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Evaluation of the Effects of Corticosteroids on Histamine Release by ex Vivo Cutaneous Microdialysis

Journal of Cosmetics, Dermatological Sciences and Applications 2013年第3期3卷 228-233页

作者： Carol Courderot-Masuyer Sophie Robin Helene Tauzin sylvain harbon Sophie Mac-Mary Alexandre Guichard Patrice Muret Philippe Humbert Bioexigence SARL Espace Lafayette8 rue Alfred de VignyBesanconFrance Plastic Surgery 9 rue KleinSaint Vincent ClinicBesanconFrance Skinexigence SAS immeuble Bioparc2 rue du Dr Paul MilleretBesanconFrance Research and Clinicl Center on the Tegument(CERT Clinical Investigation Center(CIC BT506) Department of DermatologyBesancon University HospitalBesanconFrance Laboratory of Clinical and Toxicology Pharmacology Jean Minjoz University HospitalBesanconFrance University of Franche-Comte Inserm U1098SFR FED 4234 IBCTBesanconFrance

The purpose of the study was to evaluate the effects of corticosteroids on histamine release and to compare their potency with the MacKenzie classification based on their vasoconstrictor effects. Thanks to ex Vivo cutaneous microdialysis, we studied histamine-induced release over a period of time on excised abdominal skin from women. Eight corticosteroids were topically applied with occlusive dressing onto the skin, above probes, before anti-IgE injection. Histamine levels were assessed by an EIA method. In order to compare the different corticosteroids, AUC was calculated allowing an estimation of the amount of released histamine for 60 min of ex vivo cutaneous microdialysis. Diflucortolone 0.1% and micronized betamethasone dipropionate 0.05% are considered as corticosteroids with high potency in MacKenzie classification. Betamethasone dipropionate associated with propylene glycol 0.05%, belongs to a stronger class in Mackenzie classification. Our results showed that the decrease in histamine release was more important with difluocortolone than with both of these corticosteroids. Therefore there was no correlation between the vasoconstrictor potency of topical corticosteroids and their ability to inhibit histamine release.

关键词： MacKenzie Test Corticosteroids ex Vivo Cutaneous Microdialysis Histamine

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Use of a Model of a Blood-Induced Bruise for the Evaluation of Formulations on Bruising

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Journal of Cosmetics, Dermatological Sciences and Applications 2015年第1期5卷 7-14页

作者： Sophie Robin Carol Courderot-Masuyer Helene Tauzin sylvain harbon Marlene Chavagnac-Bonneville Benoit Cadars Eric Jourdan Sandra Trompezinski Philippe Humbert Bioexigence SAS Espace LafayetteBesanconFrance Plastic Surgery Saint-Vincent ClinicBesanconFrance Laboratoire Bioderma LyonFrance Naos Group Recherche Aix-en-ProvenceFrance Laboratory of Cutaneous Biology Department of DermatologyUniversity of Franche-ComteBesanconFrance

Esthetic treatments can induce swelling and bruises. Thus, a treatment that would prevent or hasten the resolution of bruising should be very useful. Generally, the regression of bruising was conducted with patients or animals models. So we decided firstly to develop an ex vivo model in order to test antibruising properties of topical formulations and secondly to evaluate a curative effect of a cream (mixture of arnica extract and apigenin) in comparison with a positive control (vulnerary cream) and also to estimate the preventive interest of this cream. The results showed that the injection of 25 μl of blood into the dermis of skin fragments was sufficient to create a model of induced-bruise. The duration of 24 hours was chosen to compare the effects of actives on the decrease in the size of the bruise. Joint effects of a pretreatment and a treatment of a mixture of arnica extract and apigenin decreased significantly the area of bruising compared to the treatment group, the control group and the positive control group. Many topical products claim to improve bruising on their package label. Our model can demonstrate their efficacy and determinate the best topical antibruising formulation. The mechanism involved in anti-inflammatory activity of active compounds of topical formulations is often not fully understood. Our blood-induced model may bring some responses through the study of mediators of the inflammation.

关键词： Bruise Apigenin Arnica Skin Explants

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