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therapeutic effects of tender coconut water on oxidative stress in fructose fed insulin resistant hypertensive rats

Asian Pacific Journal of tropical Medicine 2012年第4期5卷 270-276页

作者： D Bhagya L Prema t rajamohan Department of Biochemistry University of Kerala.Kariavattom CampusKeralaTrivandrum695581India Department of Food Science and Nutrition Agricultural CollegeVellayaniTrivandrumKeralaIndia Department of Biochemistry University of Kerala Kariavattom CampusKeralaTrivandrum695581India

Objective:to investigate whether tender coconut water(tCW) mitigates oxidative stress in fructose fed hypertensive ***:Male Sprague Dawley rats were fed with fructose rich diet and treated with tCW(4 mL/100 g of body weight) for 3 subsequent *** blootl pressure was measured every three days using the indirect tail cuff *** the end of the experimental period,plasma glucose and insulin,serum triglycerides and free fatly acids, lipid peroxidation markers(MDA,hydroperoxides and conjugated dienes) and the activities of antioxidant enzymes were analyzed in all the ***:treatment with tCW significandy lowered the systolic blood pressure and reduced serum triglycerides and free fatty *** glucose and insulin levels and lipid peroxidation markers such as MDA,hydroperoxides and conjugated dienes were significantly reduced in fructose fed rats treated with *** of antioxidant enzymes are up regulated significantly in tCW treated *** analysis of liver showed that tCW treatment reduced the lipid accumulation and inflammatory infiltration without any significant hepatocellular ***:the overall results suggest that, tCW treatment could prevent and reverse high blood pressure induced by high fructose diet probably by inhibition of lipid peroxidation,upregulation of antioxidant status and improved insulin sensitivity.

关键词： tender coconut water Hypertension Oxidative stress Hyperinsulinemia Lipid peroxidation Histopathology

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Cytoprotective,antihyperglycemic and phytochemical properties of Cocos nucifera(L.) inflorescence

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Asian Pacific Journal of tropical Medicine 2013年第10期6卷 804-810页

作者： RS Renjith AM Chikku t rajamohan Department of Biochemistry University of KeralaThiruvananthapuram-695581KeralaIndia

Objective:to analyze the eytoproteetive and antidiabetic activities as well as phytochemical composition of the immature inflorescence of Cocas nucifera belonging to the Arecaceae ***:the phytochemical screening of inflorescence was done to determine the major constituents present in Cocos nucifera *** free radical scavenging potential of inflorescence extracts were evaluated using in vitro radical scavenging assay ***:the phytochemical analyses on inflorescence showed the presence of phenolic compounds,*** and *** macronutrient analyses,on the other hand,showed the presence of carbohydrate,proteins and *** of the methanol extract of coconut inflorescence to the diabetic rats showed dose dependent reduction in *** cytoprotective property of coconut inflorescence was evidenced from the acute toxicological *** levels of serum aspartate aminotransferase,alanine aminotransferase,and alkaline phosphatase were significantly decreased in the diabetic rats treated with inflorescence when compared with the diabetic control ***:the results obtained from the present study apparently proved the non-toxic nature and the eytoproteetive and antihyperglycemic properties of coconut inflorescence.

关键词： Antihyperglycemic Coconut inflorescence Cytoprotective property Phenolic compound Phytochemical Stroptozotocin

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