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国外石油机械 1994年第1期6卷 8-15页

作者：赵天财 t.m.warren 西南石油学院科技情报室

介绍旋转导向的短半径曲线井段钻进装置的发展和试验。曲线井段钻进装置由逆旋转聚晶金刚石复合片(PDC)钻头、柔性接头、偏心变向套、方位指示器和柔性钻柱组成。此装置可用于从现有井钻排泄孔以增加老油田的产量。

关键词：钻井工具侧钻 [结构特点] 钻井试验

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套管钻井系统设计考虑

石油勘探开发情报 2001年第6期 49-51页

作者： t·m·warren 王金旗

套管-钻井系统（CDS）可用钻柱普通套管来代替常规钻井系统，该系统可随钻下套管，从而降低钻井成本，更重要的是由于减少了起下钻时间和处理时间，潜在节约了大量资金，减少井眼问题节约的资金更加明显，由于CDS工艺有能力使井连续循... 详细信息

套管-钻井系统（CDS）可用钻柱普通套管来代替常规钻井系统，该系统可随钻下套管，从而降低钻井成本，更重要的是由于减少了起下钻时间和处理时间，潜在节约了大量资金，减少井眼问题节约的资金更加明显，由于CDS工艺有能力使井连续循环，因此，起下常规钻柱时要比井处于静态更安全。因CDS减少了起下钻柱时间，从而也降低了波动-抽吸压力波动。CDS已经开发了三年，用这种系统已钻了两口定向的试验井，最近，用CDS钻了10口井，这10口井将做为首批现场试验井。

关键词：石油钻井套管钻井系统设计 CDS 定向井

在硬岩石中使用聚晶金刚石复合片钻头可产生钻铤扭力共振

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石油石化节能 1999年第8期 23-25页

作者： t.m.warren J．H．Oster 戴敏鄢明雄江汉石油管理局经济发展研究中心江汉石油管理局钻头厂技术开发研究所

本文通过在阿莫科Catoosa试验现场使用井下钻柱动力传感器提供的振动数据，说明在硬岩石中使用聚晶金刚石复合片（PDC）钻头可产生钻铤扭力共振，造成PDC齿很快损坏。描述了PDC钻头回旋和钻柱卡钻/打滑的情况及其特征，以及反向旋转对产... 详细信息

本文通过在阿莫科Catoosa试验现场使用井下钻柱动力传感器提供的振动数据，说明在硬岩石中使用聚晶金刚石复合片（PDC）钻头可产生钻铤扭力共振，造成PDC齿很快损坏。描述了PDC钻头回旋和钻柱卡钻/打滑的情况及其特征，以及反向旋转对产PDC齿失效的影响，同时分析了PDC齿损坏的原因。

关键词： POC钻头扭力共振振动数据回旋卡钻打滑

在硬岩石中使用聚晶金刚石复合片钻头可产生钻铤扭力共振

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国外油田工程 1999年第8期15卷 23-25页

作者： t.m.warren J.H.Oster 戴敏鄢明雄江汉石油管理局钻头厂技术开发研究所江汉石油管理局经济发展研究中心

关键词： PDC钻头扭力共振钻铤钻井钻头石油开采

transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied mathematics and mechanics(English Edition) 2025年第1期46卷 177-192页

作者： m.NAVEED m.ImRAN t.ASGHAR Z.ABBAS Department of mathematics Division of Science and TechnologyUniversity of Education Department of mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAm).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： Peclet number

the impact of alpha-fetoprotein(AFP),child-turcotte-pugh(CtP)score and disease staging on the survival of hepatocellular carcinoma(HCC)patients:a retrospective cohort from single oncology center

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Oncology Research 2025年第1期33卷 149-160页

作者： NASSER mULLA YOUSEF KAtIB ASIm m.ALmUGHAmSI DUAA S.ALKHAYAt mOHAmED mOSAAD SAmIR t.ALFOtIH RAWAN ALAOFI Department of Internal medicine Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Radiology Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Surgery Faculty of MedicineTaibah UniversityMadinah42278Saudi Arabia Department of Endemic and Infectious Diseases Suez Canal UniversityIsmailia41522Egypt King Salman bin Abdulaziz medical City Madinah42311Saudi Arabia Prince mohammed Bin Abdulaziz Hospital Madinah41511Saudi Arabia

Background:Hepatocellular carcinoma(HCC)is the most common cause of cancer-related death in Saudi *** study aimed to investigate the patterns of HCC and the effect of tNm staging,Alfa-fetoprotein(AFP),and Child-turcotte Pugh(CtP)on patients’overall survival(OS).methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to *** patients had to fulfill one of the following criteria:(a)a liver lesion reported as definitive HCC on dynamic imaging and/or(b)a biopsy-confirmed ***:the mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:*** patients were stratified into two groups:viral HCC(n=22,51%)and non-viral HCC(n=21,49%).Among viral-HCC patients,55%were due to HBV and 45%due to *** was diagnosed in 79%of *** and sex did not significantly statistically differ in OS among viral and non-viral HCC patients(p-value>0.05).About 65%of patients had tumor size>5 cm during the diagnosis,with a significant statistical difference in OS(p-value=0.027).AFP was>400 ng/ml in 45%of the *** was a statistically significant difference in the OS in terms of AFP levels(p-value=0.021).A statistically significant difference was also observed between the CtP score and OS(p-value=0.02).CtP class B had the longest *** was the most common treatment provided to HCC patients followed by sorafenib *** was a significant statistical difference in OS among viral and non-viral HCC patients(p-value=0.008).Conclusions:the most common predictors for OS were the underlying cause of HCC,AFP,and tumor *** having non-viral etiology,a tumor size>5 cm,an AFP>400 ng/mL,and a CtP score class C were all negatively associated with OS.

关键词： Hepatocellular carcinoma Pattern Alpha-fetoprotein(AFP) Child-turcotte-pugh Progression free survival

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. the generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. this adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. the role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. this organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. these mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology Research 2025年第1期33卷 235-243页

作者： HASSAN m.OtIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-StAt)pathways play pivotal roles in GC progression,making them attractive targets for therapeutic ***:this study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases,as evidenced by molecular docking scores and molecular dynamics *** interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target ***-JP-0004 displayed an half-maximal inhibitory concentration(IC_(50))value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KAtOIII and SNU-5 cells,with half-maximal growth inhibitory concentration(GI50)values of 250.8 and 516.3 nm,respectively.A significant elevation in the early phase apoptosis(28.53%in KAtOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KAtOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:the results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 molecular docking molecular dynamics simulation

mitochondria–cGAS–StING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

the word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Stress and Springback Analyses of API X70 Pipeline Steel Under 3-Roller Bending via Finite Element method

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Acta metallurgica Sinica(English Letters) 2017年第5期30卷 470-482页

作者： Wenbo Zhao t.warren Liao Lampros Kompotiatis Department of mechanical and Industrial Engineering Louisiana State UniversityBaton RougeLA 70803USA Vice President of technology STUPP Corporation12555 Ronaldson Rd.Baton RougeLA 70807USA

3-Roller bending is a widely applied manufacturing process, particularly in structural steel pipe ***, due to the difficulty and high cost of measuring stress distribution inside sheet material via traditional method,internal stress/strain response during forming is largely unexplored. the focuses of this study are two：（1） to map the radii of curvature as well as the stress inside the work piece during forming by utilizing the meshing mechanism of finite element method, and（2） to further provide some numeric guidelines for the configuration of the rolling system in order to improve production efficiency and product quality. the results of this study indicate that：（1） it is crucial to properly choose forming parameter in order to produce product with desired radii;（2） much like a gradual springback process, the radii of curvature gradually increase from the top roller to the exit-side bottom roller;（3） under the assumptions made in this study, to produce pipes with a specified diameter with varying configurations of the 3-roller system will not significantly change the final residual stress; and（4） finally, shifting of the neutral axis up to 2.0% of the thickness toward the compressing side during the forming process is observed.

关键词： Asymmetrical 3-roller bending Residual stress Springback Pipe manufacturing