检索结果-南通市图书馆

Chinese Physics Letters 2023年第5期40卷 123-123页

作者：黄楚怡张俊佩叶凡秦泽聪 syed mohd Amir Zachary Norris Buck Ahmed Salman Wolfgang Kreuzpaintner 齐欣王天昊童欣 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China

In our published paper,国an important affiliation(University of Chinese Academy of Sciences,Beijing 100049,China)should be added as the 3rd affiliation for the first author,as given ***[1]Huang C,ZhangJ,Ye F,Qin Z,Ami... 详细信息

关键词： Polarized

DPHL:A DIA Pan-human Protein mass Spectrometry Library for Robust Biomarker Discovery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2020年第2期18卷 104-119页

作者： Tiansheng Zhu Yi Zhu Yue Xuan Huanhuan Gao Xue Cai Sander R.Piersma Thang V.Pham Tim Schelfhorst Richard R.G.D.Haas Irene V.Bijnsdorp Rui Sun Liang Yue Guan Ruan Qiushi Zhang mo Hu Yue Zhou Winan J.Van Houdt Tessa Y.S.Le Large Jacqueline Cloos Anna Wojtuszkiewicz Danijela Koppers-Lalic Franziska Bottger Chantal Scheepbouwer Ruud H.Brakenhoff Geert J.L.H.van Leenders Jan N.m.Ijzermans John W.m.martens Renske D.m.Steenbergen Nicole C.Grieken Sathiyamoorthy Selvarajan Sangeeta mantoo Sze S.Lee Serene J.Y.Yeow syed m.F.Alkaff Nan Xiang Yaoting Sun Xiao Yi Shaozheng Dai Wei Liu Tian Lu Zhicheng Wu Xiao Liang man Wang Yingkuan Shao Xi Zheng Kailun Xu Qin Yang Yifan meng Cong Lu Jiang Zhu Jin'e Zheng Bo Wang Sai Lou Yibei Dai Chao Xu Chenhuan Yu Huazhong Ying Tony K.Lim Jianmin Wu Xiaofei Gao Zhongzhi Luan Xiaodong Teng Peng Wu Shi'ang Huang Zhihua Tao Narayanan G.Iyer Shuigeng Zhou Wenguang Shao Henry Lam Ding ma Jiafu Ji Oi L.Kon Shu Zheng Ruedi Aebersold Connie R.Jimenez Tiannan Guo Zhejiang Provincial Laboratory of Life Sciences and Biomedicine Westlake UniversityHangzhou 310024China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China School of Computer Science Shanghai Key Laboratory of Intelligent Information ProcessingFudan UniversityShanghai 200433China Thermo Fisher Scientific(BREmEN)GmbH Bremen 28195Germany OncoProteomics Laboratory Department of Medical OncologyVU University Medical CenterVU UniversityAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamUrologyCancer Center AmsterdamAmsterdam 1011The Netherlands Thermo Fisher Scientific Shanghai 201206China The Netherlands Cancer Institute Surgical OncologyAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamSurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamPediatric Oncology/HematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamHematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamMedical OncologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamNeurosurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamPathologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UmC Vrije Universiteit AmsterdamOtolaryngology/Head and Neck SurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Erasmus mC University medical Center PathologyRotterdam 1016LVThe Netherlands Erasmus mC University medical Center SurgeryRotterdam 1016LVThe Netherlands Erasmus mC University medical Center Medical OncologyRotterdam 1016LVThe Netherlands Department of Anatomical Pathology Singapore General HospitalSingapore 169608Singapore Division of medical Scie

To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(mS)-based targeted proteomic techniques,including the selected reaction monitoring(SRm),parallel reaction monitoring(PRm),and massively parallel dataindependent acquisition(DIA),have been *** optimal performance,they require the fragment ion spectra of targeted peptides as prior *** this report,we describe a mS pipeline and spectral resource to support targeted proteomics studies for human tissue *** build the spectral resource,we integrated common open-source mS computational tools to assemble a freely accessible computational workflow based on *** then applied the workflow to generate DPHL,a comprehensive DIA pan-human library,from 1096 data-dependent acquisition(DDA)mS raw files for 16 types of cancer *** extensive spectral resource was then applied to a proteomic study of 17 prostate cancer(PCa)***,PRm validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was *** a second application,the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma(DLBCL)patients and 18 healthy control *** expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-mS and confirmed by *** data demonstrate that the DPHL supports DIA and PRm mS pipelines for robust protein biomarker *** is freely accessible at https://***/page/***?id=IPX0001400000.

关键词： Data-independent acquisition Parallel reaction monitoring Spectral library Prostate cancer Diffuse large B cell lymphoma

阿兹特克钻石的m-多项式和拓扑指数（英文）

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

昆明学院学报 2018年第6期40卷 43-47页

作者：穆罕默德.阿西夫赛义德.穆罕默德.奥马尔拉合尔大学数学系拉合尔54000 明哈吉大学数学系拉合尔54000

为计算基于度的阿兹特克钻石拓扑指数,通过基本微积分计算了Aztec钻石的m-多项式,并给出9类基于度的拓扑指数,即第1类萨格勒布指数、第2类萨格勒布指数、修正的第2类萨格勒布指数、Randic'和逆Randic'指数、对称分割指数、调和指数、逆... 详细信息

为计算基于度的阿兹特克钻石拓扑指数,通过基本微积分计算了Aztec钻石的m-多项式,并给出9类基于度的拓扑指数,即第1类萨格勒布指数、第2类萨格勒布指数、修正的第2类萨格勒布指数、Randic'和逆Randic'指数、对称分割指数、调和指数、逆和指数和增强的萨格勒布指数.

关键词：阿兹特克钻石萨格勒布指数 Randic’指数 m-多项式

methylated PLK2 is a prognostic biomarker in taxane-treated breast cancers

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Discussion of Clinical Cases 2020年第2期7卷 7-12页

作者： Priti Chivers Laura Lattanzio Ornella Garrone Daniela Vivenza Nel syed marco C.merlano Tim Crook Helen m.Coley Cristiana Lo Nigro Faculty of Health and medical Sciences University of SurreyGuildfordSurreyUK Oncology Department S.Croce&Carle Teaching HospitalCuneoItaly Neuro-Oncology Department Imperial CollegeLondonUK Oncology Department Royal Surrey County HospitalGuildfordSurreyUK Laboratory Department Galliera HospitalGenovaItaly

Background:In search of potential biomarkers of drug responsiveness the tumour suppressor PLK2 has been identified as a mediator of taxane sensitivity in some tumour types,based on its role of G2m checkpoint ***:The current study set out to evaluate PLK2 methylation in breast cancer treated with neo-adjuvant chemotherapy including a taxane,as a biomarker of disease ***:Silencing of PLK2 in mCF-7 cells followed by taxane treatment was assessed using apoptotic readout for proof of *** was extracted from 64 cases of diagnostic surgical FFPE *** pyrosequencing,levels of PLK2 promoter methylation were ***:Silencing of PLK2 resulted in a significantly reduced apoptotic response following paclitaxel treatment(compared with scramble transfected controls).An association with higher levels of CpG island promoter methylation was seen for those cases with a progression-free survival(PFS)of less than 12 ***-meier analysis showed there was an association between overall survival(OS)and level of methylation(p=.06).Conclusions:Thus,based on data obtained from this pilot study,further larger studies evaluating the utility of PLK2 methylation as a potential predictive biomarker in breast cancer are warranted.

关键词： Breast cancer PLK2 DNA methylation Drug resistance Taxanes

Detailed Kinetic mechanism of CNG Combustion in an IC Engine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry

Advances in Chemical Engineering and Science（化学工程与科学期刊） 2011年第3期

作者： muhammad mansha Javed syed Hassan Anwar Rashid Saleemi Badar m.Ghauri

来源：评论

学校读者我要写书评

暂无评论

World Journal of Critical Care medicine 2022年第2期11卷 102-111页

作者： Aysun Tekin Shahraz Qamar Romil Singh Vikas Bansal mayank Sharma Allison m Lemahieu Andrew C Hanson Phillip J Schulte marija Bogojevic Neha Deo Simon Zec Diana J Valencia morales Katherine A Belden Smith F Heavner margit Kaufman Sreekanth Cheruku Valerie C Danesh Valerie m Banner-Goodspeed Catherine A St Hill Amy B Christie syed A Khan Lynn Retford Karen Boman Vishakha KKumar John C O'Horo Juan Pablo Domecq Allan J Walkey Ognjen Gajic Rahul Kashyap Salim Surani TheSociety of Critical Care medicine(SCCm)Discovery Viral Infection and Respiratory Illness Universal Study(VIRUS):COVID-Registry Investigator Group Department of Anesthesiology Mayo ClinicRochesterMN 55905United States Post-baccalaureate Research education Program Mayo Clinic College of Medicine and ScienceRochesterMN 55905United States Division of Pulmonary and Critical Care medicine Department of Internal MedicineMayo ClinicRochesterMN 55905United States Division of Clinical Trials and Biostatistics Department of Quantitative Health SciencesMayo ClinicRochesterMN 55905United States Alix School of medicine Mayo ClinicRochesterMN 55905United States Division of Infectious Diseases Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Prisma Health GreenvilleSC 29605United States Englewood Health EnglewoodNJ 07631United States Divisions of Cardiothoracic Anesthesiology and Critical Care medicine Department of Anesthesiology and Pain ManagementUT Southwestern Medical CenterDallasTX 75390United States Center for Applied Health Research Baylor Scott and White HealthDallasTX 75246United States Department of Anesthesiology Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterBostonMA 02215United States Allina Health MinneapolisMN 55407United States Department of Critical Care Atrium Health NavicentMaconGA 31201United States Division of Critical Care medicine Mayo Clinic Health SystemMankatoMN 56001United States Society of Critical Care medicine Mount ProspectIL 60056United States Division of Infectious Diseases Mayo ClinicRochesterMN 55905United States Division of Nephrology and Hypertension Department of Internal MedicineMayo ClinicRochesterMN 55905United States Pulmonary Center Division of PulmonaryAllergyCritical Care and Sleep MedicineDepartment of MedicineEvans Center of Implementation and Improvement SciencesBoston University School of MedicineBostonMA 02118United States Department of Pulmonary and Critical Care medicine Texas A&M UniversityBryanTX 77807United States 不详

BACKGROUND The coronavirus disease 2019(COVID-19)course may be affected by environmental *** studies previously suggested a link between climatological factors and COVID-19 fatality ***,individual-level impact of these factors has not been thoroughly evaluated *** To study the association of climatological factors related to patient location with unfavorable outcomes in *** In this observational analysis of the Society of Critical Care medicine Discovery Viral Infection and Respiratory Illness Universal Study:COVID-19 Registry cohort,the latitudes and altitudes of hospitals were examined as a covariate for mortality within 28 d of admission and the length of hospital *** for baseline parameters and admission date,multivariable regression modeling was *** estimating equations were used to fit the *** Twenty-two thousand one hundred eight patients from over 20 countries were *** median age was 62(interquartile range:49-74)years,and 54%of the included patients were *** median age increased with increasing latitude as well as the frequency of ***,the percentage of comorbidities was lower in elevated *** within 28 d of hospital admission was found to be 25%.The median hospital-free days among all included patients was 20 *** the significant linear relationship between mortality and hospital-free days(adjusted odds ratio(aOR)=1.39(1.04,1.86),P=0.025 for mortality within 28 d of admission;aOR=-1.47(-2.60,-0.33),P=0.011 for hospital-free days),suggesting that adverse patient outcomes were more common in locations further away from the Equator;the results were no longer significant when adjusted for baseline differences(aOR=1.32(1.00,1.74),P=0.051 for 28-day mortality;aOR=-1.07(-2.13,-0.01),P=0.050 for hospital-free days).When we looked at the altitude’s effect,we discovered that it demonstrated a non-linear association with mortality wi

关键词： 28 d mortality Altitude COVID-19 Hospital-free days Latitude Outcomes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

巴基斯坦原发性耐多药结核病流行情况

国际结核病与肺部疾病杂志 2008年第2期3卷 73-77页

作者： A.Javaid R.Hasan A.Zafar A.Ghafoor A.J.Pathan A.Rab A.Sadiq C.m.Akram I.Burki K.Shah m.Ansari N.Rizvi S.U.Khan S.R.Awan Z.A.syed Z.H.lqbal Z.Shaheen N.ur Rehman 邢超 Department of Pulmonology Postgraduate Medical InstituteLady Reading Hospital Peshawar Department of microbiology Agha Khan University HospitalKarachi TB Control Programme North West Frontier Province(NWFP)Peshawar Institute of Chest Diseases Kotri Department of Pulmonology Ayub Teaching HospitalAbbotabad Oiha Institute of Chest Diseases Karachi Gulab Devi Hospital Lahore Lyari General Hospital Karachi National TB Control Programme Islamabad Liaqat National Hospital Karachi Jinnah Postgraduate medical Centre Karachi King edwards medical University Lahore Nishtar medical College Multan Allama Iqbal medical Lahore Wyeth(Pvt) Limited KarachiPakistan

背景:巴基斯坦是世界第6位结核病高负担国家。据世界卫生组织(WHO)估计,巴基斯坦结核病发病率为181/10万,全国每年新增结核病患者28.6万例。来自于医院的资料表明:巴基斯坦耐多药结核病(mDR-TB)问题已十分严重,急需在社区水平对耐多药... 详细信息

背景:巴基斯坦是世界第6位结核病高负担国家。据世界卫生组织(WHO)估计,巴基斯坦结核病发病率为181/10万,全国每年新增结核病患者28.6万例。来自于医院的资料表明:巴基斯坦耐多药结核病(mDR-TB)问题已十分严重,急需在社区水平对耐多药结核病的严重程度开展评估。本研究为针对巴基斯坦耐药结核病流行状况开展的横段面研究,所使用的痰标本来自于巴基斯坦全国742例未经治疗的新诊断的肺结核患者。目的:评估巴基斯坦原发性耐药的流行情况结果:在672例痰培养阳性患者中,有76例(11.3%)出现了对1种或多种抗结核药物耐药。36例(5.4%)患者对链霉素(10μg/ml)耐药; 51例(7.6%)患者对异烟肼(1μg/ml)耐药;15例(2.2%)患者对利福平(5μg/ml)耐药;12例(1.8%)患者对乙胺丁醇(10μg/ml)耐药;22例(3.3%)患者对吡嗪酰胺耐药。有46例(6.8%)患者痰标本中分离的结核菌株耐1种抗结核药物, 10例(1.5%)同时耐2种抗结核药物,12例(1.8%)同时耐3种抗结核药物,6例(0.9%)同时耐4种抗结核药物,2例(0.3%)同时耐全部5种抗结核一线药。原发性耐多药率为1.8%,(n= 12)(异烟肼1μg/ml,利福平5μg/ml)。结论:研究结果表明,巴基斯坦原发性耐多药率<2%,需要进一步实施有效的DOTS策略。

关键词：原发性耐药耐多药结核病巴基斯坦

Removal of moisture Content in Paper machine Using Soft Computing Techniques

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Circuits and Systems 2016年第9期7卷 2542-2550页

作者： m. Senthil Kumar K. mahadevan Department of Electrical and Electronics Engineering Syed Ammal Engineering College Landhai Tamil Nadu India Department of Electrical and Electronics Engineering PSNA College of Engineering and Technology Dindigul Tamil Nadu India

The choice of this investigation is to tune the proportional-integral-derivative (PID) parameters separately for controlling the moisture content in paper industry by using Particle Swarm Optimization (PSO). This paper boon a new algorithm for PID controller tuning based particle swarm optimization. PSO algorithm has recently developed as a very powerful method for real parameter optimization. This new process is proposed to combine both the algorithms to get better optimization values. The proposed algorithm tuned the PID parameters and its performance has been compared with PID algorithm. Compared to PID algorithm technique, dynamic performance requirements such as rise time settling time and peak overshoot optimal values produced by PSO. The plant model represented by the transfer function is obtained by the system identification toolbox.

关键词： PID Controller Particle Swarm Optimization Industrial Application

Effect of temperature and strain rate on compressive response of extruded magnesium nano-composite

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of magnesium and Alloys 2015年第3期3卷 224-230页

作者： B.Selvam P.marimuthu R.Narayanasamy V.Senthilkumar K.S.Tun m.Gupta Department of mechanical Engineering Mookambigai College of EngineeringPudukkottaiTamilnadu 622502India syed Ammal Engineering College RamanathapuramTamilnadu 623502India Department of Production Engineering National Institute of TechnologyTiruchirappalliTamilnadu 620015India Department of mechanical Engineering National University of Singapore9 Engineering Drive 1Singapore 117576Singapore

The hot deformation behaviour of extruded magnesium-zinc oxide nano composite has been studied using hot compression *** test was conducted in the temperature range of 250-400℃ and in the strain rate range of 0.01 to 1.5 s^(−1).The processing map was obtained using the power dissipation efficiency with the functions of temperature and strain *** workability and instability domains were observed in the processing map for a nano *** optical microscopy(Om),scanning electron microscopy(SEm)and transmission electron microscopy(TEm)images were used to confirm the formation of dynamic recrystallization(DRX),dynamic recovery(DRY)and instability *** workability region of the composite was identified at a working temperature of 400℃ and the strain rate of 0.01 s^(−1) from the processing *** instability regions were observed at higher strain rates(>0.1 s^(−1))and temperatures(250-400℃).

关键词： metal matrix composites Powder metallurgy Processing map Strain rate Instability Nano-composite

Efﬁciency and safety of sofosbuvir in Bangladeshi children with chronic hepatitis C virus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

iLIVER 2023年第3期2卷 146-150页

作者： Salahuddin mahmud Jahida Gulshan mdBelayet Hossain madhabi Baidya Rafia Rashid Farhana Tasneem Ahmed Rashidul Hasan Tanzila Farhana m.ham.ed Reaz mobarak mdJahangir Alam syed Shafi Ahmed Department of Pediatric Gastroenterology Hepatology&NutritionBangladesh Shishu Hospital&InstituteDhakaBangladesh Institute of Statistical Research and Training(ISRT) University of DhakaDhakaBangladesh Department of Pediatric Hematology&Oncology Bangladesh Shishu Hospital&InstituteDhakaBangladesh Department of Pediatric Gastroenterology Dr.M R Khan Shishu Hospital&Institute of Child HealthDhakaBangladesh Department of Pediatrics BIHS General HospitalDiabetic Association of BangladeshDhakaBangladesh Department of Epidemiology&Research Bangladesh Shishu Hospital&InstituteDhakaBangladesh Bangladesh Shishu Hospital&Institute DhakaBangladesh

Background and aims:Currently,treatment with oral direct-acting antivirals is recommended for all hepatitis C virus(HCV)-infected pediatric *** aim of this study was to evaluate the efficacy and safety of sofosbuvir and ribavirin combination ther apy for children and adolescents in Bangladesh who are living with chronic HCV in ***:An experimental study was performed from January 2021 to December *** polymerase chain reaction(PCR)-positive thalassemic children,who were 6–18 years of age,were enrolled by consecutive non-probability *** features were recorded,and investigations were *** patients were initially treated with sofosbuvir(200 mg for 6-to 11-year-olds and 400 mg for 12-to 18-year-olds)and ribavirin(10–15 mg/kg/day)and were assessed clinically on a four-weekly basis,along with liver-function *** total duration of therapy was 24 *** PCR was done at the end of treatment and 12 weeks after the completion of treatment to see the sustained virological ***:There were 26 cases in total,with a mean age of 9.26?2.82 years;14 were males(53.8%),and 12 females(46.2%).Twenty-five(96.15%)patients achieved a sustained virological response,and the end-of-treatment PCR was *** patient(3.85%)was a nonresponder even after 24 weeks of *** medication was well received,with only four patients(15.3%)reporting headaches that were reported ***:The combination of sofosbuvir and ribavirin is effective in treating chronic HCV infection and is not accompanied by any major negative side effects.

关键词： Hepatitis C virus Direct-acting antivirals Sofosbuvir Ribavirin