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Decoding molecular mechanisms:brain aging and Alzheimer's disease

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Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay ali syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

Debating the magnesium-selenium battery technology

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Journal of Magnesium and Alloys 2020年第4期8卷 980-988页

作者： Muhammad Rashada syed Danish ali zaidi Muhammad Asif School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003JiangsuChina Advanced Rechargeable Batteries Laboratory Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Department of Chemical Sciences School of Natural SciencesUniversity of LimerickLimerick V94 T9PXIreland

Magnesium ion batteries(MIBs)have received tremendous research attention owing to their low cost,dendrite free electroplating,and high theoretical capacities compared with lithium ion batteries(LIBs).Despite these advantages,the launching of MIBs is hindered by sluggish kinetics of the magnesium ions inside the host ***,several magnesium-selenium batteries have been developed to achieve the fast kinetics of magnesium ions inside the selenium-based ***,we have critically reviewed the five-year advancements made in the field of selenium cathode design,selenium loadings,compatible organic and inorganic electrolytes,their resultant reversible capacities,working voltages,cycle life,and specific *** selenium-based cathodes were critically debated in terms of their electrochemical performance and *** the end of this review article,several irmovative directions are proposed to shed light on future research.c 2020 Published by Elsevier *** behalf of Chongqing University.

关键词： Magnesium-selenium batteries Energy storage Selenium cathodes Electrolytes Electrochemical properties

Polymer-free electrospun separator film comprising silica nanofibers and alumina nanoparticles for Li-ion full cell

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Journal of Energy Chemistry 2020年第3期29卷 217-226页

作者： syed Danish ali zaidi Chong Wanga Qinjun Shao Jing Gao Shengdong Zhu Haifeng Yuan Jian Chen Advanced Rechargeable Batteries Laboratory Dalian Institute of Chemical PhysicsChinese Academy of Sciences457 Zhongshan RoadDalian 116023LiaoningChina University of Chinese Academy of Science Beijing 100039China

A separator film for high-performance Li-ion batteries was prepared by electrospinning. The film had a hybrid morphology of silica nanofibers(SNFs) and alumina nanoparticles(ANPs), with a smooth surface, polymer-free composition, high porosity(79%), high electrolyte uptake(876%), and excellent thermal stability. Contact angle measurements demonstrated the better immersion capability of the SNF-ANP separator film for commercial liquid electrolytes than a commercial CELGARD 2500 separator film. Moreover,compared to the commercial CELGARD 2500 separator, the ionic conductivity of the SNF-ANP separator film was nearly three times higher, the bulk resistance was lower at elevated temperature(120 ℃), the interfacial resistance with lithium metal was lower, and the electrochemical window was wider. Full cells were fabricated to determine the cell performance at room temperature. The specific capacity of the full cell with the SNF-ANP separator film was 165 mAh g-1;the cell was stable for 100 charge/discharge cycles and exhibited a capacity retention of 99.9%. Notably, the electrospun SNF-ANP separator film can be safely used in Li-ion or Li-S rechargeable batteries.

关键词： Electrospun nanofiber Hybrid materials Separator film Silica nanofiber Li-ion batteries

TRUSED:A Trust-Based Security Evaluation Scheme for A Distributed Control System

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Computers, Materials & Continua 2023年第2期74卷 4381-4398页

作者： saqib ali Raja Waseem Anwar Sultan Qaboos University Muscat123Sultanate of OMAN Arab Open University Muscat130Sultanate of OMAN

Distributed control systems(DCS)have revolutionized the communication process and attracted more interest due to their pervasive computing nature(cyber/physical),their monitoring capabilities and the benefits they ***,due to distributed communication,flexible network topologies and lack of central control,the traditional security strategies are inadequate formeeting the unique characteristics ***,malicious and untrustworthy nodes pose a significant threat during the formation of a DCS ***-based secure systems not only monitor and track the behavior of the nodes but also enhance the security by identifying and isolating the malicious node,which reduces the risk and increases network *** this research,we offer TRUSED,a trust-based security evaluation scheme that both,directly and indirectly,estimates each node’s level of trustworthiness,incorporating the cumulative trust *** addition,simulation results show that the proposed technique can effectively identify malicious nodes,determine their node’s trustworthiness rating,and improve the packet delivery ratio.

关键词： Malicious network lifetime risk management security trust untrustworthy

Incorporation of layered tin(Ⅳ) phosphate in graphene framework for high performance lithium-sulfur batteries

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Journal of Energy Chemistry 2021年第2期30卷 99-108,I0004页

作者： Haifeng Yuan Na Zhang Leiwu Tian Lei Xu Qinjun Shao syed Danish ali zaidi Jianping Xiao Jian Chen Advanced Rechargeable Battery Laboratory Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina University of Chinese Academy of Sciences.Beijing 100049 China

To anchor the polysulfide and enhance the conversion kinetics of polysulfide to disulfide/sulfide is critical for improving the performance of lithium-sulfur *** this purpose,the graphene-supported tin(Ⅳ) phosphate(Sn(HPO_4)_2·H_2 O,SnP) composites(SnP-G) are employed as the novel sulfur hosts in this *** compared to the graphene-sulfur and carbon-sulfur composites,the SnP-G-sulfur composites exhibit much better cycling performance at 1.0 C over 800 ***,the pouch cell fabricated with the SnP-G-sulfur cathodes also exhibits excellent performance with an initial capacity of1266.6 mAh g^(-1)(S) and capacity retention of 76.9% after 100 cycles at 0.1 *** adsorption tests,density functional theory(DFT) calculations in combination with physical cha racterizations and electrochemical measurements provide insights into the mechanism of capture-accelerated conversion mechanism of polysulfide at the surface of *** calculations indicate that the Li-O bond formed between Li atom(from Li_2 S_n,n=1,2,4,6,8) and O atom(from PO_3-OH in SnP) is the main reason for the strong interactions between Li_2 S_n and *** a result,SnP can effectively restrain the shuttle effect and improving the cycling performance of Li-S *** addition,by employing the climbing-image nudged elastic band(ciNEB) methods,the energy barrier for lithium sulfide decomposition(charging reaction) on SnP is proved to decrease significantly compared to that on *** can be concluded that SnP is an effective sulfur hosts acting as dual-functional accelerators for the conversion reactions of polysulfude to sulfide(discharging reaction) as well as polysulfide to sulfur(charging reaction).

关键词： Lithium-sulfur battery Tin(Ⅳ)phosphate Dual-functional accelerator Sulfur host Density functional theory calculations

Robust stability analysis of Takagi-Sugeno uncertain stochastic fuzzy recurrent neural networks with mixed time-varying delays

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Chinese Physics B 2011年第8期20卷 1-15页

作者： M.syed ali Department of Mathematics Thiruvalluvar UniversityVellore-632 106TamilnaduIndia

In this paper, the global stability of Takagi-Sugeno （TS） uncertain stochastic fuzzy recurrent neural networks with discrete and distributed time-varying delays （TSUSFRNNs） is considered. A novel LMI-based stability criterion is obtained by using Lyapunov functional theory to guarantee the asymptotic stability of TSUSFRNNs. The proposed stability conditions are demonstrated through numerical examples. Furthermore, the supplementary requirement that the time derivative of time-varying delays must be smaller than one is removed. Comparison results are demonstrated to show that the proposed method is more able to guarantee the widest stability region than the other methods available in the existing literature.

关键词： recurrent neural networks linear matrix inequality Lyapunov stability time-varyingdelays TS fuzzy model

Novel delay-dependent stability analysis of Takagi-Sugeno fuzzy uncertain neural networks with time varying delays

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Chinese Physics B 2012年第7期21卷 49-60页

作者： M. syed ali Department of Mathematics Thiruvalluvar University

This paper presents the stability analysis for a class of neural networks with time varying delays that are represented by the Takagi^ugeno IT-S） model. The main results given here focus on the stability criteria using a new Lyapunov functional. New relaxed conditions and new linear matrix inequality-based designs are proposed that outperform the previous results found in the literature. Numerical examples are provided to show that the achieved conditions are less conservative than the existing ones in the literature.

关键词： neutral neural networks linear matrix inequality Lyapunov stability time varying delays

Stability analysis of Markovian jumping stochastic Cohen Grossberg neural networks with discrete and distributed time varying delays

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Chinese Physics B 2014年第6期23卷 131-137页

作者： M.syed ali Department of Mathematics Thiruvalluvar University

In this paper, the global asymptotic stability problem of Markovian jumping stochastic Cohen-Grossberg neural networks with discrete and distributed time-varying delays （MJSCGNNs） is considered. A novel LMI-based stability criterion is obtained by constructing a new Lyapunov functional to guarantee the asymptotic stability of MJSCGNNs. Our results can be easily verified and they are also less restrictive than previously known criteria and can be applied to Cohen-Grossberg neural networks, recurrent neural networks, and cellular neural networks. Finally, the proposed stability conditions are demonstrated with numerical examples.

关键词： Cohen-Grossberg neural networks global asymptotic stability linear matrix inequality Lyapunovfunctional time-varying delays

Survey and technological analysis of laser and its defense applications

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Defence Technology（防务技术） 2021年第2期17卷 583-592页

作者： syed Affan Ahmed Mujahid Mohsin syed Muhammad Zubair ali Department of Avionics Engineering-College of Aeronautical Engineering(CAE) National University of Sciences and Technology(NUST)RisalpurKPKPakistan

The laser technology has made remarkable progress over the past couple of *** is being widely employed in diverse domains,such as holography,space sciences,spectroscopy,medical sciences,micro and power electronics,industrial engineering,and most distinctively,as directed energy military *** to their active transmissions,laser systems are similar to microwave radars to some extent;however,unlike conventional radars,the laser operates at very high frequencies thus making it a potent enabler of narrow-beam and high energy aerial deployments,both in offensive and defensive *** modern avionics systems,laser target indicators and beam riders are the most common devices that are used to direct the Laser Guided Weapons(LGW)accurately to the ground ***,compact size and outstanding angular resolution of laser-based systems motivate their use for drones and unmanned aerial ***,the narrow-beam divergence of laser emissions offers a low probability of intercept,making it a suitable contender for secure transmissions and safety-critical ***,the developments in space sciences and laser technology have given synergistic potential outcomes to use laser systems in space *** paper comprehensively reviews laser applications and projects for strategic defense actions on the ground or in ***,a detailed analysis has been done on recent advancements of the laser technology for target indicators and *** also reviews the advancements in the field of laser communications for surveillance,its earlier state of the art,and ongoing scientific research and advancements in the domain of high energy directed laser weapons that have revolutionized the evolving military *** offering a comprehensive taxonomy,the paper also critically analyzes some of the recent contributions in the associated domains.

关键词： Laser systems Laser military applications Directed energy weapons Non-lethal weapons Laser military projects Survey Taxonomy