检索结果-南通市图书馆

The Primary Motor Cortex Stimulation Attenuates Cold Allodynia in a Chronic Peripheral Neuropathic Pain Condition in <i>Rattus norvegicus</i>

引用

World Journal of Neuroscience 2019年第3期9卷 138-152页

作者： Priscila Medeiros sylmara esther negrini-ferrari Ana Carolina Medeiros Lais Leite Ferreira Josie Resende Torres da Silva José Aparecido da Silva Norberto Cysne Coimbra Renato Leonardo de Freitas Neurosciences aboratory of Pain & Emotions and Multi-User Centre of Neuroelectrophysiology Department of Surgery and Anatomy Ribeir&atilde o Preto Medical School of the University of Sã o Paulo Ribeir&atilde o Preto S&atilde o Paulo Brazil Laboratory of Neuroanatomy and Neuropsychobiology Department of Pharmacology Ribeir&atilde o Preto Medical School of the University of Sã o Paulo (FMRP-USP) Ribeir&atilde o Preto (SP) Brazil Biomedical Sciences Institute Federal University of Alfenas (UNIFAL-MG) Alfenas Minas Gerais (MG) Brazil Motricity Sciences Institute UNIFAL-MG Alfenas MG Brazil Post-Graduate Program of Biosciences Applied to Health (PPGB) UNIFAL Biomedical Sciences Institute Alfenas MG Brazil Department of Psychology Ribeir&atilde o Preto School of Philosophy Sciences and Literature of the University of S&atilde o Paulo FFCLRP-USP Ribeir&atilde o Preto Brazil Department of Psychology Federal University of Juiz de Fora (UFJF-MG) Juiz de Fora (MG) Brazil Behavioural Neurosciences Institute (INeC) Ribeir&atilde o Preto (SP) Brazil

Background: The primary motor cortex (M1) stimulation (MCS) is a useful tool for attenuation of the peripheral neuropathic pain in patients with pharmacologically refractory pain. Furthermore, that neurological procedure may also cause antinociception in rodents with neuropathic pain. Cold allodynia is a frequent clinical finding in patients with neuropathic pain, then, we evaluated if an adapted model of neuropathy induced by chronic constriction injury (CCI) of the ischiadicus nervus (sciatic nerve) produces cold allodynia in an animal model of chronic pain. In addition, we also investigated the effect of the electrical stimulation of the M1 on chronic neuropathic pain condition in laboratory animals. Methods: Male Wistar rats were used. An adapted model of peripheral mononeuropathy induced by CCI was carried out by placing a single loose ligature around the right sciatic nerve. The acetone test was used to evaluate the cold allodynia in CCI or Sham (without ligature) rats. The MCS (M1) was performed at low-frequency (20 μA, 100 Hz) during 15 s by deep brain stimulation (DBS-Thomas Recording device) 21 days after CCI or Sham procedures. The cold allodynia was measured before and immediately after the neurostimulation of M1 in the following time-window: 0, 15 and 30 min after MCS. Results: Cold allodynia threshold increased in animals with chronic neuropathic pain submitted to the acetone test 21 days after the CCI surgery. The M1-stimulation by DBS procedure decreased the cold allodynia immediately and until 30 min after M1-stimulation in rats with chronic neuropathic pain. Conclusion: The current proposal for a CCI model by a single loose ligature of the sciatic nerve can be employed as an experimental model of chronic neuropathic pain in rats submitted to peripheral nervous system injury. The M1-stimulation produced antinociception in rats with chronic neuropathic pain. Thus, we reinforced that the MCS decreases cold allodynia in laboratory animals submitted to

关键词： Peripheral Neuropathic Pain Chronic Pain Sciatic Nerve Chronic Constriction Injury Cold Allodynia Primary Motor Cortex Stimulation Antinociception

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：