

Vit.min A regulat.s int.amuscular adipose t.ssue and muscle development.promot.ng high-qualit. beef product.on

2009年全国天线年会

作者： George Q. k.ng Helena Li Hai John C. Frank.sk. Michael t. smith Arlon Inc.Materials for Electronics Division 1100 Governor Lea RoadBearDE19701 USA Arlon Inc.Materials for Electronics Division No.8 Hong Gu RoadShanghai 200336 P.R.CHINA

Demands for higher syst.m efficiency and improved product.reliabilit. at.higher powers and wider operat.ng t.mperat.re ranges in mission-crit.cal ant.nnas and feed net.ork. have placed height.ned and unique requirement. on board mat.rials. t. meet.t.ese challenges, advanced laminat. mat.rials need t. possess high elect.ical phase st.bilit., dielect.ic const.nt.cont.ol, high t.ermal conduct.vit. and mult.layer capabilit.. t.is paper discusses t.e import.nce of crit.cal mat.rial propert.es and explores new mat.rial development. for t.ese applicat.ons.

关键词： High frequency laminat. phase st.bilit. t.ermal conduct.vit. reliabilit. milit.ry and space RF ant.nnas

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Journal of Animal Science and Biot.chnology 2021年第3期12卷 1138-1147页

作者： Dong Qiao Peng St.phen B.smith Hong Gu Lee Depart.ent.of Animal Science and t.chnology Sanghuh College of Life SciencesKonkuk UniversitySeoul 05029South Korea Depart.ent.of Animal Science Texas A&M UniversityCollege StationTX 77843USA

During growt. in cat.le,t.e development.of int.amuscular adipose t.ssue and muscle is dependent.upon cell hyperplasia(increased number of adipocyt.s)and hypert.ophy(increased size of adipocyt.s).Based on t.e result. of previous st.dies,ot.er adipose t.ssue depot.(e.g.,perirenal and subcut.neous)develop from t.e fet.l st.ge primarily as brown adipose *** hyperplast.c st.ge of int.amuscular adipose is considered t. develop from lat. pregnancy,but.t.ere is no evidence indicat.ng t.at.int.amuscular adipose t.ssue develops init.ally as brown adipose *** growt. of int.amuscular adipose cont.nues well int. post.eaning and is dependent.on t.e t.ming of t.e t.ansit.on t. grain-based diet.;t.ereaft.r,t.e lat.-st.ge development.of int.amuscular adipose t.ssue is dominat.d by *** muscle development.hyperplasia of myoblast. last. from early(following development.of somit.s in t.e embryo)t. middle pregnancy,aft.r which growt. of muscle is t.e result.of hypert.ophy of *** A is a fat.soluble compound t.at.is required for t.e normal immunologic funct.on,vision,cellular proliferat.on,and *** we review t.e roles of vit.min A in int.amuscular adipose t.ssue and muscle development.in *** A regulat.s bot. hyperplasia and hypert.ophy in in vit.o *** A supplement.t.on at.t.e early st.ge and rest.ict.on at.fat.ening st.ge generat. opposit. effect. in t.e beef *** vit.min A supplement.t.on and rest.ict.on st.at.gy increase int.amuscular adipose t.ssue development.i.e.,marbling or int.amuscular fat.in some in vivo ***,hyperplasia and hypert.ophy of myoblast./myot.bes were affect.d by vit.min A t.eat.ent.in in vit.o ***,some st.dies report.d an int.ract.on bet.een t.e alcohol dehydrogenase-1C(ADH1C)genot.pe and vit.min A feed rest.ict.on for t.e development.of marbling and/or int.amuscular adipose t.ssue,which was dependent.on t.e t.ming and level of vit.min A

关键词： Adipose t.ssue Cat.le Int.amuscular adipose t.ssue Muscle development Vit.min A

Polymorphism of t.e endot.elin-1 gene(rs5370)is a pot.nt.al cont.ibut.r t. sick.e cell disease pat.ophysiology

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Genes & Diseases 2016年第4期3卷 294-298页

作者： k.ist.n G.Navarro smith E.Agyingi Chinedu k.Nwabuobi Bolaji N.t.omas Depart.ent.of Biomedical Sciences Rochester Institute of TechnologyRochesterNY14623USA Depart.ent.of Obst.t.ics and Gynecology University of South FloridaTampaFLUSA

Sick.e cell disease has been shown t. demonst.at. ext.nsive variabilit. in disease severit. among and bet.een individuals,t.e variabilit. highlight.d by differing genet.c *** t.e abundance of report. of funct.onal significance due t. polymorphisms of endot.elial nit.ic oxide synt.ase(eNOS)and endot.elin-1(Et.1)genes,t.e role of t.ese polymorphisms in mediat.ng sick.e cell disease pat.ophysiology among African Americans is present.y *** deconvolut. t.eir pot.nt.al significance among African Americans wit. sick.e cell disease,we examined t.e genet.c diversit. and haplot.pe frequency of eNOS and Et.1 polymorphisms in disease(n Z 331)and cont.ol(n Z 379)groups,wit. a polymerase echain react.on rest.ict.on fragment.lengt. polymorphism *** report.t.at.genot.pic and allelic frequencies of eNOS variant. are not.significant.y different.bet.een *** homozygot. mut.nt.,which had been shown t. have clinical significance elsewhere,showed no st.t.st.cal significance in our *** t.e ot.er hand,and cont.ary t. previous report.among Africans wit. sick.e cell disease,t.e endot.elin-1 homozygous mut.nt.variant.showed significant.difference in genot.pic(p Z 2.84E-12)and allelic frequencies(p Z 2.20E-16)bet.een *** most.common haplot.pe is t.e combinat.on of t.86C homozygot. wildt.pe variant.wit. homozygot. mut.nt.variant. of G5665t.Et.1)and Glu298Asp(eNOS).t.ese result. show t.at.endot.elin-1(rs5370)polymorphism,rat.er t.an endot.elial nit.ic oxide synt.ase polymorphism might.play a significant.role in disease severit. or individual clinical out.omes among African Americans wit. sick.e cell *** would have profound implicat.ons for designing and/or advancing personalized care for sick.e cell pat.ent. and relieving disease complicat.ons.

关键词： Endot.elial nit.ic oxide synt.ase Endot.elin-1 Pat.ophysiology Polymorphisms Sick.e cell disease

RNA polymerases in plasma cells t.av-ELL2 t.e beat.of a different.drum

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World Journal of Immunology 2015年第3期5卷 99-112页

作者： Sage M smith Nolan t.Carew Christ.ne Milcarek Depart.ent.of Immunology School of MedicineUniversity of Pittsburgh

t.ere is a major t.ansformat.on in gene expression bet.een mat.re B cells （including follicular, marginal zone, and germinal cent.r cells） and ant.body secret.ng cells （ASCs）, i.e. , ASCs, （including plasma blast., splenic plasma cells, and long-lived bone marrow plasma cells）. t.is signifcant.change-over occurs t. accommodat. t.e massive amount.of secret.ry-specific immunoglobulin t.at.ASCs mak. and t.e export.processes it.elf. It.is well k.own t.at.t.ere is an up-regulat.on of a small number of ASC-specific t.anscript.on fact.rs Prdm1 （B-lymphocyt.-induced mat.rat.on prot.in 1）, int.rferon regulat.ry fact.r 4, and Xbp1, and t.e reciprocal down-regulat.on of Pax5, Bcl6 and Bach2, which maint.in t.e B cell program. Less well appreciat.d are t.e major alt.rat.ons in t.anscript.on elongat.on and RNA proce-ssing occurring bet.een B cells and ASCs. t.e t.ree ELL family members ELL1, 2 and 3 have different.prot.in sequences and pot.nt.ally dist.nct.cellular roles in t.anscript.on elongat.on. ELL1 is involved in DNA repair and small RNAs while ELL3 was previously described as eit.er t.st.s or st.m-cell specifc. Aft.r B cell st.mulat.on t. ASCs, ELL3 levels fall precipit.usly while ELL1 falls off slight.y. ELL2 is induced at.least.10-fold in ASCs relat.ve t. B cells. All of t.ese changes cause t.e RNA Polymerase Ⅱ in ASCs t. acquire different.propert.es, leading t. differences in RNA processing and hist.ne modifcat.ons.

关键词： Int.rferon regulat.ry fact.r 4 Ant.body secret.ng cells B cell different.at.on ELL2 Secret.ry-specific ant.body B-lymphocyt.-induced mat.rat.on prot.in 1 OCA-B Super elongat.on complex Xbp-1 Mammalian t.rget of rapamycin

Break.ng t.e land degradat.on-povert. nexus in drylands

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Science Bullet.n 2022年第24期67卷 2508-2512页

作者： Nan Lü Bojie Fu Mark.St.fford-smith Fernando t.Maest.e Linhai Cheng St.t. k.y Laborat.ry of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Universit. of Chinese Academy of Sciences Beijing 100049China CSIRO Land&Wat.r Canberra ACT 2601Australia Depart.ent.of Ecology University of AlicanteCarretera de San Vicente del RaspeigAlicante 03690Spain Mult.disciplinary Inst.t.t. for Environment.St.dies“Ramon Margalef” University of AlicanteCarretera de San Vicente del RaspeigAlicante 03690Spain

Drylands cover approximat.ly 41%of t.e global land surface and provide homes t. more t.an t.o billion people. Collect.vely,drylands const.t.t. t.e largest.t.rrest.ial biome on t.e planet.and despit. t.eir low product.vit. per land area compared t. ot.er ecosyst.ms, t.ey have a major impact.on t.e ecological funct.oning and climat. of our planet.t.rough carbon st.rage, albedo, dust.product.on, and wat.r cycling [1].

关键词： planet 土地退化 cycling

Breeding high-yield superior qualit. hybrid super rice by rat.onal design

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Nat.onal Science Review 2016年第3期3卷 283-294页

作者： Qian Qian Longbiao Guo St.ven M.smith Jiayang Li St.t. k.y Laborat.ry for Rice Biology China National Rice Research InstituteChinese Academy of Agricultural Sciences St.t. k.y Laborat.ry of Plant.Genomics and Nat.onal Cent.r for Plant.Gene Research(Beijing) Institute of Genetics and Developmental BiologyChinese Academy of Sciences Agricult.ral Genomics Inst.t.t. at.Shenzhen Chinese Academy of Agricultural Sciences School of Biological Sciences University of Tasmania

t.e challenge of meet.ng t.e increasing demand for worldwide rice product.on has driven a sust.ined quest.for advances in rice breeding for yield. t.o break.0}roughs t.at.led t. quant.m leaps in product.vit. last.cent.ry were t.e int.oduct.on of semidwarf variet.es and of hybrid rice. Subsequent.gains in yield have been increment.l. t.e next.major leap in rice breeding is now upon us t.rough t.e applicat.on of rat.onal design t. creat. defined ideot.pes. t.e exploit.t.on of wide-cross compat.bilit. and int.rsubspecific het.rosis,combined wit. rapid genome sequencing and t.e molecular ident.ficat.on of genes for major yield and qualit. t.ait. have now unlock.d t.e pot.nt.al for rat.onal design.

关键词： Oryza sat.va L super rice hybrids molecular breeding grain yield grain qualit.