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64-row multi-dector computed tomography coronary image from a center with early experience: first illustration of learning curve

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Journal of Geriatric Cardiology 2006年第1期3卷 29-34页

作者： sze piaw chin Tiong Kiam ONG Chee Khoon LIEW M.Tobias Seyfarth Fong Yean Yip ALAN Houng Bang LIEW Kui Hian SIM Dept of Cardiology Sarawak General Hospital Siemens Cardiac Solutions Erlangen Germany

Background and objectives The recent joint ACCF/AHA clinical competence statement on cardiac imaging with multi-detector computed tomography recommended a minimum of 6 months training and 300 contrast examinations, of which the candidate must be directly involved in at least 100 studies. Whether this is adequate to become proficient in interpretation of coronary computed tomogsignificant coronary stenosis in a center with 1 year's experience using a 64-row scanner. Methods A total of 778 patients underwent contrast-enhanced CTA between January and December 2005. Out of these patients, 301 patients also underwent contrast-enhanced conventional coronary angiography (CCA). These patients were divided into 4 groups according to the time the examination was underwent. Group Q1: first quarter of the year (n=20), Group Q2: second quarter (n=128), Group Q3: third quarter (n=134), and Group Results The sensitivity, specificity, positive, and negative predictive values were Q1 - 64%, 89%, 49% and 94%, respectively; Q2 -79%, 96%, 74% and 97%, respectively; Q3 - 78%, 96%, 74%, 97%, respectively, and Q4 - 100% for all. Conclusions In a center with formal training and high caseload, our accuracy in CTA analysis reached a plateau after 6 months experience. Test-bolus protocols produce better image quality and can improve accuracy. New centers embarking on CTA will need to overcome an initial 6-month learning curve depending upon the caseload during which time they should consider correlation with CCA.

关键词： computed tomography training angiography coronary artery disease

Peripheral intervention before bypass surgery in the elderly:feasible and effective,but is it necessary?

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Journal of Geriatric Cardiology 2006年第2期3卷 77-页

作者： sze-piaw chin Kui-Hian SIM Department of Cardiology Sarawak General HospitalKuching 93586SarawakEast Malaysia

　　In this issue of the Journal of Geriatric Cardiology,Rigatelli and colleagues tackled the issue of concomitant noncoronary atherosclerosis among elderly patients undergoing cardiac surgery.1 Ilio-femoral disease, renal artery stenosis, carotid stenosis, and even disease of supra-aortic vessels may variously impact the patient's recovery from surgery. Also, the fact that involvement of two or more arterial beds are more common among the elderly makes this article all the more relevant at this time.……

关键词： CABG Peripheral intervention before bypass surgery in the elderly

Assessment of left ventricular ejection fraction: comparison of two dimensional echocardiography, cardiac magnetic resonance imaging and 64-row multi-detector computed tomography

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Journal of Geriatric Cardiology 2006年第1期3卷 2-8页

作者： Chee Khoon LIEW Rapaee ANNUAR Tiong Kiam ONG sze piaw chin Tobias Seyfarth Yean Yip FONG Choon Kiat ANG Houng Bang LIEW Kui Hian SIM Department of Cardiology Sarawak General Hospital Sarawak Malaysia University Malaysia Sarawak Siemens Cardiac Solutions Erlangen Germany Department of Cardiology Sarawak General Hospital SarawakMalaysia

Objectives To compare left ventricular ejection fraction (LVEF) determined from 64-row multi-detector computed tomography (64-row MDCT) with those determined from two dimensional echocardiography (2D echo) and cardiac magnetic resonance imaging (CMR). Methods Thirty-two patients with coronary artery disease underwent trans-thoracic 2D echo, CMR and contrast-enhanced 64-row MDCT for assessment of LVEF within 48 hours of each other. 64-row MDCT LVEF was derived using the Syngo Circulation software; CMR LVEF was by Area Length Ejection Fraction (ALEF) and Simpson method and 2D echo LVEF by Simpson *** The LVEF was 49.13 ± 15.91% by 2D echo, 50.72 ± 16.55% (ALEF method) and 47.65 ± 16.58%(Simpson method) by CMR and 50.00 ± 15.93% by 64-row MDCT. LVEF measurements by 64-row MDCT correlated well with LVEF measured with CMR using either the ALEF method (Pearson correlation r = 0.94, P ＜0.01) or Simpson method (r = 0.92, P＜0.01). It also correlated well with LVEF measured using 2D echo (r = 0.80, P ＜ 0.01). Conclusion LVEF measurements by 64-row MDCT correlated well with LVEF measured by CMR and 2D echo. The correlation between 64-row MDCT and CMR was better than the correlation between 2D echo with CMR. Standard data set from a 64-row MDCT coronary study can be reliably used to calculate the LVEF.

关键词： ejection fraction echocardiography magnetic resonance imaging computed tomography

Feasibility and accuracy of coronary imaging in elderly patients using the 64-row multi-detector computed tomography: a correlation study with conventional coronary angiography

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Journal of Geriatric Cardiology 2006年第1期3卷 9-14页

作者： Chee Khoon LIEW sze piaw chin Tiong Kiam ONG Seyfarth Tobias Yean Yip FONG Choon Kiat ANG Houng Bang LIEW Rapaee ANNUAR Kui Hian SIM Deptartment of Cardiology Sarawak General Hospital SarawakMalaysia Siemens Cardiac Solutions Erlangen Germany Universitv Malaysia Sarawak Malaysia

Background Elderly patients generally have higher occurrence of coronary calcification, increased heart rate and difficulty with prolonged breath-holding. The aim of our study was to investigate the feasibility and accuracy of using 64-row multi-detector computed tomography (MDCT) in the assessment of coronary artery stenoses in elderly patients. Methods One hundred and fifty two patients with suspected or known coronary artery disease were divided into 4 groups according to their age (Group A: 40-49 years,n=34; Group B: 50-59 years, n=57; Group C: 60-69 years, n=48; Group D: 70 years and above; n=13). Coronary CT angiography (CTA) using a 64-row MDCT was performed and the findings were compared with that of conventional coronary angiography (CCA).Using axial images, multi-planar reconstructions (MPR) and maximum intensity projections (MIP), coronary segments of lumen diameter = 1.5mm were analyzed for the presence of significant stenosis (= 50% ). Results Percentages of poor image quality from coronary CTA preventing reliable correlations with CCA were 21%, 14%, 19% and 62% in Groups A to D respectively. Patients in Group D had significantly higher calcium scores compared with the other groups (P＜0.001). In patients where CTA images were of acceptable quality, percentages of accurate correlations with CCA were 89.8%, 93.4%, 86.6% and 78.0% for Groups A to D *** were no significant difference in serum creatinine, heart rate and contrast volume between the 4 groups. Conclusions The 64-row MDCT coronary angiography was less accurate and feasible for patients aged 70 years or above due to heavy coronary calcification and inability to perform a satisfactory breath-hold. However, a high diagnostic accuracy with the MDCT is possible in patients aged less than 70 years.

关键词： computed tomography angiography coronary artery disease elderly

High-resolution computed tomography in patients with atypical 'cardiac' chest pain: a study investigating patients at 10-year cardiovascular risks defined by the Framingham and PROCAM scores

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Journal of Geriatric Cardiology 2006年第1期3卷 17-21页

作者： Choon Kiat ANG Alan Yean Yip FONG sze piaw chin Tiong Kiam ONG Seyfarth M Tobias Chee Khoon LIEW Rapaee ANNUAR Houng Bang LIEW Kui Hian SIM Deptartment of Cardiology Sarawak General Hospital Sarawak Malaysia Siemens Medical Solutions Germany Deptartment of Cardiology Sarawak General Hospital SarawakMalaysia University Malaysia Sarawak Malaysia

Background and objective Atypical 'cardiac' chest pain (ACCP) is not usually caused by myocardial ischaemia. Current noninvasive investigations for these symptoms are not yet as accurate as invasive coronary angiography. The latest 64-row multi-detector computed tomography (MDCT) technology is non-invasive, has high specificity and negative predictive values for the detection of significant coronary disease. Our aim was to investigate if this modality can provide more information in the assessment of outpatients with ACCP in addition to established cardiovascular risk scores. Methods Seventy consecutive patients presenting to the outpatient clinic with ACCP underwent 64-row MDCT scan of the coronary arteries. They were categorized into low, medium or high risk groups based upon the Framingham and PROCAM scores. We defined a clinically abnormal MDCT scan as coronary stenosis =50% or calcium score ＞400 Agatston. Results Fifty-three (75.7%) patients did not have clinically abnormal scans. Framingham score classified 43 patients as low-risk while PROCAM classified 59 patients as low-risk. MDCT scans were abnormal for 18.6% and 22.0% of the respective low-risk group of patients. For patients with medium-to-high risk, 33.3% and 36.4% of Framingham and PROCAM patient groups respectively had abnormal MDCT scans. Conclusion MDCT adds valuable information in the assessment of patients with ACCP by identifying a significant proportion of patients categorized as low-risk to have underlying significant coronary stenosis and coronary calcification by established cardiovascular risk scores.

关键词： multi-detector computed tomography atypical 'cardiac' chest pain coronary artery disease risk stratification

Impacts of different drying strategies on drying characteristics,the retention of bio-active ingredient and colour changes of dried Roselle

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chinese Journal of Chemical Engineering 2018年第2期26卷 303-316页

作者： Thing Chai Tham Mei Xiang Ng Shu Hui Gan Lee Suan Chua Ramlan Aziz Luqman Chuah Abdullah sze Pheng Ong Nyuk Ling chin Chung Lim Law Department of Chemical Engineering The University of Nottingham Malaysia CampusJaian Broga43500 SemenyihSelangor D.E.Malaysia Institute of Bioproduct Development Universiti Teknologi MalaysiaUTMJohor Bahru81310 SkudaiMalaysia Department of Chemical and Environmental Engineering Universiti Putra Malaysia UPM43400 SerdangSelangorMalaysia Department of Process and Food Engineering Universiti Putra Malaysia UPM43400 SerdangSelangorMalaysia

The drying kinetics of Roselle （Hibiscus sabdariffa L） of variety Terengganu （UMKL-1） and the quality attribution of Roselle were studied. The experiments were conducted using four different drying methods, including solar greenhouse drying （SD）, solar greenhouse with intermittent heat pump drying （SIHP）, hot air drying （HA） and heat pump drying （HP）. Among the four drying methods, HP achieved the highest drying rate at a range from 0.054 g H20-（g DM）-1. rain-1 to 0.212 g H20-（g DM）-1. rain 1 while SD had the lowest drying rate, measured at 0.042 g H2O. （g DM） ***- 1. The analysis on colour kinetics revealed that there is no significant colour loss （p 〉 0.05） observed from HP＇s dried Roselle. Greater amount of flavonoid compounds i.e. protocatechuic acid was found in SD and SIHP dried finished product whereas HP＇s dried Roselle contains higher percentage of catechin as compared to other drying methods.

关键词： Hibiscus sabdariffa L.Drying Heat pump Total colour change Protocatechuic acid Catechin

Hypoxia increases adipogenesis and affects adipocytokine production in orbital fibroblasts-a possible explanation of the link between smoking and Graves' ophthalmopathy

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International Journal of Ophthalmology(English edition) 2014年第3期7卷 403-407页

作者： Chiaw Ling Chng Oi Fah Lai Charmaine sze-Min Chew Yu Pei Peh Stephanie Man-Chung Fook-Chong Lay Leng Seah Daphne Hsu-chin Khoo Department of Endocrinology Singapore General HospitalLevel 3 the Academia 20 College Road 169856 Singapore Department of Clinical Research Academia Discovery Tower Level 9 Research Office 2 20 College Road 169856Singapore Oculoplastic/Aesthetic Eyeplastic Service Singapore National Eye Centre 11 Third Hospital Avenue 168751Singapore

AIM:To assess the effects of hypoxia on human orbital fibroblasts(OF)on adipogenesis and adipocytokine ***:Human OF were derived from tissues obtained from patients with Graves’ophthalmopathy(GO)and from patients without known thyroid diseases undergoing *** OF were cultured separately under normoxic and hypoxic *** of adipocytokine concentrations using multiplex ELISA and lipid accumulation in the cells using Oil Red O staining were subsequently ***:There was increased adipogenesis in OF from GO subject when exposed to hypoxic culture *** was not observed in OF from normal *** led to an increase in leptin and a decrease in MCP-1 secretion in OF ***:Hypoxia induces adipogenesis in OF and may represent a mechanism by which smoking contributes to deterioration of *** also found novel changes to leptin and MCP-1 production in OF cultures exposed to hypoxia suggesting important roles of these cytokines in the disease process.

关键词： hypoxia smoking Graves' ophthalmopathy

维普期刊数据库评论

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限流二极管扩流电路

电子产品世界 2003年第22期10卷 47-48页

作者： sze chin Central Semiconductor Corp.

简介限流二极管(CLD)或称电流调节二极管(CRD),比基于晶体管的传统电流源更为简单,因此有着明显的优势.然而,限流二极管的应用也有明显的局限性.原因之一是目前的限流二极管产品提供的最大电流仅15mA,而功率最大仅为1瓦.

关键词：二极管扩流限流电流增益

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经方治疗过敏性鼻炎的文献研究

经方治疗过敏性鼻炎的文献研究

作者：辜诗晶（Goh sze chin,Gwendelyn）南京中医药大学

学位级别：硕士

目的:通过系统收集和整理大量有关经方治疗过敏性鼻炎的临床研究及相关文献,发掘经方对过敏性鼻炎的治疗潜力,探讨经方辨治过敏性鼻炎之机理,以期为中医药治疗过敏性鼻炎方面提供有益的借鉴。研究方法和结果:本研究分为四个部分进行论述... 详细信息

目的:通过系统收集和整理大量有关经方治疗过敏性鼻炎的临床研究及相关文献,发掘经方对过敏性鼻炎的治疗潜力,探讨经方辨治过敏性鼻炎之机理,以期为中医药治疗过敏性鼻炎方面提供有益的借鉴。研究方法和结果:本研究分为四个部分进行论述:第一和第二部分通过理论文献研究,研讨中西医对过敏性鼻炎的认识,包括病因、发病机制、临床表现以及目前中西医的治疗进展。第三部分是临床文献研究。方法:通过收集经方治疗过敏性鼻炎的临床研究。每篇文献的题目、作者、发表年代、方剂名称、辨证分型、治疗例数等资料输入EXCEL 2016,对数据进行统计。结果:纳入统计的文献共164篇及所涉及的经方共24首,不同经方使用频率依次为:小青龙汤、桂枝汤、麻黄附子细辛汤、苓桂术甘汤、射干麻黄汤、小柴胡汤、柴胡桂枝汤、五苓散、薯蓣丸、半夏泻心汤、麻黄汤、葛根汤、麻杏甘石汤、金匮肾气丸、黄芪桂枝五物汤、乌梅丸、麻黄连翘赤小豆汤、大青龙汤、四逆汤、桂枝人参汤、麻桂各半汤、真武汤、甘草干姜汤和葶苈大枣泻肺汤。第四部分是小青龙汤治疗过敏性鼻炎的Meta分析。方法:“过敏性鼻炎”、“变应性鼻炎”、“鼻鼽”、“allergic rhinitis”、“小青龙汤”、“随机对照试验”作为关键词进行检索,检索数据库为中国知网、万方数据库和维普数据库。通过入选和排除标准,经筛选后纳入符合标准的文献,使用Review Manager 5.3软件进行数据处理。共纳入的文献共11篇。结果:在总有效率方面,7篇合并分析总有效率显示小青龙汤组疗效优于西药组(OR=1.15,95%CI:1.09-1.21,Z=5.19,P<0.00001);在症状评分方面,2 篇合并分析显示小青龙汤组对症状改善作用优于西药组(OR=-2.43,95%CI:-2.43--2.22,Z=23.03,P<0.00001);在视觉模拟评分(VAS)方面,2篇合并显示小青龙汤组能降低VAS 评分(OR=-2.04,95%CI:-2.35--1.73,Z=12.72,P<0.00001);在鼻眼结膜相关生活质量问卷调查量表评(RQLQ)方面,2篇合并显示小青龙汤组与西药组能降低RQLQ评分(OR=14.50,95%%CI:-2.46--31.46,Z=1.68,P=0.09),二者差异无统计学意义;在复发率方面,3篇合并分析显示小青龙汤组的复发率低于西药组(OR=0.42,95%CI:0.29-0.62,Z=4.43,P<0.00001)。结论:小青龙汤组可以显著提高过敏性鼻炎的总有效率。而且小青龙汤改善患者的临床症状和降低复发率较单纯西药有明显的优势。

关键词：经方过敏性鼻炎文献研究小青龙汤 meta分析