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Inflammatory myofibroblastic tumor of the distal common bile duct:Literature review with focus on pathological examination

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World Journal of Clinical Cases 2023年第20期11卷 4734-4739页

作者： Fleur Cordier Anne Hoorens Liesbeth Ferdinande Jo van dorpe David Creytens Department of Pathology Ghent University HospitalGhent 9000Belgium

Inflammatory myofibroblastic tumor(IMT)of the biliary tract is rare,and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological ***,IMTs are(myo)fibroblastic neoplasms with a prominent inflammatory *** are characterized by receptor tyrosine kinase gene rearrangements,most often involving an anaplastic lymphoma kinase(ALK)*** final diagnosis of IMT depends on histopathology and immunohistochemical *** this manuscript,we provide a clinical and morphomolecular overview of IMT and the difficulties that may arise in using immunohistochemical and molecular techniques in diagnosing IMT.

关键词： Inflammatory myofibroblastic tumor Fluorescence in situ hybridization Nextgeneration sequencing Mesenchymal tumors of the gastrointestinal tract

Pediatric vascular tumors of the liver:Review from the pathologist’s point of view

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World Journal of Hepatology 2021年第10期13卷 1316-1327页

作者： Fleur Cordier Anne Hoorens Jo van dorpe David Creytens Department of Pathology Ghent University HospitalGhent UniversityGhent 9000Belgium

Differential diagnosis of pediatric vascular liver tumors can be challenging due to inconsistent nomenclature,histologic overlap and the rarity of some *** we give an up-to-date overview of the most important *** discuss the clinic,histology and pathophysiology of hepatic congenital and infantile heman-gioma,hepatic epithelioid hemangioendothelioma and hepatic angio-sarcoma.

关键词： Hepatic congenital hemangioma Hepatic infantile hemangioma Hepatic epithelioid hemangioendothelioma Hepatic angiosarcoma Hepatic vascular tumors of infancy Hepatic hemangiomas

Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility

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Genes & Diseases 2023年第2期10卷 381-384页

作者： Jeroen Vierstraete Charlotte Fieuws David Creytens Jo van dorpe Andy Willaert Anne Vral Kathleen BM Claes Center for Medical Genetics Department of Biomolecular MedicineGhent University Hospital and Ghent University9000 GhentBelgium Department of Human Structure and Repair Ghent University9000 GhentBelgium Cancer Research Institute Ghent (CRIG) Ghent University and Ghent University Hospital9000 GhentBelgium Department of Pathology Ghent University and Ghent University Hospital9000 GhentBelgium

Biallelic loss-of-function variants in ATM (Ataxia Telangiectasia Mutated) cause Ataxia Telangiectasia (AT), a rare disorder associated with cerebellar degeneration and ataxia, cancer predisposition, infertility, growth retardation, etc. ATM is a phosphoinositide 3-kinase-related kinase (PIKK) with a role in DNA repair and maintenance of genome stability. Studying a multisystem genetic disease like AT requires animal models to ascertain its pathogenesis at the level of tissues, organs and the organism. Due to its small size, cheap maintenance, large progeny, rapid development and initial transparency, zebrafish (Danio rerio) is an increasingly popular vertebrate model organism, suitable for genetic modifications and large-scale in vivo therapeutic screens as embryos are chemically permeable to small compounds. Currently, no zebrafish model for AT exists.1 We generated atm knock-outs through CRIPSR-Cas9 mutagenesis. We show that atm conserved its function as a tumour suppressor gene and is involved in gametogenesis and fertility. Therefore, this mutant is of great value for further studies investigating the role of atm in reproduction and tumorigenesis.

关键词： ATM function transparency

Learning in Times of Crisis： Rural Grassroots Movement in Mexico

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Journal of Environmental Science and Engineering(B) 2013年第6期2卷 343-349页

作者： sylvia van Dijk Department of Education University of Guanajuato Guanajuato 36000 Mexico

This paper discusses transformative learning in relation to environmental crisis in rural communities in Guanajuato （Mexico）. Environmental pollution and resource depletion have triggered reflection and perspective transformation across groups of rural communities. The study is qualitative and results are based on lengthy interviews, within a well-known context for the researcher. This article is the reflection on how transformative learning took place looking fol; lessons to be learnt for communities facing environmental challenges.

关键词： Environmental crisis peasant's participation emancipatory learning grassroots movements.

Risk factors for overuse injuries in short-and long-distance running: A systematic review

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Journal of Sport and Health Science 2021年第1期10卷 14-28,I0001页

作者： Dennis van Poppel Maarten van der Worp Anouk Slabbekoorn sylvia S.P.van den Heuvel Marienke van Middelkoop Bart W.Koes Arianne P.Verhagen Gwendolyne G.M.Scholten-Peeters Research Group Diagnostics Avans University of Applied SciencesBreda4818 CRthe Netherlands Stichting Academie Instituut Fysiotherapie PLUS Utrecht3581 MDthe Netherlands Nederlands Paramedisch Institute Amersfoort3818 LAthe Netherlands Department of General Practice Erasmus MC Medical University CenterRotterdam3015 CEthe Netherlands Center for Muscle and Joint Health University of Southern DenmarkOdense5230Denmark Discipline of Physiotherapy Graduate School of HealthUniversity of TechnologySydneyChippendale NSW 2008Australia Department of Human Movement Sciences Faculty of Behavioral and Movement SciencesVrije Universiteit AmsterdamAmsterdam1081 HVthe Netherlands

Purpose:The aim of this study was to review information about risk factors for lower extremity running injuries in both short-distance(mean running distance-20 km/week and-10 km/session)and long-distance runners(mean running distance>20 km/week and>10 km/session).Methods:Electronic databases were searched for articles published up to February *** cohort studies using multivariable analysis for the assessment of individual risk factors or risk models for the occurrence of lower extremity running injuries were *** reviewers independently selected studies for eligibility and assessed risk of bias with the Quality in Prognostic Studies *** GRADE approach was used to assess the quality of the ***:A total of 29 studies were included:17 studies focused on short-distance runners,11 studies focused on long-distance runners,and 1 study focused on both types of runners.A previous running-related injury was the strongest risk factor for an injury for long-distance runners,with moderate-quality *** injuries not attributed to running was the strongest risk factor for an injury for short-distance runners,with high-quality *** body mass index,higher age,sex(male),having no previous running experience,and lower running volume were strong risk factors,with moderate quality evidence,for short-distance ***-quality evidence was found for all risk models as predictors of runningrelated injuries among short-and long-distance ***:Several risk factors for lower extremity injuries have been identified among short-and long-distance runners,but the quality of evidence for these risk factors for running-related injuries is *** injuries seem to have a multifactorial origin both in short-and long-distance runners.

关键词： Musculoskeletal health Protective factors Running-related injury

在全球化的世界中转变知识观念——面向高等教育全球化的伦理方法

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比较教育研究 2002年第S1期23卷 143-147页

作者： sylvia van de Bunt-Kokhuis 徐静荷兰Vrije大学组织管理系教育部人文社会科学研究基地北京师范大学比较教育研究中心

随着全球化的进展,高等教育不可避免地卷入其中。本文主要讨论了经济全球化和文化全球化对西方国家和边缘国家高等教育的知识、教科书和人才培养的影响,提出应从伦理学的角度对高等教育全球化进行分析。文中还讨论了“本土化的外国人”... 详细信息

随着全球化的进展,高等教育不可避免地卷入其中。本文主要讨论了经济全球化和文化全球化对西方国家和边缘国家高等教育的知识、教科书和人才培养的影响,提出应从伦理学的角度对高等教育全球化进行分析。文中还讨论了“本土化的外国人”这一概念。

关键词：全球化高等教育伦理方法

基于AEZ模型的我国水稻产量潜力的农作制区划分析

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种子 2006年第2期25卷 6-9页

作者：蔡承智 Harrij van Velthuizen Guenther Fischer sylvia Prieler 贵州省科技情报研究所贵阳550004 International Institute for Applied Systems Analysis A-2361 Laxenburg Austria

本文根据联合国粮农组织（FAO）和国际应用系统分析研究所（IIASA）基于中国1961—1997年的统计资料（经多方校正）共同开发的AEZ模型，运用GIS平台计算了中国41个农作制亚区的水稻生产潜力，并指出了单产最高潜力分布区域。研究结果表... 详细信息

本文根据联合国粮农组织（FAO）和国际应用系统分析研究所（IIASA）基于中国1961—1997年的统计资料（经多方校正）共同开发的AEZ模型，运用GIS平台计算了中国41个农作制亚区的水稻生产潜力，并指出了单产最高潜力分布区域。研究结果表明：我国水稻的最高产量潜力大约将是目前产量的2倍。这对我国水稻高产育种及栽培具有重要参考意义。

关键词： AEZ模型水稻产量潜力农作制区划

基于AEZ模型我国农作制区划的玉米产量潜力分析

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玉米科学 2006年第4期14卷 158-161页

作者：蔡承智 Harrij van Velthuizen Guenther Fischer sylvia Prieler 贵州省科技情报研究所贵阳550004 International Institute for Applied Systems Analysis A-2361LaxenburgAustria

根据联合国粮农组织(FAO)和国际应用系统分析研究所(IIASA)基于中国1961￣1997的统计资料(经多方校正)共同开发的AEZ模型,运用GIS平台计算了中国41个农作制亚区的玉米生产潜力,并指出了单产最高潜力分布区域。研究结果表明:我国玉米的... 详细信息

根据联合国粮农组织(FAO)和国际应用系统分析研究所(IIASA)基于中国1961￣1997的统计资料(经多方校正)共同开发的AEZ模型,运用GIS平台计算了中国41个农作制亚区的玉米生产潜力,并指出了单产最高潜力分布区域。研究结果表明:我国玉米的最高产量潜力大约是目前产量的2.5倍,这对我国玉米高产育种及栽培具有重要参考意义。

关键词：玉米 AEZ模型产量潜力农作制区划

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基于AEZ模型的我国农区小麦生产潜力分析

中国生态农业学报 2007年第5期15卷 182-184页

作者：蔡承智 Harrij van Velthuizen Guenther Fischer sylvia Prieler 贵州省科技情报研究所贵阳550004 International Institute for Applied Systems Analysis Schlossplatz 1

根据联合国粮农组织（FAO）和国际应用系统分析研究所（IIASA）基于中国1961～1997年的统计资料（经多方校正）共同开发的AEZ模型，运用GIS平台计算了中国41个农作制亚区的小麦生产潜力，并指出了单产最高潜力分布区域。研究结果表明，... 详细信息

根据联合国粮农组织（FAO）和国际应用系统分析研究所（IIASA）基于中国1961～1997年的统计资料（经多方校正）共同开发的AEZ模型，运用GIS平台计算了中国41个农作制亚区的小麦生产潜力，并指出了单产最高潜力分布区域。研究结果表明，我国小麦的最高产量潜力约为目前产量的2～3倍。这对我国小麦高产育种及栽培具有重要意义。

关键词： AEZ模型小麦产量潜力农作制区划