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Sirolimus,bevacizumab,5-Fluorouracil and irinotecan for advanced colorectal cancer:A pilot study

World Journal of Gastroenterology 2009年第34期15卷 4278-4283页

作者： Francois Ghiringhelli Boris Guiu Bruno Chauffert sylvain ladoire Department of Medical Oncology Georges-Francois Leclerc Cancer Center Department of Radiology Georges-Francois Leclerc Cancer Center

AIM： To evaluate the efficacy and the safety of combined 5-Fluorouracil, irinotecan, bevacizumab and sirolimus in refractory advanced colorectal carcinoma. METHODS： We initiated a regimen with at day 1 an injection （iv） of bevacizumab at 5 mg/kg, followed by 180 mg/m^2 irinotecan, followed by Leucovorin 400 mg/m^2, followed by a 5-Fluorouracil bolus 400 mg/m^2 and a 46-h infusion 2400 mg/m^2. Sirolimus was given orally as continuous administration of 2 mg twice a day every days. This treatment was repeated every 14 d. RESULTS： A total of 12 patients were enrolled. All patients presented with metastatic disease that had failed at least three lines of chemotherapy that contained oxaliplatin, irinotecan and bevacizumab. Cetuximab failure was also observed in all K-Ras wildtype patients. The median number of cycles was 8.5 （range 2-20） and clinical benefit was observed in eight patients. The median time to progression was 5 mo and the median survival was 8 too. Grade 3 neutropenia developed in four patients, and grade 3 diarrhea and stomatitis in ***： The combination regimen of 5-Fluorouracil,irinotecan, bevacizumab and sirolimus in advanced colorectal carcinoma after failure of dassical *** is feasible and promising. Further evaluation of this combination is required.

关键词： Colorectal cancer Bevacizumab 5-Fluorouracil Irinotecan Sirolimus Antineoplastic combinedchemotherapy protocols Angiogenesis

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Degarelix as a new antiangiogenic agent for metastatic colon cancer?

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World Journal of Gastroenterology 2013年第5期19卷 769-772页

作者： Francois Ghiringhelli Nicolas Isambert sylvain ladoire Unite Mixte de Recherche 866 Institut National de la Sante et de la Recherche Medicale/Universite de Bourgogne21000 DijonFrance Departement of Oncologie Medicale Centre Georges Francois Leclerc21000 DijonFrance

Recently,follicle stimulating hormone receptor was found to be selectively expressed by endothelial cells on tumor-associated blood vessels in a wide range of human *** this context,we hypothesized that degarelix,a new gonadotropin-releasing hormone receptor antagonist developed for patients with prostate cancer,may have antiangiogenic effects via its capacity to block follicle stimulating hormone(FSH)production. We report the case of a patient with metastatic colon cancer exhibiting tumor progression after failure of all conventional chemotherapeutic *** addition of degarelix to the last chemotherapeutic regimen was proposed as compassionate *** induced a rapid decrease in FSH *** treatment induced radiological stabilization and carcinoembryonic antigen stabilization during 1 ***-enhanced ultrasonography demonstrated reduction of tumor *** case represents the first report of an antitumoral effect of degarelix in metastatic colon cancer and suggests an antiangiogenic property of this drug.

关键词： Colon cancer Degarelix Chemotherapy Angiogenesis Antiangiogenic agents

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Prognostic value of chemotherapy-induced hematological toxicity in metastatic colorectal cancer patients

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World Journal of Gastroenterology 2014年第6期20卷 1565-1573页

作者： Laurie Rambach Aurelie Bertaut Julie Vincent Veronique Lorgis sylvain ladoire Francois Ghiringhelli Department of Medical Oncology Centre Georges-Fran ois Leclerc Biostatistics and Epidemiological Unit EA4184 Centre Georges-Fran ois Leclerc Institut National de la Santé et de la Recherche Médicale (INSERM) CRI-866 Faculty of Medicine School of Medicine University of Burgundy

AIM: To establish whether chemotherapy-induced neutropenia is predictive of better outcome in patients with metastatic colorectal cancer (mCRC).

关键词： Colorectal cancer Metastasis Prognostic factor Neutropenia Chemotherapy

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Hepatic arterial infusion of gemcitabine-oxaliplatin in a large metastasis from colon cancer

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World Journal of Gastroenterology 2010年第9期16卷 1150-1154页

作者： Boris Guiu Julie Vincent Séverine Guiu sylvain ladoire Pablo Ortega-Deballon Jean-Pierre Cercueil Bruno Chauffert Franois Ghiringhelli Department of Radiology INSERM U866University of BurgundyUniversity Hospital Department of Hepatology INSERM U866University of BurgundyUniversity Hospital Department of Oncology INSERM U866AVENIR TeamUniversity of Burgundy Department of Digestive Surgery INSERM U866University of BurgundyUniversity Hospital

Hepatic arterial infusion (HAI) of chemotherapy can be performed in cases of liver-confined metastatic disease,resulting in increased local drug *** we report the case of a 61-year-old man who presented with an isolated large unresectable liver metastasis of colon cancer after failure of surgery and multiple administration of systemic *** patient was treated with a combination of gemcitabine and oxaliplatin using *** tolerance was excellent and a radiological complete response was obtained after 8 cycles of *** rationale for the use of gemcitabine and oxaliplatin as well as that for the combination of the 2 drugs is discussed in this *** of gemcitabine-oxaliplatin should be evaluated in further clinical trials.

关键词： Hepatic artery Chemotherapy Colon cancer Liver metastasis Gemcitabine Oxaliplatin Contrast media Computed tomography

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