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Smoking under hypoxic condit.ons: a pot.nt.environment.l risk fact.r for inflammat.ry and aut.immune diseases

Milit.ry Medical Research 2018年第3期5卷 263-278页

作者： Md.Saddam hussain Vishwas t.ipat.i School of Biot.chnology Gautam Buddha University

Aut.immune disease management.present. a significant.challenge t. medical science. Environment.l fact.rs pot.nt.ally increase t.e risk of developing inflammat.ry and aut.immune diseases, such as mult.ple sclerosis, rheumat.id art.rit.s, and lupus. Among various environment.l st.esses, cigaret.e smoke and hypoxia have bot. been report.d t. lead t. an enhanced risk of inflammat.ry and aut.immune diseases. In t.is review, we shed light.on all report.d mechanisms whereby cigaret.e smoke and a hypoxic environment.can induce inflammat.ry and aut.immune diseases and discuss how hypoxic condit.ons influence t.e cigaret.e smoke-induced t.reat.of inflammat.ry and aut.immune disease development. Cigaret.e smoke and hypoxia bot. lead t. increased oxidat.ve st.ess and product.on of react.ve oxygen species and ot.er free radicals, which have various effect. including t.e generat.on of aut.react.ve pro-inflammat.ry t.cells and aut.ant.bodies, reduct.ons in t.regulat.ry(t.eg) cell act.vit., and enhanced expression of pro-inflammat.ry mediat.rs [e.g., int.rleukin-6(IL-6), int.rleukin-4(IL-4) and int.rleukin-8(IL-8)]. Accordingly, smoking and hypoxic environment. may synergist.cally act.as pot.nt.environment.l risk fact.rs for inflammat.ry and aut.immune diseases. t. our knowledge, no st.dies have report.d t.e direct.associat.on of cigaret.e smoke and hypoxic environment. wit. t.e risk of developing inflammat.ry and aut.immune diseases. Fut.re st.dies exploring t.e risk of aut.immune disease development.in smokers at.high alt.t.des, part.cularly milit.ry personnel and mount.ineers who are not.acclimat.zed t. high-alt.t.de regions, are required t. obt.in a bet.er underst.nding of disease risk as well as it. management.

关键词： Inflammat.ry and aut.immune diseases Cigaret.e smoke Hypobaric hypoxia Oxidat.ve st.ess Epigenet.c modificat.ons Pro-inflammat.ry mediat.rs Aut.ant.body

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Deep Learning for Financial t.me Series Predict.on:A St.t.-of-t.e-Art.Review of St.ndalone and HybridModels

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Comput.r Modeling in Engineering & Sciences 2024年第4期139卷 187-224页

作者： Weisi Chen Walayat.hussain Francesco Caut.ruccio Xu Zhang School of Soft.are Engineering Xiamen University of TechnologyXiamen361024China Pet.r Faber Business School Australian Catholic UniversityNorth Sydney2060Australia Depart.ent.of Informat.on Engineering Polytechnic University of MarcheAncona60121Italy

Financial t.me series predict.on,whet.er for classificat.on or regression,has been a heat.d research t.pic over t.e last.*** t.adit.onal machine learning algorit.ms have experienced mediocre result.,deep learning has largely cont.ibut.d t. t.e elevat.on of t.e predict.on ***,t.e most.up-t.-dat. review of advanced machine learning t.chniques for financial t.me series predict.on is st.ll lacking,making it.challenging for finance domain expert. and relevant.pract.t.oners t. det.rmine which model pot.nt.ally performs bet.er,what.t.chniques and component. are involved,and how t.emodel can be designed and *** review art.cle provides an overview of t.chniques,component. and frameworks for financial t.me series predict.on,wit. an emphasis on st.t.-of-t.e-art.deep learning models in t.e lit.rat.re from2015 t. 2023,including st.ndalonemodels like convolut.onal neural net.orks(CNN)t.at.are capable of ext.act.ng spat.al dependencies wit.in dat.,and long short.t.rm memory(LSt.)t.at.is designed for handling t.mporal dependencies;and hybrid models int.grat.ng CNN,LSt.,at.ent.on mechanism(AM)and ot.er *** illust.at.on and comparison purposes,models proposed in recent.st.dies are mapped t. relevant.element. of a generalized framework comprised of input.out.ut.feat.re ext.act.on,predict.on,and relat.d *** t.e st.t.-of-t.e-art.odels,hybrid models like CNNLSt.and CNN-LSt.-AM in general have been report.d superior in performance t. st.nd-alone models like t.e CNN-only *** remaining challenges have been discussed,including non-friendliness for finance domain expert.,delayed predict.on,domain knowledge negligence,lack of st.ndards,and inabilit. of real-t.me and highfrequency *** principal cont.ibut.ons of t.is paper are t. provide a one-st.p guide for bot. academia and indust.y t. review,compare and summarize t.chnologies and recent.advances in t.is area,t. facilit.t. smoot. and informed implement.t.on,and t

关键词： Financial t.me series predict.on convolut.onal neural net.ork long short.t.rm memory deep learning at.ent.on mechanism finance

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On Nearly σ-Embedded Subgroups of Finit. Groups

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Algebra Colloquium 2019年第4期26卷 677-688页

作者： Muhammad t.nveer hussain Chenchen Cao Li Zhang AAIvanov School of Mat.emat.cal Sciences University of Science and Technology of China Hefei 230026China School of Mat.emat.cs and St.t.st.cs Ningbo University NingboZhejiang 315211China Depart.ent.of Mat.emat.cs and Physics Anhui Jianzhu University Hefei 230022China 不详

Let.G be a finit. group,σ={σi|i∈ I}be some part.t.on of t.e set.of all primes and σ(G)={(σi|σi∩ π(G)≠0}.We say t.at.a subgroup H of G is nearly cr-cmbcdded in G if t.ere exist. a cr-permut.ble subgroup t.of G such t.at.H∩t.is at.ble subgroup of G and H C\t.HaeG^where Haec is t.e subgroup of H generat.d by all t.ose subgroups of H which are cr-permut.bly embedded in *** t.is paper,we st.dy t.e st.uct.re of G under t.e condit.on t.at.some given subgroups of G are nearly cr-embedded in *** known result. are generalized.

关键词： finit. group cr-permut.ble subgroup cr-permut.bly embedded subgroup nearly cr-embedded subgroup supersoluble group

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Anisot.opic st.llar st.uct.res in t.e f(t.t.eory of gravit. wit. quint.ssence via embedding approach

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Chinese Physics C 2021年第4期45卷 426-439页

作者： Allah Dit.a Musht.q Ahmad Ibrar hussain G.Must.fa Depart.ent.of Mat.emat.cs COMSATS University IslamabadLabore CampusPakistan Nat.onal Universit. of Comput.r and Emerging Sciences Chiniot-Faisalabad CampusPakistan School of Elect.ical Engineering and Comput.r Science National University of Sciences and TechnologyH-12IslanpabadPakistan Depart.ent.of Mat.emat.cs Shanghai UniversityShanghai 200444China

t.is work suggest. a new model for anisot.opic compact.st.rs wit. quint.ssence in f(t.gravit. by us-ing t.e off-diagonal t.t.ad and t.e power-law as f(t.=βt.(n),where t.is t.e scalar t.rsion andβand n are real *** acquired field equat.ons incorporat.ng t.e anisot.opic mat.er source along wit. t.e quint.ssence field,in f(t.gravit.,are invest.gat.d by making use of t.e specific charact.r of t.e scalar t.rsion t.for t.e observed st.rs PSRJ1614-2230,***-3,EXO1785-248,and *** is suggest.d t.at.all t.e st.llar st.uc-t.res under examinat.on are advant.geously independent.of any cent.al singularit. and are *** graphical analysis shows t.at.various physical feat.res which are crucially import.nt.for t.e emergence of t.e st.llar st.uct.res are conferred.

关键词： quint.ssence power-law model f(t.gravit. anisot.opic compact.st.rs

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t.e Effect.of an Ext.rnal Magnet.c Field on t.e Plume Expansion Dynamics of Laser-Induced Aluminum Plasma

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Plasma Science and t.chnology 2015年第8期17卷 693-698页

作者： At.f hussain 李奇郝作强高勋林景全 School of Science Changchun University of Science and Technology

In t.is work, we invest.gat.d t.e plasma morphology induced by a Nd：YAG laser wit. t.e aim of improving t.e underst.nding of t.e format.on and dynamics of t.e plasma in t.o cases, wit. and wit.out.a magnet.c field. Single laser pulse product.on of a plasma in t.e absence and presence of a magnet.c field was performed wit. an aluminum t.rget.in air. A fast.phot.graphy t.chnique was employed t. obt.in informat.on about.t.e expansion dynamics and confinement.of t.e aluminum plasma in each case. t.e generat.on of t.e laser plasma was allowed t. expand at.t.o locat.ons wit. different.magnet.c field st.engt.s, which correspond t. t.e st.engt. 0.58 t.in t.e cent.r of t.o magnet.c poles and 0.83 t.at.a dist.nce of 4 mm from t.e upper pole （N）. t.e plume showed lat.ral confinement.at.longer delays when t.e t.rget.was placed at.t.e cent.r of t.e t.o poles. When t.e t.rget.was placed at.a dist.nce of 4 mm from t.e upper pole it.was observed t.at.t.e plume was divided int. t.o lobes at.t.e init.al st.ge and t.aveled t.wards t.e cent.r of t.e magnet.c field wit. furt.er elapse of t.me.

关键词： plasma plume fast.imaging magnet.c confinement

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A dat.-mining approach t. biomarker ident.ficat.on from prot.in profiles using discret. st.t.onary wavelet.t.ansform

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Journal of Zhejiang Universit.-Science B(Biomedicine & Biot.chnology) 2008年第11期9卷 863-870页

作者： hussain MONt.ZERY-KORDY Mohammad Hossein MIRAN-BAYGI Mohammad Hassan MORADI Depart.ent.of Elect.ical and Comput.r Engineering Tarbiat Modares University Facult. of Biomedical Engineering Amir Kabir University of Technology

Object.ve: t. develop a new bioinformat.c t.ol based on a dat.-mining approach for ext.act.on of t.e most.infor- mat.ve prot.ins t.at.could be used t. find t.e pot.nt.al biomarkers for t.e det.ct.on of cancer. Met.ods: t.o independent.dat.set. from serum samples of 253 ovarian cancer and 167 breast.cancer pat.ent. were used. t.e samples were examined by surface- enhanced laser desorpt.on/ionizat.on t.me-of-flight.mass spect.omet.y (SELDI-t.F MS). t.e dat.set. were used t. ext.act.t.e informat.ve prot.ins using a dat.-mining met.od in t.e discret. st.t.onary wavelet.t.ansform domain. As a dimensionalit. re- duct.on procedure, t.e hard t.resholding met.od was applied t. reduce t.e number of wavelet.coefficient.. Also, a dist.nce measure was used t. select.t.e most.discriminat.ve coefficient.. t. find t.e pot.nt.al biomarkers using t.e select.d wavelet.coefficient., we applied t.e inverse discret. st.t.onary wavelet.t.ansform combined wit. a t.o-sided t.t.st. Result.: From t.e ovarian cancer dat.set. a set.of five prot.ins were det.ct.d as pot.nt.al biomarkers t.at.could be used t. ident.fy t.e cancer pat.ent. from t.e healt.y cases wit. accuracy, sensit.vit., and specificit. of 100%. Also, from t.e breast.cancer dat.set. a set.of eight.prot.ins were found as t.e pot.nt.al biomarkers t.at.could separat. t.e healt.y cases from t.e cancer pat.ent. wit. accuracy of 98.26%, sensit.vit. of 100%, and specificit. of 95.6%. Conclusion: t.e result. have shown t.at.t.e new bioinformat.c t.ol can be used in combinat.on wit. t.e high-t.roughput.prot.omic dat. such as SELDI-t.F MS t. find t.e pot.nt.al biomarkers wit. high discriminat.ve power.

关键词： Prot.omics Discret. st.t.onary wavelet.t.ansform Dat. mining Feat.re select.on Biomarker Cancer classificat.on

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St.bilit. st.dy on an ant.-cancer drug 4-(3,5-bis(2-chlorobenzylidene)-4-oxo-piperidine-1-yl)-4-oxo-2-but.noic acid (CLEFMA) using a st.bilit.indicat.ng HPLC met.od

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Journal of Pharmaceut.cal Analysis 2017年第1期7卷 1-9页

作者： Dhawal Raghuvanshi Gregory Nkepang Alamdar hussain Hooman Yari Vibhudut.a Awast.i Depart.ent.of Pharmaceut.cal Sciences University of Oklahoma Health Science Center 1110 N. Stonewall Avenue Oklahoma City OK 73117 USA

CLEFMA, 4-(3,5-bis(2-chlorobenzylidene)-4-oxo-piperidine-1-yl)-4-oxo-2-but.noic acid, is a new chemical ent.t. wit. ant.-cancer and ant.-inflammat.ry act.vit.es. Here, we report.it. st.bilit. in solut.on against.st.ess condit.ons of exposure t. acid/base, light. oxidant. high t.mperat.re, and plasma. t.e ident.t. of t.e degradat.on product. was ascert.ined by mass and prot.n nuclear magnet.c resonance spect.oscopy. t. facilit.t. t.is st.dy, we developed and validat.d a reverse phase high performance liquid chromat.graphy met.od for det.ct.on of CLEFMA and it. degradat.on. t.e met.od was linear over a range of 1–100 μg/m L; t.e accuracy and precision were wit.in accept.ble limit.; it.was st.bilit.-indicat.ng as it.successfully separat.d cis-/t.ans-isomers of CLEFMA as well as it. degradat.on product. t.e major degradat.on product.was produced from amide hydrolysis at.maleic acid funct.onalit. caused by an acidic buffer, oxidant.3% hydrogen peroxide),or t.mperat.re st.ess(40–60 °C). t.e log k-p H profile showed t.at.CLEFMA was most.st.ble at.neut.al p H. In accelerat.d st.bilit. st.dy we found t.at.t.e shelf-life(t.(90%)) of CLEFMA at.25 °C and 4 °C was 45 days and220 days, respect.vely. Upon exposure t. UV-light.365 nm), t.e normally prevalent.t.ans-CLEFMA at.ained cis-configurat.on. t.is isomerizat.on also involved t.e maleic acid moiet.. CLEFMA was st.ble in plasma from which it.could be efficient.y ext.act.d by an acet.nit.ile precipit.t.on met.od. t.ese result. indicat. t.at.CLEFMA is sensit.ve t. hydrolyt.c cleavage at.it. maleic acid moiet., and it.is recommended t.at.it. samples should be st.red under refrigerat.d and light.free condit.ons, and under inert.environment.

关键词： CLEFMA HPLC St.bilit. Shelf-life Isomerizat.on

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Cont.olling reduct.on degree of graphene oxide membranes for improved wat.r permeance

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Science Bullet.n 2018年第12期63卷 788-794页

作者： Qing Zhang Xit.ng Qian Khalid hussain t.ebo Hui-Ming Cheng Wencai Ren Shenyang Nat.onal Laborat.ry for Mat.rials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Mat.rials Science and Engineering University of Science and Technology of China.Shenyang 110016China Universit. of Chinese Academy of Sciences Beijing 100049China t.inghua-Berkeley Shenzhen Inst.t.t.(t.SI) Tsinghua University.Shenzhen 518055.China

t.iloring t.re pore st.uct.re and surface chemist.y of graphene-based laminat.s is essent.ally import.nt.for t.eir applicat.ons as separat.on membranes. Usually, pure graphene oxide （GO） and complet.ly reduced GO （rGO） membranes suffer florn low wat.r permeance because of t.e lack of prist.ne graphit.c sp2 domains and very small int.rlayer spacing, respect.vely. In t.is work, we st.died t.e influence of reduct.on degree on t.e st.uct.re and separat.on pert.rnrance of rGO membranes, t. was found t.at.weak reduct.on ret.ins t.e good dispersion and hydrophilicit. of GO nanosheet.. More import.nt.y, it.increases t.e number of prist.ne graphit.c sp2 domains in rGO nanosheet. while keeping t.e large int.rlayer spacing of t.e GO membranes in most.regions at.t.e same t.me. t.e result.nt.mernbranes show a high wat.r permeance of 56.3 L m^-2 h^ -1 bar^ -1, which is about.4 t.mes and over 10^4 t.mes larger t.an t.ose of t.e GO and complet.ly reduced rGO membranes, respect.vely, and high reject.on over 95700 for various dyes. Furt.ermore, t.ey show bet.er st.uct.re st.bilit. and more superior separat.on perfor- mance t.an GO membranes in acid and alkali environment..

关键词： Graphene oxide Reduct.on Separat.on membrane Wat.r permeance

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A Novel Aut.mat.c Classificat.on Syst.m Based on Hybrid Unsupervised and Supervised Machine Learning for Elect.ospun Nanofibers

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IEEE/CAA Journal of Aut.mat.ca Sinica 2021年第1期8卷 64-76页

作者： Cosimo Ieracit.no Annunziat. Paviglianit. Maurizio Campolo Amir hussain Eros Pasero Francesco Carlo Morabit. t.e DICEAM University Mediterranea of Reggio Calabria89124 Reggio CalabriaItaly Polit.cnico of t.rin 10129 TurinItaly t.e School of Comput.ng Edinburgh Napier UniversityEdinburgh EH105DTUK

t.e manufact.ring of nanomat.rials by t.e elect.ospinning process requires accurat. and met.culous inspect.on of relat.d scanning elect.on microscope(SEM)images of t.e elect.ospun nanofiber,t. ensure t.at.no st.uct.ral defect. are *** presence of anomalies prevent. pract.cal applicat.on of t.e elect.ospun nanofibrous mat.rial in ***,t.e aut.mat.c monit.ring and qualit. cont.ol of nanomat.rials is a relevant.challenge in t.e cont.xt.of Indust.y *** t.is paper,a novel aut.mat.c classificat.on syst.m for homogenous(anomaly-free)and non-homogenous(wit. defect.)nanofibers is *** inspect.on procedure aims at.avoiding direct.processing of t.e redundant.full SEM ***,t.e image t. be analyzed is first.part.t.oned int. subimages(nanopat.hes)t.at.are t.en used as input.t. a hybrid unsupervised and supervised machine learning *** t.e first.st.p,an aut.encoder(AE)is t.ained wit. unsupervised learning t. generat. a code represent.ng t.e input.image wit. a vect.r of relevant.***,a mult.layer percept.on(MLP),t.ained wit. supervised learning,uses t.e ext.act.d feat.res t. classify non-homogenous nanofiber(NH-NF)and homogenous nanofiber(H-NF)*** result.ng novel AE-MLP syst.m is shown t. out.erform ot.er st.ndard machine learning models and ot.er recent.st.t.-of-t.e-art.t.chniques,report.ng accuracy rat. up t.92.5%.In addit.on,t.e proposed approach leads t. model complexit. reduct.on wit. respect.t. ot.er deep learning st.at.gies such as convolut.onal neural net.orks(CNN).t.e encouraging performance achieved in t.is benchmark st.dy can st.mulat. t.e applicat.on of t.e proposed scheme in ot.er challenging indust.ial manufact.ring t.sks.

关键词： Anomaly det.ct.on aut.encoder(AE) elect.ospinning machine learning mat.rial informat.cs nanomat.rials

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t.aumat.c brain injury and sight.loss in milit.ry and vet.ran populat.ons–a review

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Milit.ry Medical Research 2022年第1期9卷 71-85页

作者： Syeda F.hussain Zara Raza Andrew t.G.Cash t.omas Zampieri Robert.A.Mazzoli Randy H.Kardon Renat. S.M.Gomes Research&Innovat.on Blind Veterans UK12-14 Harcourt StreetLondon W1H 4HDUK. Bravo Vict.r Research12-14 Harcourt StreetLondon W1H 4HDUK Blinded Vet.rans Associat.on 1101 King StreetSuite 300AlexandriaVirginia 22314USA Depart.ent.of Opht.almology Madigan Army Medical Center9040 Jackson AvenueTacomaWashington 98431USA lowa Cit. VA Healt. Care Syst.m and Iowa Cit. VA Cent.r for t.e Prevent.on and t.eat.ent.of Visual Loss Iowa CityIowa 52246USA depart.ent.of Opht.almology and Visual Sciences The University of IowaIowa CityIowa 52242USA Nort.ern Hub for Vet.rans and Milit.ry Families Research Department of NursingMidwifery and HealthFaculty of Health and Life SciencesNorthumbria UniversityNewcastle NE77XAUK.

War and combat.exposure pose great.risks t. t.e vision *** recent.y,vision relat.d deficiencies and impairment. have become common wit. t.e increased use of powerful explosive devices and t.e subsequent.rise in incidence of t.aumat.c brain injury(t.I).St.dies have looked at.t.e effect. of injury severit.,aet.ology of injury and t.e st.ge at.which visual problems become *** was lit.le discrepancy found bet.een t.e frequencies or t.pes of visual dysfunct.ons across blast.and non-blast.relat.d groups,however complet. sight.loss appeared t. occur only in t.ose who had a blast.relat.d ***,t.e more severe t.e injury,t.e great.r t.e likelihood of specific visual dist.rbances occurring,and a st.dy found t.t.l sight.loss t. only occur in cases wit. great.r *** of mild t.I(mt.I)is *** able t. ident.fy a pot.nt.al t.I via visual sympt.ms may offer a new avenue for diagnosis.

关键词： t.aumat.c brain injury Visual impairment Milit.ry Vet.ran

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