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Pharmacology & Pharmacy 2013年第6期4卷 478-483页

作者： Atsushi Kawase syoko wada Masahiro Iwaki Department of Pharmacy School of Pharmacy Kinki University Osaka Japan Department of Pharmacy School of Pharmacy Kinki University Osaka Japan.

Pathophysiological changes in human patients and in animal models of infection or inflammation are associated with alterations in the production of numerous liver-derived proteins including metabolizing enzymes. In this study, the effects of adjuvant-induced arthritis (AA) in rats on the levels of mRNA and activity of hepatic xenobiotic metabolizing enzymes were determined during the inflammatory response. The mRNA levels of cytochrome P450 (CYP) 1A2, CYP2C12, CYP2D1, CYP2D2, and CYP3A1 were significantly decreased compared with control levels in almost all phases of inflammation. A reduction in the activity of CYP2C and CYP3A, which are abundantly expressed in the liver, was also observed. For phase II metabolizing enzymes, mRNA levels of uridine 5’-diphospho-glucuronosyltransferase (UGT) 1A1, UGT1A6, sulfotransferase (SULT) 2A1, and glutathione S-transferase 2 were significantly decreased compared with control levels. However, the mRNA levels of UGT2B and SULT1A1 returned to control levels during the subacute (7 d after adjuvant treatment) and chronic (21 d after adjuvant treatment) phases although these levels decreased during the acute (3 d after adjuvant treatment) phase. These results suggest that the effects of inflammation on the expression of xenobiotic metabolizing enzymes differ depending on the isoform of the enzyme and could affect the pharmacokinetics of each substrate.

关键词： Inflammation Arthritis Enzyme Cytochrome Metabolism

Predictive modelling of volumetric and Marshall properties of asphalt mixtures modified with waste tire-derived char:A statistical neural

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Journal of Road Engineering 2024年第3期4卷 318-333页

作者： Nura Shehu Aliyu Yaro Muslich Hartadi Sutanto Noor Zainab Habib Aliyu Usman Abiola Adebanjo Surajo Abubakar wada Ahmad Hussaini Jagaba Department of Civil and Environmental Engineering Universiti Teknologi PETRONASSeri Iskandar 32610Malaysia Department of Civil Engineering Ahmadu Bello UniversityZaria 810107Nigeria Institute of Infrastructure and Environment Heriot-Watt UniversityDubai 294345United Arab Emirates School of Civil Engineering Central South UniversityChangsha 410075China Interdisciplinary Research Centre for Membranes and Water Security King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia

The goals of this study are to assess the viability of waste tire-derived char(WTDC)as a sustainable,low-cost fine aggregate surrogate material for asphalt mixtures and to develop the statistically coupled neural network(SCNN)model for predicting volumetric and Marshall properties of asphalt mixtures modified with *** study is based on experimental data acquired from laboratory volumetric and Marshall properties testing on WTDCmodified asphalt mixtures(WTDC-MAM).The input variables comprised waste tire char content and asphalt binder *** output variables comprised mixture unit weight,total voids,voids filled with asphalt,Marshall stability,and *** coupled neural networks were utilized to predict the volumetric and Marshall properties of asphalt *** predictive modeling,the SCNN model is employed,incorporating a three-layer neural network and preprocessing techniques to enhance accuracy and *** optimal network architecture,using the collected dataset,was a 2:6:5 structure,and the neural network was trained with 60%of the data,whereas the other 20%was used for cross-validation and testing *** network employed a hyperbolic tangent(tanh)activation function and a feed-forward *** to the results,the network model could accurately predict the volumetric and Marshall *** predicted accuracy of SCNN was found to be as high value>98%and low prediction errors for both volumetric and Marshall *** study demonstrates WTDC's potential as a low-cost,sustainable aggregate *** SCNN-based predictive model proves its efficiency and versatility and promotes sustainable practices.

关键词： Waste tire Neural network Sustainable practices Asphalt mixtures Predictive model

The research progress of an E//B neutral particle analyzer

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Plasma Science and Technology 2024年第3期26卷 10-16页

作者：马龙屈玉凡罗圆谢德豪汪彦熹王硕曲国峰任培培罗小兵刘星泉韩纪锋 Roy wada 林炜平臧临阁朱敬军 Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064People's Republic of China Southwestern Institute of Physics Chengdu 610064People's Republic of China Cyclotron Institute Texas A&M UniversityCollege StationTexas 77843United States of America

An E//B neutral particle analyzer(NPA)has been designed and is under development at Sichuan University and Southwestern Institute of *** main purpose of the E//B NPA is to measure the distribution function of fast ions in the HL-2A/3 *** E//B NPA contains three main units,*** stripping unit,the analyzing unit and the detection unit.A gas stripping chamber was adopted as the stripping *** results of the simulations and beam tests for the stripping chamber are *** electric and magnetic fields provided by a NdFeB permanent magnet and two parallel electric plates were designed and constructed for the analyzing *** calibration of the magnetic and electric fields was performed using a 50 kV electron cyclotron resonance ion source(ECRIS)*** detection unit consists of 32lutetium-yttrium oxyorthosilicate(LYSO)detector modules arranged in two *** response functions ofα,hydrogen ions(H^(+),H_(2)^(+)and H_(3)^(+))andγfor a detector module were measured with^(241)Am,^(137)Cs and^(152)Eu sources together with the 50 kV ECRIS *** overall results indicate that the designed E//B NPA device is capable of measuring the intensity of neutral hydrogen and deuteron atoms with energy higher than 20 keV.

关键词： E//B neutral particle analyzer gas stripping lutetium-yttrium oxyorthosilicate electron cyclotron resonance ion source platform

Can early precut reduce post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with difficult bile duct cannulation?

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World Journal of Gastrointestinal Endoscopy 2024年第9期16卷 519-525页

作者： Tomohiro Tanikawa Keisuke Miyake Mayuko Kawada Katsunori Ishii Takashi Fushimi Noriyo Urata Nozomu wada Ken Nishino Mitsuhiko Suehiro Miwa Kawanaka Hidenori Shiraha Ken Haruma Hirofumi Kawamoto Department of General Internal Medicine 2 Kawasaki Medical SchoolOkayama 7008505Japan

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is associated with a variety of adverse events(AEs).One of the most important AEs is post-ERCP pancreatitis(PEP),which is most common in cases of difficult biliary *** the precut technique has been reported as a PEP risk factor,recent studies indicate that early precut could reduce PEP,and that precut itself is not a risk *** To evaluate the safety of the precut technique,especially in terms of *** We conducted a retrospective study,spanning the period from November 2011 through December *** included 1556 patients,aged≥20 years,who underwent their initial ERCP attempt for biliary disease with a naïve papilla at the Kawasaki University General Medical *** compared the PEP risk between the early precut and the delayed precut *** The PEP incidence rate did not significantly differ between the precut and nonprecut ***,the PEP incidence was significantly lower in the early precut group than the delayed precut group(3.5%vs 10.5%;P=0.02).The PEP incidence in the delayed precut group without pancreatic stent insertion(17.3%)was significantly higher compared to other cases(P<0.01).CONCLUSION Our findings indicate that early precut may reduce PEP *** the precut decision is delayed,a pancreatic stent should be inserted to prevent PEP.

关键词： Endoscopic retrograde cholangiopancreatography Post-endoscopic retrograde cholangiopancreatography pancreatitis Precut Needle-knife precut papillotomy

Research and development of electric vehicles for clean transportation

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Journal of Environmental Sciences 2009年第6期21卷 745-749页

作者： wada Masayoshi Department of Human-Robotics Faculty of DevelopmentSaitama Institute of Technology

This article presents the research and development of an electric vehicle（EV） in Department of Human-Robotics Saitama Institute of Technology,*** mobile systems developed in our laboratory include a converted electric automobile,electric wheelchair and personal mobile *** mobile systems contribute to realize clean transportation since energy sources and devices from all vehicles,i.e.,batteries and electric motors,does not deteriorate the *** drive motors for vehicle traveling,robotic technologies were applied.

关键词： electric vehicle robot technology converted electric vehicle clean transportation

Flow Structure Around the Intake of a Vertical Pump

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Journal of Thermal Science 2006年第2期15卷 121-125页

作者： Akihiro wada Research and Development Dept. Torishima Pump MFG. Co. Ltd. 1-1-8 Miyata-cho Takatsuki Osaka 569-8660 Japan

The flow structure around the intake of a vertical pump is investigated experimentally and numerically in order to obtain a guideline in designing the optimum shape of the intake of vertical pumps, in which their installation area is demanded to be minimum without losing the high performance. We concentrate our attention on the expansion ratio of the intake as a representative characteristic of the shape of the pumps and investigate the effect of the expansion ratio on pump performance. It is concluded that the optimum expansion ratio ranges in 1.1-1.2 if we take into consideration that the area needed for the installation of the pump should be minimum.

关键词： vertical pump shape of intake flow structure around the intake

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中性粒子分析仪的研究现状

原子能科学技术 2024年第S02期58卷 501-511页

作者：林炜平马龙汪彦熹屈玉凡罗圆谢德豪王硕曲国峰任培培罗小兵刘星泉韩纪锋 Roy wada 臧临阁朱敬军四川大学原子核科学技术研究所辐射物理及技术教育部重点实验室四川成都610064 核工业西南物理研究院四川成都610218 Texas A&M University Texas USA 77843

中性粒子分析仪(NPA)作为托卡马克(Tokamak)装置的重要诊断工具,在等离子体物理研究中具有重要科学意义和广泛应用前景。NPA通过精确测量从等离子体中逃逸的中性粒子,可获取等离子体内部的关键信息,包括离子温度、快离子能谱分布和氢同... 详细信息

中性粒子分析仪(NPA)作为托卡马克(Tokamak)装置的重要诊断工具,在等离子体物理研究中具有重要科学意义和广泛应用前景。NPA通过精确测量从等离子体中逃逸的中性粒子,可获取等离子体内部的关键信息,包括离子温度、快离子能谱分布和氢同位素比例等。自20世纪60年代首台NPA问世以来,经过60余年的技术发展,其诊断能力已经实现了质的飞跃,并且发展出了多种类型的NPA。针对中国环流3号(HL-3)装置的快离子物理研究,四川大学与核工业西南物理研究院联合研制了基于LYSO+SiPM探测器的串联式平行电磁场结构的NPA(E//B NPA)。该E//B NPA已安装到HL-3装置,并在等离子体放电实验中成功测量到高能量氘(D)中性粒子能谱,为今后HL-3装置中性粒子诊断及快离子研究奠定了坚实的技术基础。

关键词：中性粒子分析仪能量和质量分辨托卡马克快离子物理

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Circuit Implementation of Power Converter for High-Speed Switching Operations

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Chinese Journal of Electrical Engineering 2018年第3期4卷 47-52页

作者： Keiji wada Department of Electronics Engineering and Computer Science Tokyo Metropolitan UniversityTokyo Japan

Recently,high di/dt and dv/dt switching operations of power converter circuits has been discussed for realizing a high-efficiency power converter *** this case,parasitic inductances of the bus bar between a DC capacitor and power devices may cause issues of overshoot voltage and electromagnetic interference(EMI)***,it is necessary to design the bus bar geometry while considering the minimization and optimization of the parasitic inductance of bus *** paper discusses a relationship between bus bar geometry and switching *** addition,the bus bar analysis is based on the PEEC method,and the bus bar geometry is designed by considering the stray inductance with using an inductance-map ***,this paper also presents a design procedure of acceptable stray inductance based on a standardization *** should be noted that the stray inductance is designed not for minimization,but optimization,and it is shown not as an absolute value(H),but as a percentage value(%).Finally,the oscillation waveforms under turn-off operation will be discussed depending on the bus bar geometry.

关键词： Bus bar inductance bus bar geometry circuit implementation EMI switching characteristics

Clues to the signals for chloroplast photorelocation from the lifetimes of accumulation and avoidance responses

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Journal of Integrative Plant Biology 2015年第1期57卷 120-126页

作者： Takeshi Higa Masamitsu wada Department of Biology Faculty of Sciences Kyushu University

Chloroplast photo-relocation movement is crucial for plant survival; however, the mechanism of this phenome- non is still poorly understood. Especially, the signal that goes from photoreceptor to chloroplast is unknown, although the photoreceptors （phototropin 1 and 2） have been identified and an actin structure （chloroplast actin filaments） has been characterized that is specific for chloroplast movement. Here, in gametophytes of the fern Adiantum capillus-veneris, gametophores of the moss Physcomiterella patens, and leaves of the seed plant Arabidopsis thaliana, we sought to characterize the signaling system by measuring the lifetime of the induced response. Chloroplast movements were induced by microbeam irradiation with high-intensity blue light and recorded. The lifetime of the avoidance state was measured as a lag time between switching off the beam and the loss of avoidance behavior, and that of the accumulation state was measured as the duration of accumulation behavior following the extinction of the beam. The lifetime for the avoidance response state is approximately 3-4rain and that for the accumulation response is 19-28 rain. These data suggest that the two responses are based on distinct signals.

关键词： Blue light chloroplast movement fern gametophyte intracellular signaling phototropin

Titania-supported iridium catalysts for dehydrogenative synthesis of benzimidazoles

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Chinese Chemical Letters 2020年第3期31卷 605-608页

作者： Kenji wada Han Yu Qi Feng Department of Chemistry for Medicine Kagawa UniversityMiki-ChoKita-GunKagawa 761-0793Japan Department of Advanced Materials Science Kagawa UniversityTakamatsuKagawa 761-0396Japan

In this review,development of supported catalysts for the dehydrogenative synthesis of benzimidazoles from primary alcohols and 1,2-phenyIenediamine derivatives is briefly *** them,titania-supported iridium catalysts showed excellent activities under mild reaction ***,the low-temperature activity of iridium catalyst was significantly affected by titania supports,and the reaction of 1,2-phenylenediamine and benzyl alcohol in the presence of rutilesupported catalysts proceeded smoothly at 100℃to give 2-phenylbenzimidazole in high yields of up to 88%,On the other hand,catalysts supported on anatase generally showed poor activity at 100℃.A significant relationship between CO uptake and the activity of titania-supported catalysts has been reported,indicating that well-reduced iridium species on rutile would be responsible for the predominant catalytic *** present results suggest the importance of the selection of suitable titania supports for the iridium catalysts.

关键词： Benzimidazole Iridium Titania Heterogeneous catalysts Dehydrogenation