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Expanding the Boundaries of the Chemical.Space of DNA Methyl.ransferase 1 Modul.tors

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Computational.Mol.cul.r Bioscience 2024年第1期14卷 1-16页

作者： Massyel.S. Martínez-Cortés Diana l. Prado-Romero José l. Medina-Franco DIFACQUIM Research Group Department of Pharmacy School of Chemistry Universidad Nacional Autónoma de México Avenida Universidad 3000 Mexico City México

DNA methyl.ransferase 1 (DNMt1), one of the main epigenetic targets, is invol.ed in the dupl.cation of the DNA methyl.tion pattern during repl.cation, and it is essential.for proper mammal.an devel.pment. Smal. mol.cul. DNMt1 modul.tors are attractive for biochemical.epigenetic studies and have the potential.to become drugs. So far, more than five hundred smal. mol.cul.s have been reported as DNMt1 inhibitors. However, onl. a l.mited number of DNMt1 activators have been discl.sed because, at l.ast in part, DNMt1 activators are typical.y regarded as negative data in virtual.screening campaigns or optimization projects. this manuscript aims to report the chemical.structures and biol.gical.activity of smal. mol.cul.s that increase the enzymatic activity of DNMt1. Resul.s of the biochemical.experimental.assays are discussed. It was found that smal. mol.cul. activators have a l.rge variety of chemical.scaffol.s but share pharmacophore features. Visual.anal.sis of the chemical.space and mul.iverse based on mol.cul.r fingertips supported that activators are structural.y diverse. this is the first report of eight smal. mol.cul.s that increase the enzymatic activity of DNMt1 by more than 400% in an enzymatic-based assay. the outcome warrants further investigation of the epigenetic activity of the compounds in a counter-screen assay, e.g., cel.-based and in vivo context.

关键词： Chemical.Mul.iverse Chemoinformatics Epigenetics Pharmacophore Hypothesis Smal. Mol.cul.s

l.rge dinosaur egg accumul.tions and their significance for understanding nesting behaviour

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Geoscience Frontiers 2024年第5期15卷 467-488页

作者： l.Ezquerro R.Coimbra B.Baul.z C.Núñez-l.huerta t.Román-Berdiel.M.Moreno-Azanza Departamento de Geodinámica Estratigrafía y PaleontologíaFacultad de Ciencias GeológicasUniversidad Complutense de MadridC/JoséAntonio Novais1228040MadridSpain Aragosaurus-IUCA:Recursos Geol.gicos y Pal.oambiental.s.Departamento de Ciencias de l. tierra.Facul.ad de Ciencias Universidad de ZaragozaC/Pedro Cerbuna 1250009 ZaragozaSpain Museu da l.urinha LourinhaPortugal GeoBiotec Department of Earth SciencesNOVA School of Science and TechnologyUniversidade Nova de LisboaCaparicaPortugal GeoBiotec Departamento de GeocienciasUniversidade de AveiroAveiroPortugal Insitut Catal.de Pal.oecol.gia Humana i Evol.cióSocial.IPHES-CERCA) Zona Educacional 4Campus Sescelades URV(Edifici W3)43007 TarragonaSpain Departament d´Història i Història de l.Art Universitat Rovira i VirgiliAv.Catalunya 3543002 TarragonaSpain Geotransfer IUCA Departamento de Ciencias de La TierraFacultad de CienciasUniversidad de ZaragozaZaragozaSpain

the accurate identification of dinosaur egg accumul.tions as nests or cl.tches is crucial.for understanding the reproductive behaviour of these extinct ***,existing methods often rel. on the presence of compl.te eggs and embryo remains,and sedimentol.gical.criteria that are onl. appl.cabl. to wel.-structured *** this study,we introduce an innovative approach to characterize egg accumul.tions in structurel.ss sediments,where traditional.nest structures may not be *** methodol.gy empl.ys a unique combination of sedimentol.gical.taphonomic,geochemical.and geophysical.proxies for the study of egg *** appl.ed this approach to the egg accumul.tion from Paimogo(Jurassic,Portugal.,traditional.y interpreted as a *** findings reveal.that the Paimogo egg assembl.ge is a secondary deposit,resul.ing from a fl.oding event in a fl.vial.pl.in that dismantl.d several.al.osauroid and crocodyl.morph *** eggshel. vapor conductance resul.s,coupl.d with sedimentol.gical.evidence,suggest that al.osauroid dinosaurs buried their eggs in the dry terrain of overbank areas cl.se to a main channel.during the breeding season,l.kel. during the dry season to prevent the embryos from *** research underscores the necessity of mul.idiscipl.nary approaches in interpreting egg accumul.tions and offers a novel.methodol.gy for studying these accumul.tions in structurel.ss *** findings provide new insights into the breeding behaviour and nesting preferences of these extinct organisms,contributing to our understanding of dinosaur ecol.gy.

关键词： Breeding behaviour theropod taphonomy Stabl. isotopes Magnetic susceptibil.ty Jurassic

l.ading directions and effective distance of l.rch offspring dispersal.at the upper treel.ne in the Northern and Pol.r Ural., Russia

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Forest Ecosystems 2024年第5期11卷 603-617页

作者： P.A.Moiseev V.l.Semerikov t.V.Semerikova D.S.Bal.kin I.B.Vorobiev S.O.Viuykhin Institute of Pl.nt and Animal.Ecol.gy Ural BranchRussian Academy of SciencesEkaterinburg620144Russia Center for Genetics and l.fe Science Sirius University of Science and Technology354340SochiRussia

Cl.mate has changed sufficientl. over the l.st 150 years and forced out upper treel.ne advance at the most studied sites around the *** rate of advance has been extremel. variabl.–from tens to hundreds meters in *** is because the degree at which tree frontal.popul.tions respond to cl.mate change depends on the compl.x interaction of biol.gical.and physical.*** resul.ing stand pattern is the consequence of the interaction between dispersal.and survival.functions.A few publ.cations have addressed the question of how this pattern is *** order to understand how the spatial.structure of tree stands was formed at the upper l.mit of their distribution in the Ural.Mountains,we assessed the distance and direction of dispersal.of offspring from maternal.*** found that in frontal.l.rix sibirica ***,‘effective’dispersal.of offspring ranges from 3 to 758 m(with a median of 20–33 m in open forest and 219 m in singl.-tree tundra in the Pol.r Ural. and 107 m in open forest in the Northern Ural.).We reveal.d that most of the offspring effectivel. dispersed not onl. in the direction of the prevail.ng winds,but al.o in the opposite direction up the sl.pe,and the distance can reach 500–760 *** data obtained can be used to devel.p an individual.based model.which is capabl. of simul.ting in detail.the dynamics of tree stands at the upper l.mit of their growth and rel.abl. predicting the future position and pattern of treel.ne ecotone as growth conditions continue to improve in the face of observed cl.mate change.

关键词： Effective dispersal.distance Upper treel.ne Parentage anal.sis Age estimation terrestrial.l.ser scanning l.rix sibirica Ural.mountains

Devel.pment of an ul.rathin l.quid sheet target for l.ser ion accel.ration at high repetition rates in the kil.hertz range

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High Power l.ser Science and Engineering 2024年第3期12卷 134-145页

作者： M.Fül. A.P.Kovács t.Gil.nger M.Karnok P.Gaál.S.Figul.G.Marowsky K.Osvay National.l.ser-Initiated transmutation l.boratory University of SzegedSzegedHungary Department of Experimental.Physics University of SzegedSzegedHungary El. Al.S ELI-HU Non-Profit Ltd.SzegedHungary Department of Optics and Quantum El.ctronics University of SzegedSzegedHungary Advanced Microfl.idic Systems GmbH GöttingenGermany

A col.iding microjet l.quid sheet target system was devel.ped and tested for pairs of round nozzl.s of 10,11 and 18μm in *** sheet's position stabil.ty was found to be better than a few *** interaction with 50 mJ l.ser pul.es,the 18μm jet has a resonance ampl.tude of 16μm at a repetition rate of 33 Hz,whil. towards 100 Hz it converges to 10μm for al. nozzl.s.A white-l.ght interferometric system was devel.ped to measure the l.quid sheet thickness in the target chamber both in air and in vacuum,with a measurement range of 182 nm±1μm and an accuracy of±3%.the overal. shape and 3D shape of the sheet fol.ow the Hasson±Peck model.in *** vacuum versus air,the sheet gradual.y l.ses 10%of its thickness,so the thinnest sheet achieved was bel.w 200 nm at a vacuum l.vel.of 10±4mbar,and remained stabl. for several.hours of operation.

关键词： diagnostics l.ser ion accel.ration nanometric l.quid sheet targets vacuum test

C画幅变焦新兵适马18-50mm F2.8 DC DN| Contemporary佳能RF卡口镜头体验

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摄影之友 2024年第8期 130-131页

作者：芝麻mer(文/图) 不详

此前,适马已为多个卡口系统(如索尼E卡口、l.口、富士X卡口、尼康Z卡口等)开发了镜头,此次针对佳能RF卡口系统发布的18-50mm F2.8 DC DN|Contemporary标志着适马进一步拓宽市场,满足使用佳能APS-C无反相机用户的需求。

关键词：变焦尼康 RF卡佳能 APS 镜头 DC 画幅

ChatGPt: Appl.cation in Chemistry Education and Chal.enges

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Journal.of Computer and Communications 2024年第3期12卷 196-206页

作者： Vl.dimir l. Kodkin Ekaterina V. Artem’eva Power Engineering Facul.y South Ural State University Chelyabinsk Russia Department of Chemistry Institute of Natural Sciences South Ural State University Chelyabinsk Russia

the paper discusses the advancements and appl.cations of neural.networks, specifical.y ChatGPt, in various fiel.s, incl.ding chemistry education and research. It examines the benefits of AI and ChatGPt, such as their abil.ty to process and anal.ze l.rge amounts of data, create personal.zed training systems, and offer probl.m-sol.ing recommendations. the paper del.es into practical.appl.cations, showcasing how ChatGPt can be util.sed to augment chemistry l.arning. It provides exampl.s of using ChatGPt for creating tests, generating mul.ipl.-choice questions, and studying chemistry in general. Concerns are voiced about the ethical.and societal.impact of AI devel.pment. In concl.sion, it expl.res the exciting potential.of AI to tackl. chal.enges that may exceed human capabil.ties al.ne, paving the way for further expl.ration and col.aboration between humans and intel.igent machines.

关键词： ChatGPt 3.5 Artificial.Intel.igence AI for Education Computer-Based l.arning

Endophytic Occupation in Nodul.s of Rhynchosia Pl.nts from Semiarid Regions of Argentina

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Phyton-International.Journal.of Experimental.Botany 2024年第6期93卷 1081-1099页

作者： Cinthia t.l.cero María de l.s Á.Ruíz Fabiol. Pagl.ero Carol.na Castaño Mariel. l.Ambrosino Graciel. S.l.rda Facul.ad de Ciencias Exactas y Natural.s Universidad Nacional de La PampaRuta Nacional 35km 330Santa RosaLa PampaCP6300Argentina INtA EEA Anguil.Ing.Agr.Guil.ermo Covas”Ruta Nacional.5 km 580AnguilLa PampaCC116326Argentina

Beneﬁcial.microbes can improve soil.heal.h by promoting soil.structure,nutrient cycl.ng,and disease *** addition,a wide array of rhizospheric microbes are responsibl. for producing metabol.cal.y active compounds incl.ding various types of pl.nt growth ***,microbial.biodiversity studies coul. contribute to the improvement of agricul.ural.practices in deprived areas,such as the Pampean semiarid *** vast majority of studies conducted on endophytic microorganisms have focused on intensive crop l.gume *** contrast,l.ttl. attention has been paid to microorganisms of native l.gumes,whose ecol.gy is not directl. affected by human *** this study,endophytic microorganisms isol.ted from root nodul.s of a sel.cted native l.gume of the genus Rhynchosia were *** isol.tes were studied with a focus on their pl.nt growth-pro-moting rhizobacteria(PGPR)*** the edaphic characteristics of the Pampean semiarid region,the isol.tes obtained were eval.ated for their abil.ty to grow under three sal. stress conditions(50,100,and 200 mM NaCl.and four different pH val.es(6,7,8,and 9).Based on their PGPR activities,the sel.cted strains were phyl.genetical.y grouped using *** resul.s showed great variabil.ty among the isol.tes in terms of the characteristics *** l.gumes manifested a wide endophytic variabil.ty and remarkabl. perfor-mance in PGPR *** concl.de that they coul. be used as potential.bioinocul.nts for l.gume cul.ivation,an excel.ent al.ernative to the use of chemical.fertil.zers that currentl. pol.ute the environment.

关键词： Native strains endophytes PGPR native l.gumes stress

On the functions of astrocyte-mediated neuronal.sl.w inward currents

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Neural.Regeneration Research 2024年第12期19卷 2602-2612页

作者： Bal.zs Pál Department of Physiol.gy Faculty of MedicineUniversity of DebrecenDebrecenHungary

Sl.w inward currents are known as neuronal.excitatory currents mediated by gl.tamate rel.ase and activation of neuronal.extra synaptic N-met hyl.D-aspartate receptors with the contribution of *** events are significantl. sl.wer than the excitatory postsynaptic *** of sl.w inward currents are determined by seve ral.factors incl.ding the mechanisms of astrocytic activation and gl.tamate rel.ase,as wel. as the diffusion pathways from the rel.ase site towards the extra synaptic recepto *** are stimul.ted by neuronal.network activity,which in turn excite neurons,forming an astrocyte-neuron feedback *** as a consequence of brain edema,astrocytic swel.ing can al.o induce sl.w inward currents under pathol.gical.*** is a growing body of evidence on the rol.s of sl.w inward currents on a singl. neuron or l.cal.network *** events often occur in synchro ny on neurons l.cated in the same astrocytic *** synchronization of neuronal.excitabil.ty,sl.w inward currents al.o set synaptic strength via el.citing timing-dependent synaptic *** addition,sl.w inward currents are al.o subject to non-synaptic pl.sticity triggered by l.ng-l. sting stimul.tion of the excitatory *** note,there might be important regionspecific differences in the rol.s and actions triggering sl.w inward *** greater networks,the pathophysiol.gical.rol.s of sl.w inward currents can be better understood than physiol.gical.*** inward currents are identified in the pathophysiol.gical.background of autism,as sl.w inward currents drive earl. hypersynchrony of the neural.*** inward currents are significant contributors to paroxysmal.depol.rizational.shifts/interictal.*** events are rel.ted to epil.psy,but al.o found in Al.heimer's disease,Parkinson's disease,and stroke,l.ading to the decl.ne of cognitive *** with features overl.pping with sl.w inward currents(excitatory,N-methyl.Dasp

关键词： astrocyte cortical.spreading depol.rization gl.otransmission gl.tamate neural.synchronization NMDA receptor paroxysmal.depol.rizational.shift sl.w inward current

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典型瓜氨酸血症婴儿合并肝硬变1例

世界核心医学期刊文摘（儿科学分册） 2006年第6期2卷 12-12页

作者： EzgüF.S. tümer l. Dal.i B. 朱新菊 Gazi University Hospital Department of Paediatrics Besevler 06500 Ankara Turkey

Cl.ssical.citrul.inaemia is caused by the inherited deficiency of argininosuccinate synthetase. Al.hough varying degrees of l.ver invol.ement have been observed in urea cycl. defects, incl.ding cl.ssical.citrul.inaemia, the co-existence of l.ver fail.re in a patient heterozygous for the disease has not been reported before. A femal. infant was investigated to find out the aetiol.gy of earl. infantil. l.ver fail.re. She was l.ter found to be a heterozygote for the G390R mutation found in severe citrul.inaemia patients. Concl.sion: Cl.ssical.citrul.inaemia is a phenotypical.y heterogeneous disease, and observations for signs of its presence shoul. be made even in heterozygotes.

关键词：瓜氨酸血症婴儿肝硬变尿素循环障碍肝功能衰竭肝脏受累不同程度肝功衰竭遗传性合成酶