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IgG Anti-Body Titers among Patients with Amoebic Liver Abscess in Bangui, Central African Republic

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Open Journal of Immunology 2022年第4期12卷 77-85页

作者： Wilfrid sylvain Nambei Edwige Régina Kodia-Lenguetama Junior Nguerenam-Ouefio Department of Biomedical Sciences Faculty of Health Sciences Bangui Central African Republic (CAR) National Center of Blood Donors’ Ministry of Public Health Bangui Central African Republic (CAR)

Entamoeba histolytica (Eh) is a protozoan parasite that causes amoebiasis characterized by intestinal damage and amoebic liver development and is an important cause of hospitalization in low-middle income countries. The aims of this study were to determine the prevalence and the titer of IgG anti Eh in ALA (Amoebic Liver Abscess) patients’ in Bangui according sex, age and other risk factors. This was a cross sectional study where data was collected between January 2018 and October 2020. The diagnosis of ALA was suspected based on clinical symptoms of;fever, abdominal pain (usually in the right hypochondrium or epigastrium) and clinical signs of hepatomegaly and/or tender liver with or without jaundice and abdominal ultra-sonography. ALA patients’ IgG antibody titers were measured by Indirect Hemmaglutination Assay and Chi-square test was used. A total of 1249 ALA patients were included, among whom 570 (45.64%) were positive. Of these, 244 (42.08%) had titer 1:160 or less, 223 patients’ (39.13%) had titer ranging from 1:320 to 1:640 and 103 patients (18.07%) had strong titer ranging from 1:1280 to 1:2560. The association between antibody titer results, age and sex was no significant (p = 1.0000). Our findings indicate a high prevalence of ALA and show no significant difference between the sex and age ALA patients.

关键词： Amoebic Liver Abscess Antibody Sex Difference Central African Republic

Study of liquid destabilization and stripping in a liquid-gas mixing layer

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Study of liquid destabilization and stripping in a liquid-ga...

Anticancer Activities and QSAR Study of Novel Agents with a Chemical Profile of Benzimidazolyl-Retrochalcone

23rd International Congress of Theoretical and Applied Mechanics

作者： Jean-Philippe Matas sylvain Marty Alain Cartellier LEGI CNRS-Université de Grenoble GrenobleFrance

＜正＞We study experimentally and analytically the atomization of a liquid sheet by a parallel gas flow,in order to understand the conditions of destabilization of the liquid sheet and the conditions of drop *** invis...

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Open Journal of Medicinal Chemistry 2020年第3期10卷 113-127页

作者： Ouattara Mahama Koné Aboudramane Koné Soleymane Collet sylvain Diomandé Sekou Sissouma Drissa Department of Therapeutic Chemistry and Organic Chemistry UFR SPB FHB University Abidjan C&#244 te d’Ivoire Department of Chemistry UFR Environment Jean LorougnonGuédé University Daloa C&#244 te d’Ivoire Laboratory of Organic Chemistry and Natural Substances UFR SSMT FHB University Abidjan C&#244 te d’Ivoire Chemistry and Interdisciplinarity: Synthesis Analysis Modelling (CEISAM) University of Nantes Nantes France

The present pharmacochemical and modelling work focused on a benzimidazolyl-chalcone series. These previously synthesized compounds were evaluated in vitro for their anticancer activities against a panel of seven human cancer cell lines and normal fibroblasts. Among the new benzimidazole-supported chalcones, nine (9) compounds (compounds 1 - 4, 6 - 8 and compounds 10 and 11) showed promising anticancer activities with IC50s ranging from 0.83 to 2.58 μM. Compounds 2 and 6 with IC50s of 0.83 and 0.86 μM, respectively, were shown to be potent inhibitors of HCT-116 colon cancer cell proliferation. It was therefore necessary, for a development of this new series of chalcones, to establish through a QSAR study, their quantum descriptors according to the DFT calculation method and following the B3LYP/6-31+G (d,p) theory. These descriptive and predictive studies focused on the colon HCT 116 cell line which was found to be more sensitive to the anticancer action of our benzimidazolyl-retrochalcones. QSAR study showed that the electronic energy (Eelec), lipophilicity (logP), chemical softness (S) and chemical hardness (η) of benzimidazolyl-retrochalcones play an important role in inhibiting cancer cell proliferation.

关键词： Retrochalcone Benzimidazole Anticancer Agents QSAR Quantum Descriptors DFT Method

Operational Protocol for Detection of Contamination by Actinides U,Pu and Am in Urine Using Calixarene Columns:From Mineralization to ICP-MS Measurement

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American Journal of Analytical Chemistry 2017年第5期8卷 317-333页

作者： Celine Bouvier-Capely Alexandre Legrand Aurelie sylvain Annabelle Manoury Francois Rebiere Laboratoire de Radiochimie Service de Dosimetrie InternePRP-HOMInstitut de Radioprotection et Surete Nucleaire(IRSN)Fontenay-aux-RosesFrance

Individual monitoring of workers exposed to the risk of intake of actinides requires suitable methods for measuring low level of excreted activity. The current protocols used for actinides analysis in bioassay are usually complicated and highly time consuming. In this work, a protocol based on the microwave digestion of urines followed by the separation of actinides using calix[6]arene-based chromatography columns and their measurement by a quadrupole ICP-MS is developed and validated, for the first time, on urine samples containing the three actinides, U, Pu and Am. With this protocol, the total analysis time is about 2 days, including the mineralization of urine and the chromatographic separation of actinides. Detection limits of actinides in urine are determined and compared to those obtained after “dilute and shoot” ICP-MS analysis or after alpha spectrometry measurement.

关键词： Actinides Urine CalixArene Analysis ICP-MS

Colorectal Cancer: Epidemiological, Clinical and Histopathological Aspects in Burundi

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Open Journal of Gastroenterology 2016年第3期6卷 83-87页

作者： Rénovat Ntagirabiri Richard Karayuba Gabriel Ndayisaba sylvain Niyonkuru Moebeni Amani Gastroenterology Department Kamenge University Hospital Bujumbura Burundi Surgery Department Kamenge University Hospital Bujumbura Burundi

Colorectal cancer is a major cause of morbidity and mortality throughout the world. There is no study about colorectal cancer in our country. The aim of the study was to assess epidemiological, clinical, therapeutic and histological aspects of colorectal cancer over a 10-year period (1999-2008) in Kamenge university hospital, Bujumbura, Burundi, by a descriptive retrospective study. A total of 37 cases of colorectal cancer, 22 males (59.5%) and 15 females (40.5%), mean age 50.8 years, were retrieved over the period of the study. The colorectal cancer was revealed by a rectal bleeding in 21 patients (56.8%) and an occlusive syndrome in 5 patients (13.5%). All patients underwent surgery. According to Dukes’ stages: 27% were A, 27% B, 19% C and 27% stage D. Histopathologically, 18 cases (46.7%) were differentiated adenocarcinoma, 14 cases (37.8%) undifferentiated adenocarcinoma, 2 cases of lymphoma and 2 cases of leiomyosarcoma. All patients underwent surgery. The hospitalization stay was a mean of 27 days. The prognosis was poor with a mortality rate of 13.5% in the hospital. In conclusion, colorectal cancer deserves awareness as a public health problem in our country.

关键词： Colon Cancer Adenocarcinoma Rectal Cancer Colorectal Cancer

Experimental verification of ill-defined topologies and energy sinks in electromagnetic continua

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Advanced Photonics 2022年第3期4卷 97-104页

作者： David E.Fernandes Ricardo A.M.Pereira sylvain Lannebère Tiago A.Morgado Mário G.Silveirinha University of Coimbra Instituto de Telecomunicações and Department of Electrical EngineeringCoimbraPortugal University of Aveiro Instituto de TelecomunicaçõesDepartment of ElectronicsTelecommunications and InformaticsAveiroPortugal University of Lisbon Instituto Superior Técnico and Instituto de TelecomunicaçõesDepartment of Electrical EngineeringLisboaPortugal

.It is experimentally verified that nonreciprocal photonic systems with continuous translation symmetry may have an ill-defined *** topological classification of such systems is only feasible when the material response is regularized with a spatial-frequency *** experimentally demonstrate that adjoining a small air layer to the relevant material interface may effectively imitate an idealized spatial cutoff that suppresses the nonreciprocal response for short wavelengths and regularizes the ***,it is experimentally verified that nonreciprocal systems with an ill-defined topology may be used to abruptly halt the energy flow in a unidirectional waveguide due to the violation of the bulk-edge *** particular,we report the formation of an energy sink that absorbs the incoming electromagnetic waves with a large field enhancement at the singularity.

关键词： topological photonics nonreciprocity topological singularities bulk edge correspondence.

Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2

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分子细胞生物学报:英文版 2011年第5期3卷 301-308页

作者： Mohamed Abu-Farha sylvain Lanouette Fred Elisma Veronique Tremblay Jeffery Butson Daniel Figeys Jean-Francois Couture Ottawa Institute of Systems Biology Department of BiochemistryMicrobiology and ImmunologyUniversity of Ottawa451 Smyth RoadRoger-Guindon HallOttawaONK1H8M5Canada Biochemistry and Molecular Biology Unit Dasman Diabetes InstituteDasman 15462Kuwait

The SMYD(SET and MYND domain)family of lysine methyltransferases(KMTs)plays pivotal roles in various cellular processes,including gene expression regulation and DNA damage *** identified as genuine histone methyltransferases,specific members of this family have recently been shown to methylate non-histone proteins such as p53,VEGFR,and the retinoblastoma tumor suppressor(pRb).To gain further functional insights into this family of KMTs,we generated the protein interaction network for three different human SMYD proteins(SMYD2,SMYD3,and SMYD5).Characterization of each SMYD protein network revealed that they associate with both shared and unique sets of *** those,we found that HSP90 and several of its co-chaperones interact specifically with the tetratrico peptide repeat(TPR)-containing SMYD2 and ***,using proteomic and biochemical techniques,we provide evidence that SMYD2 methylates K209 and K615 on HSP90 nucleotide-binding and dimerization domains,*** addition,we found that each methylation site displays unique reactivity in regard to the presence of HSP90 co-chaperones,pH,and demethylation by the lysine amine oxidase LSD1,suggesting that alternative mechanisms control HSP90 methylation by ***,this study highlights the ability of SMYD proteins to form unique protein complexes that may underlie their various biological functions and the SMYD2-mediated methylation of the key molecular chaperone HSP90.

关键词： SMYD proteins HSP90 lysine methylation SET domain histone methylation

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牛仔时光

明日风尚 2007年第1期 26-31页

作者： sylvain Grandadam

牛仔代表了美国人热爱自由的天性。大众对牛仔的狂热也给牛仔这一形象披上了神秘的外衣。现在,如果谁不怕吃苦,也可以在怀俄明州辽阔的牧场上尝一回当职业牛仔的滋味……

关键词：怀俄明州牧场上国家公园安格斯牛漫画书中年女子西部电影格雷格自我放逐牛群

Free Radical-Scavenging Properties and Antioxidant Activity of Fractions from Cranberry Products

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Food and Nutrition Sciences 2012年第3期3卷 337-347页

作者： Stéphane Caillet Guillaume Lorenzo Jacinthe Coté Jean-Francois sylvain Monique Lacroix Research Laboratories in Sciences Applied to Food Nutraceutical and Functional Food InstituteINRS-Institut Armand-FrappierUniversitédu QuébecLavalCanada Atoka Cranberries Inc. ManseauCanada

Lipid peroxidation inhibition capacity and antiradical activity were evaluated in HPLC fractions of different polarity obtained from two cranberry juices and three extracts isolated from frozen cranberries and pomace containing antho-cyanins, water-soluble and apolar phenolic compounds, respectively. Compounds with close polarities were collected to obtain between three and four fractions from each juice or extract. The cranberry phenols are good free radi-cal-scavengers, but they were less efficient at inhibiting the lipid peroxidation. Of all the samples tested, the intermediate polarity fraction of extract rich in apolar phenolic compounds of fruit presented the highest antiradical activity while the most hydrophobic fractions of the anthocyanin-rich extract from fruit and pomace appeared to be the most efficient at inhibiting the lipid peroxidation. The antioxidant or pro-oxidant activity of fractions increased with the con-centration. The phenol polarity and the technological process to manufacture cranberry juice can influence the antioxidant and antiradical activities of fractions.

关键词： HPLC Fractions Cranberry Juices Phenolic Extracts Free Radical Scavenging Capacity Antioxidant Activity