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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Wood-like polymeric materials by ice templating

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National Science Review 2019年第2期6卷 184-185页

作者： sylvain Deville Ceramic Synthesis and Functionalization Laboratory National Center for Scientific Research

The ice-templating method, also called freeze-casting and directional freezing,is a powerful technique for processing nanomaterials, polymers and engineering materials into various porous and dense materials [1,2] that has received considerable attention. Ice templating is mostly used to fabricate macroporous materials, with elongated pores in the5–50μm size range. Because the underlying mechanisms—the segregation of matter by the growing crystals—are

关键词： Wood-like polymeric materials by ice templating

Solar chemical looping reforming of methane combined with isothermal H2O/CO2 splitting using ceria oxygen carrier for syngas production

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Journal of Energy Chemistry 2020年第2期29卷 60-72页

作者： Srirat Chuayboon Stéphane Abanades sylvain Rodat Processes Materials and Solar Energy LaboratoryPROMES-CNRSFont-Romeu 66120France Department of Mechanical Engineering King Mongkut's Institute of Technology LadkrabangPrince of Chumphon CampusChumphon 86160Thailand Universite Grenoble Alpes Le-Bourget-du-Lac F-73375France CEA-LJTEN Laboratoire des Systemes Solaires Haute Temperature(LSHT) Grenoble F-38054France

The chemical looping reforming of methane through the nonstoichiometric ceria redox cycle(CeO2/CeO2-δ) has been experimentally investigated in a directly irradiated solar reactor to convert both solar energy and methane to syngas in the temperature range 900–1050 °C. Experiments were carried out with different ceria shapes via two-step redox cycling composed of endothermic partial reduction of ceria with methane and complete exothermic re-oxidation of reduced ceria with H2 O/CO2 at the same operating temperature, thereby demonstrating the capability to operate the cycle isothermally. A parametric study considering different ceria macrostructure variants(ceria packed powder, ceria packed powder mixed with inert Al2 O3 particles, and ceria reticulated porous foam) and operating parameters(methane flow-rate, reduction temperature, or sintering temperature) was conducted in order to unravel their impact on the bed-averaged oxygen non-stoichiometry(δ), syngas yield, methane conversion, and solar reactor performance. The ceria cycling stability was also experimentally investigated to demonstrate repeatable syngas production by alternating the flow between CH4 and H2 O(or CO2). A decrease in sintering temperature of the ceria foam was beneficial for increasing syngas selectivity, methane conversion,and reactor performance. Increasing both CH4 concentration and reduction temperature enhanced δ with the maximum value up to 0.41 but concomitantly favored CH4 cracking reaction. The ceria reticulated porous foam showed better performance in terms of effective heat transfer, due to volumetric absorption of concentrated solar radiation and uniform heating with lower solar power consumption, thereby promoting the solar-to-fuel energy conversion efficiency that reached up to 5.60%. The energy upgrade factor achieved during cycle was up to 1.19. Stable patterns in the δ and syngas yield for consecutive cycles with the ceria foam validated material performance stability.

关键词： Chemical looping Methane reforming Ceria structure Concentrated solar power Syngas production H2O/CO2 splitting

A modeling framework for the integration of electrical and thermal energy systems in greenhouses

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Building Simulation 2022年第5期15卷 779-797页

作者： Queralt Altes-Buch sylvain Quoilin Vincent Lemort Energy Systems Research Unit Faculty of Applied SciencesUniversity of LiegeAllee de la Decouverte 774000 LiegeBelgium

Greenhouse horticulture is associated to a significant energy consumption in temperate countries,mainly for lighting and for ***,the potential for energy optimization and energy savings is high but requires detailed models capable of considering various system configurations and control *** paper provides an open-source modeling framework capable of simulating and optimizing the design and the control of both the greenhouse and the generation systems covering all energy *** proposed model is composed of sub-models from different scientific fields:a greenhouse climate model,a crop yield model,a large number of energy generation and storage units models and different rule-based control *** association of such state-of-the-art models in a single framework provides a powerful tool for optimization purposes and allows the definition of completely customized systems by means of an object-oriented *** this work,various control strategies are defined and simulated,thus demonstrating the capabilities of the proposed *** indicate that,by performing minor changes to the control of the thermal screen,heating consumption can be reduced by 3%without any loss in crop *** control of heat-generation units also has a significant impact on the operational costs,which vary by up to 17%when self-consumption levels are accounted for in the control strategy.

关键词： greenhouse climate model CHP greenhouse climate control system integration energy management

A SEM-based method to determine the mineralogical composition and the particle size distribution of suspended sediment

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International Journal of Sediment Research 2019年第2期34卷 85-94页

作者： sylvain Pinet Bruno Lartiges Jean-Michel Martinez sylvain Ouillonc University of Toulouse (Paul Sabatier) Geosciences Environment ToulouseCNRS(Centre National de la Recherche Scientifique)IRD(Institut de Recherche pour le Développement) Instituto de Geosciencias Universidade de BrasiliaCampus Universitario Darcy RibeiroICC Centro University of Toulouse LEGOS(Laboratoire d'Etudes en Géophysique et Océanographie Spatiales)

A robust method for characterizing the mineralogy of suspended sediment in continental rivers is *** encompasses 3 steps:the filtration of a few milliliters of water,measurements of X-ray energy dispersive spectra using Scanning Electron Microscopy(SEM),and robust machine learning tools of *** method is applied to suspended particles collected from various Amazonian rivers.A total of more than 204,000 particles were analyzed by SEM-EDXS(Energy Dispersive X-ray Spectroscopy),*** 15,700 particles per sampling station,which lead to the identification of 15 distinct groups of mineralogical *** size distribution of particles collected on the filters was derived from the SEM micrographs taken in the backscattered electron imaging mode and analyzed with ImageJ *** determination of the main mineralogical groups composing the bulk sediment associated with physical parameters such as particle size distribution or aspect ratio allows a precise characterization of the load of the terrigenous particles in rivers or *** the case of the Amazonian rivers investigated,the results show that the identified mineralogies are consistent with previous studies as well as between the different samples *** method enabled the evolution of grain size distribution from fine to coarse material to be described in the water *** about hydrodynamic sorting of mineral particles in the water column are also briefly *** proposed method appears well suited for intensive routine monitoring of suspended sediment in river systems.

关键词： Mineralogy Scanning Electron Microscopy Suspended sediment Machine learning Particle size distribution

CONSIDERATION OF THE USE PHASE IN CERTIFICATION PROG RAMS FOR RESIDENTIAL GREEN BUILDING

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Journal of Green Building 2015年第1期10卷 150-168页

作者： Mario Patenaude sylvain Plouffe Universitéde Montréal MontréalQuébecCanada

The building industry is associated with several environmental *** consid-ering the total building lifecycle,the use phase has a strong influence on the level of *** to the literature,the use phase of residential buildings repre-sents up to 92%of energy consumption,constitutes 95%of water consumption(indoor and outdoor),accounts for 45%of the weight of materials used,and pro-duces 50%of the waste(maintenance,repair,and renovation).Green building and certification programs used in North America,such as BOMA-BESt®,LEED®,and Living Building ChallengeTM,aim to reduce the environmental footprint of ***,while these certifications provide a useful framework for practices related to buildings and their systems,a documentary analysis shows that they do not ade-quately take into account the use phase of residential *** purpose of this paper is to show that consideration of the use phase is inconsistent with the impacts associated with it.

关键词： green building residential use phase certification programs environmental impact

Stop-and-go waves induced by correlated noise in pedestrian models without inertia

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第1期7卷 52-60页

作者： Antoine Tordeux Andreas Schadschneider sylvain Lassarre School of Mechanical Engineering and Safety Engineering University of WuppertalWuppertal 42119Germany Institute for Theoretical Physics University of CologneCologne 50937Germany Engineering of Surface Transportation Networks and Advanced Computing Laboratory French Institute of Science and Technology for TransportDevelopment and NetworksMarne La Vallee E-77447France

Stop-and-go waves are commonly observed in traffic and pedestrian *** most microscopic traffic models,they occur through a phase transition and instability of the homogeneous solution after fine tuning of *** effects are believed to play an important role in this *** this article,we present a novel explanation for stop-and-go waves based on stochastic effects in the absence of *** model used is a first order optimal velocity(OV)model including an additive stochastic noise.A power spectral analysis for single-file pedestrian trajectories highlights the existence of Brownian speed *** use the Ornstein-Uhlenbeck process to describe such a correlated *** introduction of this specific colored noise in the first order OV model allows describing realistic stop-and-go behavior without requiring instabilities or phase transitions,the homogeneous configurations being systematically stochastically *** compare the stochastic model to deterministic unstable OV models and analyze individual speed autocorrelation to describe the nature of the waves in stationary *** apply the approach to pedestrian single-file motion and compare simulation results to real pedestrian *** simulation results are quantitatively very similar to the real *** discuss plausible values for the model parameters and their meaning.

关键词： Transportation engineering Pedestrian single-file motion Stop-and-go dynamics First order microscopic model Brownian noise Simulation

Inhibition of p53 inhibitors:progress,challenges and perspectives

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Journal of Molecular Cell Biology 2019年第7期11卷 586-599页

作者： Gema Sanz Madhurendra Singh sylvain Peuget Galina Selivanova Department of Microbiology Tumor and Cell BiologyBiomedicum 8CKarolinska InstituteSE17165Sweden

p53 is the major tumor suppressor and the most frequently inactivated gene in cancer.p53 could be disabled either by mutations or by upstream negative regulators,including,but not limited to MDM2 and MDMX.p53 activity is required for the prevention as well as for the eradication of *** of p53 activity in mouse models leads to the suppression of established tumors of different *** findings provide a strong support to the anti-cancer strategy aimed for p53 *** this review,we summarize recent progress in the development of small molecules,which restore the tumor suppressor function of wild-type p53 and discuss their clinical *** discuss different aspects of p53-mediated response,which contribute to suppression of tumors,including non-canonical p53 activities,such as regulation of immune *** targeting p53 inhibitors is a very promising approach,there are certain limitations and concerns that the intensive research and clinical evaluation of compounds will hopefully help to overcome.

关键词： p53 tumor suppression anti-cancer therapy targeted drugs transcription factor immune response

Natural gas pyrolysis in double-walled reactor tubes using thermal plasma or concentrated solar radiation as external heating source

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Journal of Natural Gas Chemistry 2009年第1期18卷 1-8页

作者： Stphane Abanades Stefania Tescari sylvain Rodat Gilles Flamant Processes Materials and Solar Energy Laboratory (PROMES-CNRS) 7 Rue du Four Solaire 66120 Font-Romeu France

The thermal pyrolysis of natural gas as a clean hydrogen production route is examined. The concept of a double-walled reactor tube is proposed and implemented. Preliminary experiments using an external plasma heating source are carried out to validate this concept. The results point out the efficient CH4 dissociation above 1850 K （CH4 conversion over 90%） and the key influence of the gas residence time. Simulations are performed to predict the conversion rate of CH4 at the reactor outlet, and are consistent with experimental tendencies. A solar reactor prototype featuring four independent double-walled tubes is then developed. The heat in high temperature process required for the endothermic reaction of natural gas pyrolysis is supplied by concentrated solar energy. The tubes are heated uniformly by radiation using the blackbody effect of a cavity-receiver absorbing the concentrated solar irradiation through a quartz window. The gas composition at the reactor outlet, the chemical conversion of CH4, and the yield to H2 are determined with respect to reaction temperature, inlet gas flow-rates, and feed gas composition. The longer the gas residence time, the higher the CH4 conversion and H2 yield, whereas the lower the amount of acetylene. A CH4 conversion of 99% and H2 yield of about 85% are measured at 1880 K with 30% CH4 in the feed gas （6 L/min injected and residence time of 18 ms）, A temperature increase from 1870 K to 1970 K does not improve the H2 yield.

关键词： methane hydrogen thermal cracking plasma concentrated solar energy tubular reactor