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enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

this article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

Reducing risks in the investigation, design and construction of large concrete dams

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Journal of Rock Mechanics and Geotechnical engineering 2017年第2期9卷 197-209页

作者： e.t.Brown Golder Associates Pty. Ltd. BrisbaneAustralia

An overview of the GeoSafe 2016 Symposium topic is provided using the example of large concrete dams for purposes of *** is essential that the risks associated with large dams be evaluated rigorously and managed proactively at all stages of their lives so that the risk of failure remains As Low As Reasonably Practicable(ALARP).Rock engineering features of large concrete dams that require particular attention,assessment and monitoring during the investigation,design,construction,initial filling,inservice operation,and subsequent repair and upgrade stages of the lives of concrete dams are identified and illustrated by examples from recorded experiences.A number of major concrete dam failures,including that of the *** dam,California,U.S.A.,in 1928,have led to significant developments in rock mechanics and rock engineering knowledge and techniques,as well as in dam design and review *** recent advances include a range of analytical,numerical modelling,probabilistic,reliability,failure mode and risk assessment approaches.

关键词： Concrete dam failure Dam engineering Risk assessment Rock engineering design Site investigation

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Brain-derived neurotrophic factor alterations and cognitive decline in schizophrenia:Implications for early intervention

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World Journal of Psychiatry 2025年第1期15卷 189-193页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

this manuscript explores the recent study by Cui et al which assessed the interplay between inflammatory cytokines and brain-derived neurotrophic factor(BDNF)levels in first-episode schizophrenia *** study revealed that higher levels of interleukin-6 and tumor necrosis factor-αcorrelated with reduced BDNF levels and poorer cognitive *** is a severe psy-chiatric disorder impacting approximately 1%of the global population,charac-terized by positive symptoms(hallucinations and delusions),negative symptoms(diminished motivation and cognitive impairments)and disorganized thoughts and *** research highlights the role of BDNF as a potential biomarker for early diagnosis and therapeutic *** findings from Cui et al’s study suggest that targeting neuroinflammation and enhancing BDNF levels may improve cognitive *** treatment approaches involve a com-bination of pharmacological and non-pharmacological interventions tailored to individual patient ***,monitoring cognitive and neuroinflammatory markers is essential for improving patient outcomes and quality of ***-quently,this manuscript highlights the need for an integrated approach to schizo-phrenia management,considering both clinical symptoms and underlying neuro-biological changes.

关键词： Schizophrenia Cognitive impairment Neuroinflammatory markers Brain-derived neurotrophic factor Interleukin Personalized treatment

the Hoeke-Brown failure criterion and GSI-2018 edition

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Journal of Rock Mechanics and Geotechnical engineering 2019年第3期11卷 445-463页

作者： e.Hoek e.t.Brown North Vancouver British ColumbiaV7R 4H7Canada Brisbane Queensland 4169Australia

the HoekeBrown criterion was introduced in 1980 to provide input for the design of underground excavations in *** criterion now incorporates both intact rock and discontinuities,such as joints,characterized by the geological strength index(GSI),into a system designed to estimate the mechanical behaviour of typical rock masses encountered in tunnels,slopes and *** strength and deformation properties of intact rock,derived from laboratory tests,are reduced based on the properties of discontinuities in the rock *** nonlinear HoekeBrown criterion for rock masses is widely accepted and has been applied in many projects around the ***,in general,it has been found to provide satisfactory estimates,there are several questions on the limits of its applicability and on the inaccuracies related to the quality of the input *** paper introduces relatively few fundamental changes,but it does discuss many of the issues of utilization and presents case histories to demonstrate practical applications of the criterion and the GSI system.

关键词： Hoek-Brown criterion Geological strength index(GSI) Rock mass strength Uniaxial compressive strength(UCS) tension cut-off Rock mass deformation modulus

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Glucose-6-Phosphate Dehydrogenase Deficiency: Difficulties in Diagnosis at the Souro Sanou University Hospital, Burkina Faso

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Open Journal of Blood Diseases 2023年第1期13卷 24-32页

作者： Salifo sawadogo Koumpingnin Nébié Jerôme Kouldiati Catherine traoré Salam sawadogo Aimée S. Kissou eléonore Kafando Souro Sanou University Hospital Bobo-Dioulasso Burkina Faso National Blood transfusion Center Ouagadougou Burkina Faso Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso Charles De Gaule University Pediatric Hospital Ouagadougou Burkina Faso

Glucose-6-phosphate dehydrogenase deficiency is the most common enzymopathy worldwide. the precise prevalence of G6PD is unknown in Burkina Faso. the objective of the study was to describe the difficulties to diagnose this disease at the Souro Sanou University hospital (CHUSS) in Bobo-Dioulasso. It involved five patients comprising one child with homozygous SS sickle cell disease, one adolescent screened following a family investigation, and three adults including a man and two women. Blood smear stained with May Grunwald Giemsa was performed to look for specific signs of G6PD-deficient red blood cell and brilliant cresyl Blue for Heinz Bodies. A microscope Olympus BX53 equipped with a Camera (XC10) and connected to a computer was used to read blood smears and capture images. Genes sequencing by Sanger method were performed in a specialized laboratory in molecular genetics. For each analysis, the protocol and instructions of the equipment and reagent manufacturer were applied. Of the five patients, three had anemia and only one had hyperreticulocytosis. two patients had biological signs of hemolysis and one patient had an elevated CRP. Blood smear stained with MGG and cresyl blue showed specific signs of G6PD-deficient red blood cells and Heinz bodies in all patients. Biochemical analysis and molecular typing confirmed G6PD deficiency. the presence of G6PD-deficient red blood cells in the blood smear guides the diagnosis of G6PD deficiency. the diagnosis is biochemical and is based on the combined measurement of G6PD plus pyruvate kinase and/or hexokinase.

关键词： G6PD Deficiency G6PD-Deficient Red Cell Diagnosis Difficulties Burkina Faso

Slope Stability Analysis: Case of the West Wall of the eMZ Pit at the essakane Gold Mine in Burkina Faso (West Africa)

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Geomaterials 2023年第4期13卷 109-123页

作者： Hamma Fabien Yonli Michée Banyua Lompo Nicolas Kagambega Pierre sawadogo ecole Supérieure d’Ingénierie Universitéde Fada N’Gourma Fada N’Gourma Burkina Faso Laboratoire de Physique et de Chimie de l’environnement Université Joseph KI-ZERBO Ouagadougou Burkina Faso Mine Service technique IAMGOLD ESSAKANE SA Ouagadougou Burkina Faso Laboratoire Géosciences et environnement Ouagadougou Burkina Faso

Knowledge of the state of stability of mining pits is both a basic condition, an essential axis and a safety benchmark for mining operations. this stability is largely based on the knowledge of the rock mass sheltering the mining works and this requires a perfect characterization of all of its structural formations through mapping (manual or digital). the families of discontinuities, namely family 1 (bedding), family 2 (Joint 2) and family 3 (Joint 1) obtained through structural mapping in the essakane open pit mine, made it possible to analyze the failure modes at the origin of rock instabilities. the respective dips of these different directional families are: 77˚ - 85˚/N 058˚ - 068˚, 66˚ - 74˚/N 133˚ - 143˚, 25˚ - 35˚/N115˚ - 130˚. An average safety factor of 4.3 was estimated for the area with a quality of the rock mass (RMR) estimated at 47. the results obtained reflect on the one hand the risks of instability associated with the quality of the rock mass studied and on the other hand highlights the state of stability of the study area.

关键词： Stability Cartography Discontinuities Safety Factor essakane

Physical and Mechanical Features of the Quaternary Basanites of the Cap-Vert Peninsula of Dakar (Senegal, West Africa)

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Geomaterials 2023年第4期13卷 124-138页

作者： Moussa sawadogo Déthie Sarr Geotechnical Department UFR of Engineering Sciences University of Thies Thies Senegal technosol-Ingenierie Geotechnical Design Office and Laboratory Dakar Senegal

this work presents the results of geotechnical tests carried out in the laboratory on specimens of Quaternary olivine basanites from the Cap-Vert peninsula of Dakar. the samples were taken following geotechnical investigations in the Fann-Pe, Mermoz-Ouakam, Yoff and Ngor areas respectively. the results obtained show a dry density between 20.45 and 29.30 kN/m3 which corresponds to medium to high density basanites. the porosity varies between 0.33% and 4.20%. For microlitic basanites, the porosity remains low, on the other hand, for micrograined basanites;a slight increase in porosity is noticed. As for the methylene blue adsorption test value measured, it is between 0.25 and 1.10. the uniaxial compression strength (Rc) and Young’s modulus (e) vary respectively from 12.19 MPa to 41.748 MPa and from 1477.6 MPa to 7699.1 MPa. the low strength values are recorded in altered and vesicular basanites. Also, a correlation was made between uniaxial compression strength and porosity and showed a gradual decrease in strength with increasing porosity.

关键词： Quaternary Basanites Cap-Vert Peninsula of Dakar Uniaxial Compression Strength Young Modulus Porosity Dry Density the Methylene Blue test

NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

the N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. this demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. the antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. this review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Reduced Shell Model Calculations of ^111Sb and ^112Sb

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Chinese Physics Letters 2007年第6期24卷 1521-1524页

作者： e. Dikmen t, Akyǖrek Department of Physics Sǖleyman Demirel University Isparta Turkey

the low-lying states of the mid-heavy odd-even ^111Sb and odd-odd ^112Sb isotopes are calculated for the first time within the shell model framework. the shell model calculations have been carried out within the reduced model space including the single particle orbits ld5/2,097/2, ld3/2, 2Sl/2. We obtain the energy spectra for the ^111Sb and ^112Sb isotopes in the reduced model space by using CD-Bonn two-body effective nucleon-nucleon interaction. the energy spectra are compared to the experimental results to give some discussion about the low-lying states of ^111Sb and ^112Sb.

关键词： Calculations Reduced Model