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Journal of Biomedical Science and Engineering 2020年第8期13卷 187-201页

作者： Alexie Byrns Hamdi Ben Abdessalem Marc Cuesta Marie-Andrée Bruneau sylvie belleville Claude Frasson Département d’Informatique et de Recherche Opérationnelle Université de Montréal Montréal Canada Centre de Recherche de l’Institut de Gériatrie de Montréal Montréal Canada

Alzheimer’s disease is the most common form of dementia, affecting nearly 9.9 million new people every year. The disease provokes important memory and cognitive impairment, eventually causing individuals to forget their loved ones and rendering them completely dependent on their caretakers. Alzheimer’s patients typically experience more negative emotions, such as frustration and apathy, than healthy older adults. There is currently no cure for the disease. Our research group explores how the integration of virtual reality (VR) and an EEG-based intelligent agent in music therapy can alleviate psychological and cognitive symptoms of the disease. We propose a theory explaining how, through activation of the brain reward system, music can reduce negative emotions, increase positive emotions and as a result increase performance on cognitive tasks. The results of our experimental study concord with our theory: emotional states of participants are improved, as per recorded through EEG, and performances on memory tasks show improvement following the intervention. We believe that the combination of EEG brain assessment, VR and music therapy is a promising method for emotional states and cognitive symptoms of Alzheimer’s disease.

关键词： Alzheimer’s Disease Brain Assessment Virtual Reality Music Therapy Neurofeedback Memory Cognition

Effect of Processing and Cultivar on Thermo-Chemical Properties of Australian-Grown Hemp Hurd(Cannabis sativa L.)

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Journal of Renewable Materials 2024年第8期12卷 1475-1493页

作者： Johannes Fehrmann Benoit belleville Barbara Ozarska Maya Ismayati Wahyu Dwianto School of Agriculture Food and Ecosystem Sciences(SAFES)Faculty of ScienceThe University of MelbourneMelbourne3121Australia Research Center for Biomass and Bioproducts National Research and Innovation Agency(BRIN)Jakarta16911Indonesia

This study explored the thermo-chemical properties of industrial hemp hurd with different provenances,maturity stages,and retting *** findings were then compared to hemp hurd used in the fabrication of citric acid-bonded ultra-low-density hemp hurd ***-gas chromatography-mass spectrometry(Py-GC/MS),Fourier-transform infrared spectroscopy(FTIR),and thermogravimetric analysis(TGA)were employed to document the variability of the hurd and comprehend the potential impact on biobased composite *** choice of cultivar,maturity stage,and processing modality significantly influenced the chemical composition,presence of functional groups,and thermal stability of the ***-GC/MS revealed substantial variations in the lignin-to-carbohydrate(L/C)ratio,along with the absence of fatty acids in certain *** FTIR signals confirmed consistent functional groups,differences in peak intensities were indicative of carbohydrate variations associated with maturity and retting duration,impacting the availability of hydroxyl groups for,i.e.,interparticle bonding in citric acid-based ***,it was observed that shorter retting durations initially enhanced the thermal resistance,but prolonged retting led to accelerated degradation,significantly reducing the hurd’s residual *** findings indicated notable differences among the samples,emphasizing the importance of investigating variables such as provenance/cultivar,maturity,and processing *** assessment is essential to ensure effective agronomic practices that align the raw material characteristics with the specific requirements of intended applications,such as the fabrication of biobased hemp hurd composites.

关键词： Hemp hurd material characterization chemical analysis thermal analysis

Perspectives on a collaborative Canada-China research program on diagnostic biomarkers for pre-dementia stages of Alzheimer’s disease

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Journal of Translational Neuroscience 2017年第3期2卷 1-6页

作者： Serge Gauthier Jianping Jia sylvie belleville Simon Cloutier Dessa Sadovnick Colleen Guimond Laura Robb Mario Masellis Guy A Rouleau Liyong Wu Pedro Rosa-Neto McGill Center for Studies in Aging Douglas Mental Health Research Institute Montreal H4H IR3 Canada Innovation Center for Neurological Disorders Department of Neurology Xuanwu Hospital Capital Medical University Beijing 100053 China Beijing Key Laboratory of Geriatric Cognitive Disorders Beijing 100053 China Clinical Center for Neurodegenerative Disease and Memory Impairment Capital Medical University Beijing 100053 China Center of Alzheimer's Disease Beijing Institute for Brain Disorders Beijing 100053 China Key Laboratory of Neurodegenerative Diseases Ministry of Education Beijing 100053 China National Clinical Research Center for Geriatric Disorders Beijing 100053 China Institut Universitaire de Gériatrie de Montréal Montréal H3W IW5 Canada Department of Medical Genetics University of British Columbia Vancouver V6T IZ4 Canada Division of Neurology Department of Medical Genetics University of British Columbia Vancouver V6T IZ4 Canada Division of Neurology/Department of Medicine Sunnybrook Health Sciences Centre University of Toronto Toronto M5S 3H7 Canada Hurvitz Brain Sciences Research Program Sunnybrook Research Institute Toronto M4N 3M5 Canada Montreal Neurological Institute Montréal H3A 2B4 Canada Department of Neurology Xuanwu Hospital Capital Medical University Beijing 100053 China

As biomarkers are important in the early diagnosis ofAlzheimer’s disease （AD）, the frst collab-orative work of recruiting early-onset familial AD （EO-FAD） families in Canada and China was initiated in 2012. The registration networks have collected hundreds of pedigrees, for which genetic screening, neuropsycholog-ical tests and amyloid and tau imaging was used to study diagnostic biomarkers for preclinical and mild cognitive impairment （MCI） stages of AD. Besides identifying ped-igrees with novel mutations in presenilins （PSENs）/amy-loid precursor protein （APP）, the program has benefted training of Chinese research fellows, AD clinical trials forprevention,the ethical concernsfor clinical fndings, and other collaborative projects with Chinese investiga-tors. Further research of the collaborative program may facilitate the testing and clinical use of novel treatments for EOFAD and late onset AD and contribute to dementia prevention strategies in Canada and China.

关键词： registration network early-onset fa-milial Alzheimer’s disease (EOFAD) mutation neuro-psychological testing

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疯狂英语(新策略) 2004年第8期 17-23页

作者： Bill belleville ,荷塘月

我最爱看武侠小说里的奇遇故节——主人公遭遇奇遇并练成高超的武功.就像令狐冲在思过崖遇到风清扬练就独孤九剑、神雕陪着杨过在山洪爆发的时候苦练内力等,每每看到这些地方总让我精神大振。同样的,进化的摇篮、千年老龟、火山国度、... 详细信息

我最爱看武侠小说里的奇遇故节——主人公遭遇奇遇并练成高超的武功.就像令狐冲在思过崖遇到风清扬练就独孤九剑、神雕陪着杨过在山洪爆发的时候苦练内力等,每每看到这些地方总让我精神大振。同样的,进化的摇篮、千年老龟、火山国度、冲击赤道的冰冷洋流.种种都暗示着激动人心的奇遇将要发生。毕竟,又有多少人可以如此近距离地观察鲸鱼呼吸?去感受那白茫茫中的震天长啸?可文章让我感动的还有作者寻幽访古时的心情.激功、好奇,却又夹杂着淡淡的孤独与忧伤.因为面对奇妙的大自然.我也看到了我们的渺小! (Al Ho)

关键词：加拉帕戈斯达尔文爬行动物火山口

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英语辅导（高中年级） 2004年第8期 17-23页

作者： Bill belleville 荷塘月

关键词：高中英语双语阅读学习辅导