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GDF-15 Level Correlates with CMKLR1 and VEGF-A in Tumor-free Margin in Colorectal Cancer

Current Medical Science 2021年第3期41卷 522-528页

作者： sylwia mielcarska Kamila Stopifnska Miriam Dawidowicz Agnieszka Kula Pawel Kicamer Alicja Prawdric Senkowska Ewa Nowakowska Zajde Katarzyna Walkiewicz Dariusz Waniczek Elzbieta Swietochowska Department of Medical and Molecular Biology Faculry of Medical Sciences in ZabrceMedical University of SilesicaZabrce41-808.Polard Department and Chair of Pathomorphology.Faculty of Medical Sciences in Zabrze Medical University of SilesiaZabrce 41-800Polardl Department of Nutrition Related Disease Prevention Department of Metabolic Disease PreventionSschool of Public Heath inByron.Medical Universiry of SilesiaByrom 41-902Polandd Department of Surgical Nursing cand Ssurgery Propedeutics.Chair of General.Colorectal and Trauma Surgery SHS in Katowice.Medical Universiry of SilesiaBytom 41-902Poland

Colorectal cancer(CRC)is the third most frequently diagnosed cancer worldwide,responsible for over 880000 deaths each ***/differentiation factor 15(GDF-15)is reported to be a promising diagnostic and prognostic factor in *** induces pleiotropic effects in tumor cells:proliferation,sternness,invasion and *** studies indicate that GDF-15 may stimulate angiogenesis in malignant ***,it has not been investigated in CRC *** aim of our study was to determine the level of GDF-15 and the concentrations of hypoxia-inducible factor-la(HIF-1α),VEGF-A and chemokine-like receptor 1(CMKLR1)in tumor and margin specimens of CRC in relation to histological grade and TNM *** study comprised 33 samples of tumor and margin tissues obtained from CRC *** assess the concentration of GDF-15,HIF-1α,VEGF-A and CMKLR1,commercially available enzyme-linked immunosorbent assay(ELISA)kits were *** found significantly increased levels of GDF-15 and CMKLR1 in tumor tissue compared to margin tissue and higher concentrations of HIF-1α and VEGF-A in margin tissue than in tumor *** levels of GDF-15 and HIF-1α were significantly correlated with VEGF-A and CMKLR1 in margin *** CRC,the increased level of GDF-15 might stimulate angiogenesis through upregulation of HIF-1α,VEGF A and CMKLR1 *** study is the first one to reveal the correlation between the levels of GDF-15 and CMKLR1 in *** elevated levels of HIF-1α and VEGF-A in tumor-free margin tissues suggest that noncancer cells in the tumor microenvironment are an important source of proangiogenic factors.

关键词： colorectal cancer growth/differentiation factor 15(GDF-15) chemokine-like receptor 1(CMKLR1) VEGF-A angiogenesis

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