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Argyrophilic grain disease is common in older adults and may be a risk factor for suicide:a study of Japanese forensic autopsy cases

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translational Neurodegeneration 2023年第1期12卷 654-665页

作者： Koji yoshida Yukiko Hata Shojiro Ichimata Keitaro Okada Naoki Nishida Department of Legal Medicine Faculty of MedicineUniversity of Toyama2630 SugitaniToyama-shiToyama 930-0194Japan tanz Centre for Research in Neurodegenerative Disease Krembil Discovery TowerUniversity of Toronto60 Leonard Ave Toronto OnTorontoON M5T 0S8Canada Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada.

Background Neuropathological diagnosis of argyrophilic grain disease(AGD)is currently based primarily on the combination of argyrophilic grain(AG)visualized using Gallyas-Braak silver staining,phosphorylated tau-positive pretangles,coiled bodies,and ballooned neuron *** AGD is common in patients with dementia and/or prominent psychiatric symptoms,whether it is a distinct neurological disease entity or a by-product of the aging process remains *** In 1449 serial forensic autopsy cases>40 years old(823 males and 525 females,aged 40-101 years,mean age 70.0±14.1 years),we examined the frequency and comorbid pathology of AGD cases and investigated the clini-cal appearance by comparing those with non-AGD cases using the propensity *** Of the 1449 cases,we detected 342 AGD cases(23.6%;mean age 79.7 years;177 males and 165 females).the AGD frequency and stage increased with age(Ptients had dementia,and 51(15.2%)had a history of psychiatric hospital *** frequency of suicide and history of psychiatric disorders were significantly higher in AGD cases than in AGD-negative cases,matched for age,sex,and comorbidity pathol-ogy,with a relative risk of suicide of 1.72(1.30-2.26).the frequency of suicide was significantly higher in AGD cases than in non-AGD cases in female but not male *** relative risk of suicide increased to 2.27(1.20-4.30)and 6.50(1.58-26.76)in AGD patients with Lewy and progressive supranuclear palsy pathology,respectively,and decreased to 0.88(0.38-2.10)in those with advanced AD *** AGD cases,23.4%had dementia;however,the difference was not significant after controlling for age,sex,and comorbid *** Our study demonstrated that AGD is a significant and isolated risk factor for psychiatric hospital visits and suicide *** older adults,AGs may contribute to the progression of functional impairment of the limbic system,which leads to psychiatric dis

关键词： Amygdala Argyrophilic grains Dementia Forensic autopsy Psychiatric disorder Suicide

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SiC/C薄膜的制备及其力学性能

复合材料学报 2005年第1期22卷 74-78页

作者：王新华 YOSHI DA t 浙江大学材料科学与工程系杭州310027 东京大学材料工程系

　以SiC超细粉为原料、采用热等离子体物理气相沉积(tPPVD)技术快速制备出了高质量SiC/C薄膜,最大沉积速度达到225nm/s,高于常规物理气相沉积(PVD)和化学气相沉积(CVD)法两个数量级。用扫描电子显微镜、高分辨透射电子显微镜和X射线光... 详细信息

　以SiC超细粉为原料、采用热等离子体物理气相沉积(tPPVD)技术快速制备出了高质量SiC/C薄膜,最大沉积速度达到225nm/s,高于常规物理气相沉积(PVD)和化学气相沉积(CVD)法两个数量级。用扫描电子显微镜、高分辨透射电子显微镜和X射线光电子谱对薄膜的形貌和微结构进行了观察和分析,并用纳牛力学探针测定了薄膜的力学性能。研究结果表明,向等离子体中导入CH4,SiC/C薄膜沉积速度增大,薄膜中C含量增加,薄膜断面呈现柱状结构。薄膜硬度和弹性模量随薄膜中C含量增加而降低,在接触深度为40nm时由纳牛力学探针测得沉积薄膜的最大硬度达到38GPa。

关键词：薄膜 SiC/C 硬度力学性能

Degradation rates and products of fluticasone propionate in alkaline solutions

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Journal of Pharmaceutical Analysis 2017年第5期7卷 297-302页

作者： tadakazu tokumura Naoko yoshida Kanami Mori-Yasumoto Osamu Shirota takuro Kurita Laboratory of Pharmaceutics Kagawa School of Pharmaceutical Sciences Tokushima Bunri University Department of Pharmaceutical Sciences School of Pharmacy International University of Health and Welfare Laboratory of Pharmacognosy and Natural Products Chemistry Kagawa School of Pharmaceutical Sciences Tokushima Bunri University

the apparent degradation rate constant of fluticasone propionate(FLt) in 0.1 M NaOH:methanol=1:1 at 37 °C was previously reported to be 0.169 ± 0.003 h^(-1), and four degradation products(products 1–4) were observed in the solution. the aims of the present study were to assess the degradation rates of FLt in other alkaline solutions and clarify the chemical structures of the four degradation products in order to obtain basic data for designing an enema for inflammatory bowel disease. the apparent degradation rate constants in 0.05 M NaOH and 0.1 M NaOH:CH_3CN=1:1 were 0.472 ± 0.013 h^(-1) and 0.154 ± 0.000 h^(-1)(n=3), respectively. the chemical structures of products 1–4 in 0.1 M NaOH:methanol=1:1 were revealed by nuclear magnetic resonance(NMR)and mass spectrometry data. the chemical structure of products 2 was that the 17-position of the thioester moiety of FLt was substituted by a carboxylic acid. the degradation product in 0.1 M NaOH:CH_3CN=1:1 was found to be product 2 based on ~1H NMR data. the degradation product in 0.05 M NaOH was considered to be product 2 based on the retention time of HPLC. these results are useful for detecting the degradation products of FLt by enzymes of the intestinal bacterial flora in the large intestine after dosing FLt as an enema.

关键词： Fluticasone propionate Degradation rate Degradation products Chemical structure Alkaline solution

New Species of Meconopsis(Papaveraceae) from Laojun Shan and Yao Shan,Northern Yunnan,China

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植物分类与资源学报 2012年第2期34卷 145-149页

作者： yoshida toshio BOUFFORD David E Hoshiya 330-6 Oamishirasato-machiSambu-gunChiba 299-3222Japan Harvard University Herbaria 22 Divinity AvenueCambridgeMA 02138-2020U.S.A.

two new species,Meconopsis muscicola and ***(Papaveraceae),are described and *** separating them from similar species are discussed and photos showing their diagnostic features are provided.

关键词： Meconopsis M.muscicola M.yaoshanensis New species Yunnan Laojun Shan Yao Shan

Microstructural analyses of all-solid-state Li–S batteries using LiBH4-based solid electrolyte for prolonged cycle performance

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Journal of Energy Chemistry 2020年第11期29卷 424-429页

作者： Kazuaki Kisu Sangryun Kim Ryuga yoshida Hiroyuki Oguchi Naoki toyama Shin-ichi Orimo Advanced Institute for Materials Research(WPI-AIMR) Tohoku UniversityKatahira 2-1-1Aoba-kuSendai 980-8577Japan Institute for Materials Research(IMR) Tohoku UniversityKatahira 2-1-1Aoba-kuSendai 980-8577Japan

Complex hydride materials have been widely investigated as potential solid electrolytes because they have good compatibility with the lithium metal anodes used in all-solid-state batteries. However, the development of all-solid-state batteries utilizing complex hydrides has been difficult as these cells tend to have short cycle lives. this study investigated the capacity fading mechanism of all-solid-state lithium–sulfur(Li–S) batteries using Li4(BH4)3I solid electrolytes by analyzing the cathode microstructure. Crosssectional scanning electron microscopy observations after 100 discharge–charge cycles revealed crack formation in the Li4(BH4)3I electrolyte and an increased cathode thickness. Raman spectroscopy indicated that decomposition of the Li4(BH4)3I solid electrolyte occurred at a constant rate during the cycling *** combat these effects, the cycle life of Li–S batteries was improved by increasing the amount of solid electrolyte in the cathode.

关键词： All-solid-state battery Complex hydride solid electrolyte Li metal anode Li–S battery Microstructure

Measurement　of　Excursion　of　Finger　Flexor　tendons　Produced　by　a　Continuous　Passive　Motion　Machine

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中华骨科杂志 1995年第2期15卷 76-83页

作者： yoshida E Dent JA Rowley JI University of Dundee 苏格兰

ＭｅａｓｕｒｅｍｅｎｔｏｆＥｘｃｕｒｓｉｏｎｏｆＦｉｎｇｅｒＦｌｅｘｏｒＴｅｎｄｏｎｓＰｒｏｄｕｃｅｄｂｙａＣｏｎｔｉｎｕｏｕｓＰａｓｓｉｖｅＭｏｔｉｏｎＭａｃｈｉｎｅＹｏｓｈｉｄａＥ；ＤｅｎｔＪＡ；ＲｏｗｌｅｙＪＩ... 详细信息

ＭｅａｓｕｒｅｍｅｎｔｏｆＥｘｃｕｒｓｉｏｎｏｆＦｉｎｇｅｒＦｌｅｘｏｒＴｅｎｄｏｎｓＰｒｏｄｕｃｅｄｂｙａＣｏｎｔｉｎｕｏｕｓＰａｓｓｉｖｅＭｏｔｉｏｎＭａｃｈｉｎｅＹｏｓｈｉｄａＥ；ＤｅｎｔＪＡ；ＲｏｗｌｅｙＪＩＲｅｃｅｉｖｅｄ９Ａｕｇｔｔｓｔ１...

关键词：掌指关节指尖手指指间关节指关节 Continuous Excursion Finger Flexor Machine Measurement Motion Passive Produced tendons

Hepatoid adenocarcinoma of the colon in a patient with inflammatory bowel disease

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World Journal of Gastroenterology 2014年第35期20卷 12657-12661页

作者： Yuanyuan Chen David F Schaeffer Eric M yoshida Division of Gastroenterology University of British Columbia Department of Pathology and Laboratory Medicine University of British Columbia

A case is presented of a 36-year-old male with primary sclerosing cholangitis-associated inflammatory bowel disease(PSC-IBD) and two synchronous stage 1 adenocarcinomata of the colon,who was initially treated with a subtotal colectomy with *** year later,the patient presented with extensive intra-abdominal lymphadenopathy and peritoneal carcinomatosis,as well as a markedly elevated serum level of alpha-fetoprotein(AFP).Fine needle aspiration biopsy of a porta hepatis lymph node revealed a metastatic hepatoid *** review of the previous colectomy specimen showed that one of the previously identified adenocarcinomata had features suggestive of a hepatoid colonic *** patient was subsequently treated with a cytotoxic regimen of FOLFOX(oxaliplatin,leucovorin,5-fluorouracil) and bevacizumab,with stable results being achieved after six *** case presents the first known report of PSC-IBD associated with synchronous typical and hepatoid adenocarcinomata of the colon and highlights the importance of considering hepatoid adenocarcinoma as a differential diagnosis in patients with an increasing serum AFP level.

关键词： Hepatoid adenocarcinoma Inflammatory bowel disease Colon cancer Alpha-fetoprotein Ulcerative colitis Primary sclerosing cholangitis Recurrence Metastasis

High-strain-rate superplasticity in oxide ceramics:a trial of microstructural design based on creep-cavitation mechanisms

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Acta Metallurgica Sinica(English Letters) 2011年第3期24卷 195-204页

作者： Keijiro HIRAGA Byung-Nam KIM Koji MORItA Hidehiro yoshida Yoshio SAKKA Masaaki tABUCHI National Institute for Materials Science

From existing knowledge about high-temperature cavitation mechanisms, necessary conditions were discussed for the suppression of cavitation failure during superplastic deformation in ceramic materials. the discussion, where special attention was placed on the relaxation of stress concentrations during grain-boundary sliding and cavity nucleation and growth, leaded to a conclusion that cavitation failure could be retarded by the simultaneous controlling of the initial grain size, the number of residual defects, diffusivity, dynamic grain growth and the homogeneity of microstructure. On the basis of this conclusion, high-strain-rate superplasticity （defined as superplasticity at a strain rate higher than 0.01 s^-1） could be intentionally attained in some oxide ceramic materials. this was shown in tetragonal zirconia and composites consisting of zirconia, a-alumina and a spinel phase.

关键词： Grain-boundary sliding Accommodation Stress concentration Diffusional relaxation Cavity nucleation Cavity growth Dynamic grain growth

New methods for the management of esophageal varices

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World Journal of Gastroenterology 2007年第11期13卷 1641-1645页

作者： Hiroshi yoshida Yasuhiro Mamada Nobuhiko taniai takashi tajiri Department of Surgery Nippon Medical School Tokyo 1138603 Japan

Bleeding from esophageal varices (EVs) is a catastrophic complication of chronic liver disease. Many years ago, surgical procedures such as esophageal transection or distal splenorenal shunting were the only treatments for EVs. In the 1970s, interventional radiology procedures such as transportal obliteration, left gastric artery embolization, and partial splenic artery embolization were introduced, improving the survival of patients with bleeding EVs. In the 1980s, endoscopic treatment, endoscopic injection sclerotherapy (EIS), and endoscopic variceal ligation (EVL), further contributed to improved survival. We combined IVR with endoscopic treatment or EIS with EVL. Most patients with EVs treated endoscopically required follow- up treatment for recurrent varices. Proper management of recurrent EVs can significantly improve patients’ quality of life. Recently, we have performed EVL at 2-mo (bimonthly) intervals for the management of EVs. Longer intervals between treatment sessions resulted in a higher rate of total eradication and lower rates of recurrence and additional treatment.

关键词： Esophageal varices Surgery Interventional radiology Embolization Endoscopic treatment Bi-rnonthly