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Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India

World Journal of Gastroenterology 2005年第45期11卷 7165-7168页

作者： Zahid Hussain syed s ali syed A Husain Mohammad Raish Deepika R sharma Premashis Kar PCR Hepatitis Laboratory Panacea Biotec Ltd Mohammad Raish

AIM：（1） To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDs students who are at an increased risk of getting hepatitis B infection and come under high risk groups. （2） To assess the efficacy and safety of En/vac- HB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B accine developed and manufactured in India. METHODs： A prospective, comparative, and single blinded trial of rapid （0, 1, and 2 mo） hepatitis B immunization schedulewas reported. A total of three hundred and seven （212 females and 95 males） healthy volunteers divided into three age groups （18-29, 30-39, and 40-49） were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo. REsULTs： Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 （96.5%） subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/ mL, while that in the age group of 30-39 years was 2 096.0 mlU/mL. In third age group of 40-49 years, anti- HBs titer was 1 592.0 mIU/mL. Hyper-responses （anti-HBs≥100 mIU/mL） were shown in 88.0% （271/307） of subjects. Eleven （3.5%） subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions （ADRs）. CONCLUsION： This vaccine （Enivac-HB） is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended

关键词： Enivac-HB Pichia pastoris Anti-HBsantibody Hepatitis B vaccine

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Vagus nerve stimulation in intracerebral hemorrhage:the need for further research

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Neural Regeneration Research 2025年第11期20卷 3213-3214页

作者： sheharyar s.Baig ali N.ali Arshad Majid sheffield Institute for Translational Neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus nerve stimulation(VNs)and stroke:stroke is the second leading cause of death and the third leading cause of disability worldwide(Baig et al.,2023).There have been significant paradigm shifts in the management of acute ischemic stroke through mechanical *** chronic ischemic stroke,invasive VNs paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved(Baig et al.,2023).There are no treatments of similar efficacy in acute intracerebral hemorrhage(ICH)where several promising trials,e.g.,TICH-2,sTOP-AUsT,and TRAIGE did not show improvements in functional outcomes(Puy et al.,2023).

关键词： stimulation acute

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Decoding molecular mechanisms:brain aging and Alzheimer's disease

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Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay ali syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish sBhatti shahid Bashir Atta-ur-Rahman school of Applied Biosciences(AsAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

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Novel delay-dependent stability analysis of Takagi-sugeno fuzzy uncertain neural networks with time varying delays

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Chinese Physics B 2012年第7期21卷 49-60页

作者： M. syed ali Department of Mathematics Thiruvalluvar University

This paper presents the stability analysis for a class of neural networks with time varying delays that are represented by the Takagi^ugeno IT-s） model. The main results given here focus on the stability criteria using a new Lyapunov functional. New relaxed conditions and new linear matrix inequality-based designs are proposed that outperform the previous results found in the literature. Numerical examples are provided to show that the achieved conditions are less conservative than the existing ones in the literature.

关键词： neutral neural networks linear matrix inequality Lyapunov stability time varying delays

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Robust stability analysis of Takagi-sugeno uncertain stochastic fuzzy recurrent neural networks with mixed time-varying delays

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Chinese Physics B 2011年第8期20卷 1-15页

作者： M.syed ali Department of Mathematics Thiruvalluvar UniversityVellore-632 106TamilnaduIndia

In this paper, the global stability of Takagi-sugeno （Ts） uncertain stochastic fuzzy recurrent neural networks with discrete and distributed time-varying delays （TsUsFRNNs） is considered. A novel LMI-based stability criterion is obtained by using Lyapunov functional theory to guarantee the asymptotic stability of TsUsFRNNs. The proposed stability conditions are demonstrated through numerical examples. Furthermore, the supplementary requirement that the time derivative of time-varying delays must be smaller than one is removed. Comparison results are demonstrated to show that the proposed method is more able to guarantee the widest stability region than the other methods available in the existing literature.

关键词： recurrent neural networks linear matrix inequality Lyapunov stability time-varyingdelays Ts fuzzy model

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stability analysis of Markovian jumping stochastic Cohen Grossberg neural networks with discrete and distributed time varying delays

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Chinese Physics B 2014年第6期23卷 131-137页

作者： M.syed ali Department of Mathematics Thiruvalluvar University

In this paper, the global asymptotic stability problem of Markovian jumping stochastic Cohen-Grossberg neural networks with discrete and distributed time-varying delays （MJsCGNNs） is considered. A novel LMI-based stability criterion is obtained by constructing a new Lyapunov functional to guarantee the asymptotic stability of MJsCGNNs. Our results can be easily verified and they are also less restrictive than previously known criteria and can be applied to Cohen-Grossberg neural networks, recurrent neural networks, and cellular neural networks. Finally, the proposed stability conditions are demonstrated with numerical examples.

关键词： Cohen-Grossberg neural networks global asymptotic stability linear matrix inequality Lyapunovfunctional time-varying delays

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survey and technological analysis of laser and its defense applications

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Defence Technology（防务技术） 2021年第2期17卷 583-592页

作者： syed Affan Ahmed Mujahid Mohsin syed Muhammad Zubair ali Department of Avionics Engineering-College of Aeronautical Engineering(CAE) National University of Sciences and Technology(NUST)RisalpurKPKPakistan

The laser technology has made remarkable progress over the past couple of *** is being widely employed in diverse domains,such as holography,space sciences,spectroscopy,medical sciences,micro and power electronics,industrial engineering,and most distinctively,as directed energy military *** to their active transmissions,laser systems are similar to microwave radars to some extent;however,unlike conventional radars,the laser operates at very high frequencies thus making it a potent enabler of narrow-beam and high energy aerial deployments,both in offensive and defensive *** modern avionics systems,laser target indicators and beam riders are the most common devices that are used to direct the Laser Guided Weapons(LGW)accurately to the ground ***,compact size and outstanding angular resolution of laser-based systems motivate their use for drones and unmanned aerial ***,the narrow-beam divergence of laser emissions offers a low probability of intercept,making it a suitable contender for secure transmissions and safety-critical ***,the developments in space sciences and laser technology have given synergistic potential outcomes to use laser systems in space *** paper comprehensively reviews laser applications and projects for strategic defense actions on the ground or in ***,a detailed analysis has been done on recent advancements of the laser technology for target indicators and *** also reviews the advancements in the field of laser communications for surveillance,its earlier state of the art,and ongoing scientific research and advancements in the domain of high energy directed laser weapons that have revolutionized the evolving military *** offering a comprehensive taxonomy,the paper also critically analyzes some of the recent contributions in the associated domains.

关键词： Laser systems Laser military applications Directed energy weapons Non-lethal weapons Laser military projects survey Taxonomy

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Robust H_∞ control for uncertain Markovian jump systems with mixed delays

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Chinese Physics B 2016年第7期25卷 108-113页

作者： R saravanakumar M syed ali Department of Mathematics Thiruvalluvar University

We scrutinize the problem of robust H∞control for a class of Markovian jump uncertain systems with interval timevarying and distributed delays. The Markovian jumping parameters are modeled as a continuous-time finite-state Markov chain. The main aim is to design a delay-dependent robust H∞control synthesis which ensures the mean-square asymptotic stability of the equilibrium point. By constructing a suitable Lyapunov–Krasovskii functional（LKF）, sufficient conditions for delay-dependent robust H∞control criteria are obtained in terms of linear matrix inequalities（LMIs）. The advantage of the proposed method is illustrated by numerical examples. The results are also compared with the existing results to show the less conservativeness.

关键词： linear matrix inequality Lyapunov method Markovian jumping parameters robust H∞ control

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Potassium ferro-cyanide trihydrate complex catalyzed one-pot synthesis of 2-phenylimidazo[4,5-f][1,10] phenanthroline

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Chinese Chemical Letters 2011年第7期22卷 793-796页

作者： syed shahed ali Organic Laboratory Department of Sir Sayyed CollegeDr.Babasaheb Ambedkarb Marathwada UniversityAurangabad 431001India

Various 2-phenylimidazo [4,5-f] [1,10] phenanthrolines were synthesized from potassium ferro-cyanide trihydrate （KFCT） complex catalyzed three component reaction of 1,10-phenanthroline-5,6-dione, aromatic aldehydes and ammonium acetate at room temperature in excellent isolated yield. This is a simple and straight forward, high yielding, not involving any hazardous or expensive catalyst method.

关键词： 2-Phenylimidazo [4,5-f] phenanthrolines Aromatic aldehyde K4[Fe(CN)6]·3H2O Ammonium acetate

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sTOCHAsTIC sTABILITY OF UNCERTAIN RECURRENT NEURAL NETWORKs WITH MARKOVIAN JUMPING PARAMETERs

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Acta Mathematica scientia 2015年第5期35卷 1122-1136页

作者： M.syed ali Department of Mathematics Thiruval luvar University

In this paper, global robust stability of uncertain stochastic recurrent neural networks with Markovian jumping parameters is considered. A novel Linear matrix inequal- ity（LMI） based stability criterion is obtained to guarantee the asymptotic stability of uncertain stochastic recurrent neural networks with Markovian jumping parameters. The results are derived by using the Lyapunov functional technique, Lipchitz condition and s-procuture. Finally, numerical examples are given to demonstrate the correctness of the theoretical results. Our results are also compared with results discussed in [31] and [34] to show the effectiveness and conservativeness.

关键词： Lyapunov functional linear matrix inequality Markovian jumping parameters recurrent neural networks

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